tranexamic acid IV / Generic mfg. - LARVOL DELTA

Use of Plant-Based Absorbable Hemostatic Powder and Intravenous Tranexamic Acid in Breast Reduction Patients Reduces Hematoma Rates. (PubMed, Ann Plast Surg) - "IV TXA significantly reduces postoperative hematoma rates following reduction mammaplasty, with the addition of Arista providing a modest incremental benefit. Although TXA remains the primary agent for hematoma prophylaxis, Arista may be selectively useful in patients contraindicated for TXA. Further prospective studies are warranted."

Journal • Infectious Disease

Effectiveness and safety of intraosseous regional administration versus intravenous tranexamic acid in primary total knee arthroplasty: a randomized, triple-blind, placebo-controlled trial. (PubMed, Int J Surg) - "This study is the first to evaluate IORA-TXA in TKA. In manual primary TKA with femoral canal opening, IORA-TXA showed hemostatic efficacy and safety comparable to IV-TXA and reduced pain at POD14. The combination of IORA- and IV-TXA further reduced total blood loss, and showed a lower CRP levels at POD 3 as well as reductions in pain scores and flexion contracture at POD14, without increasing complications. These findings suggest IORA-TXA as an effective and safe strategy in primary manual TKA."

Journal • Orthopedics • Pain • CRP

Perioperative anaphylaxis due to intravenous tranexamic acid following cutaneous exposure. (PubMed, JA Clin Rep) - No abstract available

Journal

Intravenous Tranexamic Acid Reduces Perioperative Blood Loss in Mastectomy With Immediate Implant-Based Reconstruction: A Randomized, Triple-Blinded, Placebo-Controlled Trial. (PubMed, Aesthet Surg J) - "Pre-incisional intravenous TXA safely reduces perioperative bleeding and fibrinolytic activity after mastectomy with immediate implant-based reconstruction. These findings suport incorporation of IV TXA into perioperative protocols."

Journal • Cardiovascular

One Dose Versus Two Doses of Intravenous Tranexamic Acid in Revision Total Joint Arthroplasty. (PubMed, J Am Acad Orthop Surg Glob Res Rev) - "In this study, no association was found between a single dose of perioperative TXA during revision TJA and increased rates of post-operative complications when compared with two-doses, suggesting comparable efficacy."

Clinical • Journal • Retrospective data • Orthopedics • Pain

Dose-effect relationship of intravenous tranexamic acid on perioperative haemoglobin drop in total hip arthroplasty (PRADO study): study protocol for a randomised, double-blind, placebo-controlled, dose-response study. (PubMed, BMJ Open) - P2 | "Results will be disseminated at conferences and published in peer-reviewed journals. CTIS 2022-502532-38-01; NCT03822793."

Clinical protocol • Journal • Anesthesia • Musculoskeletal Diseases • Orthopedics

TXA-FemNail: Effectiveness of Tranexamic Acid in Reducing Blood Loss During Femoral Nail Surgery (clinicaltrials.gov) - P4 | N=43 | Completed | Sponsor: Masaka Regional Referral Hospital

New P4 trial • Hematological Disorders • Musculoskeletal Diseases • Orthopedics

A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery (clinicaltrials.gov) - P4 | N=107 | Completed | Sponsor: University of Michigan | N=500 ➔ 107

Enrollment change

Successful Management of Intracranial Hemorrhage with Emicizumab in a Newborn with Severe Hemophilia a: A Case Report (ASH 2023) - "Neonate received tranexamic acid infusions 40 mg/kg die and 50 IU/Kg of intravenous recombinant factor VIII concentrate (octocog alfa). ConclusionsThe combined use of emicizumab and antifibrinolytics was successful in treating acute intracranial hemorrhage. To the best of our knowledge, this is the first pediatric case of successful management of intracranial hemorrhage with emicizumab in a newborn with severe HA."

Case report • Clinical • Cerebral Hemorrhage • CNS Disorders • Epilepsy • Hematological Disorders • Hemophilia • Hemophilia A • Pediatrics • Rare Diseases

Combined Nebulized and IV Tranexamic Acid for Hemoptysis Management: A Case Report and Brief Literature Review. (PubMed, Clin Case Rep) - "A brief review of 30 cases highlights nebulized TXA's high success rate with doses ranging from 250 to 2000 mg, though rare side effects like bronchospasm and serotonin-like syndrome warrant caution. Playing a role as a potential alternative approach for antifibrinolytic administration in hemoptysis, especially for high-thrombotic-risk patients, and serving as a vital stabilization and bridging strategy before definitive interventional procedures, could be the main area for future studies."

Journal • Bronchiectasis • Chronic Obstructive Pulmonary Disease • Immunology • Pulmonary Disease • Respiratory Diseases

Effect of infusion of tranexamic acid at different drip rates on the incidence of nausea and vomiting in patients undergoing lumbar interbody fusion via transforaminal approach: a prospective, double-blind, randomised controlled clinical study protocol (ChiCTR) - P4 | N=180 | Not yet recruiting | Sponsor: West China Tianfu Hospital, Sichuan University; Sichuan University West China Tianfu Hospital

New P4 trial

Topical versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: Systematic Review and Meta-Analysis of Randomized Clinical Trials (AHA 2025) - "Topical TXA provides similar hemostatic efficacy to intravenous TXA in cardiac surgery while slightly reducing the risk of postoperative seizures. Future research should focus on investigating specific patient subgroups who might derive maximal benefit from this administration route."

Retrospective data • Review • Surgery • Cardiovascular • CNS Disorders • Epilepsy • Hematological Disorders

Efficacy Study of Intradermal Injection of Tranexamic Acid at Different Concentrations for the Treatment of Melasma and Post-Inflammatory Hyperpigmentation After Phototherapy (ChiCTR) - P=N/A | N=120 | Recruiting | Sponsor: Plastic Surgery Hospital, Chinese Academy of Medical Sciences; Plastic Surgery Hospital, Chinese Academy of Medical Sciences

New trial • Dermatology • Dermatopathology

IVTXA: Investigating the Use of Intravenous Tranexamic Acid in Gender Affirming Mastectomy (clinicaltrials.gov) - P2 | N=150 | Recruiting | Sponsor: University of California, San Francisco | Trial completion date: May 2025 ➔ May 2026 | Trial primary completion date: May 2025 ➔ May 2026

Trial completion date • Trial primary completion date

The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery (clinicaltrials.gov) - P4 | N=150 | Suspended | Sponsor: Montefiore Medical Center | Recruiting ➔ Suspended

Trial suspension

Intra‑articular tranexamic acid improves 1‑ and 3‑month functional recovery but does not reduce early post‑operative pain after arthroscopic ACL reconstruction: A triple‑blind randomised trial. (PubMed, J Exp Orthop) - "Our aim is to investigate whether an intra-articular injection of tranexamic acid (TXA), administered alongside a standard multimodal analgesic cocktail, improves postoperative pain control and functional recovery...One hundred patients with isolated, unilateral, chronic ACL tears were randomised 1:1 to receive either an intra-articular injection containing TXA (1 g), morphine sulphate, ketorolac, lidocaine and normal saline (intervention group) or an identical injection without TXA (control group)...However, it was associated with modest improvements in functional recovery at 1 and 3 months postoperatively, as measured by KOOS and Lysholm scores. Level I."

Clinical • Journal • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatology

Comparative analysis of hemostatic efficacy and safety: absorbable gelatin sponge with hemostatic fluid gelatin vs. tranexamic acid in posterior cervical expansive open-door laminoplasty. (PubMed, Front Surg) - "A retrospective analysis was conducted on 75 patients undergoing posterior cervical expansive open-door laminoplasty at Ningxia Medical University General Hospital from January 2022 to January 2024, with stratification into two groups based on intraoperative hemostatic materials: the GS-HFG group (absorbable gelatin sponge combined with hemostatic fluid gelatin, n = 30) and the GS-TXA group (absorbable gelatin sponge combined with intravenous tranexamic acid, n = 45), with subsequent comparison of baseline demographics, operative duration, intraoperative blood loss, total postoperative drainage volume, Visual Analog Scale (VAS) pain scores, Japanese Orthopaedic Association (JOA) functional assessments, postoperative adverse events, and complications...No thromboembolic events or other adverse reactions occurred. Both the GS-HFG and GS-TXA protocols effectively reduce perioperative bleeding without increasing the risk of complications in posterior cervical expansive..."

Journal • Cardiovascular • Orthopedics • Pain

Burn specific venous thromboembolism prophylaxis: a two-year quality improvement project. (PubMed, J Burn Care Res) - "In 2022, a new prophylaxis guideline was introduced for adults with burns >20% total body surface area: enoxaparin 40mg twice daily, renally and weight adjusted...To mitigate this, intravenous tranexamic acid and increased transfusion rates were implemented after 12 months, eliminating major bleeding events in the subsequent period...Despite an initial increase in bleeding complications, intraoperative adjustments resolved these issues, demonstrating a learning curve. The guideline was successfully implemented and appears effective in reducing venous thromboembolic risk with acceptable complications."

Journal • Cardiovascular • Thermal Injury • Venous Thromboembolism

Intraoperative Hemostasis and Transfusion Strategy in Infant Craniectomy: A Case of Intracranial Dermoid Cyst Removal in a 10-Month-Old Patient (ASA 2025) - "Tranexamic acid infusion, preinduction blood availability, and early transfusion thresholds were also employed. This case underscores the importance of proactive management strategies in infants undergoing complex craniofacial neurosurgical procedures."

Clinical • Anesthesia • Hematological Disorders

WHEN A 'PROLAPSE' WASN'T PROLAPSE: A RARE VAGINAL POLYP MASQUERADING AS GENITAL PROLAPSE IN A HIGH-RISK PATIENT (FIGO 2025) - "IV tranexamic acid + hematinics... Never Skip Pelvic Exams: Imaging alone risks missing critical findings. Anemia ≠ Bleeding Source: Severe anemia requires urgent investigation regardless of active bleeding. Cultural Competency Matters: Patient delayed care due to cultural normalization of "prolapse-like" symptoms."

Clinical • Anemia • Solid Tumor • Uterine Leiomyoma

INTRINSIC: Indian Trial of Tranexamic Acid in Spontaneous Intracerebral Haemorrhage (clinicaltrials.gov) - P4 | N=3400 | Recruiting | Sponsor: Christian Medical College and Hospital, Ludhiana, India | Trial completion date: Mar 2025 ➔ Nov 2026 | Trial primary completion date: Mar 2025 ➔ Nov 2026

Trial completion date • Trial primary completion date • Cardiovascular • Cerebral Hemorrhage • Hematological Disorders

A randomised controlled trial of verbal guidance versus verbal guidance supplemented by a photographic aid for bystander identification of intramuscular tranexamic acid injection sites in a simulated road injury scenario. (PubMed, BMC Emerg Med) - "Supplementing verbal guidance with a photographic aid significantly improves bystander accuracy in identifying safe IM TXA injection sites in a simulated setting. This finding supports the potential integration of visual aids into emergency dispatch protocols to enhance early haemorrhage control in trauma care. Further research is needed to assess real-world application and impact."

Journal • Infectious Disease

Evidence on oral tranexamic acid versus intravenous tranexamic acid for perioperative blood management in total knee arthroplasty: a systematic review and meta-analysis. (PubMed, EFORT Open Rev) - "Based on available evidence, there is no significant difference observed between oral and intravenous TXA in patients undergoing TKA. However, the wide confidence intervals for several outcomes indicate important uncertainty, and further high-quality studies are needed to confirm the comparative effectiveness and safety."

Journal • Retrospective data • Orthopedics • Pain

The effect of single-dose intravenous tranexamic acid in simultaneous bilateral total hip arthroplasty: a retrospective study. (PubMed, Can J Surg) - "We found a low transfusion rate (6.5%) after SBTHA among patients administered a single dose of 20 mg/kg of TXA, with young patients and male patients at lower risk of requiring transfusions. Our results suggest that performing SBTHA with current blood management protocols is effective in patients with bilateral hip disease."

Journal • Retrospective data • Hematological Disorders • Orthopedics

TXA: Intravenous Tranexamic Acid (clinicaltrials.gov) - P=N/A | N=128 | Not yet recruiting | Sponsor: Ain Shams University

New trial • Obesity