timolol oral / Generic mfg. - LARVOL DELTA

Pharmacologic Interaction in an Elderly Patient with Kidney Dysfunction: Acetazolamide and Aspirin in Focus (KIDNEY WEEK 2025) - "He was managed with brimonidine, brinzolamide, timolol, and oral acetazolamide 250 mg twice daily, and was discharged. He was concurrently on aspirin (81mg), furosemide, empagliflozin, atorvastatin, and sertraline...Although rare, there is no warning sign on EMR for these medications to commence in CKD patients concurrently. Recognizing such interactions is critical to improving medication safety in older adults with CKD."

Clinical • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Geriatric Disorders • Glaucoma • Metabolic Disorders • Mood Disorders • Nephrology • Ophthalmology • Psychiatry • Renal Disease

Efficacy and safety of oral propranolol and topical timolol in the treatment of infantile hemangioma: a meta-analysis and systematic review. (PubMed, Front Pharmacol) - "Compared with topical timolol, oral propranolol had a greater response rate (OR = 2.12, P < 0.001), but it was also associated with a greater risk of adverse events (OR = 2.31, P < 0.001). Additionally, propranolol at a dosage of 2 mg/kg/d offers greater efficacy with a comparable safety profile, whereas the 1.0∼1.5 mg/kg/d propranolol dosage shows no significant difference in efficacy compared to timolol but is associated with more adverse events. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024603724, identifier CRD42024603724."

Journal • Retrospective data • Review

Efficiency of Topical Beta-Blockers for Epistaxis Control in Ulcerated Infantile Hemangioma. (PubMed, Cureus) - "The mainstay and first-line treatment for IHs currently consists of topical beta-blockers (such as Timolol) and oral propranolol. In this case, the topical application of Timolol effectively controlled the bleeding and restore function but had limited impact on overall tumor regression, necessitating additional systemic therapy. Although systemic treatment may not always be readily available or may be limited due to potential side effects, early use of topical beta-blockers can be considered a relatively simple and safe first-line treatment option for controlling the symptoms of an intranasal IH in the early life of an infant."

Journal • Oncology • Pain

A comparative study of the therapeutic effect between early and delayed pulsed dye laser combined with beta blocker for infantile hemangioma (WCD 2023) - "MATERIALS AND We retrospectively reviewed IHs patients who were treated with topical timolol, oral propranolol or PDL in Pusan National University Hospital (Busan and Yangsan) from 2012 to 2022. Early PDL treatment combined with BB showed more rapid clearance and shorter duration of total treatment than delayed PDL with BB, even though requiring more laser sessions"

Dermatology

Inter- and intra-observer variability in the selection of therapy for infantile hemangiomas among pediatric dermatologists in Spain. (PubMed, Pediatr Dermatol) - "Raters chose therapy among observation, topical timolol, or oral propranolol. The inter-rater agreement between pediatric dermatologists on the treatment of IH is only fair. Variability was most significant with intermediate- and low-risk hemangiomas."

Journal • Dermatology • Pediatrics

Itraconazole Oral Solution for a Case of Infantile Hemangioma: Monitoring the Efficacy by Dermoscopy and MRI. (PubMed, Dermatol Ther (Heidelb)) - "Treatment options include oral propranolol, topical timolol, and oral corticosteroids. Treatment compliance of oral itraconazole in infants has been reported to be good. Dermoscopy and magnetic resonance imaging (MRI) played a crucial role in in vivo observation of the hemangioma changes with vascular regression during the treatment process."

Clinical • Journal • Oncology • MRI

Effect of antiglaucoma agents on short-term intraocular pressure fluctuations after intravitreal bevacizumab injections. (PubMed, Int Ophthalmol) - P=N/A | "Although it is advisable to prevent IOP spikes, our study showed that use of prophylactic pressure-lowering medications with every mechanism of action has no effect in IOP spikes following intravitreal bevacizumab injections in non-glaucomatous eyes. Trial registrationThe study was registered with clinicaltrails.gov (ID# NCT02140450). Trial registration date: 05.09.2014."

Journal • Glaucoma • Ophthalmology

Do beta-adrenergic blocking agents increase asthma exacerbation? A network meta-analysis of randomized controlled trials. (PubMed, Sci Rep) - "Overall NMA revealed that only oral timolol [risk ratio (RR) = 3.35 (95% confidence interval (CI) 1.04-10.85)] and infusion of propranolol [RR = 10.19 (95% CI 1.29-80.41)] were associated with significantly higher incidences of asthma attack than the placebo, whereas oral celiprolol [RR = 0.39 (95% CI 0.04-4.11)], oral celiprolol and propranolol [RR = 0.46 (95% CI 0.02-11.65)], oral bisoprolol [RR = 0.46 (95% CI 0.02-11.65)], oral atenolol [RR = 0.51 (95% CI 0.20-1.28)], infusion of practolol [RR = 0.80 (95% CI 0.03-25.14)], and infusion of sotalol [RR = 0.91 (95% CI 0.08-10.65)] were associated with relatively lower incidences of asthma attack than the placebo. In participants with a baseline asthma history, in addition to oral timolol and infusion of propranolol, oral labetalol, oxprenolol, propranolol, and metoprolol exhibited significantly higher incidences of asthma attack than did the placebo. In conclusion, oral timolol and infusion of propranolol were..."

Journal • Retrospective data • Asthma • Cardiovascular • Immunology • Respiratory Diseases

Rho kinase inhibitors as new local therapy option in primary open angle glaucoma (PubMed, Ophthalmologe) - "The Rho-kinase inhibitors are an interesting new introduction for glaucoma therapy, as each new pressure-lowering therapy represents an additional chance to reach the individually defined target pressure level in a glaucoma patient with local therapy; however, many of the pleiotropic effects associated with Rho-kinase inhibitors have so far only been found experimentally and will require clinical confirmation in the future."

Journal • Review • Glaucoma • Ophthalmology

"Always thought timolol was just an eyedrop. https://t.co/7nlOHMxhDX" (@DrDavidWarriner)

Short-term efficacy of latanoprostene bunod for the treatment of open-angle glaucoma and ocular hypertension: a systematic literature review and a network meta-analysis. (PubMed, Br J Ophthalmol) - "LBN was significantly more effective than the PGA unoprostone and most of the beta-blockers. Compared with the most widely used PGAs, LBN numerically outperformed latanoprost and travoprost and was similar to bimatoprost 0.01%."

Journal • Retrospective data • Review • Glaucoma • Hypertension • Ophthalmology

Developing a framework regarding a complex risk based methodology in the evaluation of hazards associated with medicinal products sourced via the internet. (PubMed, Saudi Pharm J) - "With the application of the tool a dorzolamide & timolol combination eye drop represented the highest overall patient safety risk score. Notably, the fully comprehensive analysis of the internet pharmaceutical market and the test purchase of all online available medicines is unrealistic. Therefore, we developed a method to aid online surveillance researches and targeted international organizational led joint actions against the uncontrolled sale of falsified and substandard medications (e.g.: Operation Pangea)."

Journal

Comparison between propranolol 2% cream versus timolol 0.5% gel for the treatment of Kaposi sarcoma. (PubMed, Int J Dermatol) - No abstract available

Journal • Kaposi Sarcoma • Oncology • Sarcoma • Solid Tumor

Development of additive systemic effects when taking β-blockers in patients with glaucoma and concurrent chronic diseases (PubMed, Vestn Oftalmol) - "The most severe multifactorial adverse reactions developed due to long-term use of combinations of systemic and local β-blockers: 100 mg metoprolol or 10 mg bisoprolol with 0.5% timolol."

Clinical • Journal • Cardiovascular • Glaucoma • Hypotension • Ophthalmology

Use of Topical Timolol Maleate as Re-Epithelialization Agent for Treatment of Recalcitrant Wounds of Varying Etiologies. (PubMed, J Drugs Dermatol) - "Chronic wounds are a source of severe morbidity to patients.1 Wounds are also a notable burden on the healthcare system, with reported prevalence of 4.64% in the U.S. and an annual cost of over 25 billion dollars.2,3 Moreover, wounds are associated with >15% of all skin disease-related deaths4 and the 5 year mortality of some chronic wounds is greater than that of many cancers.5."

Journal • Dermatology • Oncology

"Topical BB such as eye drops in patients with Glaucoma frequently cause significant bradycardia using old timolol in old patients @DrDavidWarriner #CardioTwitter" (@AAlMohammad87)

Clinical • Cardiovascular • Glaucoma • Ophthalmology

Tube Obstruction of a Non valved Glaucoma Drainage Device by a Dislocated Soemmering's Ring. (PubMed, J Glaucoma) - "The IOP in the left eye was 22▒mmHg with three IOP topical lowering medications (timolol 0.5%, brimonidine 0.2% and latanoprost 0.005%)...The IOP spike was initially controlled with oral acetazolamide and topical IOP lowering medications (fixed combination of timolol 0.5% and brimonidine 0.2%)...In aphakic eyes undergoing non valved glaucoma drainage device implantation, a complete pars plana vitrectomy combined with any lens remnant removal may be considered. It helps to avoid tube obstruction due to these lens remnants which can migrate anteriorly along with the aqueous currents."

Journal • Glaucoma • Ophthalmology

Topical Treatment of Elevated Intraocular Pressure in Patients with Graves' Orbitopathy. (PubMed, Int J Environ Res Public Health) - "However, the latanoprost eye drops decreased intraocular pressure more effectively than drops containing brimonidine and timolol. Topical ocular hypotensive treatment is effective in reducing intraocular pressure in GO and decreases intraocular pressure more effectively than systemic corticosteroid therapy alone."

Clinical • Journal • Ophthalmology

Exploring the phototransformation and assessing the in vitro and in silico toxicity of a mixture of pharmaceuticals susceptible to photolysis. (PubMed, Sci Total Environ) - "Namely, three antibiotics (ciprofloxacin, levofloxacin, moxifloxacin), three antidepressants (bupropion, duloxetine, olanzapine), three anti-inflammatory drugs (diclofenac, ketoprofen, nimesulide), two beta-blockers (propranolol, timolol) and the antihistamine ranitidine were treated under simulated solar irradiation in ultra-pure and river water. Additionally, an in vitro approach to the toxicity assessment of daphnids was contrasted with ecotoxicity data based on the Ecological Structure Activity Relationships (ECOSAR) software comprising the in silico tool to determine the adverse effects of the whole mixture of photolabile parent compounds and TPs. The results demonstrated that photolysis of the target mixture leads to a decrease of the observed toxicity."

Journal • Preclinical

A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma. (PubMed, Int J Mol Sci) - "The effects of melatonin/agomelatine were compared with those of timolol (a beta blocker with prevalent hypotensive activity) or brimonidine (an alpha 2 adrenergic agonist with potential neuroprotective efficacy), two drugs commonly used to treat glaucoma. Concomitantly, gliosis-related inflammation and the Bax-associated apoptosis were partially prevented, thus leading to RGC survival and recovered retinal dysfunction. We suggest that topical melatoninergic compounds might be beneficial for ocular health."

Journal • Preclinical • Glaucoma • Immunology • Inflammation • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain

Comparison of the efficacy between topical timolol and pulsed dye laser in the treatment of ulcerated infantile haemangiomas: a randomised controlled study. (PubMed, J Eur Acad Dermatol Venereol) - "To date, oral propranolol has been most widely used in ulcerated IHs. Meanwhile, pulsed dye laser (PDL) may also promote the resolution of ulcerated IHs. However, there are no clinical studies comparing the efficacy of these two localised therapies in promoting ulcer healing in IHs."

Clinical • Journal • Oncology

"Timolol helps migraine? Is it the IOP lowering or something else? @migreenw @JohnBerdahl @MalikKahook" (@n8radcliffe)

CNS Disorders • Migraine

Mucoadhesive and responsive nanogels as carriers for sustainable delivery of timolol for glaucoma therapy. (PubMed, Mater Sci Eng C Mater Biol Appl) - "Timolol can efficiently diminish the intraocular pressure (IOP) of the eye; however the topical application as a solution of timolol maleate (TM) has poor therapeutic index and presents severe side effects. In vivo sustained efficacy of the NGs-timolol nanoformulations was demonstrated in rabbit's glaucoma model, in which the IOP could be diminished and maintained constant for 48 h with only one application. Overall, the synthesized NGs in combination with timolol have potential as drug delivery system for glaucoma therapy."

Journal • Glaucoma • Ophthalmology

Comparative evaluation of Latanoprostene Bunod, Timolol Maleate, and latanoprost Ophthalmic Solutions to assess their safety and efficacy in lowering intraocular pressure for the management of Open-Angle Glaucoma. (PubMed, Clinics (Sao Paulo)) - "Latanoprostene bunod was superior to latanoprost and timolol for the treatment of open-angle glaucoma."

Clinical • Journal • Glaucoma • Ophthalmology

Successful Treatment of Refractory Ischemic Diabetic Foot Ulcers by Combination Therapy of Autologous Platelet-rich Gel and Topical β Adrenergic Receptor Blocker: a Case Report (PubMed, Sichuan Da Xue Xue Bao Yi Xue Ban) - "The specific scheme used clopidogrel for antiplatelet agglutination, Low Molecular Weight Heparin (Clexane) and warfarin for anticoagulation, lipo-alprostadil for vasodilation, as well as local debridement and ultrasonic debridement...So the patient was treated with vacuum-assisted closure and autologous platelet-rich gel therapy for the next 7 weeks, then applied with 1 drop of timolol maleate 0.5% ophthalmic solution per cm wound area every other day for another 6 weeks, the wound rapidly healed and re-epithelialized basically. The follow-up for 5 weeks showed that the wound healed completely without any discomfort. No side effect was found."

Clinical • Combination therapy • Journal • Cardiovascular • Chronic Kidney Disease • Diabetes • Hematological Disorders • Hypertension • Metabolic Disorders • Nephrology • Ophthalmology • Renal Disease • Respiratory Diseases • Thrombosis