enkephalin (PES200) / Virpax Pharma - LARVOL DELTA

MOUSE MODELS FOR NEUROINFLAMMATORY AND NEURODEGENERATIVE DISEASES (ADPD 2024) - " A microdialysis probe (PP-PES200 2/3, CRL, the Netherlands) or a microperfusion cannula (Joanneum Research) was positioned in the right cortex of adult male C57Bl/6J mice and an ICV cannula in left ventricle... Our research has demonstrated that neuroinflammation of mouse brain tissue, without any major peripheral effects is feasible in a reproducible fashion both in an acute setting and in freely-moving cannulated animals. Microdialysis and microperfusion in mouse brain tissue will require further experimental optimization to establish a robust in vivo mouse model for the development of drugs that target neuroinflammatory processes."

Preclinical • CNS Disorders • Inflammation • IL1B