GS-9723
/ Gilead
- LARVOL DELTA
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April 24, 2023
Identification of biomarkers co-associated with M1 macrophages, ferroptosis and cuproptosis in alcoholic hepatitis by bioinformatics and experimental verification.
(PubMed, Front Immunol)
- "Finally, we validated these potential biomarkers using GEO datasets (GSE155907, GSE142530 and GSE97234) and a mouse model of AH...Combining bioinformatics analysis with a mouse model of AH, we found that ALDOA, COL3A1, LUM, THBS2 and TIMP1 may be potential biomarkers co-associated with M1 macrophages, ferroptosis and cuproptosis in AH patients. We identified 5 potential biomarkers that are promising new targets for the treatment and diagnosis of AH patients."
Biomarker • Journal • Hepatitis B • Hepatology • Inflammation • ALDOA • COL3A1 • THBS2 • TIMP1
March 30, 2023
Predicting Key Genes and Therapeutic Molecular Modelling to Explain the Association between Porphyromonas gingivalis (P. gingivalis) and Alzheimer's Disease (AD).
(PubMed, Int J Mol Sci)
- "Two Gene Expression Omnibus (GEO) datasets, GSE5281 for AD (n = 84 Alzheimer's, n = 74 control) and GSE9723 (n = 4 P. gingivalis, n = 4 control), were downloaded from the GEO database...The best target, 11364421, was used to conduct the molecular dynamics simulations. The results of this study unravel novel genes to P. gingivalis-associated AD that warrant further validation."
Journal • Alzheimer's Disease • CNS Disorders • HES1 • PLK2 • RASGRF1 • UCHL1 • ZFP36 • ZFP36L1
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