ImmunoRel (immunoglobulin G) / Reliance Life Sci - LARVOL DELTA

Preparation of diatom frustules incorporated with protein A-fused C-terminal silica-binding peptide and interpenetrating polymer network for targeted drug delivery. (PubMed, World J Microbiol Biotechnol) - "Finally, tetracycline-incorporated diatoms exhibited an antibacterial activity against methicillin-resistant Staphylococcus aureus. Collectively, this study was a groundwork for further diatom-based antibiotic delivery paradigms in antimicrobial applications."

Journal • Infectious Disease

Effects of seaweed on blood plasma immunoglobulin concentration, mucosal immunity, small intestine histomorphology, cecal microbial population, and volatile fatty acid profile in broiler chickens. (PubMed, Vet World) - "The results suggest that BS and GS supplementation may serve as sustainable feed additives to enhance broiler performance while reducing reliance on synthetic supplements. Future studies should focus on identifying the bioactive compounds responsible for these effects and their broader implications for poultry production."

Journal • IFNG • IL10 • IL6

Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. (PubMed, Proc Natl Acad Sci U S A) - "Thus, 3F6-based clearance of S. aureus in mice relies on a strain-specific contribution of variable FcγR- and complement-dependent pathways. We surmise that these variabilities are the result of genetic polymorphism(s) that may be encountered in other mammals including humans and may have clinical implications in predicting the efficacy of mAb-based therapies."

Journal • Preclinical • ITGAM

Fibrillary Glomerulonephritis and Monoclonal Gammopathy: Potential Diagnostic Challenges. (PubMed, Front Oncol) - "The discovery of DnaJ homolog subfamily B member 9 (DNAJB9) allows diagnosis for FGN with less reliance on EM, and the summary of recent studies revealed that genuine MGRS is extremely rare among FGN. Further research integrating IF-P, IgG subtyping, VH or VL domain monoclonality confirmation, and DNAJB9 as diagnostic modalities, with corresponding clinical data including treatment response and prognosis, is required for a better understanding of this subject."

Journal • Review • Glomerulonephritis • Hematological Malignancies • Lupus Nephritis • Monoclonal Gammopathy • Nephrology • Renal Disease

Treatment of pemphigus vulgaris and foliaceus with efgartigimod, a neonatal Fc receptor inhibitor: a phase 2 multicentre, open-label feasibility trial. (PubMed, Br J Dermatol) - P2 | "Efgartigimod was well-tolerated and exhibited an early effect on disease activity and outcome parameters, providing support for further evaluation as a therapy for pemphigus. The study is registered at ClinicalTrials.gov (identifier: NCT03334058)."

Clinical • Journal • P2 data • Dermatology • Immunology • Pemphigus Vulgaris

Subcutaneous immunoglobulin treatment for chronic inflammatory demyelinating polyneuropathy. (PubMed, Muscle Nerve) - "SCIg preference may be a result of the independence and flexibility associated with self-infusion, whereas IVIg preference may be a result of familiarity and reliance on a healthcare professional for infusions. In practice, individualizing maintenance dosing based on disease behavior and determining the minimally effective IgG dose for individuals are key considerations irrespective of the administration route chosen."

Journal • Review • Pain

SARS-CoV-2 Antibody Point-of-Care Testing in Dialysis and Kidney Transplant Patients With COVID-19. (PubMed, Kidney Med) - "Symptomatic dialysis patients and transplant recipients commonly develop an immune response against SARS-CoV-2 infection that can be detected using an LFIA. Used diligently, an LFIA could be used to help screen the dialysis populations or confirm exposure on a patient level, especially in facilities in which laboratory resources are limited."

Clinical • Journal • Infectious Disease • Nephrology • Novel Coronavirus Disease • Renal Disease • Respiratory Diseases • Transplantation