tranexamic acid IV / Generic mfg. - LARVOL DELTA

Tranexamic acid in shoulder arthroplasty: A meta-analysis of randomized controlled trials. (PubMed, J Orthop Sci) - "The use of tranexamic acid in total shoulder arthroplasty can improve hematological outcomes post-operation without any effect on length of stay, operative time, or pain scores."

Journal • Retrospective data • Hematological Disorders • Orthopedics • Pain

Nebulized Versus Intravenous Tranexamic Acid on Surgical Field Quality in Patients Undergoing Endoscopic Sinus Surgeries (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: Cairo University | Recruiting ➔ Completed

Trial completion • Otorhinolaryngology

Effect of a single dose of tranexamic acid on perioperative blood loss in dogs undergoing spinal surgery. (PubMed, Vet Anaesth Analg) - "Preoperative injection of TXA at 15 mg kg-1 did not reduce perioperative blood loss in this population. As such, routine use in all dogs undergoing spinal surgery is not supported by these data. Future work should focus on identifying the patient groups and dosing protocols in which TXA may offer measurable clinical advantage."

Journal • Anesthesia

Evaluating the Effectiveness of Intramuscular Versus Intravenous Tranexamic Acid for Minimizing Blood Loss After Total Hip Arthroplasty: A Randomized Controlled Trial (clinicaltrials.gov) - P1 | N=128 | Recruiting | Sponsor: Alexandria University

New P1 trial • Orthopedics

Efficacy of Sublingual Misoprostol Versus Intravenous Tranexamic Acid in Reducing Blood Loss Among Full-Term Pregnant Women Undergoing Primary Lower Segment Caesarean Section: A Randomized Controlled Trial. (PubMed, Cureus) - "Sublingual 600 µg misoprostol was more effective than 1 g intravenous tranexamic acid in reducing intraoperative blood loss during primary LSCS. It was associated with a smaller postoperative decline in haemoglobin and a reduced need for additional uterotonic agents and blood transfusion, while maintaining an acceptable safety profile. These findings support the use of sublingual misoprostol as an effective and economical option for preventing excessive blood loss during primary LSCS."

Journal • Hematological Disorders • Hypotension • Obstetrics • Postpartum Hemorrhage

The Influence of Multiple Doses of Intravenous Tranexamic Acid on Transfusions and Complications in the Treatment of Fragility Hip Fractures. (PubMed, J Orthop Trauma) - "Intravenous tranexamic acid (TXA) reduced transfusion needs without an increased complication rate in comparison to not using TXA. Regression analysis demonstrated that three and four doses of TXA did significantly reduce the transfusion rate beyond a single dose of TXA, but did not provide significant reduction beyond two-doses."

Journal • Cardiovascular • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Venous Thromboembolism

Timing of Subcutaneous Tranexamic Acid Injection in Mohs Micrographic Surgery (clinicaltrials.gov) - P=N/A | N=500 | Not yet recruiting | Sponsor: The Cooper Health System

Head-to-Head • New trial

Comment on "Equivalence of oral and intravenous tranexamic acid in knee arthroplasty: a systematic review and meta-analysis of randomized clinical trials". (PubMed, Int J Surg) - No abstract available

Clinical • Journal • Retrospective data • Orthopedics

Tourniquet with Intravenous Tranexamic Acid versus Tourniquet with Vaginal Misoprostol for Blood Loss Reduction during Open Myomectomy: A Double-Blind Randomised Trial. (PubMed, Niger Med J) - "There were no untoward side effects noted in either group. The results of this study suggest that the use of a tourniquet with intravenous tranexamic acid has a better effect in reducing blood loss than a tourniquet with vaginal misoprostol during open myomectomy."

Journal • Gynecology • Solid Tumor • Uterine Leiomyoma • Women's Health

Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft (clinicaltrials.gov) - P4 | N=62 | Recruiting | Sponsor: University of Kansas Medical Center | Trial primary completion date: Dec 2026 ➔ Dec 2027 | Trial completion date: Dec 2026 ➔ Dec 2027

Trial completion date • Trial primary completion date • Thermal Injury

The Role of Intravenous Tranexamic Acid for Posterior Spinal Fusion in Pediatric Non-Idiopathic Scoliosis: A Systematic Review and Meta-Analysis. (PubMed, J Clin Med) - "However, the available evidence remains limited, particularly regarding perioperative complications, and further high-quality prospective studies are required to strengthen the evidence base. Clinical relevance: Exploring the use of TXA in scoliosis surgery has the potential to influence the standard of care, especially if associated with significantly more desirable post-operative and long-term outcomes."

Journal • Retrospective data • Review • Pediatrics

Effect of Perioperative Tranexamic Acid on Blood Loss in Posterior Acetabular Fracture Fixation. (PubMed, J Orthop Trauma) - "Perioperative IV TXA use was not independently associated with calculated TBL following posterior approach acetabular fracture fixation. Instead, longer operative duration and fracture-related characteristics were independently associated with greater TBL. TXA use was also not associated with differences in transfusion requirements or short-term postoperative outcomes."

Journal • Cardiovascular • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Intramuscular tranexamic acid results in lower peak plasma concentrations but comparable systemic absorption to intravenous administration in healthy dogs. (PubMed, Am J Vet Res) - "To determine the pharmacokinetics of IM and IV tranexamic acid (TXA) in healthy dogs...Although the prolonged time to Cmax associated with IM administration may limit its use in patients requiring rapid intervention, it offers practical advantages when IV access is delayed, allowing prehospital treatment prior to definitive veterinary care. Further investigation into IM dosing protocols is needed before it can be recommended in clinical patients."

Journal • Hematological Disorders

The Impact of Combined Intravenous and Topical Tranexamic Acid in Abdominoplasty with Scarpa Fascia Preservation: A Pilot Study. (PubMed, Aesthetic Plast Surg) - "Combined TXA use in abdominoplasty with Scarpa fascia preservation significantly reduces drain output, hospital stay, and time until drain removal without increasing complication rates. These findings support TXA's potential role in improving recovery after abdominoplasty."

Journal • Aesthetic Medicine • Anesthesia • Cardiovascular

Effects of prophylactic tranexamic acid on bleeding during transbronchial lung biopsy: a double-blind, randomized controlled trial. (PubMed, Ann Med Surg (Lond)) - "Participants in the intervention group received 10 mg/kg of intravenous tranexamic acid in normal saline, administered 20 minutes prior to the procedure...We assessed the need for bleeding control interventions, such as epinephrine or ice saline use, the incidence of tachycardia or hypotension, uncontrolled bleeding, and procedure length...Additionally, tranexamic acid had a statistically significant effect on post-operative hemoglobin levels (F = 14.08, P < 0.001, partial η2 = 0.207). Tranexamic acid can be effective in preventing bleeding in individuals undergoing transbronchial lung biopsy and in enhancing procedural speed."

Journal • Cardiovascular • Hematological Disorders • Hypotension

EXACYLCA: A Study Aiming to Demonstrate That the Addition of Intravenous (IV) Tranexamic Acid-Compared to Placebo-During Anterior Cruciate Ligament (ACL) Reconstruction Results in Reduced Blood Loss and Postoperative Pain. (clinicaltrials.gov) - P=N/A | N=100 | Completed | Sponsor: GCS Ramsay Sant pour l'Enseignement et la Recherche

New trial • Pain

Comparison of the Efficacy of Misoprostol and Tranexamic Acid for Postpartum Hemorrhage Prophylaxis in Cesarean Delivery (clinicaltrials.gov) - P4 | N=192 | Completed | Sponsor: Ankara Etlik City Hospital | Phase classification: P ➔ P4

Phase classification • Hematological Disorders • Postpartum Hemorrhage

Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes (clinicaltrials.gov) - P3 | N=80 | Not yet recruiting | Sponsor: Prince of Wales Hospital, Shatin, Hong Kong

New P3 trial • Aesthetic Medicine • Anesthesia • Pain

The Prophylactic Role of Tranexamic Acid in Reducing Blood Loss During Cesarean Delivery: A Prospective Randomized Controlled Trial. (PubMed, Cureus) - " This study supports the prophylactic use of TXA during cesarean delivery to reduce intraoperative blood loss. The significant reduction in mean EBL, combined with the absence of major adverse effects, underscores the role of TXA as a safe and effective adjunct to standard uterotonic therapy."

Journal • Cardiovascular • Hematological Disorders • Postpartum Hemorrhage

TRANSCAB: Oral Versus Intravenous Tranexamic Acid in Off-Pump Coronary Artery Bypass Surgery (clinicaltrials.gov) - P4 | N=160 | Not yet recruiting | Sponsor: Clinique Saint-Luc

Head-to-Head • New P4 trial • Cardiovascular • Coronary Artery Disease

The 2025 Society for Obstetric Anesthesia and Perinatology Gerard W. Ostheimer lecture: a focused review on the studies that will impact obstetric anesthesia practice. (PubMed, Int J Obstet Anesth) - "Key topics include cardiac arrest in pregnancy; pain during cesarean delivery; dural puncture epidural technique for labor analgesia; postdural puncture headache management; guidelines for continuous intrathecal labor analgesia following an unintentional dural puncture; intravenous calcium chloride, optimizing oxytocin dosing strategies, second-line uterotonic selection, and intravenous tranexamic acid for postpartum hemorrhage; video laryngoscopy for neonatal intubation; and reconsideration of anesthetic approaches for postpartum tubal ligation. The results of these studies offer practical findings that may help anesthesiologists deliver safer and more effective, patient-centered care."

Journal • Review • Anesthesia • Cardiovascular • Hematological Disorders • Obstetrics • Pain • Postpartum Hemorrhage

Kaolin-based Hemostatic Gauze in Total Knee Arthroplasty (clinicaltrials.gov) - P4 | N=140 | Completed | Sponsor: Chang Gung Memorial Hospital | Recruiting ➔ Completed

Trial completion • Orthopedics • Rheumatology

Intravenous versus oral tranexamic acid in shoulder arthroplasty. (PubMed, Arch Orthop Trauma Surg) - "In this large propensity-matched analysis, oral TXA demonstrated equivalent safety, complication rates, and postoperative laboratory profiles compared with IV TXA following TSA. These findings support oral TXA as a clinically effective alternative to IV administration, offering potential advantages in cost reduction and resource utilization without compromising patient safety. Future prospective studies should evaluate optimal dosing strategies, patient-specific selection criteria, and formal cost-effectiveness analyses to further define the role of oral TXA in shoulder arthroplasty pathways."

Clinical • Journal • Retrospective data • Acute Kidney Injury • Cardiovascular • Coronary Artery Disease • Hematological Disorders • Infectious Disease • Myocardial Infarction • Myocardial Ischemia • Orthopedics • Pulmonary Embolism • Renal Disease • Respiratory Diseases

Tranexamic Acid Versus Misoprostol to Reduce Blood Loss During and After Cesarean Section (clinicaltrials.gov) - P4 | N=214 | Completed | Sponsor: Medicare Hospital (Pvt) Limited

New P4 trial

TEAPOT Study Multisite (clinicaltrials.gov) - P1 | N=30 | Recruiting | Sponsor: The University of Texas Health Science Center at San Antonio | Not yet recruiting ➔ Recruiting

Enrollment open • Hematological Disorders • Pediatrics