flucloxacillin sodium / Generic mfg. - LARVOL DELTA

Cefazolin Versus Antistaphylococcal Penicillins in Methicillin-Susceptible Staphylococcus aureus Bone and Joint Infections: A Narrative Review. (PubMed, Antibiotics (Basel)) - "This narrative review summarizes the randomized and observational evidence with emphasis on osteoarticular populations and discusses the cefazolin inoculum effect, bone pharmacokinetics, the safety of prolonged therapy, outpatient practicality and current guidelines. We conclude that cefazolin is a rational first-line option for most patients with MSSA BJI, outline the remaining uncertainties in high-inoculum and implant-associated infection, and propose a focus-specific research agenda."

Journal • Review • Infectious Disease • Inflammation

Gut phages are linked to off-target antimicrobial resistance genes in orthopedic patients receiving peri-surgical antibiotics. (PubMed, Front Microbiol) - "This study investigates the effects of predominantly flucloxacillin- and gentamicin-based perioperative antibiotic prophylaxis on phage and ARG dynamics in orthopedic trauma patients. Our findings suggest perioperative antibiotics may contribute to phage-associated dissemination of off-target ARGs. Understanding how ARGs spread in the gut microbiome is important for improving antibiotic stewardship and protecting vulnerable patients from difficult to treat infections."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

A Rare Case of Pyroglutamic Acidosis After Cardiac Surgery. (PubMed, Cureus) - "We report the case of a 59-year-old patient who developed high-anion-gap metabolic acidosis after surgical treatment for mediastinitis, caused by the concomitant use of flucloxacillin and paracetamol...Although rare, this interaction may cause a severe and potentially fatal reaction, particularly in patients with renal failure, sepsis, or malnutrition. As such, the possible diagnosis of pyroglutamic acidosis should be kept in mind in these settings, and the use of these medications should be discontinued immediately."

Journal • Cardiovascular • Infectious Disease • Metabolic Disorders • Renal Disease • Septic Shock

When flexures look septic: febrile purpuric flucloxacillin-induced SDRIFE (EADV 2026) - No abstract available

A new era in the treatment ofStaphylococcus aureusbacteremia: cefazolin becomes first choice (PubMed, Ned Tijdschr Geneeskd) - "Cefazolin is non-inferior to flucloxacillin in the treatment of MSSA bacteremia and is associated with less AKI."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

Comparative evaluation of biogenic hydroxyapatite derived from fish bones and synthetic hydroxyapatite for the removal of flucloxacillin sodium. (PubMed, Discov Nano) - "Furthermore, the regeneration experiments demonstrated that the adsorbent could retain ~ 92% of the initial adsorption capacity after five adsorption-desorption cycles with a slight decrease in removal efficiency from 83.0 to 76.1%, showing the excellent operational stability and reusability of the adsorbent. Finally, these results showed the great potential of B-CaHAp as an efficient, sustainable and reusable adsorbent for the removal of pharmaceutical contaminants from aqueous media."

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Initial Negative MRI Spine and Persistent Staphylococcus aureus Bacteraemia Lead to Delayed Diagnosis of Lumbar Spondylodiscitis and Epidural Abscess: A Case Report. (PubMed, Cureus) - "As the patient remained neurologically intact, a multidisciplinary team involving microbiology, radiology, cardiology, and spinal surgery agreed on conservative management with prolonged intravenous flucloxacillin...This case highlights the importance of maintaining a high index of suspicion for vertebral infection in patients with persistent S. aureus bacteremia (SAB) and ongoing back pain despite initially negative imaging. It also emphasises the value of repeat MRI when clinical suspicion persists and demonstrates that carefully selected patients with spinal epidural abscess may be successfully managed without surgery through a multidisciplinary approach."

Journal • Back Pain • Cardiovascular • CNS Disorders • Infectious Disease • Inflammation • Lumbar Back Pain • Musculoskeletal Pain • Pain

Therapeutic drug monitoring of high-dosage intravenous flucloxacillin and mortality in patients with Staphylococcus aureus bacteremia: a retrospective cohort study using inverse probability weighting. (PubMed, Eur J Clin Microbiol Infect Dis) - "TDM in patients with SAB treated with high-dosage ASPs is associated with lower antibiotic consumption without a statistically significant difference in mortality. We found no evidence of a decrease in antibiotic-associated adverse events."

Journal • Retrospective data • Infectious Disease

Effect of Microdoses of Incisional Antibiotics on the Rate of Surgical Site Infections in Skin Cancer Surgery: A Randomized Clinical Trial. (PubMed, JAMA Surg) - "Patients received an incision site injection of buffered local anesthetic alone (control), buffered local anesthetic with microdosed flucloxacillin (500 µg/mL), or buffered local anesthetic with microdosed clindamycin (500 µg/mL). The significant reduction in SSI with locally applied microdosed incisional clindamycin provides robust evidence to inform treatment guidelines in this area, which are currently lacking. anzctr.org.au Identifier: ACTRN12616000364471."

Clinical • Journal • Surgery • Anesthesia • Genetic Disorders • Infectious Disease • Oncology • Skin Cancer

Acute kidney injury in Staphylococcus aureus bacteraemia: a multicentre cohort study of incidence, timing, recovery and associations with antibiotic treatment. (PubMed, J Antimicrob Chemother) - "Flucloxacillin was associated with increased AKI risk compared with cefazolin, with most AKI episodes occurring early after index blood culture and recovery decreasing with increasing AKI severity. Lower flucloxacillin doses were not associated with reduced AKI risk, suggesting that dose reduction alone may not mitigate flucloxacillin-associated nephrotoxicity."

Journal • Retrospective data • Acute Kidney Injury • Nephrology • Renal Disease

Hidden in Plain Sight: Nocardia farcinica Posterior Shoulder Abscess Temporally Associated With Sports Massage in an Immunocompetent Host. (PubMed, Cureus) - "Microbiological culture identified heavy growth of N. farcinica, necessitating cessation of empirical intravenous flucloxacillin and initiation of linezolid, followed by a planned six-month course of oral co-trimoxazole...The patient achieved satisfactory clinical improvement with preserved neurovascular function at follow-up. This case represents a potentially novel mechanism of nocardial inoculation via vigorous deep soft-tissue massage and underscores the importance of considering atypical pathogens in deep soft-tissue infections that follow an unexpected or treatment-refractory clinical course."

Journal • Esophageal Cancer • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Oncology • Pain

Sustainable UHPLC-MS/MS assay for ultra-sensitive simultaneous quantification of amoxicillin and flucloxacillin with application to a bioequivalence study. (PubMed, Anal Bioanal Chem) - "The method's sustainability was comprehensively evaluated by the recently introduced Sustainability Assessment Method for Instrumental Analysis (SAMI), highlighting the study's alignment with the United Nations Sustainable Development Goals (UN-SDGs). Furthermore, the developed method was successfully applied in a bioequivalence study involving 33 healthy volunteers following oral administration of a single 5 mL dose of Flucamox® 250 mg, enabling comprehensive pharmacokinetic evaluation while promoting sustainable and resource-efficient analytical practices."

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Protein Binding Determination of Cefepime, Flucloxacillin, Meropenem, Piperacillin and Tazobactam by Ultrafiltration in Critically Ill Patients: The Choice of Device Matters. (PubMed, Clin Pharmacokinet) - "These findings underscore significant differences in results between ultrafiltration devices, depending on the drug, influenced by NSB. Such factors should be considered when developing methods for determining unbound concentrations of beta-lactam antibiotics."

Journal • Critical care

Cefazolin Versus Flucloxacillin for Methicillin-Susceptible Staphylococcus aureus Bone and Joint Infections: A Retrospective Single-Center Comparative Study of Effectiveness and Renal Safety of Intravenous Monotherapy. (PubMed, Antibiotics (Basel)) - " We retrospectively analyzed all adults at a single center with culture-confirmed, monomicrobial MSSA BJI treated with inpatient intravenous cefazolin or flucloxacillin monotherapy (January 2022-January 2025)-a selected population excluding rifampicin-based combination therapy, outpatient parenteral therapy, polymicrobial infection, and concurrent bacteremia/endocarditis. In this selected inpatient monotherapy cohort, cefazolin was associated with numerically fewer AKI events, without statistically significant differences in any comparison. These exploratory findings support cefazolin as a rational targeted option for MSSA BJI, pending prospective confirmation."

Journal • Monotherapy • Retrospective data • Acute Kidney Injury • Cardiovascular • Infectious Disease • Inflammation • Nephrology • Renal Disease

Sputum antimicrobial susceptibility patterns and clinical outcomes among adult Aboriginal Australians with bronchiectasis. (PubMed, Ther Adv Respir Dis) - "The greatest frequency of antimicrobial resistance was recorded against Ampicillin for Haemophilus spp. (5.8%), Ceftazidime for Pseudomonas spp. (7.7%), Erythromycin for Streptococcus pneumoniae (20.5%), Flucloxacillin and Amoxycillin/Clavulanate for Staphylococcus spp...and patients with multi-antimicrobial resistance recorded a higher hospitalisation rate (median 14 vs. 8), more hours in intensive care (median 225.5 vs. 131) and left upper lobe bronchiectasis (41.9 vs 20.4%). Although, statistically not significant, the overall mortality was higher among patients demonstrating multi-antimicrobial resistance, including younger age at death.ConclusionThe results of this study may be of utility in advocating antimicrobial stewardship among adult Aboriginal/Indigenous patients with bronchiectasis."

Clinical data • Journal • Retrospective data • Bronchiectasis • Critical care • Infectious Disease • Pneumococcal Infections • Pneumonia • Pulmonary Disease • Respiratory Diseases

Stevens-Johnson Syndrome identified at the University Hospital Center of Libreville, Gabon: Four case reports. (PubMed, Int J Risk Saf Med) - "Therefore, this study aimed to describe the clinical characteristics, drug causality assessment, therapeutic management, and direct medical costs of four confirmed cases of SJS managed at the Libreville University Hospital Center (CHUL).Case reportFour confirmed cases of SJS related respectively to lidocaine, allopurinol, amoxicillin/clavulanic acid, and flucloxacillin were identified...Therapeutic management was based on symptomatic and supportive treatment, including Polaramine, Solumedrol, Dacryoserum, eosin solution, Fucithalmic, sodium bicarbonate, Fungizone, Dexeryl, ciprofloxacin, and Exomuc, with favorable clinical outcomes observed in all patients. The mean direct medical cost of management was estimated at 225,089 CFA francs (343.14 €), with a total cost of 860,355 CFA francs (1311.60 €) for the four cases.ConclusionSJS remains a severe dermatological emergency associated with substantial management costs despite favorable clinical outcomes. These findings..."

Journal • Steven-Johnson Syndrome

Biofilm sensitization to break Staphylococcus aureus tolerance to cold atmospheric plasma therapy. (PubMed, J Med Microbiol) - "In contrast, H2O2 enhanced flucloxacillin activity in a strain-dependent manner, sensitizing S. aureus biofilms to otherwise sub-lethal concentrations of antibiotic.Conclusion...However, the inability of H2O2 to reproduce this effect highlights the importance of additional plasma-derived reactive species in mediating this dual-action killing. Together, these findings position biofilm sensitization as a central concept emerging from this study, whereby a non-lethal adjunct can lower the threshold for CAP-mediated killing without acting primarily as a direct antimicrobial."

Journal • Infectious Disease

Safe shortening of antibiotic treatment duration for complicated Staphylococcus aureus bacteremia (SAFE-trial) (clinicaltrialsregister.eu) - P2/3 | N=300 | Completed | Sponsor: Stichting Amsterdam UMC | Active, not recruiting ➔ Completed

Trial completion • CRP

Secondary Staphylococcus capitis Infection of a Long-Standing Non-Coronary Sinus of Valsalva-to-Right Atrial Fistula Initially Misdiagnosed as a Gerbode Defect: A Case Report. (PubMed, J Clin Med) - "The fistula was closed with an autologous pericardial patch, and intravenous flucloxacillin was administered because of probable localized infective involvement...Persistent high-velocity flow may contribute to endocardial injury and create a substrate for subsequent bacterial colonization, although causality cannot be established from a single case. Isolation of a low-virulence skin commensal from pathological cardiac tissue should be interpreted in the complete clinical, operative, microbiological, and histopathological context rather than automatically classified as contamination."

Journal • Cardiovascular • Infectious Disease • Pulmonary Disease

Isolation and characterisation of novel lytic bacteriophages for therapeutic applications in biofilm-associated prosthetic joint infections. (PubMed, Sustain Microbiol) - "Subsequently, we combined them into a phage cocktail, which effectively re-sensitized biofilms to vancomycin and flucloxacillin. Notably, this phage cocktail demonstrated low cytotoxicity in vitro to human epithelial cells, even when used alongside antibiotic treatments. These findings highlight the potential of the phage cocktail as a tool to increase antibiotic treatment success in prosthetic joint infections."

Journal • Infectious Disease • Orthopedics

Utility of monocyte-derived cells to investigate immune-mediated drug-induced liver injury. (PubMed, Toxicol Lett) - "The sensitivity of MH generated from seven patients with immune checkpoint inhibitor (ICI)-induced hepatotoxicity was ICI-dependent, responding to nivolumab and/or ipilimumab (4 out of 5), but not to pembrolizumab (0 out of 2). Additionally, DILI-derived MH were not sensitive to non-DILI drugs. In conclusion, monocyte-derived cells may serve as an additional tool for drug-specific mechanistic studies of immune-mediated DILI."

IO biomarker • Journal • Hepatology • Inflammation • Liver Failure • Oncology

Predictive performance of an antibiotic precision dosing software program in critically ill adults with infection. (PubMed, J Antimicrob Chemother) - "In a heterogenous adult ICU population, the a priori predictive performance of vancomycin was shown to be acceptable. Conversely, the a priori predictive performance for the beta-lactams was not acceptable. Although predictive performance improved with the a posteriori approach for beta-lactams, only cefepime met acceptance criteria."

Journal • Infectious Disease

Preparation of Silica-Based Chitosan Chiral Stationary Phases by Two Synthetic Approaches and Evaluation of Their Enantioseparation Performance by HPLC. (PubMed, Biomed Chromatogr) - "The CSPs demonstrated good enantioseparation performance for most of the tested chiral analytes, and the enantioselective separation of flucloxacillin was comparable with that of commercial Chiralcel OD-H and Chiralpak AD-H. We gained a deeper understanding of the chiral recognition mechanism by modifying the mobile phase composition and the position of chlorine substituents in the phenyl group. Furthermore, the CSP-2 overcomes the dissolution and high expansion problems of traditional coating-type CSP in unconventional eluents, and the separation performance achieved for some of the tested chiral compounds is even superior to that of CSP-1."

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Staphylococcal scalded skin syndrome: a pediatric dermatology emergency (PubMed, Dermatologie (Heidelb)) - "Under parenteral flucloxacillin and clindamycin combined with antiseptic wound care and supportive treatment, the skin healed completely within 1 week. Because delayed treatment can substantially increase mortality, prompt recognition of SSSS and the immediate initiation of empirical antibiotic therapy are decisive for prognosis."

Journal • Dermatology • Infectious Disease • Pain • Pediatrics • Steven-Johnson Syndrome

Mass Spectrometric Characterization of Flucloxacillin Binding to Serum Albumin in Hospitalized Patients With Hypoalbuminemia: An Observational Pilot Study. (PubMed, Ther Drug Monit) - "Prolonged flucloxacillin treatment and low serum albumin concentrations were associated with a high stoichiometry of flucloxacillin/albumin complexes in hospitalized patients with serum hypoalbuminemia. This study illustrates that protein binding is not a constant, thereby contributing to current understanding of the pharmacokinetics, effectiveness, and toxicity of flucloxacillin."

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