GS-9723 / Gilead - LARVOL DELTA

Identification of biomarkers co-associated with M1 macrophages, ferroptosis and cuproptosis in alcoholic hepatitis by bioinformatics and experimental verification. (PubMed, Front Immunol) - "Finally, we validated these potential biomarkers using GEO datasets (GSE155907, GSE142530 and GSE97234) and a mouse model of AH...Combining bioinformatics analysis with a mouse model of AH, we found that ALDOA, COL3A1, LUM, THBS2 and TIMP1 may be potential biomarkers co-associated with M1 macrophages, ferroptosis and cuproptosis in AH patients. We identified 5 potential biomarkers that are promising new targets for the treatment and diagnosis of AH patients."

Biomarker • Journal • Hepatitis B • Hepatology • Inflammation • ALDOA • COL3A1 • THBS2 • TIMP1

Predicting Key Genes and Therapeutic Molecular Modelling to Explain the Association between Porphyromonas gingivalis (P. gingivalis) and Alzheimer's Disease (AD). (PubMed, Int J Mol Sci) - "Two Gene Expression Omnibus (GEO) datasets, GSE5281 for AD (n = 84 Alzheimer's, n = 74 control) and GSE9723 (n = 4 P. gingivalis, n = 4 control), were downloaded from the GEO database...The best target, 11364421, was used to conduct the molecular dynamics simulations. The results of this study unravel novel genes to P. gingivalis-associated AD that warrant further validation."

Journal • Alzheimer's Disease • CNS Disorders • HES1 • PLK2 • RASGRF1 • UCHL1 • ZFP36 • ZFP36L1