ondansetron / Generic mfg. - LARVOL DELTA

Study to Assess Safety and Tolerability of KarXT With Administration of Antiemetics in Healthy Volunteers (clinicaltrials.gov) - P4 | N=225 | Recruiting | Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company | Not yet recruiting ➔ Recruiting

Enrollment open

Modulation of the serotonergic system affects ventilation parameters and activity of respiratory nerves in a streptozotocin-induced Alzheimer's disease rat model. (ERS 2026) - "After 3 weeks, plethysmography experiments with fluoxetine (FLX, selective serotonin reuptake inhibitor) were conducted under conditions of normoxia, hypoxia and hypercapnia. Afterward, activity of hypoglossal and phrenic nerves was measured in anaesthetized rats during hypoxia before and after treatment with ondansetron (5-HT3 receptor antagonist)... Stimulation of the serotonergic system during hypoxia and hypercapnia, eliminates differences in minute ventilation between the study groups, suggesting its therapeutic potential. 5-HT3 receptor inhibition affected respiratory nerves activity only in STZ rats, which may be associated with an increased incidence of sleep apneas in AD. The study was funded by the National Science Centre 2022/45/B/00221."

Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Apnea • Sleep Disorder

Association of Gestational Maternal Medications and Microtia Incidence (AAO-HNSF 2026) - "Several opioids were positively associated with microtia, including morphine (1.35, 95% CI: 1.28-1.42) and hydromorphone (OR: 1.15, 95% CI: 1.06 – 1.24). Betamethasone (OR 1.63, 95% CI: 1.51-1.76), metoclopramide (OR: 1.25, 95% CI: 1.18-1.32), ondansetron (OR: 1.10, 95% CI: 1.03 – 1.17), gabapentin (OR: 1.23, 95% CI: 1.05 – 1.44) and nitrofuran derivatives (OR: 1.14, 95% CI: 1.05 – 1.23) were also associated with higher microtia incidence. Fluoxetine (OR: 0.66, 95% CI: 0.53 – 0.83), doxylamine (OR: 0.77, 95% CI: 0.70 – 0.85), lamotrigine (OR: 0.57, 95% CI: 0.39 – 0.83), hydrocodone (OR: 0.90, 95% CI: 0.85 – 0.96), oxycodone (OR: 0.90, 95% CI: 0.84 – 0.96), and fentanyl (OR: 0.78, 95% CI: 0.73 – 0.83) were associated with lower odds of microtia incidence... This analysis suggests several gestational medications associated with increased odds of microtia in patients. Further clinical investigation is warranted to differentiate between maternal conditions and environmental..."

Cisplatin Disposition and Kidney Injury (clinicaltrials.gov) - P3 | N=45 | Active, not recruiting | Sponsor: University of Colorado, Denver | N=72 ➔ 45

Enrollment change • Renal Disease

Stability Evaluation of Compounded Multidrug Oral Liquids in a Dual-Vehicle Suspending System. (PubMed, Int J Pharm Compd) - "This study evaluated the chemical, physical, and microbiological stability of formulations containing topiramate, omeprazole, gabapentin, ondansetron, and levofloxacin prepared in Flavor Sweet™ SF and Flavor Plus™, also known as Syra Sweet™ SF and Syra Plus™. All formulations showed consistent pH and acceptable microbiological quality, although precipitation in some samples led to discontinuation of analysis. These results support the suitability of the vehicle system and highlight the importance of formulation parameters in stability and beyond-use dating."

Journal

SOGC Clinical Practice Guideline No. 471: Alcohol and Pregnancy. (PubMed, J Obstet Gynaecol Can) - "RECOMMENDATIONS: (Recommendations IN BOLD are new to this guideline update; an overview of the updated supporting literature for all recommendations is provided in Appendix B)."

Clinical guideline • Journal • Addiction (Opioid and Alcohol) • Obstetrics

Real-World Efficacy and Safety of Selinexor, Bortezomib, and Dexamethasone (Svd) Utilizing a Novel Dose Ramp-Up Strategy in Lenalidomide-Refractory Multiple Myeloma (IMS 2026) - "Antiemetic prophylaxis with ondansetron was mandated for all patients. A selinexor dose ramp-up approach, coupled with routine antiemetic prophylaxis, radically improves the tolerability profile of the SVd regimen, effectively eliminating nausea and minimizing high-grade thrombocytopenia. In a difficult-to-treat, lenalidomide-refractory population, this optimized dosing strategy yielded a 100% ORR ( with 4/8 achieving CR ), substantially outperforming the 67.9% ORR seen in the BOSTON trial's lenalidomide-refractory cohort. Furthermore, positioning SVd in anti-CD38-naive patients fills a critical clinical gap, offering a highly effective, tolerable, and innovative sequencing approach for early RRMM, including reliable utility as a bridge to ASCT."

Clinical • Real-world • Real-world effectiveness • Real-world evidence • Cardiovascular • Coronary Artery Disease • Heart Failure • Hematological Disorders • Hematological Malignancies • Multiple Myeloma • Myocardial Infarction • Thrombocytopenia

Primary analysis of the phase 3 randomized trial of selinexor and lenalidomide versus lenalidomide alone as maintenance therapy post autologous stem cell transplant for patients with newly diagnosed multiple myeloma (ALLG MM23; SEALAND) (ASH 2025) - P3 | "Introduction:Selinexor (S) is an oral selective exportin 1 inhibitor approved in relapsed multiple myeloma (MM) incombination with bortezomib (V) and dexamethasone (d)...Patients received ondansetron 8mg immediately prior to, and 8-hours following each S dose.Additional ondansetron and low-dose olanzapine were used as required for break-through nausea andvomiting...In this randomized phase III study, the addition of low-dose S to R maintenance following ASCT did notresult in a significant PFS benefit compared to R alone in NDMM. Although a higher CR rate was observedwith SR, this came at the cost of increased toxicity, including more infections, cytopenias andgastrointestinal AEs. Quality of life, as assessed by EORTC QLQ-C30 and MY20, was comparable betweenarms."

Clinical • P3 data • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Infectious Disease • Multiple Myeloma • Neutropenia • Thrombocytopenia • Transplantation • XPO1

The effect of dexmedetomidine versus saline placebo combined with esketamine on postpartum depression in patients undergoing cesarean section (ChiCTR) - P=N/A | N=306 | Not yet recruiting | Sponsor: Women and Children's Medical Center Affiliated to Guangzhou Medical University; Women and Children's Medical Center Affiliated to Guangzhou Medical Un | Initiation date: Feb 2026 ➔ Jul 2026

Trial initiation date • CNS Disorders • Depression • Mood Disorders • Postpartum Depression • Psychiatry

Vitamin B6 for Preventing Nausea and Vomiting After Primary Total Joint Replacement Surgery (ChiCTR) - P=N/A | N=240 | Not yet recruiting | Sponsor: West China Hospital of Sichuan University; West China Hospital of Sichuan University

New trial • Orthopedics

Biased μ-opioid receptor agonist tegileridine for postoperative analgesia after gynecologic laparoscopy or abdominal surgery: a prospective, double-blind, randomized controlled trial (ChiCTR) - P=N/A | N=124 | Not yet recruiting | Sponsor: Maternal and Child Health Hospital of Jiangxi Province; Maternal and Child Health Hospital of Jiangxi Province

New trial

Antiemetic-Associated QT Prolongation: A Clinical Review and Risk-Stratified Prescribing Framework for Long QT Syndrome. (PubMed, Eur Heart J Cardiovasc Pharmacother) - "Antiemetic-associated arrhythmia is largely preventable. Structured risk assessment, electrolyte correction, ECG monitoring, and a stepwise selection strategy favouring agents with minimal QT liability allow clinicians to manage nausea and vomiting safely, even in high-risk populations."

Journal • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Migraine • Pain • KCNH2

Multimodal Analgesia Effect on Post Surgical Patient (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: University of California, Davis | Active, not recruiting ➔ Completed

Trial completion • Genetic Disorders • Obesity

Lateral Semicircular Canal Occlusion in Patients with Refractory Meniere's Disease. (PubMed, J Int Adv Otol) - "Lateral semicircular canal occlusion seems to be an effective surgical option for patients with refractory Meniere's disease."

Journal • Anesthesia • Otorhinolaryngology • Vertigo

Addition of lidocaine to prophylactic ondansetron and dexamethasone in high-risk adults for postoperative nausea and vomiting: a randomized, controlled, double-blinded study. (PubMed, Ann Med Surg (Lond)) - "No adverse events were observed during the trial. In high-risk patients, the addition of lidocaine to ondansetron and dexamethasone effectively reduced the incidence of postoperative nausea and vomiting and improved the quality of recovery."

Journal • Anesthesia

Treating Intractable Nausea and Vomiting in Cerebellar and Medullary Stroke. (PubMed, Cureus) - "Ondansetron and metoclopramide provided only limited or temporary relief. Symptoms improved after sequential escalation to ondansetron, chlorpromazine, prochlorperazine, and amitriptyline; transdermal scopolamine was included in the discharge regimen...Because multiple medications were introduced over a short interval and natural neurologic recovery may have contributed, the effect of any individual agent or combination cannot be determined. This case suggests that receptor-diverse pharmacotherapy may be considered when initial treatment fails while underscoring the need for further study of efficacy, safety, and medication sequencing."

Journal • Cardiovascular • Diabetes • Gastrointestinal Disorder • Metabolic Disorders

A Double-Blinded Randomized Trial Comparing Dexamethasone to Ondansetron as the First-Line Antiemetic After Cesarean Delivery. (PubMed, Anesth Analg) - "We found no differences in the number of medications used to treat pain, nausea, or pruritus in the first 24 hours after cesarean delivery between women who received either ondansetron or dexamethasone. We also found no difference in pain despite prior research showing improvement with dexamethasone, which may be due to the low pain scores and rate of breakthrough postoperative pain in our study."

Clinical • Journal • Anesthesia • Dermatology • Pain • Pruritus

Effect of Intravenous Pantoprazole on Clinical Outcomes in Pediatric Acute Gastroenteritis: A Placebo-Controlled RCT. (PubMed, Pediatr Emerg Care) - "Intravenous pantoprazole does not reduce vomiting or improve oral tolerance in children with acute gastroenteritis. Furthermore, it is associated with longer hospital stays. Empirical PPI use in this setting is not supported by current evidence."

Clinical data • Journal • Gastroenterology • Gastrointestinal Disorder • Pediatrics

Palliative radiotherapy versus best supportive care in patients with painful hepatic cancer (CCTG HE1): a multicentre, open-label, randomised, controlled, phase 3 study. (PubMed, Lancet Oncol) - P=N/A | "Single-fraction radiotherapy plus best supportive care improved pain compared with best supportive care alone in patients with liver cancer, and could be considered a standard palliative treatment."

Journal • P3 data • Gastrointestinal Cancer • Hepatocellular Cancer • Hepatology • Liver Cancer • Oncology • Pain • Palliative care • Solid Tumor

Comment on: Preoperative ondansetron lozenge for prevention of postoperative nausea and vomiting in pediatrics undergoing squint surgeries: a randomized controlled trial. (PubMed, Minerva Anestesiol) - No abstract available

Journal • Pediatrics • Strabismus

Association of common QT-prolonging medications with arrhythmic risk in patients with bundle branch block: A stratified cohort analysis in left bundle branch block vs. right bundle branch block phenotypes. (PubMed, Heart Lung) - "Common non-cardiac QT-prolonging medications were not associated with increased risk in patients with BBB, even with prolonged QTc. The divergence between composite and sensitivity results for amiodarone highlights the influence of confounding by indication. Medication alerts should incorporate stratification by drug class rather than QTc alone."

Journal • Cardiovascular • CNS Disorders • Congestive Heart Failure • Critical care • Heart Failure

Primary Care Ondansetron Use and Subsequent Emergency Department Utilization in Children With Acute Gastroenteritis. (PubMed, J Paediatr Child Health) - "Outpatient ondansetron prescription during PC visits for paediatric AGE was not associated with reduced ED utilization within 7 days. These findings should not be interpreted as evidence that ondansetron lacks clinical benefit but rather that downstream healthcare utilization is influenced by factors beyond symptom control alone. Ondansetron should continue to be considered an adjunct to oral rehydration therapy in appropriately selected children with AGE."

Journal • Gastroenterology • Gastrointestinal Disorder • Pediatrics

Pharmacology of Commonly Used Sedative Agents. (PubMed, Dent Clin North Am) - "The article discusses commonly used sedative and adjunct medications, including midazolam, remimazolam, propofol, ketamine, opioids such as fentanyl and remifentanil, and supportive drugs like dexmedetomidine, diphenhydramine, atropine, glycopyrrolate, and ondansetron. Newer agents such as remimazolam and ketofol combinations may offer improved safety and recovery profiles. Overall, the article emphasizes individualized patient care and thorough pharmacologic knowledge to ensure safe and effective outpatient dental sedation."

Journal • Review • Anesthesia • CNS Disorders • Depression • Mood Disorders • Pain • Psychiatry

Comparison of enhanced recovery after surgery protocol and standard protocol for cesarean delivery: A two-center, double-blind, randomized controlled trial. (PubMed, Int J Surg) - "The ERAC bundle included: preoperative personalized and information-based education; intraoperative prophylactic phenylephrine infusion, mandatory non-opioid analgesia (intravenous acetaminophen and ketorolac), prophylaxis for postoperative nausea and vomiting (ondansetron/dexamethasone), and active fluid warming; and postoperative scheduled ketorolac. No significant differences were found in pain at rest, length of stay, or anxiety scores. An anesthesiologist-led, bundled ERAC protocol significantly reduced perioperative adverse events and enhanced the quality of recovery after elective cesarean delivery compared to conventional care."

Journal • Anesthesia • Dermatology • Hypotension • Pain • Pruritus • Psychiatry

Acute Pediatric Toxic Ingestion of Automotive Grease: Full Remission via Conservative Management. (PubMed, Int Med Case Rep J) - "Significant improvement was observed following the administration of ondansetron and prednisolone. This is a rare and significant clinical presentation of pediatric ingestion of automotive grease with successful conservative management. The case emphasizes the importance of timely intervention and meticulous follow-up in managing unusual toxic exposures in emergency settings."

Journal • Gastroenterology • Gastrointestinal Disorder • Pain • Pediatrics