zolpidem sublingual / Generic mfg. - LARVOL DELTA

Editorial for "Sublingual Zolpidem for MRI in Claustrophobic Patients: A Prospective, Non-Randomized Noninferiority Study". (PubMed, J Magn Reson Imaging) - No abstract available

Head-to-Head • Journal

Sublingual Zolpidem Spray for Refractory Catatonia: A Case Report. (PubMed, Hosp Pharm) - "Treatment with lorazepam was initiated and gradually escalated to 12 mg/day over 2 weeks, resulting in only transient improvement. The sublingual spray formulation offers rapid absorption and ease of administration. This case highlights the potential utility of zolpidem sublingual spray as an effective treatment option for refractory catatonia and highlights the need for further research to establish its efficacy and safety."

Journal • Psychiatry

Sublingual Zolpidem for MRI in Claustrophobic Patients: A Prospective, Non-Randomized Noninferiority Study. (PubMed, J Magn Reson Imaging) - "Sublingual zolpidem was noninferior to conventional intravenous sedation for MRI completion in selected claustrophobic adults, demonstrating favorable safety and substantially lower procedural cost."

Head-to-Head • Journal • Anesthesia

The Effects of Castration on the Pharmacokinetics of Zolpidem After Single Dose Administration In Men With Prostate Cancer Undergoing Androgen Deprivation Therapy Compared to Normal Healthy Females (clinicaltrials.gov) - P1 | N=12 | Terminated | Sponsor: National Cancer Institute (NCI) | Completed ➔ Terminated; Slow/insufficient accrual

Trial termination • Genito-urinary Cancer • Oncology • Solid Tumor

Enhancing Memory Consolidation in Older Adults (clinicaltrials.gov) - P4 | N=10 | Terminated | Sponsor: University of California, Irvine | The new lab was not adequately equipped to handle the sleep research and it was too far from the main lab. Funding was running out.

Enrollment change • Trial termination

Drugs for chronic insomnia. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Insomnia • Sleep Disorder

Expanded table: Some oral drugs for chronic insomnia. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Insomnia • Sleep Disorder

Safety and Efficacy of Zolpidem in the Long-Term Treatment of Insomnia (clinicaltrials.gov) - P3 | N=358 | Not yet recruiting | Sponsor: EMS

New P3 trial • CNS Disorders • Insomnia • Sleep Disorder

Daridorexant (Quviviq) for insomnia. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Insomnia • Sleep Disorder

[VIRTUAL] Lipidome signatures of higher BMI and systemic inflammation in pregnant African American women (Fertility 2021) - "Higher levels of lipid species diglyceride(DG) DG(40:5), phosphatidylcholine(PC) PC 16:0, PC(O-47:2), PC(Ox26:0), triglyceride(TG) TG(49:1) TG(49:2), TG(55:6), TG(57:9), TG(64:7), and TG(66:9) were associated with the higher BMI group, whereas PC(O-37:3), PC(Ox22:00), fatty acid(FA) FA23:3, FA23:4, phosphatidylethanolamine(PE) PE(20:0), and PE(30:0) were associated with the lower BMI group... Maternal BMI and inflammatory markers are related to lipidomic profiles and detailed investigation of these markers may lead to identification of the metabolic pathways associated with higher BMI and systemic inflammation among pregnant African American women."

Clinical • Cardiovascular • Diabetes • Genetic Disorders • Immunology • Inflammation • Metabolic Disorders • Obesity • Oncology • CRP • CXCL8 • IL10 • IL6 • TNFA

Aytu BioScience announces first ZolpiMist clinical study results demonstrating more rapid sleep onset with lingual spray zolpidem versus oral tablet (Market Watch) - "Aytu BioScience...announced today the publication of a clinical study in the journal Pharmacy and Pharmacology, demonstrating that ZolpiMist, Aytu BioScience's lingual spray formulation of zolpidem, achieves sleep onset more quickly than the oral tablet form of zolpidem...in patients seeking short-term treatment for insomnia."

Retrospective data