ketamine / Generic mfg. - LARVOL DELTA

Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP) (clinicaltrials.gov) - P1 | N=5 | Suspended | Sponsor: University of Wisconsin, Madison | Trial completion date: Mar 2027 ➔ Sep 2027 | Trial primary completion date: Mar 2027 ➔ Sep 2027

Trial completion date • Trial primary completion date • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

Ultrasound-guided transversus abdominis plane block in cesarean delivery: a randomized trial of ketamine versus neostigmine as bupivacaine adjuvants. (PubMed, J Anesth Analg Crit Care) - "Both adjuvants effectively controlled postoperative pain, with stable intraoperative hemodynamics and high patient satisfaction levels. Ketamine demonstrated superior analgesic efficacy compared with neostigmine in cesarean delivery patients undergoing TAP blocks. An individualized treatment approach is needed to tailor the selection of adjuvants to optimize outcomes."

Journal • Anesthesia • Pain

Pharmacotherapy in Disorders of Consciousness: A Mechanism-Based Review. (PubMed, CNS Drugs) - "Current pharmacological interventions explored in disorders of consciousness target distinct molecular systems, including dopaminergic modulators (amantadine, levodopa, apomorphine, bromocriptine, selegiline, methylphenidate, and modafinil), GABAergic agents (zolpidem and baclofen), and other neuromodulatory compounds acting on glutamatergic, opioid, or serotonergic receptors (ketamine, remifentanil, and psilocin). Safety profiles associated with these treatments are also critically evaluated to guide clinical decision making. By integrating current knowledge on pharmacological modulation of key neural systems, including dopaminergic and GABAergic pathways, this article provides a comprehensive framework for understanding treatment strategies in disorders of consciousness."

Journal • Review

Successful Emergency Removal of a Titanium Penile Constriction Ring Using Blood Aspiration and Nonpowered Bolt Cutters. (PubMed, Cureus) - "The patient underwent ketamine procedural sedation and dorsal penile nerve block...The patient was observed, successfully voided, and was discharged with urologic follow-up. This case highlights a practical approach for emergent removal of titanium penile constriction rings when standard equipment fails, emphasizing multidisciplinary coordination and staff safety precautions."

Journal • Anesthesia • Cardiovascular • Musculoskeletal Diseases • Orthopedics • Pain

NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine. (PubMed, Mol Psychiatry) - "Similarly, short hairpin RNA knockdown of NOX-1 in the mPFC sustained the antidepressant-like effects of ketamine and suppressed LHb bursting activity. These results indicate that NOX-1 suppression prolongs the antidepressant-like effect of ketamine and represents a promising target for maintenance strategies in TRD."

Journal • CNS Disorders • Depression • Psychiatry

Letter to the editor: The impact of ketamine on ICU mortality in patients with sepsis: A retrospective cohort study. (PubMed, J Crit Care) - "Stratified analysis of subgroup population by race and SOFA or APACHEII. These key points emphasize the need to improve multi angle analysis by incorporating the results of stratified analysis."

Journal • Retrospective data • Infectious Disease • Septic Shock

Perspectives opened up by the physiopathological understanding of psychiatric disorders (PubMed, Rev Prat) - "Similarly, ketamine, an antagonist of NMDA-type glutamatergic receptors, has shown efficacy in the management of suicidal crises and in the treatment of depressive disorders. Finally, antagonism of orexin receptors offer a new avenue for treating insomnia."

Journal • Review • Bipolar Disorder • CNS Disorders • Depression • Insomnia • Mental Retardation • Mood Disorders • Psychiatry • Sleep Disorder

Impact of subanesthetic ketamine delivered via AmyloLipid nanovesicle (ALN)-based intranasal system on biobehavioral responses in an animal model of PTSD. (PubMed, Transl Psychiatry) - "The results suggest that low-dose ketamine-ALN modulates a hippocampal circuit involving HCN1, BDNF, and NPY to foster adaptive stress responses. Collectively, ketamine-ALN represents a promising targeted therapy for PTSD, with HCN1 channels as a key mediator of stress-induced neuronal dysfunction and ketamine's therapeutic action, thus advancing the prospects for precision treatment of stress-related disorders."

Journal • Preclinical • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry • BDNF

Ketamine Versus Etomidate in Rapid Sequence Intubation: What Difference Would Convince You?: April 2026 Annals of Emergency Medicine Journal Club. (PubMed, Ann Emerg Med) - No abstract available

Intubation • Journal

Propofol versus ketamine in rapid sequence intubation in critically ill patients: a prospective, randomized, controlled trial. (PubMed, Intensive Care Med) - P2 | "Among critically ill patients undergoing RSI, Ketamine resulted in a less pronounced decrease in MAP in the first 10 min compared with propofol, but the difference was not clinically meaningful or sustained. These findings challenge sedative selection based solely on perceived risk of hypotension and highlight the need for larger trials to determine the optimal induction agent."

Intubation • Journal • Cardiovascular • Hypotension

Ketamine with a twist: The first reported case of ketamine-induced torsades de pointes. (PubMed, HeartRhythm Case Rep) - No abstract available

Journal • Cardiovascular • Ventricular Tachycardia

Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach. (PubMed, J Cereb Blood Flow Metab) - "Our multimodal analysis revealed that participants showing an increase in [11C]-UCBJ volume distribution (VT), a putative index of synaptic plasticity, showed a correlated reduction in intrinsic activity within regions belonging to the default mode network (DMN). By linking molecular, cellular and network-level changes, our results point to the DMN as a central hub where ketamine may reshape brain hierarchies in the long term, providing new directions for understanding its therapeutic mechanisms and developing targeted treatments."

Journal

Ketamine-induced torsades de pointes: Coincidence or causality? (PubMed, HeartRhythm Case Rep) - No abstract available

Journal

Preoperative Anxiety and Postoperative Delirium: A Mini Review of the Association, Mechanisms, and Preventive Strategies. (PubMed, J Multidiscip Healthc) - "Pharmacological interventions (eg, dexmedetomidine, ketamine in pediatric patients) and non-pharmacological strategies (eg, music therapy, virtual reality-based cognitive-behavioral interventions) effectively alleviate preoperative anxiety and reduce POD incidence. Despite progress, the mechanisms linking preoperative anxiety to POD remain incompletely understood, particularly the roles of neuroinflammatory pathways, blood-brain barrier disruption, and the comparative effectiveness of pharmacological versus non-pharmacological interventions. Targeted research in these areas is needed to optimize preventive strategies and improve surgical outcomes."

Journal • Review • CNS Disorders • Cognitive Disorders • Inflammation • Pain • Pediatrics • Psychiatry

Letter to the editor: "The impact of ketamine on ICU mortality in patients with sepsis: A retrospective cohort study". (PubMed, J Crit Care) - No abstract available

Journal • Retrospective data • Infectious Disease • Septic Shock

Letter to the editor "The impact of ketamine on ICU mortality in patients with sepsis: A retrospective cohort study". (PubMed, J Crit Care) - No abstract available

Journal • Retrospective data • Infectious Disease • Septic Shock

Intraocular pressure distribution in old and young cynomolgus monkeys following general anesthesia and mydriasis. (PubMed, Mol Vis) - "A total of 158 young and 252 old cynomolgus monkeys, aged 3.95 (1.61; range, 1.38 to 5.97) and 18.80 (1.67; range, 15.21 to 24.69) years, respectively, were subjected to general anesthesia (intramuscular injection of Zoletil 4 mg/kg mixed with xylazine/ketamine 0.2 mg/kg). IOP was measured using an Icare tonometer at three time points: immediately following the onset of anesthesia, after stabilization but before mydriasis, and after mydriasis (induced by 1% tropicamide eye drops)...Furthermore, monkeys of different age groups had different reductions in IOP under different interventions (anesthesia, mydriasis). Additionally, within the M. fascicularis colony, IOP was equivalent between males and females, as well as between the right and left eyes."

Journal • Anesthesia • Ophthalmology • ACACA

Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts (clinicaltrials.gov) - P4 | N=12 | Not yet recruiting | Sponsor: New York State Psychiatric Institute | Trial completion date: Sep 2027 ➔ May 2028 | Trial primary completion date: Sep 2027 ➔ May 2028

Trial completion date • Trial primary completion date • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • Suicidal Ideation

Erector Spinae Block Vs Ketamine-based Multimodal Analgesia Protocol in Lumber Decompressive Surgery (clinicaltrials.gov) - P=N/A | N=62 | Completed | Sponsor: Kasr El Aini Hospital | Recruiting ➔ Completed | Trial completion date: Sep 2025 ➔ Dec 2025 | Trial primary completion date: Sep 2025 ➔ Dec 2025

Trial completion • Trial completion date • Trial primary completion date

Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery (clinicaltrials.gov) - P=N/A | N=100 | Not yet recruiting | Sponsor: Bursa City Hospital

New trial • Anesthesia • Cardiovascular • Pain

Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression (clinicaltrials.gov) - P1 | N=100 | Suspended | Sponsor: Texas A&M University | Recruiting ➔ Suspended

Biomarker • Trial suspension • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Neuroprotective role of Bougainvillea spectabilis in ketamine-induced neurotoxicity: targeting oxidative stress and neuroinflammation. (PubMed, J Complement Integr Med) - "The study demonstrates that B. spectabilis extract exerts neuroprotective effects through antioxidant and anti-inflammatory mechanisms. These findings suggest that the extract may represent a promising adjunct therapeutic strategy for mitigating neurotoxicity associated with oxidative stress and neuroinflammation."

Journal • CNS Disorders • Inflammation • Psychiatry • Schizophrenia • TNFA

Ketamine's Immediate Analgesia and Opioid-Sparing Benefits in Laparoscopic Cholecystectomy: A Meta-Analysis of Time Points, Anesthesia Protocols, and Bolus/Infusion Strategies. (PubMed, Clin J Pain) - "Ketamine reduced opioid use and postoperative pain at 30 minutes, with efficacy varying by administration method. Future RCTs should standardize dosage, anesthesia protocols, and pain management strategies to enhance evidence consistency."

Journal • Retrospective data • Anesthesia • Pain

Consumer wearables, cardiology and clinical practice (PubMed, Ugeskr Laeger) - "Eventually, a Bricker bladder was created. The case highlights ketamine-associated uropathy as an ongoing and underrecognized issue, stressing the importance of early cessation and targeted intervention."

Journal • Acute Kidney Injury • Cardiovascular • Fibrosis • Genito-urinary Cancer • Immunology • Nephrology • Oncology • Renal Disease • Solid Tumor • Testicular Cancer

Similar destabilization of neural dynamics under different general anesthetics. (PubMed, Cell Rep) - "To explore this, we analyze intracortical electrophysiological recordings during infusions of propofol, ketamine, and dexmedetomidine, applying a rigorous method to estimate the stability of population dynamics during anesthesia. Destabilization is most prevalent in the low-frequency band of the population dynamics, linking it to the well-known increase in low-frequency power during anesthesia. Together, these findings suggest that cortical destabilization may be a shared neural correlate of anesthetic-induced unconsciousness and provide a plausible link to the low-frequency oscillations observed during anesthesia."

Journal • Anesthesia