flucloxacillin sodium / Generic mfg. - LARVOL DELTA

POTENTIAL FOR PHARMACOGENOMICS TO IMPROVE MEDICATION SAFETY AND EFFICACY IN AUSTRALIAN HAEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS (EBMT 2026) - "Paired supportive care medications included allopurinol, sertraline, omeprazole, pantoprazole, voriconazole, ondansetron, tramadol, tacrolimus, flucloxacillin, carbamazepine and amikacin. We have demonstrated the prevalence of clinically relevant high-risk PGx phenotypes in a diverse paediatric oncology cohort. Many supportive care medications prescribed for paediatric HSCT patients are likely to be affected, with high prescribing rates observed for some medications with available PGx prescribing guidelines. These results highlight the potential for PGx guided prescribing to improve medication efficacy and reduce toxicity in a paediatric HSCT setting."

Biomarker • Clinical • Bone Marrow Transplantation • Transplantation • ABCG2 • CYP2C19 • CYP3A5 • HLA-B • NUDT15

POTENTIAL FOR PHARMACOGENOMICS TO IMPROVE MEDICATION SAFETY AND EFFICACY IN AUSTRALIAN HAEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS (EBMT 2026) - "Paired supportive care medications included allopurinol, sertraline, omeprazole, pantoprazole, voriconazole, ondansetron, tramadol, tacrolimus, flucloxacillin, carbamazepine and amikacin. We have demonstrated the prevalence of clinically relevant high-risk PGx phenotypes in a diverse paediatric oncology cohort. Many supportive care medications prescribed for paediatric HSCT patients are likely to be affected, with high prescribing rates observed for some medications with available PGx prescribing guidelines. These results highlight the potential for PGx guided prescribing to improve medication efficacy and reduce toxicity in a paediatric HSCT setting."

Biomarker • Clinical • Bone Marrow Transplantation • Transplantation • ABCG2 • CYP2C19 • CYP3A5 • HLA-B • NUDT15

Gonococcal Dacryoadenitis: A Case Report. (PubMed, Case Rep Ophthalmol) - "Following IV ceftriaxone and flucloxacillin, topical steroid and chloramphenicol eye drops, the patient saw marked clinical improvement. This case demonstrates that NG may present with unusual features, and clinicians should have a low threshold for conjunctival cultures and promptly explore the sexual and social histories of patients presenting with similar symptomology."

Journal • Conjunctivitis • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Scleritis

Palliative Management of Advanced Breast Carcinoma Complicated by Myiasis: First Case Report From Bangladesh. (PubMed, Clin Med Insights Case Rep) - "She was treated with morphine, flucloxacillin, ivermectin, and albendazole, which resulted in significant symptomatic relief...This report underscores the importance of early recognition and integrated management of malignant wound myiasis, particularly in resource-constrained environments. It also draws attention to the broader psychosocial impacts of such conditions and the essential role of end-of-life care in mitigating suffering."

Journal • Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Infectious Disease • Oncology • Pain • Palliative care • Solid Tumor • HER-2

Emphysematous gastritis: diagnostic histology in the absence of classic radiological features. (PubMed, BMJ Case Rep) - "The patient was treated with broad-spectrum intravenous antibiotics, including flucloxacillin, metronidazole and gentamicin. She improved with conservative management, avoiding the need for surgery. This case highlights the importance of early clinical suspicion and using a multidisciplinary approach with endoscopic, microbiological and histological correlation in diagnosing emphysematous gastritis."

Journal • Gastrointestinal Disorder • Infectious Disease • Pain • Respiratory Diseases

REFRACTORY DIGITAL ULCERS AND CHRONIC OSTEOMYELITIS COMPLICATING DIFFUSE SYSTEMIC SCLEROSIS: A REAL-LIFE CASE (SSWC 2026) - "Digital ulcers were refractory to nifedipine 60 mg/day, prompting escalation to alprostadil in 2013 and iloprost in 2016, both initially effective...Sildenafil (up to 150 mg/day, 2024–2025) proved ineffective. Bosentan, initiated in January 2025, was discontinued after re-hospitalization in August 2025 for multiple ulcers and chronic osteomyelitis of the right fifth digit...Osteomyelitis developed in the right second digit in 2019, requiring multiple antibiotic courses (flucloxacillin, amoxicillin–clavula- nate, clindamycin, trimethoprim–sulfamethoxazole) following Staphylococcus aureus isolation, with relapse in 2020 managed with ciprofloxacin...Mycophenolate mofetil (2017–2019) was used for progressive skin fibrosis and NSIP but discontinued due to recurrent osteomyeli- tis. Nintedanib (2021–2024) was initiated for progressive pulmonary fibrosis but withdrawn due to severe diarrhea and weight loss... This case illustrates the complex therapeutic challenges in SSc..."

Clinical • Cardiovascular • Fibrosis • Hepatology • Hypotension • Immunology • Infectious Disease • Inflammation • Interstitial Lung Disease • Musculoskeletal Diseases • Orthopedics • Pneumonia • Primary Biliary Cholangitis • Pulmonary Disease • Respiratory Diseases • Scleroderma • Systemic Sclerosis • Venous Ulcer

Cefazolin and benzylpenicillin cause less acute kidney injury than flucloxacillin in a global trial of Staphylococcus aureus bloodstream infection. (UKKW 2026) - "Introduction Staphylococcus aureus (S. Discussion Rates of AKI were found to be higher with (flu)cloxacillin than cefazolin or (benzyl)penicillin. These finding suggest that cefazolin and (benzyl) penicillin have clinical benefits over (flu)cloxacillin, with equivalent efficacy."

Clinical • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease • Septic Shock

Pyroglutamic Acidosis (UKKW 2026) - "Escalated from 2G flucloxacillin to Piperacillin-tazobactam and clindamycin on day -15 of flucloxacillin. The diagnosis was further confirmed by urine organic acids measurement, showing a markedly elevated level of pyroglutamic acid Conclusion Pyroglutamic acidosis is usually a diagnosis of exclusion supported by the appropriate clinical scenario combined with plasma and/or urine pyroglutamic acid levels. This lady developed pyroglutamic acidosis due to co-prescription of flucloxacillin and paracetamol with underlying malnutrition , sepsis as risk factor"

Infectious Disease • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • Renal Disease • Septic Shock

Pyroglutamic Acidosis (UKKW 2026) - "Escalated from 2G flucloxacillin to Piperacillin-tazobactam and clindamycin on day -15 of flucloxacillin. The diagnosis was further confirmed by urine organic acids measurement, showing a markedly elevated level of pyroglutamic acid Conclusion Pyroglutamic acidosis is usually a diagnosis of exclusion supported by the appropriate clinical scenario combined with plasma and/or urine pyroglutamic acid levels. This lady developed pyroglutamic acidosis due to co-prescription of flucloxacillin and paracetamol with underlying malnutrition , sepsis as risk factor"

Infectious Disease • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • Renal Disease • Septic Shock

Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals. (PubMed, Nat Med) - "Clindamycin, fluoroquinolones and flucloxacillin accounted for most of the associations with the abundance of individual species. Use of these antibiotics 4-8 years earlier was associated with altered abundance of 10-15% of the species studied; penicillin V, extended-spectrum penicillins and nitrofurantoin were associated with only a few species. Similar results were found comparing one antibiotic course 4-8 years before sampling versus none in the past 8 years. These findings indicate that antibiotics may have long-lasting consequences for the gut microbiome."

Journal • Cardiovascular • Metabolic Disorders

A collagen hydrogel-based 3D Heparg model for enhanced hepatocyte function and assessment of cholestatic drug-induced liver injury. (PubMed, Arch Toxicol) - "When incubated with cholestatic antibiotics, such as cloxacillin, flucloxacillin, and nafcillin, the 3D model reproduced cholestatic DILI features, showing increased cytotoxicity in the presence of bile acids and after prolonged exposure. Functionally, cloxacillin induced oxidative stress, mitochondrial dysfunction, and activation of apoptotic signaling pathways. Overall, the collagen hydrogel-based 3D HepaRG model provided a robust and physiologically relevant platform for investigating antibiotic-induced cholestatic DILI and its underlying mechanisms, offering improved predictivity over traditional 2D systems and valuable potential for preclinical drug safety assessment."

Journal • Cholestasis • Hepatology • Liver Failure • Metabolic Disorders

Addressing Analytical Challenges to Improve Laboratory Consistency in Unbound Flucloxacillin Measurement. (PubMed, Ther Drug Monit) - "A validated LC-HRMS method for quantifying unbound FLU was developed using UF. Cross-validation showed that comparable results can be achieved across laboratories when key UF parameters, such as device type and temperature, are harmonized. Because of the limited stability of FLU in ultrafiltrate, sample storage in plasma matrix is recommended."

Journal

Use of a Scattered Light Integrating Collector for Point of Care Testing to Detect Bacteria in Fluid Samples from Prosthetic Joint Infections of the Hip (AAOS 2026) - "Six antibiotics typically used in PJIs were selected for testing: vancomycin, gentamicin, flucloxacillin, rifampicin, cefuroxime, and cotrimoxazole. We demonstrate that in organisms typical for PJI, SLIC detects infection rapidly, shows a high PPV for the presence of antimicrobial resistance, and has strong concordance with BMD in defining AST, at 60 and 120 minutes. This timescale compares favourably to the current laboratory standard (culture and colorimetry), which typically returns results in 48h or longer. SLIC also obviates the need for a priori knowledge pertaining to the likely organism, as is often required by rapid molecular methods."

Infectious Disease • Orthopedics • Septic Shock

Pharmacokinetic drug-drug interactions with flucloxacillin and other isoxazolyl penicillins: A systematic literature review and practical guide. (PubMed, Br J Clin Pharmacol) - "Recent years have seen a notable increase in the number of publications concerning pharmacokinetic drug-drug interactions involving the isoxazolyl penicillins cloxacillin, dicloxacillin, flucloxacillin and oxacillin. Although pointing towards induction of cytochrome P450 enzymes, diphosphate-glucuronosyltransferase enzymes and P-glycoprotein as most plausible mechanism for most interactions, the exact interaction mechanisms could not be fully elucidated due to the quality of the study designs and heterogeneity in endpoints. Clinicians should be aware of a potential clinically relevant interaction when combining isoxazolyl penicillins with drugs with a small therapeutic window that undergo extensive metabolism."

Journal • PK/PD data • Review

Identification of Novel Trypanosoma cruzi Cysteine Protease Inhibitors via Ligand-Based Virtual Screening of FDA-Approved Drugs with Trypanocidal Activity. (PubMed, Diseases) - "These results encourage the development of new and more potent anti-Trypanosoma cruzi agents using FDA-approved drugs as scaffolds."

FDA event • Journal

32522: The DALBA-studynIntroduction of the antibiotic dalbavancin in orthopaedic surgery an evaluation of:ntHealth economic costsntPatient-reported outcomes on quality of lifentLocal bone and soft tissue concentrationsntEffect on the gut microbiomenA randomised controlled study of dalbavancin versus standard antibiotic treatment of Gram-positive periprosthetic joint infections. (clinicaltrialsregister.eu) - P4 | N=50 | Recruiting | Sponsor: Region Midtjylland

HEOR • New P4 trial • Infectious Disease • Orthopedics

Letter to the editor: Flucloxacillin-induced acute kidney injury in a critically ill patient. (PubMed, Saudi J Anaesth) - No abstract available

Journal • Acute Kidney Injury • Nephrology • Renal Disease

An Unusual Case of 5-Oxoproline Acidosis. (PubMed, Kidney Med) - "Although there have been plenty of case reports of this condition because of the coadministration of paracetamol/acetaminophen and flucloxacillin/oxacillin, to our knowledge, this is only the second published case of 5-oxoproline acidosis without paracetamol use, making it either highly unusual or potentially underdiagnosed. Therefore, we suggest considering 5-oxoproline/pyroglutamic acidosis when evaluating the etiology of metabolic acidosis in patients on high-dose flucloxacillin/oxacillin, even without a history of concomitant or previous paracetamol exposure or other classical risk factors."

Journal • Metabolic Disorders

Covalent binding of flucloxacillin to 14-3-3 proteins promotes naive T-cell activation. (PubMed, J Allergy Clin Immunol) - No abstract available

Journal

Exploring the opportunity for therapeutic drug monitoring (TDM) and precision dose antimicrobials in an outpatient antimicrobial therapy (OPAT) service: a prospective observational study. (PubMed, J Antimicrob Chemother) - "We have demonstrated that drug monitoring is practicable in the OPAT setting of a large institution with no on-site analytical capability. Current dosage regimens result in acceptable PK-PD target attainment. Our findings provide an initial step towards supporting TDM in OPAT."

Journal • Observational data • Cardiovascular

Dicloxacillin and Flucloxacillin Inhibit Hepatic Uptake Transporters-In Vitro Investigations and Physiologically Based Pharmacokinetic Modeling. (PubMed, Clin Transl Sci) - "PBPK model simulations predicted no major change in rosuvastatin, a substrate for OATPs and BCRP, pharmacokinetics when co-administered with dicloxacillin or flucloxacillin. Simulations with dicloxacillin and P-gp substrates dabigatran or digoxin also predicted limited inhibition of P-gp transport."

Journal • PK/PD data • Preclinical • Breast Cancer • Oncology • Solid Tumor • SLCO2B1

Drug-associated tongue discoloration: a comprehensive assessment of USFDA adverse event reporting system using disproportionality analysis. (PubMed, BDJ Open) - "This comprehensive signal detection revealed several high-priority drug-tongue condition associations using large-scale pharmacovigilance data. Findings carry implications for guiding clinical practice through enhancing adverse effect monitoring for high-risk medications. Priority signals merit validation through further research to optimize benefit-risk assessment and reduce preventable tongue disorders."

Adverse events • Journal

Staphylococcal Toxic Shock Syndrome: The Critical Role of Early Recognition and Prompt Intervention. (PubMed, Ir Med J) - "Perineal swabs grew methicillin-sensitive Staphylococcus aureus resistant to clindamycin...Broad-spectrum antibiotics were started, later rationalised to IV flucloxacillin after isolation of methicillin-susceptible S. aureus...Early recognition and management with microbiological testing are essential. Public education on safe tampon use remains vital to prevent this rare but life-threatening condition."

Journal • Critical care • Hematological Disorders • Infectious Disease • Renal Disease • Septic Shock • Thrombocytopenia

Management of Bilateral Endogenous Methicillin-Sensitive Staphylococcus aureus (MSSA) Endophthalmitis Without Intravitreal Sampling or Injection. (PubMed, Cureus) - "She received systemic intravenous flucloxacillin without intravitreal sampling or intravitreal antibiotic injection...Our experience suggests that when the systemic source of infection is identified and ocular signs are improving, a conservative approach without routine intravitreal tap and inject on presentation may be reasonable. However, treatment should be individualized, and further studies are needed to define the role of intravitreal intervention in endogenous endophthalmitis."

Journal • Immunology • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Rheumatology

Effect of Microdoses of Incisional Antibiotics on the Rate of Surgical Site Infections in Skin Cancer Surgery: A Randomized Clinical Trial. (PubMed, JAMA Surg) - "Patients received an incision site injection of buffered local anesthetic alone (control), buffered local anesthetic with microdosed flucloxacillin (500 µg/mL), or buffered local anesthetic with microdosed clindamycin (500 µg/mL). The significant reduction in SSI with locally applied microdosed incisional clindamycin provides robust evidence to inform treatment guidelines in this area, which are currently lacking. anzctr.org.au Identifier: ACTRN12616000364471."

Clinical • Journal • Surgery • Anesthesia • Genetic Disorders • Infectious Disease • Oncology • Skin Cancer