REGPARA / Kyowa Kirin - LARVOL DELTA

GENETIC BIOMARKERS PREDICTING PROGNOSIS IN PATIENTS WITH CHOLANGIOCARCINOMA; A BIOINFORMATICS APPROACH STUDY (DDW 2024) - "After reviewing ENRICHER dataset these genes are potential targets for certain pharmacologic options such as Cladribine Amsacrine Etoposide and Fulvestrant. Identification of certain genes by bioinformatic approach can optimize prognostication in patients with CC. It also shed light into mechanistic pathways and suggest potential pharmacologic targets for management of CC."

Biomarker • Clinical • Biliary Cancer • Cholangiocarcinoma • Gastrointestinal Cancer • Oncology • Solid Tumor • ANLN • ER • PLAU

Influence of the TNFα/ TNFα Receptor Axis on Human Kidney Graft Survival (ATC 2024) - "TNF-α/CD120a/CD120b/TACE balance is critical in the long-term survival of rejection-free kidney allografts."

Transplant Rejection • Transplantation • ADAM17 • FOXP3 • TLR4 • TNFA • TNFRSF1A • TNFRSF1B

Noise-Adaptive Non-Blind Image Deblurring. (PubMed, Sensors (Basel)) - "The system is shown to operate well for input noise in a three orders of magnitude range (0.01-10.0) and a wide spectrum of 1D or 2D Gaussian blur kernels, well outside the scope of most previously explored image blur and noise degrees. The proposed method is found to significantly outperform several leading state-of-the-art approaches."

Journal

Cinacalcet Versus Parathyroidectomy in Peritoneal Dialysis Patients (clinicaltrials.gov) - P4; N=67; Completed; Sponsor: The University of Hong Kong; Recruiting ➔ Completed; Phase classification: PN/A ➔ P4

Clinical • Phase classification • Trial completion • Endocrine Disorders • Renal Disease • Secondary Hyperparathyroidism

MicroRNA related prognosis biomarkers from high throughput sequencing data of kidney renal clear cell carcinoma. (PubMed, BMC Med Genomics) - "The current study provided novel insights into the miRNA related mRNA network in KIRC and those 2 DEGs biomarkers and 3 DEMs biomarkers may be independent prognostic signatures in predicting the survival of KIRC patients."

Biomarker • Journal • Clear Cell Renal Cell Carcinoma • Oncology • Renal Cell Carcinoma • Solid Tumor • MIR21 • MIR223

MicroRNA-Related Prognosis Biomarkers from High-Throughput Sequencing Data of Colorectal Cancer. (PubMed, Biomed Res Int) - "In this study, we firstly downloaded miRNA (COAD, 8 controls vs. 455 tumors; READ, 3 controls vs. 161 tumors) and mRNA (COAD, 41 controls vs. 478 tumors; READ, 10 controls vs. 166 tumors) data from The Cancer Genome Atlas (TCGA) database and then used DESeq2, RegParallel, miRDB, TargetScanHuman 7.2, DAVID 6.8, STRING, and Cytoscape software to identify the potential prognosis biomarkers. In this study, we found several candidate prognostic biomarkers which have been identified in various cancers and also found several new prognosis biomarkers of COAD and READ. In conclusion, this analysis based on theoretical knowledge and clinical outcomes we have done needs further confirmation by more researches."

Biomarker • Journal • Colorectal Adenocarcinoma • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Efficacy and Safety of Cinacalcet in Ca, P and iPTH Levels in Patients With Mild, Moderate and Severe SHPT (clinicaltrials.gov) - P4; N=750; Completed; Sponsor: Kyowa Hakko Kirin China Pharmaceutical Co., LTD.; Active, not recruiting ➔ Completed; Trial primary completion date: Aug 2019 ➔ Apr 2019

Clinical • Trial completion • Trial primary completion date • FGF23

ACTIVE: Efficacy and Safety of Cinacalcet in Ca, P and iPTH Levels in Patients With Mild, Moderate and Severe SHPT (clinicaltrials.gov) - P4; N=750; Active, not recruiting; Sponsor: Kyowa Hakko Kirin China Pharmaceutical Co., LTD.; Recruiting ➔ Active, not recruiting; Trial primary completion date: Apr 2019 ➔ Aug 2019

Clinical • Enrollment closed • Trial primary completion date