lofepramine / Generic mfg. - LARVOL DELTA

Dopamine receptor D2 modulates the pathways mediating estrogen-induced thrombosis (ISTH 2025) - "Lofepramine, the neuroactive hit with the largest anti-thrombotic effect against mestranol, was used for subsequent experiments...This excluded the possibility that inhibition of dopaminergic neurons of the enteric nervous system simply affects mestranol absorption. Table or Figure Upload"

Cardiovascular • Gastrointestinal Disorder • Hematological Disorders • Thrombosis • DRD2

The cardiovascular safety of tricyclic antidepressants in overdose and in clinical use. (PubMed, Ther Adv Psychopharmacol) - "Amitriptyline, clomipramine, dothiepin/dosulepin, doxepin, trimipramine and imipramine showed broadly similar toxicity and were usually reported to be less toxic than desipramine...With respect to the risk of cardiovascular events at clinically relevant exposure, amitriptyline, nortriptyline and lofepramine were associated with a greater risk of in-use cardiotoxicity. All measures of overdose toxicity were subject to external influences and confounding. The continued use of TCAs in depression and other conditions should be minimized when considering their undoubted toxicity in overdose and possible toxicity in normal clinical use."

Journal • Review • Cardiovascular • CNS Disorders • Depression • Psychiatry

Tricyclic antidepressants versus 'active placebo', placebo or no intervention for adults with major depressive disorder: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis. (PubMed, Syst Rev) - "Tricyclic antidepressants are recommended by clinical guidelines and frequently used worldwide in the treatment of major depressive disorder. There is a need for a thorough systematic review to provide the necessary background for weighing the benefits against the harms. This review will ultimately inform best practice in the treatment of major depressive disorder."

Journal • Retrospective data • Review • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry

Beneficial and harmful effects of antidepressants versus placebo, 'active placebo', or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses. (PubMed, Syst Rev) - "As antidepressants are commonly used to treat major depressive disorder in adults, a systematic review evaluating their beneficial and harmful effects is urgently needed. This review will inform best practice in treatment and clinical research of this highly prevalent and burdensome disorder."

Clinical • Journal • Review • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • Suicidal Ideation

These drugs could be subject to shortages after Brexit, according to Norwich medics (Eastern Daily Press) - "Following more Brexit debacles in parliament last week, the entrepreneurs have published a list of medications which could be subject to shortages post-Brexit. It includes: high blood pressure, or hypertension, medications such as telmisartan, valsartan and nebivolol; anti-depressants such as sertraline, dosulepin and citalopram and anti-psychotic drugs; medications used to slow the development of Parkinson's disease; medications for epilepsy, arthritis and insomnia; and steroids, antibiotics and antiviral drugs."

Commercial

"As would lofepramine. The mechanism for some TCAs eg nortriptyline beguiles me. Re reboxerine - Dr Turner, v astute." (@sameerjauhar)

Antidepressants and Hyponatremia in a patient with Colectomy - a Case Report. (PubMed, Psychiatr Danub) - "...He was restarted on Paroxetine and the dose was increased up to 50 mg along with Olanzapine 15 mg per day. As he did not improve, he was switched to Sertraline with which he developed Hyponatremia. Further to this, he was tried on Venlafaxine and Lofepramine and he developed Hyponatremia with both of them...Fluoxetine augmentation at this stage by the GP led to another episode of Hyponatremia...Recently, he has been started on Vortioxetine and the dose has been titrated to 15 mg OD and in addition, he is on Mirtazapine 45 mg OD and Aripiprazole 5 mg OD...This is the first time we have come across a patient with colectomy developing severe Hyponatremia. In this article, we have discussed possible reasons for Hyponatremia following colectomy and the management strategies that could help."

Clinical • Journal