Dulera (mometasone/formoterol) / Novartis, Organon - LARVOL DELTA

Treatment for Mild Asthma: What Matters to Providers (ACAAI 2025) - "Specialists were more likely to utilize MART therapy than generalists (budesonide/formoterol: 62.5% vs. 60.0% p 0.002, mometasone/formoterol 58.5% vs. 34.8% p 0.019). Similarly, specialists were more likely to prescribe budesonide-albuterol for reliever therapy than generalists (20.1% vs. 4.5%, p<0.001), and attendings more than trainees (17.5% vs. 6.2%, p 0.025)...Lastly, specialists are more likely to utilize asthma action plans (63.5% vs. 43.4%, p 0.030). Conclusion Significant heterogeneity exists in the definition and treatment of mild asthma."

Asthma • Gynecology • Immunology • Obstetrics • Pediatrics • Respiratory Diseases

GRANULOMATOUS RESTRICTIVE LUNG DISEASE IN T-CELL ACTIVATION DYSFUNCTION AND HYPOGAMMAGLOBULINEMIA (CHEST 2025) - "The obstructive component of his lung disease was treated with a mometasone-formoterol combination inhaler, montelukast, cetirizine and Dupilumab, an IL-4 and IL-13 pathway inhibitor...In addition, he receives monthly IVIG infusions and bi-monthly inhaled tobramycin...GLILD treatment strategies typically include immunosuppressive agents such as glucocorticoids, rituximab, azathioprine, and mycophenolate mofetil [2]... The necrotizing nature of our patient's granulomas suggests a unique immune dysregulation mechanism, potentially involving defective granuloma resolution and chronic inflammation-driven airway remodeling. Given the absence of a confirmed genetic etiology, further molecular research is warranted to better understand the underlying immune dysfunction."

Asthma • Bronchiectasis • CNS Disorders • Endocrine Disorders • Epilepsy • Hypoparathyroidism • Immunology • Infectious Disease • Inflammation • Interstitial Lung Disease • Primary Immunodeficiency • Pulmonary Disease • Respiratory Diseases • Tuberculosis • Vasculitis • HAVCR2 • IFNG • IL13 • IL4

Trends in Single Maintenance and Reliever Therapy-congruent Prescriptions for Asthma in the United States Before and After Updated GINA Recommendations (ATS 2025) - "Despite a major paradigm shift in asthma recommendations that occurred in 2019, prescriptions for budesonide-formoterol 160-4.5µg and mometasone-formoterol 100-5µg (which could be congruent with a MART prescription) have not changed. Based on these findings, more efforts are likely needed to improve the adoption of MART in the U.S."

Clinical • Asthma • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Wheezing Child? Don't Always Incyst on Asthma (ATS 2025) - "Despite treatment with daily high dose inhaled Mometasone/Formoterol and Tiotropium, she continued to have asthma-like symptoms. She started biologic therapy with Dupilumab in August - 2023, which led to only mild improvement of lung function and respiratory symptoms...Subpleural cysts (SPC) are often associated with trisomy 21 and other inherited or acquired conditions due to altered alveolar growth. This case illustrates the importance of having high suspicion and considering atypical causes when standard treatments fail and highlights the need for a multidisciplinary approach for accurate diagnosis and management."

Clinical • Acute Respiratory Distress Syndrome • Allergic Rhinitis • Asthma • Cough • Genetic Disorders • Immunology • Inflammation • Interstitial Lung Disease • Obesity • Obstructive Sleep Apnea • Pediatrics • Pulmonary Disease • Respiratory Diseases • Rheumatology • Sleep Disorder • Vasculitis

Correct use of inhalers for asthma. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Drugs for asthma. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Comparison chart: Some inhaled drugs for treatment of asthma. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

REMISSION OF EOSINOPHILIC GASTRITIS IN A YOUNG ATOPIC FEMALE WITH DUPILUMAB FOR CONCURRENT EOSINOPHILIC ESOPHAGITIS (ACAAI 2024) - "Her asthma was better controlled with mometasone/ formoterol combination inhaler but required initiation of dupilumab (300mg q2wk) for asthma and comorbid recurrent nasal polyps. (B) Repeat biopsy six months later while on dupilumab therapy demonstrating no pathologic eosinophilic infiltration. Magnification 100x."

Clinical • Allergic Rhinitis • Asthma • Chronic Rhinosinusitis With Nasal Polyps • Eosinophilic Esophagitis • Gastrointestinal Disorder • Immunology • Inflammation • Nasal Polyps • Otorhinolaryngology • Pain • Rare Diseases • Respiratory Diseases • Sinusitis

Drugs for COPD. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections • Tobacco Cessation

Pan-positive PET-CT - Metastasis or Multisystem Sarcoidosis? (ATS 2024) - "Description A 36-year-old woman with a history of mild childhood exercise-induced asthma developed an upper respiratory infection after exposure to sick contacts, after which she developed shortness of breath with no improvement with albuterol, budesonide-formoterol and a short steroid course...She was prescribed daily prednisone, methotrexate, and mometasone-formoterol, which gradually led to improvement in shortness of breath and resolution of serum hypercalcemia...Infliximab was added to her treatment regimen with resolution of hypercalciuria. The patient subsequently had gradual onset of sarcoid arthropathy, worsened with cold exposure and is being considered for hydroxychloroquine...This patient displayed a constellation of unusual findings due to sarcoidosis, including multiple lesions mimicking metastatic neoplasm, diffuse splenic involvement, and hypercalciuria and nephrolithiasis without hypercalcemia. Biopsy is vital for accurate diagnosis and timely management..."

Asthma • Cardiovascular • Cough • Endocrine Disorders • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Oncology • Pulmonary Disease • Renal Calculi • Respiratory Diseases • Rheumatology • Sarcoidosis

Utilization of Single Maintenance and Reliever Therapy (SMART) for Moderate and Severe Asthma (ATS 2024) - "Notably, patients prescribed ICS-formoterol (Symbicort or Dulera) as a baseline controller inhaler were more likely to be prescribed SMART. SMART is under prescribed to patients who qualify, with most patients prescribed SMART concurrently being prescribed a SABA. Patients with private insurance may be more likely to be prescribed SMART than patients with public insurance. Providers may be more likely to prescribe SMART to patients using ICS-formoterol as a controller inhaler compared to other controllers, and these patients may be more open to a SMART prescription."

Clinical • Allergy • Asthma • Genetic Disorders • Immunology • Obesity • Pulmonary Disease • Respiratory Diseases

New Onset Severe Asthma in a College Student? (ATS 2024) - "At time of referral was being treated with mometasone/formoterol 200/5mcg and as needed albuterol...They were placed on a fluticasone furoate/umeclidinium/vilanterol 200/62...Many patients find that their symptoms respond poorly to standard asthma medications. There are limited reports of anticholinergic therapies in RADS and our success may prove helpful for other clinicians."

Asthma • CNS Disorders • Cough • Depression • Immunology • Infectious Disease • Mood Disorders • Pain • Pediatrics • Psychiatry • Pulmonary Disease • Respiratory Diseases

Chronic Cough and Paroxysmal Exacerbations of Dyspnea and Hypoxemia: A Case of Allergic Bronchopulmonary Mycosis Due to Penicillium in a Child (ATS 2024) - "There was questionable improvement on medium-dose inhaled mometasone/formoterol, albuterol, and systemic corticosteroids...Our diagnosis is based on clinical symptoms, evidence of peripheral and airway allergic inflammation, markedly elevated total IgE, Penicillium-specific IgG and IgE, and isolated Penicillium in BAL fluid and the home environment. Penicillium is a possible cause of ABPM in children and should be considered in treatment-refractory chronic cough."

Clinical • Allergic Bronchopulmonary Aspergillosis • Allergy • Chronic Cough • Cough • Dermatology • Eosinophilia • Immunology • Inflammation • Pediatrics • Pulmonary Disease • Respiratory Diseases

Central Adrenal Insufficiency from Inhaled Mometasone Manifesting as Growth Deceleration (ENDO 2024) - "She also took cetirizine daily and albuterol as needed...A growth hormone stimulation test with arginine and clonidine was performed...She was diagnosed with central adrenal insufficiency and prescribed 11 mg/m2 BSA/day of hydrocortisone divided three times daily, with stress dosing and emergency hydrocortisone injection instructions. The existing literature suggests that Dulera (mometasone furoate and formoterol fumarate) does not significantly influence adrenal function nor growth velocity... The existing literature suggests that Dulera (mometasone furoate and formoterol fumarate) does not significantly influence adrenal function nor growth velocity. However, we present the case of a child with 3 years of inhaled Dulera use and significant central adrenal insufficiency. This case report is the first of its kind to detail decreased adrenal function with Dulera in particular.Unless otherwise noted, all abstracts presented at ENDO must not be released to the press or the..."

Asthma • Endocrine Disorders • Fatigue • Immunology • Nephrology • Pain • Pulmonary Disease • Renal Disease • Respiratory Diseases • IGF1 • IGFBP3

Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Gelb, Arthur F., M.D. | Trial completion date: Jun 2022 ➔ Jun 2027 | Trial primary completion date: Jun 2022 ➔ Jun 2027

Trial completion date • Trial primary completion date • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

RECURRENCE OF MRSA EMPYEMA THORACIS IN A PATIENT WITH ASTHMA ON SUCCESSIVE BIOLOGIC THERAPY WITH DUPILUMAB AND BENRALIZUMAB (CHEST 2023) - "She was treated for pneumonia a week earlier with levofloxacin...The patient has a history of severe persistent asthma and chronic sinusitis on a mometasone-formoterol inhaler for ten years...The bronchoscopy and intraoperative culture revealed methicillin-resistant Staphylococcus aureus (MRSA), and she received an extended course of trimethoprim-sulfamethoxazole...A left-sided chest tube was placed on admission, and meropenem and vancomycin were started empirically...She was started on six weeks of vancomycin and amoxicillin-clavulanic acid therapy... Our case illustrates the rare possibility of bacterial pneumonia and empyema with biologics and the risk of recurrence with continued use, irrespective of the class of biologic used."

Clinical • Asthma • Cough • Immunology • Infectious Disease • Otorhinolaryngology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Sinusitis • IL13 • IL4 • IL5

Replication of the P04334 Asthma Trial in Healthcare Claims Data (clinicaltrials.gov) - P=N/A | N=10288 | Completed | Sponsor: Brigham and Women's Hospital | Active, not recruiting ➔ Completed

Trial completion • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Asthma With Pneumonia Secondary to Influenza (ATS 2023) - "The chest-x-ray revealed a right medial infiltrate and the polymerase chain reaction was positive for Influenza A and negative for infuenza B. Tamiflu at 75 mg twice per day treated the Influenza along with rest. Ceftriaxone and azithromax treated the pneumonia. Dulera and prednisone 40 mg for 5 days treated the asthma...The chest-x-ray revealed a right medial infiltrate and the polymerase chain reaction was positive for Influenza A and negative for infuenza B. Tamiflu at 75 mg twice per day treated the Influenza along with rest. Ceftriaxone and azithromax treated the pneumonia. Dulera and prednisone 40 mg for 5 days treated the asthma...Estimating Influenza-associated deaths in the United States. AJPH 2009;99:S225-S230."

Asthma • Cough • Immunology • Infectious Disease • Influenza • Novel Coronavirus Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Chronic Obstructive Pulmonary Disease Exacerbations and Pneumonia Hospitalizations Among New Users of Combination Maintenance Inhalers. (PubMed, JAMA Intern Med) - "Combination LAMA-LABA inhalers (aclidinium-formoterol, glycopyrronium-formoterol, glycopyrronium-indacaterol, tiotropium-olodaterol, or umeclidinium-vilanterol) and combination ICS-LABA inhalers (budesonide-formoterol, fluticasone-salmeterol, fluticasone-vilanterol, or mometasone-formoterol). These findings were robust across a range of prespecified subgroup and sensitivity analyses. In this cohort study, LAMA-LABA therapy was associated with improved clinical outcomes compared with ICS-LABA therapy, suggesting that LAMA-LABA therapy should be preferred for patients with COPD."

Clinical • Journal • Asthma • Chronic Obstructive Pulmonary Disease • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

"@Merck My 82 year old mother just paid $350 for Dulera. No generic is available, not eligible for a coupon. HELP!" (@neenakdavis)

A Retrospective Review of an Inhaler to Nebulizer Therapeutic Interchange Program Across a Health System. (PubMed, J Pharm Pract) - "The first phase of implementing the SAHS inhaler to nebulizer therapeutic interchange program was operationally and clinically successful. The program is projected to continue to reduce medication waste and provide cost savings for the health system."

Journal • Retrospective data • Review • Asthma • Chronic Obstructive Pulmonary Disease • Immunology • Infectious Disease • Novel Coronavirus Disease • Pulmonary Disease • Respiratory Diseases

A 12 Year Old Male in Drug Induced Adrenal Crisis (ATS 2022) - "Patient’s medication history included a high-dose ICS, mometasone/formoterol 200/5 mcg, daily as prescribed for his severe asthma. He had received multiple courses of oral prednisone for asthma exacerbations earlier in his lifetime...Altered mental state resolved after initial steroid dose was given, and IV hydrocortisone (50 mg/5mL) was maintained every 6 hours during admission...Secondary AI in relation to chronic, high-dose ICS therapy is caused by the suppression of the hypothalamic-pituitary-adrenal function. Detailing patient history and medication usage are vital in distinguishing the types of AI."

Asthma • Endocrine Disorders • Immunology • Infectious Disease • Nephrology • Pain • Pediatrics • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases

Concomitant Use of Mepolizumab and Ixekizumab in a Patient with Severe Eosinophilic Asthma and Psoriasis: A Case Study (ATS 2022) - "She had a longstanding history of asthma and was currently treated with mometasone-formoterol metered-dose inhaler (MDI) 200 mcg/5 mcg 2 inhalations twice daily, tiotropium soft mist inhaler 2.5 mcg 2 inhalations once daily, and salbutamol MDI 100 mcg when necessary. This patient with severe eosinophilic asthma had no side effects after the addition ofmepolizumab. To the author’s knowledge, this is the first published report of concurrent mepolizumab and ixekizumab therapies."

Clinical • Allergy • Asthma • Dermatology • Immunology • Psoriasis • Pulmonary Disease • Respiratory Diseases • IL17A • IL5

A 56-Year-Old Man With Emphysema, Rash, and Arthralgia. (PubMed, Chest) - "Based on pulmonary function tests from an outside provider, he had received a diagnosis of exercise-induced asthma and had been prescribed an albuterol inhaler to use on an as-needed basis, which failed to improve his symptoms. He was later prescribed a mometasone-formoterol inhaler, still with no symptomatic improvement."

Journal • Alopecia • Anorexia • Asthma • Cardiovascular • Immunology • Infectious Disease • Musculoskeletal Pain • Pain • Pulmonary Disease • Respiratory Diseases • Rheumatology

ORGANON & CO. Management's Discussion and Analysis of Financial Condition and Results of Operations (form 10-Q) (Market Screener) - "Worldwide sales of Singulair, a once-a-day oral medicine for the chronic treatment of asthma and for the relief of symptoms of allergic rhinitis, increased 22% in the third quarter of 2021...Singulair sales in the first nine months of 2021 decreased 11% primarily attributable to the impact of VBP in China...Global sales of Dulera, a combination medicine for the treatment of asthma, decreased 5% in the third quarter of 2021 primarily due to higher discount rates in the United States. For the first nine months of 2021, global sales of Dulera decreased 19% largely due to significant buy-in during 2020 related to the COVID-19 pandemic..."

Sales • Asthma • Respiratory Diseases