C2C_ASC110 / Cell2Cure ApS - LARVOL DELTA

ARIISE: ASCs in Recently Diagnosed Non-ischemic Heart Failure (clinicaltrials.gov) - P2 | N=0 | Withdrawn | Sponsor: Cell to Cure ApS | N=90 ➔ 0 | Completed ➔ Withdrawn

Enrollment change • Trial withdrawal • Cardiovascular • Congestive Heart Failure • Heart Failure

ARIISE: ASCs in Recently Diagnosed Non-ischemic Heart Failure (clinicaltrials.gov) - P2 | N=90 | Completed | Sponsor: Cell to Cure ApS | Not yet recruiting ➔ Completed

Trial completion • Cardiovascular • Congestive Heart Failure • Heart Failure

Adipose tissue-derived mesenchymal stromal cell therapy in nonischemic heart failure with reduced ejection fraction - ARIISE study design. (PubMed, Future Cardiol) - P2 | "ARIISE is a Danish, multicenter, randomized, double-blinded, placebo-controlled study evaluating the efficacy and safety of intravenous allogeneic ASC therapy (C2C_ASC110) in patients with NIHF and reduced left ventricular ejection fraction (LVEF ≤ 45%). Secondary endpoints include other echocardiographic measurements, functional capacity, biomarkers, quality of life (QOL), and safety outcomes. If successful, ARIISE may establish clinical evidence for intravenous ASC therapy as a safe, feasible, and effective regenerative treatment for patients with NIHF.Clinical trial registration: EU CT number: 2025-520837-22-00, UTN number: U1111-1315-7011, Clinicaltrials.gov number: NCT06840275."

Clinical • Journal • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Immunology • Inflammation

ARIISE - ASCs in recently diagnosed non-ischemic heart failure (clinicaltrialsregister.eu) - P1/2 | N=90 | Not yet recruiting | Sponsor: Cell2Cure ApS

New P1/2 trial • Cardiovascular • Congestive Heart Failure • Heart Failure

An open label safety and efficacy study of allogenic adipose tissue-derived mesenchymal stromal cells on autism and gastrointestinal symptoms (clinicaltrialsregister.eu) - P1 | N=40 | Sponsor: Cell to Cure ApS

New P1 trial • Autism Spectrum Disorder • Genetic Disorders

ARIISE: ASCs in Recently Diagnosed Non-ischemic Heart Failure (clinicaltrials.gov) - P2 | N=90 | Not yet recruiting | Sponsor: Cell2Cure ApS

New P2 trial • Cardiovascular • Congestive Heart Failure • Heart Failure