Macuneos (BIO-201) / Biophytis - LARVOL DELTA

Poster Session: Achromatic biases in noise images. (PubMed, J Vis) - "(Current Bio 2015) examined the effects of luminance on the perceived color categories selected for uniform square patches...The perceived achromatic gamut for the noise again tended to vary along bluish-yellowish directions, but was markedly broader compared to the uniform patches. The broadening of the gray category may partly reflect attributions of some of the color to the illuminant, a tendency which may be stronger in the spatially variegated patterns."

Journal

Preclinical antitumor activity of an anti-HER2/Trop-2 bispecific antibody-drug conjugate with a new DNA topoisomerase I inhibitor. (ASCO 2023) - "BIO-201 also showed similar anti-tumor activity to Herceptin-DXd. Taken together, these findings suggest that anti-HER2/Trop-2 bispecific ADC has potential as an effective therapy for a variety of cancers that co-express HER2/Trop-2 or express either of the targets. BIO-201 may be expected to have a similar clinical activity to Enhertu or Trodelvy but treat more patient sub-populations and indications."

Preclinical • Oncology

Anti-Inflammatory Effects and Photo- and Neuro-Protective Properties of BIO203, a New Amide Conjugate of Norbixin, in Development for the Treatment of Age-Related Macular Degeneration (AMD). (PubMed, Int J Mol Sci) - "9'-cis-norbixin (norbixin/BIO201) protects RPE cells against phototoxicity induced by blue light and N-retinylidene-N-retinylethanolamine (A2E) in vitro and preserves visual functions in animal models of age-related macular degeneration (AMD) in vivo...In conclusion, we report here that BIO203 and norbixin share similar modes of action and protective effects in vitro and in vivo. BIO203, with its improved pharmacokinetic and stability properties, could be developed for the treatment of retinal degenerative diseases such as AMD."

Journal • Age-related Macular Degeneration • Macular Degeneration • Ophthalmology • Retinal Disorders • CXCL8 • IL6 • NF-κβ

"Kangen bgt #BIO2019" (@ericloud__)

Oncology

"The replies 😵‍💫😵‍💫😵‍💫 Pertama kali #Ngistora di #BIO2019. Waktu itu bagiku udah mahal, tiket BLUE (VIP sekarang) di QF. Tapi memang kalau dari replies di sini jauuuuh lebih baik di 2019." (@Lrzyw)

Oncology

"Bagi yang demen bulutangkis, Indonesia Open pasti ditunggu-tunggu. #BIO2019 itu megah banget. Istora, bagian luarnya cakep banget. Banyak spot foto, buat istirahat juga enak santai di beanbag (waktu itu hamil muda)." (@Lrzyw)

Oncology

"My 1st and maybe last ngistora. 🤣🤣 #BIO2019" (@Lrzyw)

Oncology

"Ganda Putra Indonesia TAK TERKALAHKAN di turnamen Individual di Istora sejak Indonesia Masters 2018! #DIM2018 🔥 #BIO2018 🔥 #AsianGames2018 🔥 #DIM2019 🔥 #BIO2019 🔥 #DIM2020 🔥 #DIM2022 🔥🔥🔥 All hail Naga Api, Naga Air, dan Naga2 Istora" (@alfianto_ian)

Oncology

"Details of the 35 unbeaten matches: #DIM2018: 5 wins #BIO2018: 5 wins #AsianGames2018 team event: 3 wins #AsianGames2018 individual event: 4 wins #DIM2019: 5 wins #BIO2019: 5 wins #DIM2020: 5 wins #DIM2022: 3 wins, 1 loss 35-1 record in new Istora, a very incredible record!" (@BadmintonTalk)

Oncology

Missing Anatomy Background: Microlearning Can Help. (PubMed, FASEB J) - "The microlearning method is a workable technique that has a good effect on healthcare students in multiple aspects such as studying, memorizing, and performing procedures (De Gagne, 2019). In our experience, the overall satisfaction was 6.1/10. We identified many technical issues which affected the performance of the technique. We believe that this technique can help students without previous anatomy background; 73% of students responded "Content" helped achieve goals. The next step will identify a better platform and measure outcomes between groups. REF: De Gagne JC, Park HK, Hall K, Woodward A, Yamane S, Kim SS. Microlearning in Health Professions Education: Scoping Review. JMIR Med Educ. 2019;5(2):e13997. Published 2019 Jul 23. doi:10.2196/13997."

Journal

To touch or not to touch: evaluating student laboratory outcomes of hands-on versus visual examination of prosected cadavers. (PubMed, FASEB J) - "It is imperative that anatomy faculty recognize that exposure to cadaveric donors may impact the overall learning experience, as students are better prepared for identification-based practical assessments when they are encouraged to touch, handle, and manipulate anatomical structures."

Journal

Inhibiting contractility using an in vitro model of proliferative vitreoretinopathy (ARVO 2022) - "A p38 inhibitor (Comms Bio 2019; 2: 1-14) and nicotinamide (Stem Cell Rep 2020; 14: 631-647) prevented these aggressive contractile masses in RPE... Both the p38 inhibitor and nicotinamide prevented membrane contraction showing promise to become a therapeutic treatment for patients at risk of developing PVR and individuals with already formed membranes, both treatments warrant further study in an in vivo model of PVR."

Preclinical • Ophthalmology • Retinal Disorders • COL1A2 • SNAI1 • TGFB1 • TNFA

A dataset for the study of identity at scale: Annual Prevalence of American Twitter Users with specified Token in their Profile Bio 2015-2020. (PubMed, PLoS One) - "Further, tools and theory for working with the data are presented. A demonstration analysis provides evidence that personal, individual development and changing cultural norms can be observed with these data and methods."

Journal

Longitudinal study on the effect of surgical weight loss on beat-to-beat blood pressure variability in patients undergoing bariatric surgery: a study protocol. (PubMed, BMJ Open) - "The study has been approved by the Institutional Review Board at the American University of Beirut (IRB ID: BIO-2018-0040). Study results will be made available to the public through publications in peer-reviewed journals and conference papers and/or presentations."

Clinical • Journal • Observational data • Genetic Disorders • Hypertension • Obesity

"Nitip memories #BIO2019 https://t.co/waClQLwks9" (@yanlili01)

Oncology

"#BIO2019 kita mah bilingual banget yah anaknya😆😆😆 Fotonya emang blur, fotografernya grogi cenah liat cogan wkwk cc: @bas1234516" (@yanlili01)

Oncology

Increasing faculty involvement in the undergraduate interdisciplinary learning experience. (PubMed, Integr Comp Biol) - "To make interdisciplinary biology education more successful we need biologists, who for one reason or another have not been part of these conversations in the past, more involved. We also need to increase communication and collaboration between biologists and educational researchers."

Journal • Cognitive Disorders

"$BPTS Biophytis Receives €980,000 DeepTech Funding from BPI France for the development of Macuneos (BIO201) in Dry AMD https://t.co/lbwXcqXEDX" (@stock_titan)

Dry Age-related Macular Degeneration

Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment. (PubMed, EBioMedicine) - "Our results demonstrate that pulmonary live tuberculosis vaccines efficiently revert established asthma in mice. These data support the further exploration of this approach as potential therapy against asthma."

Clinical • Journal • Asthma • Eosinophilia • Immunology • Infectious Disease • Respiratory Diseases • Tuberculosis

[VIRTUAL] Recurrent Crebbp Mutations in Follicular Lymphoma Appear Localized to the Committed B-Cell Lineage (ASH 2020) - "Chromatin modifying genes (CMGs) including KMT2D, CREBBP, EZH2, and EP300 are almost ubiquitously mutated in FL. HSCs are believed to be the cell of origin in several lymphoid leukemias, and mouse models have demonstrated lymphoma development with induced CREBBP lesions in HSCs (Horton et al Nat Cell Bio 2017). However, in sorted hematopoietic cell populations from marrow and peripheral blood, we observed CREBBP mutations in B-cell lineages but never in CD34+/CD20- precursor populations or paired lymphoid/myeloid disease. Our data therefore are not in support of HSCs as a precursor reservoir in FL."

IO Biomarker • Follicular Lymphoma • Hematological Disorders • Hematological Malignancies • Leukemia • Lymphoma • Oncology • Sarcoma • Solid Tumor • BCL2 • CD20 • CD34 • CREBBP • EP300 • EZH2 • KMT2D • NRAS

"Otra impecable edición de @biblioactivista @PuntoaparteEd Gran trabajo @LuzA_MorenoG @cronopio987 @GIAndradeP #BIO2019 👏🏼👏🏼👏🏼 @Ruperta45" (@maravilla71)

Oncology

[VIRTUAL] Clinical Trial to Evaluate an Approved ITP Therapy Targeting Spleen Tyrosine Kinase (SYK) for Prevention and Treatment of COVID-19 Related Complications (ASH 2020) - "Fostamatinib is a potent SYK inhibitor that targets activation of both the innate and acquired immune systems caused by tissue damage or pathogen signals via C-type lectin receptors (CLR) as well as by antibody-antigen immune complexes via Fc receptors (Figure 1). Trial in Progress"

Clinical • Acute Kidney Injury • Acute Lung Injury • Acute Respiratory Distress Syndrome • Cardiovascular • Hematological Disorders • Immune Modulation • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Nephrology • Novel Coronavirus Disease • Oncology • Renal Disease • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Thrombocytopenia • Thrombocytopenic Purpura • IL6 • SYK

Real-time, high-resolution microscopy of invasive cancer cells in the tumor microenvironment context. (PubMed, J Biomol Tech) - "Using our unique intravital imaging approaches (Perrin et al, 2019 Canc Rep; Bayarmagnai et al, 2018 Meth Mol Biol.), we previously demonstrated that invadopodia in vivo are necessary for intravasation and consequent lung metastasis (Gligorijevic et al, Plos Bio 2014)...A close look at the regulators of G1 revealed that the cell cycle regulator p27kip1 localizes to the sites of invadopodia assembly and overexpression of p27kip1 causes faster turnover of invadopodia and increased ECM degradation. Taken together, these findings suggest that invadopodia assembly in the perivascular niche, is necessary for lung metastasis and function is controlled by the cell cycle."

Biomarker • Journal • Tumor microenvironment • Breast Cancer • Lung Cancer • Oncology • Solid Tumor

[VIRTUAL] Colorectal cancer genetic variants are also associated with Serrated polyposis syndrome susceptibility (ESHG 2020) - "Genetic variants for CRC risk are also involved in SPS susceptibility, being the most relevant ones rs4779584- GREM1 , rs16892766- EIF3H and rs3217810- CCND2 . Grant support: FJCI-2017-32593, 2019FI_B2_00203, LCF/BQ/DI18/11660058, Fondo de Investigacion Sanitaria/FEDER (16/01292, 17/00878), AECC (GCB13131592CAST), Spanish Ministry of Science (SAF2016-80888-R, BIO2017-89754-C2-2R), PERIS (SLT002/16/00398, SLT002/16/0037), Generalitat de Catalunya (GRPRE 2017SGR21, GRC 2017SGR653, 2017SGR723, 2017SGR861, 2017SGR1282), COST Action CA17118, CIBEREHD, CIBERONC and CIBERER."

Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • CCND2 • LAMA5 • TCF7L2

[VIRTUAL] Germline mutations in FAF1 are associated with hereditary colorectal cancer (ESHG 2020) - "Conclusions : Our findings suggest that FAF1 may be involved in inherited predisposition to CRC, being resistance to apoptosis the plausible pathogenic mechanism. Grant support : FJCI-2017-32593, 2019FI_B2_00203, LCF/BQ/DI18/11660058, Fondo de Investigacion Sanitaria/FEDER (16/01292, 17/00878), AECC (GCB13131592CAST), Spanish Ministry of Science (SAF2016-80888-R, BIO2017-89754-C2-2R), PERIS (SLT002/16/00398, SLT002/16/0037), Generalitat de Catalunya (GRPRE 2017SGR21, GRC 2017SGR653, 2017SGR723, 2017SGR861, 2017SGR1282), COST Action CA17118, CIBEREHD, CIBERONC, CIBERER."

Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor