CNP-102 / Cour Pharma - LARVOL DELTA

Preclinical studies to determine myelin peptide-specific nanoparticle tolerance mechanisms and clinical translation (IMMUNOLOGY 2024) - "TIMP treatment also modulates spread epitope-specific T cells associated with disease progression, but not encapsulated within the TIMP, i.e. tissue-specific tolerance. Therefore, treatment activates various Ag-specific regulatory T cell subsets capable of inhibiting disease-associated autoantigens not encapsulated within the TIMP via release of immunoregulatory cytokines, and CNP-102 has proven efficacious in preclinical mouse models of MS."

Preclinical • Celiac Disease • CNS Disorders • Immunology • Multiple Sclerosis • CD4 • FOXP3 • IFNAR1 • IL10 • STING

Preclinical studies to determine myelin peptide-specific nanoparticle tolerance mechanisms and clinical translation (IMMUNOLOGY 2024) - "TIMP treatment also modulates spread epitope-specific T cells associated with disease progression, but not encapsulated within the TIMP, i.e. tissue-specific tolerance. Therefore, treatment activates various Ag-specific regulatory T cell subsets capable of inhibiting disease-associated autoantigens not encapsulated within the TIMP via release of immunoregulatory cytokines, and CNP-102 has proven efficacious in preclinical mouse models of MS."

Preclinical • Celiac Disease • CNS Disorders • Immunology • Multiple Sclerosis • CD4 • FOXP3 • IFNAR1 • IL10 • STING

Preclinical Studies to Determine Myelin Peptide-Specific Nanoparticle Tolerance Mechanisms and Clinical Translation (ACTRIMS Forum 2024) - "Treatment thus activates various Ag-specific regulatory T cell subsets capable of regulating responses to disease-relevant autoepitopes not encapsulated within the TIMP via release of immunoregulatory cytokines within the inflammatory site. Finally, the present data show the efficacy of CNP-102 in preclinical mouse models of MS."

Preclinical • Allergy • Celiac Disease • CNS Disorders • Immunology • Inflammation • Multiple Sclerosis • CD4 • FOXP3 • IFNA1 • IFNAR2 • IL10 • STING