flucloxacillin sodium / Generic mfg. - LARVOL DELTA

Clinical presentation and management of snakebite envenoming in northern Ghana. (PubMed, PLoS Negl Trop Dis) - "The annual hospital attendance rate on account of snakebite to the Wa Municipal Hospital and the Baptist Medical Centre is estimated at 55 persons per 100,000 population per year. Mortality was low, with antivenom available to most of the patients. More evidence is needed on the indication and dosing of antivenom and to improve appropriate ancillary care."

Journal • Pain • Thrombosis

PA23 A case of neonatal scabies. (PubMed, Br J Dermatol) - "However, subsequent HSV polymerase chain reaction was negative and aciclovir was therefore ceased. Empirical treatment with flucloxacillin and gentamycin was also stopped due to no evidence of ongoing infection...Here we present an immunocompromised neonate who was successfully treated with permethrin 5%. Skin lesions can include erythematous papules, nodules and crusts, and in the absence of positive skin scrapings a careful history and examination of close contacts should lead to the eventual diagnosis."

Journal • Atopic Dermatitis • Critical care • Dermatology • Hepatology • Herpes Simplex • Immunology • Infectious Disease • Pediatrics • Pulmonary Disease • Respiratory Diseases • Septic Shock

P103 Beyond the surface: cutaneous vasculitis as a sign of fatal underlying conditions. (PubMed, Br J Dermatol) - "Staphylococcus aureus was isolated from peripheral blood cultures and a leg ulcer swab, prompting the initiation of intravenous flucloxacillin and an urgent inpatient transthoracic echocardiography (TTE) based on the microbiologist's advice...This highlights the importance of considering infection as a cause of vasculitis, particularly when atypical clinical features, systemic symptoms or progressive organ dysfunction are present. This case emphasizes the need for a comprehensive diagnostic approach before initiating immunosuppressive therapy, as timely identification and management of infection-driven vasculitis are crucial for optimizing patient outcomes."

Journal • Acute Kidney Injury • Cardiovascular • Hematological Disorders • Infectious Disease • Nephrology • Palliative care • Renal Disease • Vasculitis • MPO

BI22 First reported UK case of Kaposi sarcoma in an HIV-negative patient taking pre-exposure prophylaxis. (PubMed, Br J Dermatol) - "This had rapidly increased in size over the last 3 months, was not painful and had not improved with a course of flucloxacillin...Furthermore, this is a solitary lesion of the upper limb, which is unique in the literature and highly unusual for KS. This highlights the need for heightened awareness among healthcare providers when diagnosing KS, especially in patients with risk factors for HHV-8 and HIV, even when on PrEP."

Journal • Epstein-Barr Virus Infections • Human Immunodeficiency Virus • Infectious Disease • Kaposi Sarcoma • Oncology • Pain • Sarcoma • Solid Tumor • Spindle Cell Sarcoma

β-Lactam dosing in critically ill children: predictors for target non-attainment. (PubMed, J Antimicrob Chemother) - "This study found an eGFR ≥90 mL/min/1.73 m2 to be associated with target non-attainment, indicating that kidney function should be taken into account when identifying individuals who may require higher dosages. These results may help identify subpopulations of paediatric patients requiring higher dosages or continuous infusion in order to achieve adequate β-lactam exposure."

Journal • Pediatrics

BI05 Cemiplimab toes: a new entity in the expanding spectrum of immune checkpoint inhibitor skin toxicities. (PubMed, Br J Dermatol) - "As pain was severe, the initial concern was of a vasculitic process and oncology started prednisolone 2 mg kg-1 per day (120 mg per day) and flucloxacillin, with symptoms improving rapidly...Although she responded well to oral steroids and suspending cemiplimab, her skin flared with subsequent cycles with prednisolone doses below 10 mg per day despite topical treatment with clobetasol propionate, tacrolimus and calcipotriol-betamethasone ointments, fludroxycortide tape, Fucibet cream and potassium permanganate soaks...Clinically some features were reminiscent of 'COVID toes', but the underlying mechanism is unknown. This case of 'cemiplimab toes' is a striking reminder of the ever-evolving spectrum of cutaneous irAEs associated with immunotherapy and the challenges in diagnosing and managing these effectively to mitigate morbidity while continuing oncological treatment."

Checkpoint inhibition • Journal • Atopic Dermatitis • Dermatitis • Dermatology • Hematological Disorders • Immunology • Myositis • Non-melanoma Skin Cancer • Novel Coronavirus Disease • Oncology • Pain • Squamous Cell Carcinoma • Squamous Cell Skin Cancer • Vasculitis

CD24 Irritant contact dermatitis from Dieffenbachia schott: a case report of a florid reaction to a common household plant. (PubMed, Br J Dermatol) - "Management involved oral flucloxacillin for 1 week, topical betamethasone dipropionate with clotrimazole applied twice daily for 2 weeks, potassium permanganate soaks, Dermol 500 as a soap substitute, and white soft paraffin as a moisturizer. The history of hyacinth bulb allergy may have predisposed her to a lower threshold for a reaction. We present this case for wider acknowledgement of plant eruptions and suggest that gardening gloves are a useful adjunct for handling outdoor as well as indoor plants."

Journal • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Pain • CD24 • CRP

DP06 Decoding histology: γδ T-cell lymphoma vs. tumour-stage mycosis fungoides. (PubMed, Br J Dermatol) - "A trial of flucloxacillin produced no improvement, and an urgent ultrasound revealed nonspecific skin thickening, prompting a skin biopsy...In this case, the absence of systemic involvement on imaging and the atypical immuno-phenotypic features underscore the complexity of distinguishing between tumour-stage MF and PCGDTCL. This case highlights the role of detailed histopathological evaluation of rare cutaneous lymphomas and emphasizes the need for a multidisciplinary approach to design both local and systemic treatment strategies for individual patients."

IO biomarker • Journal • Bladder Cancer • Cutaneous T-cell Lymphoma • Dermatology • Genito-urinary Cancer • Hematological Malignancies • Hemophagocytic lymphohistiocytosis • Immunology • Lymphoma • Mycosis Fungoides • Oncology • Rare Diseases • Solid Tumor • T Cell Non-Hodgkin Lymphoma • CD2 • CD4 • CD5 • CD7 • CD8 • JAK3 • MAPK1

P012 Metastatic Staphylococcus aureus bacteraemia in atopic dermatitis: a case series. (PubMed, Br J Dermatol) - "IV, intravenousPatientClinical manifestationsComplications of SABTreatment of metastatic SABOutcome1Diaphoresis, rigors, nausea, fatigueMitral/aortic valve IE8 weeks IV flucloxacillinRecommenced on methotrexate; good control of AD2ErythrodermaMitral valve IE6 weeks IV flucloxacillinCommenced on dupilumab; excellent control of AD3Pyrexia and rigors following abscess development at footMitral/aortic valve IE6 weeks IV cefazolinMitral valve repair for mitral regurgitation. Recent commencement of dupilumab; AD improving4Erythroderma, subjective fevers, fatigueMRSA bacteraemia with mitral valve IETotal duration 6 weeks 6 days: IV vancomycin → IV daptomycin → IV ceftaroline + vancomycin → oral linezolidRecent recommencement of tralokinumab; AD improving5Right shoulder painSeptic arthritis of right shoulderIV flucloxacillin + vancomycin → 8 weeks daptomycin + rifampicin → 6 weeks doxycyclineCommenced on dupilumab; excellent control of ADAD, atopic dermatitis; IE, infective..."

Journal • Atopic Dermatitis • Cardiovascular • Cognitive Disorders • Dermatitis • Dermatology • Dermatopathology • Immunology • Infectious Disease • Inflammation • Musculoskeletal Pain • Pain • Rheumatology

CD12 Severe allergic contact dermatitis to jagua henna temporary tattoo. (PubMed, Br J Dermatol) - "She required treatment with a 7-day course of oral steroid, flucloxacillin and fexofenadine as it was not responding to topical steroid creams. The patch tests also showed positive reactions to balsam of Peru, fragrance mix I, hydroperoxide of linalool, and 2-n-octylisothiazolinone. We report a case of allergic contact dermatitis caused by jagua henna temporary tattoo, which highlights the presence of an emerging allergenic substance 'genipin' used in temporary tattoos."

Journal • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Oncology • Pain • Solid Tumor

Increasing trend in fusidic acid resistance among MRSA isolates in the Netherlands, 2016-23. (PubMed, JAC Antimicrob Resist) - "Since fusidic acid and flucloxacillin are the main treatment options for impetigo, increasing resistance limits treatment possibilities...In conclusion, an increasing trend in fusidic acid resistance was found among MRSA isolates. Since impaired treatment for impetigo might ease the spread of (fusidic acid-resistant) MRSA, extra vigilance is warranted."

Journal • Dermatology

Therapeutic drug monitoring and target attainment of unbound flucloxacillin in hospitalized patients with measured MICs (FLUTE). (PubMed, J Antimicrob Chemother) - "Target attainment of unbound flucloxacillin was achieved in one third of patients, while a substantial number of patients had an unbound flucloxacillin concentration >10 mg/L, which was associated with increased toxicity. We advise routine TDM of unbound flucloxacillin for patients with impaired renal function and a high daily dose to mitigate the risk of flucloxacillin-associated nephrotoxicity and neurotoxicity."

Journal

Effect of ibuprofen on the pharmacokinetics of intravenous flucloxacillin in healthy adults. (PubMed, Int J Antimicrob Agents) - "Orally administered ibuprofen had no measurable effect on plasma flucloxacillin PK in healthy adults. Given the lack of drug-drug interaction, there is no benefit to prescribe ibuprofen alongside flucloxacillin to increase flucloxacillin exposure."

Journal • PK/PD data • Infectious Disease • Pain

ElastoMeric Infusion Pumps for Hospital AntibioTICs (EMPHATIC): A Feasibility Study. (PubMed, Antibiotics (Basel)) - "This proof of concept feasibility study shows that it may be feasible to use EMPs in the inpatient setting. There is potential to improve patient and staff experience; however, cost and residual volume are potential barriers to implementation, with further studies required."

Journal

Taste-Masked Diclofenac Sodium Microparticles Prepared by Polyelectrolyte Complexation: Formulation Using Different Fatty Acids and Taste Evaluation by Human Panel. (PubMed, Pharmaceutics) - "Building on previous proof-of-concept work with flucloxacillin sodium, this study investigated the effects of fatty-acid chain length on the formation, stability, dissolution, and sensory acceptability of diclofenac sodium (DS)-Eudragit® EPO (EE)-fatty acid (FA) polyelectrolyte complexes (PECs)... Fatty-acid chain length influenced PEC formation and taste acceptability, but not the PEC stability and drug dissolution profile. Palmitic acid (DS-EE-PA) offered the best overall profile and represents a promising candidate for further development of paediatric-appropriate diclofenac formulations."

Journal • Pediatrics

Persistent Hepatocellular Secretory Failure Secondary to Flucloxacillin-Induced Liver Injury: A Case With Successful Response to Rifampicin. (PubMed, Cureus) - "This case highlights the importance of maintaining a high index of suspicion for hepatocellular secretory failure in patients with persistent hyperbilirubinemia following withdrawal of a potential hepatotoxic agent. Targeted therapy with rifampicin can result in both symptomatic and biochemical improvement in hepatic function."

Journal • Cholestasis • Dermatology • Hepatology • Immunology • Infectious Disease • Liver Failure • Pruritus

An Unusual Culprit: Staphylococcus capitis Native Mitral Valve Endocarditis Following Scalp Surgery. (PubMed, Cureus) - "The unusual flucloxacillin susceptibility of the isolate further underscores the variability of antimicrobial resistance patterns in S. capitis. Clinicians should maintain a high index of suspicion when S. capitis is repeatedly isolated from blood cultures, and prompt echocardiography is essential to prevent diagnostic delay and adverse outcomes."

Journal • Cardiovascular • Cholestasis • Hematological Disorders • Hepatology • Infectious Disease • Musculoskeletal Pain • Pain • Thrombocytopenia

Dicloxacillin and flucloxacillin inhibit hepatic uptake transporters - in vitro investigations and physiologically based pharmacokinetic modelling. (PubMed, bioRxiv) - "PBPK model simulations predicted no major change in rosuvastatin, a substrate for OATPs and BCRP, pharmacokinetics, when co-administered with dicloxacillin or flucloxacillin. Simulations with dicloxacillin and P-gp substrates dabigatran or digoxin also predicted limited inhibition of P-gp transport."

Journal • PK/PD data • Preclinical • Breast Cancer • Oncology • Solid Tumor • SLCO2B1

Changing Staphylococcus aureus Resistance in Atopic Dermatitis: Implications for Topical Antimicrobial Use From a Regional Study in the United Kingdom. (PubMed, Cureus) - "aureus (MRSA) defined by flucloxacillin/oxacillin resistance...Adults demonstrated greater resistance to erythromycin, clindamycin, and tetracycline.   This study highlights changing staphylococcal epidemiology with concerningly high MRSA and fusidic acid resistance in dermatological isolates...The findings underscore the need for dermatology-led antimicrobial stewardship to mitigate escalating community resistance in S. aureus infections."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Pediatrics

Risk factors for treatment failure in lactational mastitis: a retrospective cohort study in China. (PubMed, Int Breastfeed J) - No abstract available

Journal • Retrospective data

Tacrolimus Pharmacokinetics in Pediatric Liver Transplant Recipients During the First Month After Transplantation. (PubMed, Eur J Drug Metab Pharmacokinet) - "TDM of tacrolimus is often not enough to obtain the concentrations in the therapeutic range. Identifying cofounders for variability a priori is essential for guiding efficient and accurate dosing, shifting the focus from reactive TDM towards better dosing strategies that improve PK predictions and ultimately improve therapy for pediatric LTx recipients."

Journal • PK/PD data • Pediatrics • Transplantation

Differences in prescription for impetigo and cellulitis across years in three European countries. (PubMed, J Antimicrob Chemother) - "Prescribing patterns are very heterogeneous across European countries and publication of guidelines did not affect prescribing habits."

Journal • Dermatology • Dermatopathology • Infectious Disease

PHARMACOGENOMICS IMPLEMENTATION IN PAEDIATRIC ONCOLOGY: UTILISING THE MARVEL-PIC TRIAL TO GENERATE EVIDENCE FOR PRE-EMPTIVE TESTING (SIOP 2025) - "Paired medications include allopurinol, sertraline, omeprazole, voriconazole, ondansetron, flucloxacillin, amikacin and mercaptopurine...Ondansetron, mercaptopurine, omeprazole, pantoprazole and voriconazole were commonly prescribed medications with PGx prescribing recommendations, with highest actionability rates for the latter three... Our analysis reveals a high prevalence of clinically relevant PGx phenotypes across this cohort, highlighting the utility of PGx testing in paediatric oncology patients across a range of genes and commonly prescribed medications. Study findings provide evidence that broad, pre-emptive PGx testing in oncology patients could improve treatment safety and efficacy of both chemotherapeutics and supportive care. The MARVEL-PIC primary endpoints will validate this new approach to treatment protocols in children with cancer."

Biomarker • Pediatrics • ABCG2 • CYP2C19 • HLA-B • NUDT15

Post-market quality monitoring of medicines in Christian Health Association of Ghana health institutions. (PubMed, Ghana Med J) - "All samples from ceftriaxone injection 1 g, ciprofloxacin 500 mg, metronidazole 200 mg, and metformin 500 mg passed the Truscan RM test. High passes were also recorded for paracetamol 500 mg (96.6%), artemether/lumefantrine 80/480 mg (95.8%), and oral rehydration salts (94%). Conversely, all the forty-two (42) samples obtained and tested for flucloxacillin 250 mg failed the Truscan analyser test. Relatively high failures were also recorded for lisinopril 10 mg (90.5%) and albendazole 400 mg (89.8%)...For future application of Truscan, a check of standard spectra is essential, and the choice of tracer medicines should include those with limited fluorescence materials in formulations and a relatively high percentage of active ingredients. This study was funded by Pharmaccess Foundation Ghana and the Netherlands."

Journal • P4 data

The Impact of an Ex Vivo Pediatric Extracorporeal Membrane Oxygenation Circuit on Sequestration of Antimicrobials. (PubMed, Crit Care Explor) - "The lipophilicity of an antimicrobial is a predictor of antimicrobial recovery in ECMO. Concentrations were significantly reduced at 7 hours for greater than 60% of the study antimicrobials in the ECMO models. Clinical studies are required for children receiving ECMO to determine if the current dosing regimens for antimicrobials provide therapeutic concentrations."

Journal • Preclinical • Pediatrics