prednisone / Generic mfg. - LARVOL DELTA

SENIOR-IPI: An easily applicable prognostic index for first-line large B-cell lymphomas patients >80 years treated with curative intent. (PubMed, Br J Haematol) - "Using LYmphoma Study Association clinical trials combining 438 first-line large B-cell lymphomas (LBCL) patients >80 years old, we defined SENIOR-IPI, an easily applicable prognostic index for this elderly population treated with an anti-CD20-miniCHOP (cyclophosphamide, doxorubicin, vincristine and prednisone)-based regimen. Restricted mean survival times at 2 and 5 years were also evaluated: at 2 years, 10 additional SENIOR-IPI points led to 3.7 and 3.6 months of survival lost, respectively, in the training and validation cohorts. Overall, SENIOR-IPI is an easily applicable and reproducible prognostic index, using only readily available clinical and biological data, which better stratifies prognosis of LBCL patients >80 years old fit for age-adapted immunochemotherapy than IPI, aaIPI and NCCN-IPI."

Journal • B Cell Lymphoma • Hematological Malignancies • Large B Cell Lymphoma • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

A Study of JNJ-95566692 in Participants With Non-Hodgkin Lymphoid Malignancies (clinicaltrials.gov) - P1 | N=340 | Recruiting | Sponsor: Janssen Research & Development, LLC | N=130 ➔ 340 | Trial completion date: Aug 2028 ➔ Oct 2029

Enrollment change • First-in-human • Trial completion date • B Cell Lymphoma • Hematological Malignancies • Indolent Lymphoma • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • Primary Mediastinal Large B-Cell Lymphoma • BCL2 • IRF4

Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma. (PubMed, N Engl J Med) - P3 | "Among patients with previously untreated intermediate-risk or high-risk DLBCL, the risk of disease progression, relapse, or death was lower among those who received pola-R-CHP than among those who received R-CHOP. (Funded by F. Hoffmann-La Roche/Genentech; POLARIX ClinicalTrials.gov number, NCT03274492.)."

Journal • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • CD79B

Brentuximab vedotin plus cyclophosphamide, doxorubicin, etoposide, and prednisone followed by brentuximab vedotin consolidation in CD30-positive peripheral T-cell lymphomas: a multicentre, single-arm, phase 2 study. (PubMed, Lancet Haematol) - P2 | "In patients with mostly CD30-expressing peripheral T-cell lymphomas other than non-anaplastic large-cell lymphoma, CHEP-BV (with or without autologous HSCT) followed by brentuximab vedotin consolidation was safe and active."

Journal • P2 data • Bone Marrow Transplantation • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Leukopenia • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Novel Coronavirus Disease • Oncology • Peripheral T-cell Lymphoma • T Cell Non-Hodgkin Lymphoma • Thrombocytopenia • Transplantation • TNFRSF8

Diffuse Large B-Cell Lymphoma Presenting as an Infiltrative Masticator Space Lesion Mimicking Inflammatory Disease: A Case Report. (PubMed, Cureus) - "The patient was classified as having limited-stage disease and received four cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) chemotherapy, achieving complete metabolic remission. More than three years after treatment completion, she remains disease-free. This case highlights the importance of including lymphoma in the differential diagnosis of infiltrative lesions of the masticator space and emphasizes the need for adequate tissue sampling when initial investigations are inconclusive."

Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Follicular Lymphoma • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • TNFRSF8

Survey of Local and Systemic Corticosteroids Use in Adults with Chronic Rhinosinusitis with Nasal Polyps in Chile. (PubMed, J Inflamm Res) - "Prednisone is the most commonly used systemic corticosteroid (86.5%), especially in short bursts during exacerbations...The use of systemic corticosteroids should be rational, assessing risks and benefits. Given the heterogeneity of the results obtained in this study regarding steroid prescription, the development of clinical guidelines to standardize the rational use of topical and systemic corticosteroids in Chile should be considered."

Journal • Chronic Rhinosinusitis With Nasal Polyps • Immunology • Nasal Polyps • Otorhinolaryngology • Respiratory Diseases • Sinusitis

SAFETY AND EFFICACY OF OD-001, A FIRST-IN-CLASS ORAL RIPK2 SCAFFOLDING INHIBITOR, IN PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS: RESULTS FROM A PHASE 2A TRIAL (NCT06850727) (UEGW 2026) - P2 | "Median baseline fecal calprotectin was 1,785 µg/g and 21% of enrolled patients were on concomitant steroids (≤ 20 mg prednisone equivalent). OD-001 demonstrated a significant reduction of the MMS and clinically meaningful, significant induction of clinical remission in patients with moderately to severely active UC, irrespective of advanced therapy experience. Along with a favorable safety profile, these data support continued clinical development of OD-001 for UC, including a phase 2b monotherapy placebo-controlled, trial and one, or more, phase 2a combination trials with standard of care."

Clinical • P2a data • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Ulcerative Colitis • RIPK2 • XIAP

BEYOND BMI: HIDDEN CLINICAL AND PRECLINICAL OBESITY PHENOTYPES IN INFLAMMATORY BOWEL DISEASE (UEGW 2026) - "Current treatments included biologics (50.4%), azathioprine (35.7%), mesalamine (26.4%), and prednisone (15.5%). BMI underestimates obesity in IBD. Comprehensive reclassification identified 82.2% with adipose tissue dysfunction, with clinical and preclinical phenotypes differing significantly across metabolic, anthropometric, and disease-related parameters. Obesity in IBD exists on a spectrum invisible to BMI integrated adiposity assessment is essential for high-risk identification and personalized management."

Preclinical • Cardiovascular • Diabetes • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hypertension • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Dysfunction-Associated Steatotic Liver Disease • Obesity • Ulcerative Colitis

Synchronous Triple Malignancy Presentation of Multiple Myeloma and Prefibrotic Primary Myelofibrosis in a Patient With Mucinous Breast Carcinoma: A Case Report From Rural South Africa. (PubMed, Case Rep Hematol) - "The patient commenced therapy with melphalan and prednisone for myeloma and anastrozole for breast carcinoma, with multidisciplinary input guiding treatment sequencing. Triple synchronous primary malignancies are exceedingly rare and diagnostically challenging. This case emphasises the necessity of a systematic, multidisciplinary approach to evaluation and management, even in low-resource settings, to ensure accurate diagnosis and optimal coordination of care across multiple oncologic pathologies."

Journal • Breast Cancer • Hematological Disorders • Hematological Malignancies • HER2 Breast Cancer • HER2 Negative Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Positive Breast Cancer • Multiple Myeloma • Musculoskeletal Diseases • Myelofibrosis • Myeloproliferative Neoplasm • Oncology • Plasmacytoma • Solid Tumor • Thrombocytosis • HER-2 • JAK2 • PGR

THE RELEVANCE OF LIVER BIOPSY IN PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS AND CHOLESTASIS: A CASE OF HEPATIC TUBERCULOSIS MIMICKING DRUG-INDUCED LIVER INJURY (UEGW 2026) - "Suspected drug-induced liver injury (DILI) prompted a switch to amikacin, levofloxacin, ethambutol, and meropenem...The patient was discharged on levofloxacin, rifampicin, isoniazid, and ethambutol, in addition to prednisone, ART, and standard treatment for neurotoxoplasmosis.Two months later, he was readmitted with vomiting and jaundice...Microscopy for acid-fast bacilli was negative, but the Xpert MTB/RIF confirmed hepatic tuberculosis and rifampicin resistance.A multidrug-resistant tuberculosis regimen was initiated (levofloxacin, clofazimine, bedaquiline, and terizidone) leading to an 80% reduction in alkaline phosphatase and normalization of serum bilirubin within three months.This case highlights the challenge of distinguishing DILI from opportunistic infections in advanced HIV, particularly in cholestatic presentations with hepatotoxic drug exposure. Noninvasive tests may be insufficient, emphasizing the role of liver biopsy and molecular testing in management."

Biopsy • Clinical • Cholestasis • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Liver Failure • Respiratory Diseases • Septic Shock • Tuberculosis

WHEN IMMUNOSUPPRESSION MIMICS IBD: LATE-ONSET MYCOPHENOLATE-INDUCED COLITIS (UEGW 2026) - "Clinical Case Summary: A 55-year-old male with a history of kidney transplantation due to hypertension in 2015, currently presenting chronic graft dysfunction, was on daily mycophenolate, prednisone, and antihypertensive therapy...A follow-up colonoscopy was scheduled to assess endoscopic remission and to re-evaluate and resect the polypoid lesion.Gastrointestinal involvement is a common adverse effect of mycophenolate, with a broad spectrum of clinical presentations. This case illustrates an atypical presentation of mycophenolate-induced colitis occurring after 11 years of drug use, highlighting the variability in its clinical manifestations."

Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hypertension • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

CHOLESTASIS FOLLOWING IMMUNOTHERAPY: IMMUNE-MEDIATED INJURY OR DIRECT DRUG-INDUCED LIVER INJURY? THE IMPORTANCE OF LIVER BIOPSY IN DISTINGUISHING BETWEEN THE TWO (UEGW 2026) - "Given the suspicion of immune-mediated liver injury, prednisone 1 mg/kg was initiated, but there was no improvement; a percutaneous liver biopsy was then performed, which showed severe loss of interlobular bile ducts, without ductular reaction or cholangitis and moderated amount of cholestasis, in kupffer cells and hepatocytes, consistent with Vanishing syndrome. Based on the pattern of injury, the condition was attributed to nivolumab, and ursodeoxycholic acid 10 mg/kg/day was initiated, resulting in partial improvement of serum liver enzymes in two days (AST 128 U/L / ALT 88 U/L / AP 498 U/L / GGT 653 U/L / total bilirubin 20 mg/dL / direct fraction 15 mg/dL).Vanishing syndrome is a rare condition characterized by progressive ductopenia, resulting in persistent colitis (1). It may be associated with chemotherapy through mechanisms of direct toxicity and immune-mediated response (2). This report presents a relevant hypothesis that should be considered in patients with..."

Biopsy • Cholestasis • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Hepatology • Immunology • Liver Failure • Solid Tumor

DIFFUSE LARGE B-CELL LYMPHOMA MASQUERADING AS CHOLANGIOCARCINOMA IN A YOUNG ADULT: A CASE REPORT (UEGW 2026) - "He was started on prednisone followed by Pola-R-CHP (polatuzumab, rituximab, cyclophosphamide, doxorubicin, prednisone). Lymphoma should be in the differential of a hepatic tumor with biliary strictures. This distinction is crucial because DLBCL involving the liver is highly treatable with chemoimmunotherapy."

Case report • Clinical • B Cell Lymphoma • Back Pain • Biliary Cancer • Cholangiocarcinoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Hepatocellular Cancer • Hepatology • Infectious Disease • Liver Cancer • Lymphoma • Musculoskeletal Pain • Non-Hodgkin’s Lymphoma • Oncology • Solid Tumor • CEACAM5

ACUTE HEPATITIS FLARE REVEALING UNDERLYING PRIMARY BILIARY CHOLANGITIS-AUTOIMMUNE HEPATITIS OVERLAP SYNDROME (UEGW 2026) - "This case highlights the importance of recognizing acute-on-chronic presentations of AIH–PBC overlap syndrome. Despite hepatocellular dysfunction at presentation, early initiation of dual therapy leads to excellent outcomes, underscoring the importance of prompt diagnosis and timely management are essential to improve prognosis."

Autoimmune Hepatitis • Cholestasis • Fibrosis • Hepatology • Immunology • Inflammation • Primary Biliary Cholangitis

WHEN ABSCESSES MIMIC METASTASES: A RARE CASE OF PERFORATED COLORECTAL CANCER AND BRAIN ABSCESS IN CROHN'S PATIENT POST LIVER TRANSPLANTATION (UEGW 2026) - "After years of mesalazine-controlled intestinal disease, CD flares developed despite unchanged post-OLT immunosuppression with tacrolimus, mycophenolate mofetil and prednisone. In 2024, after seven months of vedolizumab therapy, he presented with recurrent abdominal pain...This case shows that colorectal cancer in PSC-IBD may be masked by chronic inflammation despite surveillance, and that post-transplant extraintestinal lesions require histological verification and interval imaging before metastases are assumed. The atypical presentation as intestinal perforation and diagnostic pitfalls of pseudometastatic lesions are worth discussion."

Clinical • Brain Cancer • CNS Disorders • Colorectal Adenocarcinoma • Colorectal Cancer • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Hepatology • Immunology • Oncology • Primary Sclerosing Cholangitis • Solid Tumor • Transplantation

PRIMARY COLON SQUAMOUS CELL CARCINOMA OCCULT IN A SMALL COLONIC POLYP (UEGW 2026) - "Clinical Case Summary: A 61-year-old male underwent colonoscopy due to positive fecal occult blood.He had a 3-year history of colonic polypectomy and 6-month systemic lupus erythematosus, with long-term oral hydroxychloroquine sulfate, prednisone acetate, etc. No family malignancy history. 2) No prior literature reports the link between long-term systemic lupus erythematosus (immune dysfunction) and colon SCC. 3) Occult SCC was detected via complete EMR or ESD, highlighting the importance of standardized polyp resection to avoid missed diagnosis."

Colonic Polyps • Gastroenterology • Immunology • Inflammatory Arthritis • Leukopenia • Lupus • Oncology • Squamous Cell Carcinoma • Systemic Lupus Erythematosus

LOW-DOSE SUBCUTANEOUS METHOTREXATE AS AN INDIVIDUALISED SALVAGE STRATEGY IN FRAIL ELDERLY ACUTE SEVERE ULCERATIVE COLITIS WITH RECURRENT BIOLOGIC INFUSION REACTIONS (UEGW 2026) - "Intravenous methylprednisolone 40 mg/day induced only partial response, and symptoms persisted on oral prednisone. Vedolizumab rescue (300 mg at weeks 0/2/6) was initiated while colectomy was assessed, but endoscopic activity remained severe (Mayo endoscopic subscore 3), and an urticarial infusion reaction led to discontinuation. Infliximab 5 mg/kg reduced stool frequency; however, the second dose was delayed by mixed bacterial/fungal pneumonia with marked inflammatory rise (C-reactive protein 225.2 mg/L)...This case highlights the challenge of managing frail elderly acute severe ulcerative colitis when biologic rescue is limited by recurrent infusion reactions, intercurrent infection, and refusal of colectomy, and suggests that carefully monitored low-dose subcutaneous methotrexate may be a feasible individualised salvage option in highly selected patients. Written informed consent for anonymised publication was obtained."

Clinical • Cardiovascular • Chronic Obstructive Pulmonary Disease • Gastroenterology • Gastrointestinal Disorder • Geriatric Disorders • Immunology • Infectious Disease • Inflammatory Bowel Disease • Pneumonia • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Ulcerative Colitis • Urticaria • CRP

WHEN CROHN'S DISEASE WAS NOT THE ONLY DIAGNOSIS: ILEAL KAPOSI SARCOMA IN A TRANSPLANT RECIPIENT PRESENTING WITH SUBOCCLUSIVE SYMPTOMS (UEGW 2026) - "We report the case of a 69-year-old kidney transplant recipient on long-term immunosuppression with everolimus, tacrolimus, and prednisone, who presented with recurrent abdominal pain, diarrhea, fever, and subocclusive symptoms. It also illustrates that surgery may be both diagnostic and therapeutic, allowing complete resection of an occult KS lesion while resolving mechanical obstruction. A timeline of the clinical course will be provided in the poster to clearly display the sequence of symptoms, investigations, surgery, pathology, and follow-up."

Clinical • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Kaposi Sarcoma • Sarcoma • Solid Tumor • Transplantation • Ulcerative Colitis

EOSINOPHILIC GASTROENTERITIS COMPLICATED BY ACUTE PANCREATITIS AND EOSINOPHILIC ASCITES IN A YOUNG WOMAN (UEGW 2026) - "She had a dramatic clinical and ultrasonographic response to prednisone 40 mg daily, with complete resolution of bowel wall thickening and ascites, and was tapered over 12 weeks . This case highlights pancreatic involvement and the diagnostic value of integrating imaging, fluid analysis, endoscopic biopsy, and hematologic exclusion of clonal disease."

Clinical • Eosinophilia • Eosinophilic Esophagitis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Pancreatitis

HIDDEN IN THE JEJUNUM: CAPSULE ENDOSCOPY DIAGNOSIS OF BLEEDING VARICES CAUSED BY RETROPERITONEAL FIBROSIS (UEGW 2026) - "Prednisone 40 mg/day led to hemoglobin normalization (11.7 g/dL) and clinical stabilization.Idiopathic retroperitoneal fibrosis is a rare fibroinflammatory disease, and mesenteric vascular involvement causing venous hypertension and small-bowel varices is exceptionally uncommon. This case highlights capsule endoscopy as a key non-invasive tool for identifying jejunal varices and establishing the bleeding source in OGIB."

Cardiovascular • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hypertension • Immunology • Pulmonary Disease • Thrombosis

THE EFFECTIVENESS OF ALLOGENEIC MESENCHYMAL STROMAL CELLS OF BONE MARROW IN PATIENTS WITH REFRACTORY CROHN'S DISEASE - 12 YEARS OF OBSERVATION (UEGW 2026) - "The first group of patients with CD (n=30) received MSCs, the dose of prednisone was not more than 20 mg/day. Transplantation of MSCs contributes to longer-term clinical and endoscopic remission in patients with refractory Crohn's disease compared with therapy with corticosteroids and Azathioprine."

Clinical • Stroma • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • CRP

ASSOCIATION OF ENDOSCOPIC HEALING WITH CLINICAL OUTCOMES IN INFLAMMATORY BOWEL DISEASE: A RETROSPECTIVE STUDY (UEGW 2026) - "At baseline, more patients in the non-healing cohort were on prednisone, budesonide, mesalamine, adalimumab, and vedolizumab (all p<0.05), while significantly more patients in the healing cohort were on infliximab compared with the non-healing cohort. These findings suggest that endoscopic healing is associated with improvements in clinical disease activity, resulting in reduced corticosteroid use and IBD-related surgery.Table. Percentage of Patients With Post-Index Surgical Interventions*p<0.05; **p<0.001."

Clinical data • Retrospective data • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

A comparative analysis of growth and developmental outcomes in infants with proliferative hemangiomas treated with oral propranolol versus prednisone. (PubMed, Front Public Health) - "These findings suggest that propranolol may offer advantages over prednisone in terms of efficacy, safety, and developmental outcomes, supporting its use as a preferred first-line therapy for proliferative IHs. However, given the limited sample size and short follow-up of this study, large prospective studies are warranted to confirm these observations."

Clinical • Journal • Retrospective data • Constipation • Gastroenterology • Gastrointestinal Disorder • Hypoglycemia • Hypotension • Infectious Disease • Pediatrics • Respiratory Diseases

Calcineurin Inhibitor-Based Triple Immunosuppressive Therapy Induces Profibrotic Changes in the Jejunal Mucosa of Male Rats: A Digital Image Analysis of Collagen Fibers. (PubMed, Biomedicines) - " Animals were treated for six months with regimens containing either cyclosporine A (CyA) or tacrolimus (TAC) in combination with rapamycin and prednisone. These findings suggest that long-term administration of CNI-based triple immunosuppressive therapy may be associated with changes consistent with fibrotic remodeling of the jejunal mucosa. The present study provides novel data on the effects of clinically relevant multidrug immunosuppressive protocols, whereas most previous experimental studies investigating the effects of immunosuppressive agents have focused on single-drug exposure in animal models or in vitro systems."

Journal • Preclinical • Fibrosis • Gastrointestinal Disorder • Solid Organ Transplantation • Transplantation

Sex- and age-specific musculoskeletal adverse events of isotretinoin: disproportionality analysis of the FAERS database combined with a clinical case series. (PubMed, Front Pharmacol) - "Stratified ROR analyses were further conducted to evaluate reporting patterns associated with the concomitant use of oral contraceptives, tetracyclines, and prednisone. Sex- and age-stratified analyses identified several exploratory differences in reporting patterns. These exploratory findings provide hypothesis generating insights that warrant further validation in prospective clinical studies."

Adverse events • Journal • Acne Vulgaris • Back Pain • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Rheumatology