caflanone (FBL-03G) / Flavocure Biotech - LARVOL DELTA

Biomarkers. (PubMed, Alzheimers Dement) - "Results demonstrate precision delivery of Caflanone labeled liposomes bearing an MRI diagnostic payload to activated microglia in three different mouse models of neurodegenerative disorders. These nanoparticles can also deliver a therapeutic payload with similar precision, opening a new frontier for the development of both diagnostics and therapeutics for neuroinflammation."

Biomarker • Journal • Alzheimer's Disease • CNS Disorders • Inflammation • Movement Disorders • Parkinson's Disease • CSF1 • CSF1R

Alzheimer's Imaging Consortium. (PubMed, Alzheimers Dement) - "Results demonstrate precision delivery of Caflanone labeled liposomes bearing an MRI diagnostic payload to activated microglia in three different mouse models of neurodegenerative disorders. These nanoparticles can also deliver a therapeutic payload with similar precision, opening a new frontier for the development of both diagnostics and therapeutics for neuroinflammation."

Journal • Alzheimer's Disease • CNS Disorders • Inflammation • Movement Disorders • Parkinson's Disease • CSF1 • CSF1R

Engineered multifunctional nanoparticles for enhanced radiation therapy: three-in-one approach for cancer treatment. (PubMed, Mol Cancer) - "The lipo-polymeric hybrid nanoparticles, synthesized using a modified hydrogel isolation method, were loaded with a natural plant-derived anti-cancer agent "Caflanone." These nanoparticles were further subjected to in-situ reduction for a surface coating of gold, which provided enhanced radiosensitivity, radiation triggered drug delivery and X-ray/CT imaging...A significant increase (p = 0.01) in the survival of breast tumor-bearing mice treated with a combinational approach was also demonstrated. The engineered multifunctional nanoparticles enhanced the radiation therapy and triggered the drug release at the tumor site, triggering the action of encapsulated chemotherapeutic agents while providing image guidance."

Journal • Brain Cancer • Breast Cancer • CNS Tumor • Glioblastoma • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor

Customizable Lyophilized Agent for Radiotherapy Imaging and TherapY (CLARITY). (PubMed, J Funct Biomater) - "In this study, we investigate a novel Customizable Lyophilized Agent for Radiotherapy Imaging and TherapY (CLARITY) biomaterial, which can be loaded with immunoadjuvants (anti-CD40 monoclonal antibody or Caflanone (FBL-03G)) at the point of care...A significant increase in survival (***, p = 0.0006) was observed for mice treated with CLARITY biomaterial loaded with immunoadjuvant for up to 10 weeks post-treatment compared to those without treatment. These initial results demonstrate the potential of CLARITY biomaterial to serve as a smart multifunctional radiotherapy biomaterial and provide the impetus for further development and optimization as a point-of-care technology for combination radiotherapy and immunotherapy."

IO biomarker • Journal • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor

Alternate pain management strategies: targeting pancreatic cancer-related pain with Flavonoid (AACRPanCa 2024) - "Such an acute effect occurs much more rapidly than the previously published in vitro suppression of KPC cell growth (assayed after 9-12d of treatment) or the reduction of tumor size (1-7 weeks) in vivo and suggest that the anti-hyperalgesic affect is due to mechanisms that do not involve reduction in tumor mass. The findings, using a single dose and a small number of mice, appear promising for further studies that examine a range of doses or FBL-03G and its actions in intra-pancreatic tumors."

Gastrointestinal Cancer • Hepatology • Oncology • Pain • Pancreatic Cancer • Solid Tumor