tranexamic acid IV / Generic mfg. - LARVOL DELTA

Does Intravenous Tranexamic Acid Impact Risk of Venous Thromboembolism in Plastic & Reconstructive Surgery of the Head and Neck? (PubMed, Plast Reconstr Surg) - "IV TXA use was not associated with increased postoperative VTE risk in plastic and reconstructive surgery of the head and neck, supporting its continued use as a safe hemostatic adjunct in this patient population."

Journal • Cardiovascular • Hematological Disorders • Respiratory Diseases • Venous Thromboembolism

Exploration of a standardized dosing regimen of tranexamic acid during the perioperative period of high tibial osteotomy (ChiCTR) - P=N/A | N=144 | Recruiting | Sponsor: Tianjin Hospital; Tianjin Hospital

New trial • Orthopedics

Safety of Intraoperative Intravenous Tranexamic Acid Use in Facial Feminization Surgery Among Patients on Estrogen Supplementation. (PubMed, Facial Plast Surg Aesthet Med) - No abstract available

Journal

Injectable Tranexamic Acid Use in Arthroscopic Rotator Cuff Repair Is Safe and Associated with Reduced Postoperative Opioid Use. (PubMed, J Clin Med) - "Furthermore, TXA use is linked to reduced postoperative opioid consumption, suggesting benefits in pain management and recovery. Prospective studies are warranted to further explore these findings."

Journal • Cardiovascular • Infectious Disease • Orthopedics • Osteoarthritis • Pain

Efficacy of Intra-Articular Tranexamic Acid in Addition to Intravenous Tranexamic Acid in Enhancing Pain Relief and Function after Arthroscopic Anterior Cruciate Ligament Reconstruction: A Randomized Clinical Trial (AAOS 2026) - "Intra-articular TXA did not significantly reduce early postoperative pain or opioid use."

Clinical • Orthopedics • Pain

The Effectiveness and Safety of High and Low Dosages of Intraoperative Intravenous Tranexamic Acid During Surgical Treatment of Adult Spinal Deformity: A Network Meta-Analysis (AAOS 2026) - "High-dose IV tranexamic acid reduces blood loss more than no TXA but not low-dose in adult spinal deformity surgery, with no increase in complications; evidence certainty is low."

Retrospective data • Movement Disorders

Hyperfibrinolysis during intra-aortic balloon pump support: a case report on targeted tranexamic acid therapy. (PubMed, Front Cardiovasc Med) - "Targeted intravenous tranexamic acid (TXA) therapy effectively controlled bleeding and corrected fibrinolysis, without inducing thrombotic complications, thereby allowing successful bridging to heart transplantation. This case underscores the importance of considering secondary hyperfibrinolysis in IABP-supported patients with infection or hemodynamic instability."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Transplantation

Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery (clinicaltrials.gov) - P4 | N=160 | Recruiting | Sponsor: Massachusetts General Hospital | Not yet recruiting ➔ Recruiting

Enrollment open • Estrogen Receptor Positive Breast Cancer

Local Tranexamic Acid Infiltration for Prophylactic Hemorrhage Control in Vaginal Hysterectomy: Double-Blinded Randomized Placebo-Controlled Trial. (PubMed, Int Urogynecol J) - "Local prophylactic tranexamic acid did not reduce total blood loss. Vaginal hysterectomy remains a safe procedure with minimal bleeding."

Journal • Cardiovascular • Gynecology • Hematological Disorders

A prospective, double-blind, randomised controlled trial comparing oral versus intravenous tranexamic acid for blood loss reduction in primary total knee arthroplasty. (PubMed, Eur J Orthop Surg Traumatol) - "Oral TXA administered preoperatively demonstrates non-inferiority to intravenous TXA for reducing perioperative blood loss in primary TKA. Despite a clinically relevant but statistically non-significant trend toward higher transfusion rates with oral TXA in this small sample, oral administration represents a safe and substantially more cost-effective alternative (80% cost savings), particularly suitable for resource-constrained healthcare environments and ambulatory surgery settings."

Clinical • Journal • Anesthesia • Cardiovascular • Orthopedics • Pain

Efficacy and safety of intravenous tranexamic acid in elective abdominoplasty: A randomized, triple-blinded, placebo-controlled clinical trial. (PubMed, J Plast Reconstr Aesthet Surg) - P4 | "A single preoperative 10 mg/kg IV dose of TXA did not significantly reduce perioperative blood loss or affect coagulation parameters in abdominoplasty. TXA was safe and well tolerated, supporting its selective rather than routine use, particularly in high-risk or combined procedures."

Clinical • Journal • Aesthetic Medicine • Cardiovascular

Single Versus Multi-Dose Oral and Intravenous Tranexamic Acid Patients at High Risk for Blood Transfusion After Spine Surgery (clinicaltrials.gov) - P1 | N=604 | Recruiting | Sponsor: Rush University Medical Center | Trial completion date: Jan 2026 ➔ Jan 2027 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Orthopedics

Intravenous tranexamic acid shows limited efficacy in arthroscopic shoulder surgery: a systematic review and meta-analysis of randomized-controlled trials. (PubMed, EFORT Open Rev) - "Current evidence does not support a significant clinical benefit of IV TXA in arthroscopic shoulder surgery. Further high-quality RCTs are needed to clarify its role under standardized protocols."

Journal • Retrospective data • Orthopedics

Prophylactic Regimen of Intravenous Oxytocin, Intravenous Tranexamic Acid, and Intramuscular Ergot Derivative for Primary Prevention of Postpartum Hemorrhage in Intrapartum Cesarean Section Versus Intravenous Carbetocin Alone (clinicaltrials.gov) - P=N/A | N=80 | Not yet recruiting | Sponsor: Cairo University

New trial • Hematological Disorders • Postpartum Hemorrhage

Results of Total Knee Arthroplasty with Robotic Assistance (PubMed, Rev Bras Ortop (Sao Paulo)) - "All surgeries were performed without the use of a tourniquet and included administration of intravenous tranexamic acid...Robotic-assisted TKA was not associated with measurable improvements in blood loss, operative time, or postoperative complications. However, it contributed to a reduction in hospital stay compared with the conventional technique."

Journal • Orthopedics • Pain

Results of Total Knee Arthroplasty with Robotic Assistance. (PubMed, Rev Bras Ortop (Sao Paulo)) - "All surgeries were performed without the use of a tourniquet and included administration of intravenous tranexamic acid...Robotic-assisted TKA was not associated with measurable improvements in blood loss, operative time, or postoperative complications. However, it contributed to a reduction in hospital stay compared with the conventional technique."

Journal • Orthopedics • Pain

Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial (clinicaltrials.gov) - P3 | N=826 | Active, not recruiting | Sponsor: Bayside Health | Recruiting ➔ Active, not recruiting | Trial completion date: Dec 2025 ➔ Aug 2026 | Trial primary completion date: Dec 2025 ➔ Aug 2026

Enrollment closed • Trial completion date • Trial primary completion date • Alzheimer's Disease • CNS Disorders • Dementia • Infectious Disease

Efficacy of nebulised versus intravenous tranexamic acid in management of non-massive haemoptysis: A randomised controlled trial. (PubMed, Lung India) - "Nebulised TXA is as effective as IV TXA in managing non-massive haemoptysis."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Impact of Intravenous Tranexamic Acid at Hospital Admission on Blood Transfusion Rates in Geriatric Extracapsular Hip Fracture Patients. (PubMed, Adv Orthop) - "Early TXA administration may not adequately address hidden blood loss in geriatric hip fractures, possibly due to high comorbidity burden, pre-existing anemia, and delayed surgery. Further research is necessary to explore alternative strategies for managing early blood loss and optimizing outcomes in this population."

Journal • Cardiovascular • Hematological Disorders • Musculoskeletal Diseases • Orthopedics

Successful Management of Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema With Tranexamic Acid: A Case Report. (PubMed, Cureus) - "His history included hypertension treated with a recently up-titrated dose of ramipril, type 2 diabetes, gout, and prior deep vein thrombosis. Initial management following anaphylaxis protocol with intramuscular adrenaline, intravenous hydrocortisone, chlorphenamine, and adrenaline nebulisers produced no improvement. Given the strong suspicion of bradykinin-mediated angioedema, 1 g of intravenous tranexamic acid (TXA) was administered...This case highlights TXA as a safe, effective, and accessible therapeutic option for ACEI-induced angioedema, particularly in settings where targeted therapies are unavailable. It underscores the importance of recognizing this distinct clinical entity and the need for further prospective studies to define TXA's role in treatment algorithms."

Journal • Cardiovascular • Diabetes • Gout • Hematological Disorders • Hypertension • Inflammatory Arthritis • Metabolic Disorders • Otorhinolaryngology • Pulmonary Disease • Rheumatology • Thrombosis • Type 2 Diabetes Mellitus

Combining topical and intravenous tranexamic acid in cardiac surgery: does it really matter? - a systematic review and meta-analysis. (PubMed, Int J Cardiol Heart Vasc) - "Combined topical and IV TXA application is associated with reduced total blood loss after cardiac surgery compared to an IV-only approach. However, no significant differences were observed in transfusion rates, blood product utilization, or mortality."

Journal • Retrospective data • Cardiovascular

Route Matters: Topically Applied Versus Locally Injected Tranexamic Acid for the Reduction of Post-rhinoplasty Edema and Ecchymosis. (PubMed, Aesthet Surg J) - "Compared with locally injected TXA, topically applied TXA administered immediately after osteotomy achieved greater early reduction in postoperative periorbital edema and ecchymosis. These findings underscore the importance of the administration route in optimizing aesthetic recovery after rhinoplasty."

Clinical • Journal • Aesthetic Medicine • Orthopedics

Dose-Dependent Effects of Intraoperative Tranexamic Acid on Surgical Bleeding and Transfusion Requirements in Multilevel Thoracolumbar Spinal Surgery (clinicaltrials.gov) - P=N/A | N=62 | Completed | Sponsor: Dr. Lutfi Kirdar Kartal Training and Research Hospital

New trial • CNS Disorders

The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery (clinicaltrials.gov) - P4 | N=150 | Recruiting | Sponsor: Montefiore Medical Center | Suspended ➔ Recruiting

Enrollment open

Effectiveness of tranexamic acid in intervening postpartum vaginal lacerations. (PubMed, BMC Pregnancy Childbirth) - P | "Topical tranexamic acid application resulted in similar reductions in bleeding compared with IV administration, and no statistically significant difference was detected between the two routes in this specific context of limited blood loss (< 500 ml). Given its practical advantages, topical application may be a viable alternative to IV administration. Further research is warranted to confirm these findings in cases of more significant postpartum hemorrhage."

Journal • Hematological Disorders • Postpartum Hemorrhage