ketamine / Generic mfg. - LARVOL DELTA

Comparative effects of Pistacia atlantica leaf and phenytoin ointment on rat skin wound healing: histopathological changes and bioactive compounds. (PubMed, Inflammopharmacology) - "Thirty-five rats were anesthetized using ketamine and xylazine, and standardized excisional skin wounds were created on the dorsal region. The results indicated that wound healing using an ointment containing Pistacia atlantica leaf extract occurred in a dose-dependent manner and accelerated the healing process through histopathological mechanism without adverse effects compared with phenytoin. The findings support its potential as a safe and effective phytotherapeutic alternative for wound management."

Journal • Preclinical • Anesthesia

Perioperative Ketamine or Esketamine for Acute Postoperative Pain after Laparoscopic Cholecystectomy: A Systematic Review and Meta-analysis with Meta-regression. (PubMed, Anaesth Crit Care Pain Med) - "With a very low level of certainty, this meta-analysis demonstrated that ketamine/esketamine might help reduce acute postoperative pain and postoperative opioid needs in patients undergoing LC. Furthermore, ketamine may slightly increase the risk of some adverse events. However, dose-related meta-regression for adverse events was not performed due to inconsistent reporting across studies."

Journal • Retrospective data • Review • Ophthalmology • Pain

Efficacy and adverse effects of three delivery methods for aerosolized salbutamol in anesthetized European moose (Alces Alces Alces): a case series. (PubMed, Acta Vet Scand) - "Aerosolized salbutamol was well tolerated, but did not provide a clear benefit for hypoxemia compared to placebo. Further studies with higher salbutamol doses, alternative delivery routes, or modified anesthetic protocols are recommended."

Adverse events • Journal • Anesthesia • CNS Disorders • Depression • Hypotension • Metabolic Disorders • Psychiatry

General anaesthesia in non-human great apes: a scoping review. (PubMed, Vet Anaesth Analg) - "This is the first evidence synthesis on general anaesthesia in great apes, and findings highlight the need for targeted research on underrepresented species and improved reporting of anaesthesia practices and AEs."

Journal • Review • Anesthesia • Cardiovascular

Factors for predicting response to electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS) and ketamine in patients with treatment-resistant depression: a systematic review. (PubMed, Int J Psychiatry Clin Pract) - "Larger studies are required to identify clinically useful predictors. Additionally, for optimal treatment decision-making, comparative studies are necessary."

Journal • Review • CNS Disorders • Depression • Inflammation • Mood Disorders • Psychiatry • BDNF • IL6

Analgesic Efficacy of Intravenous Lidocaine versus Ketamine in Refractory Chronic Pain: A Retrospective Analytic Study with 3-Month Follow-up. (PubMed, Pain Med) - "Intravenous lidocaine, ketamine, and combination infusions provide immediate and sustained pain relief in refractory chronic pain. Combination therapy may offer additional benefit beyond monotherapy, supporting its consideration in clinical practice."

Journal • Retrospective data • Pain

PAIN MANAGEMENT PRACTICES DURING PAEDIATRIC ALLOGENEIC HAEMATOPOIETIC STEM CELL TRANSPLANTATION: A RETROSPECTIVE COHORT STUDY (EBMT 2026) - "During days 1–30, median duration of opioid use was 18 days (IQR 9–25) for morphine, 11 days (IQR 4–19) for fentanyl, and 2 days (IQR 1–4) for oxycodone...Common adjuvant agents included ketamine (112/190, 59.0%; median 10 days, IQR 4–15.5) and gabapentin (35/190, 18.4%; median 12 days, IQR 0–22).Although most pain assessments indicated no or mild pain (88%), 137 children (72%) experienced at least one episode of severe pain... Children undergoing HSCT experience a substantial and enduring pain burden requiring complex multimodal analgesia, with severe pain episodes remaining common despite widespread pharmacological and supportive care use. Specialist pain and palliative care services were accessed in a subset of patients and were often initiated later in the transplant course. These findings provide important real-world evidence of current pain management practices during paediatric HSCT and identify opportunities to optimise the timing, coordination, and..."

Retrospective data • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Hematological Malignancies • Leukemia • Mucositis • Pain • Palliative care • Pediatrics • Transplantation

PAIN MANAGEMENT WITH NARCOTIC INFUSION IN PEDIATRIC HEMATOPOIETIC STEM CELL TRANSPLANTATION: A SINGLE-CENTER RETROSPECTIVE STUDY (EBMT 2026) - "Infusion was discontinued in one patient due to tampering with the infusion pump.Switching from morphine to fentanyl infusion was required in fifteen patients, primarily due to uncontrolled pain (n=9) or pruritus (n=4). Only two patients required the addition of ketamine infusion for refractory pain.The median time to initiation of narcotic infusion was 5 days post-transplant (range: 2–580 days), and the median duration of infusion was 8 days (range: 3–35 days). Mucositis was the most prevalent cause of pain during the post-transplant period in pediatric HSCT recipients. Narcotic infusion proved to be a safe and well-tolerated strategy for pain management, with a low incidence of significant adverse effects and no life-threatening complications observed."

Retrospective data • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Aplastic Anemia • Bone Marrow Transplantation • Dermatology • Eye Cancer • Hematological Malignancies • Hemophagocytic lymphohistiocytosis • Immunology • Leukemia • Lymphoma • Mucositis • Musculoskeletal Pain • Myelodysplastic Syndrome • Neuroblastoma • Pain • Pediatrics • Primary Immunodeficiency • Pruritus • Rare Diseases • Retinal Disorders • Retinoblastoma • Solid Tumor • Transplantation

Recommendations for repeated dosings of ketamine/esketamine rest on an uncertain evidence base. Response to. (PubMed, J Affect Disord) - No abstract available

Journal

Age-related moderation of adjunctive psychotherapy and early life stress effects on depression symptom reductions following ketamine treatment: Initial insights from a large, naturalistic sample. (PubMed, J Affect Disord) - "Furthermore, the relationship between higher ACE scores and greater symptom reduction may be particularly strong within younger adults, with this association reversing at older ages (time*ACE*age: β = 0.02, [0.002, 0.04]). In summary, enhanced magnitude of symptom reduction for those with greater early life stress exposure, especially in younger adults, suggests a potentially unique and targeted benefit of ketamine over conventional antidepressants for this population."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Ketamine-assisted psychotherapies for mental disorders: A historical overview and systematic review. (PubMed, Clin Psychol Rev) - "Clinical effects are generally reported to be quite positive across psychiatric indications, however, there is a clear need for well-controlled trials to test for potential additive or synergistic effects of the combined use of ketamine and psychotherapy and to identify optimal therapeutic protocols."

Journal • Review • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Obsessive-Compulsive Disorder • Post-traumatic Stress Disorder • Psychiatry

Effectiveness of ketamine-assisted psychotherapy as a treatment for treatment-resistant depression: a systematic review. (PubMed, Psychopharmacology (Berl)) - "KAP shows promise as a treatment for TRD, potentially offering meaningful and sustained symptom relief. However, limited evidence and methodological variability underscore the need for more rigorous research-particularly randomized controlled trials-to better understand its efficacy and mechanisms."

Journal • Review • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Rapid antidepressant effects of Aurantii Fructus are mediated by hypoxanthine-caspase-4 axis in CUMS mice. (PubMed, J Ethnopharmacol) - "Acute AF produces rapid, ketamine-like antidepressant effects by targeting the hypoxanthine-caspase-4 pathway. This study reveals a novel purinergic mechanism underlying AF's traditional use for emotional disorders and offers a promising therapeutic strategy for rapid-acting antidepressant development."

Journal • Preclinical • CNS Disorders • Depression • Psychiatry • BDNF • CASP4

Transferrin-Functionalized Chitosan Nanoparticles Enable Intranasal Brain Delivery of Cariprazine with Enhanced Neuropharmacological Efficacy. (PubMed, ACS Chem Neurosci) - "Behavioral studies in ketamine-induced schizophrenia models confirmed the normalization of locomotor activity, anxiolytic effects, and reduced catalepsy. These findings establish TfCZNP as a safe, effective nose-to-brain delivery platform that enhances Cariprazine's therapeutic potential in neuropsychiatric disorders."

Journal • CNS Disorders • Mental Retardation • Psychiatry • Schizophrenia

Distinct allosteric paths mediate Ca2+-dependent increase in the NMDA receptor sensitivity to open-channel blockers. (PubMed, Biophys J) - "This regulatory mechanism is shared with ketamine and memantine, two synthetic compounds that are clinically effective for treating depression and Alzheimer's disease, respectively. Further, the effect of Ca2+ on block by memantine required intracellular Ca2+ and functional calmodulin, whereas the effect of Ca2+ on block by Mg2+ required the extracellular residue GluN1-D658. We conclude that extracellular Ca2+ fluctuations modulate the sensitivity of NMDA receptors to open-channel blockers by discrete mechanisms, which may explain the distinct clinical profiles of NMDA receptor blockers."

Journal • Alzheimer's Disease • CNS Disorders • Depression • Psychiatry

Reduction Of Chronic Post-surgical Pain with Ketamine - ROCKet Trial (ANZCTR) - P3/4 | N=4884 | Active, not recruiting | Sponsor: The University of Melbourne | Recruiting ➔ Active, not recruiting

Enrollment closed • Anesthesia • Orthopedics • Pain

Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT) (clinicaltrials.gov) - P3 | N=770 | Recruiting | Sponsor: University of Virginia | Not yet recruiting ➔ Recruiting

Enrollment open • Epilepsy

Local infrared stimulation modulates spontaneous cortical slow wave dynamics in anesthetized rats. (PubMed, Sci Rep) - No abstract available

Journal • Preclinical • Anesthesia

A Randomized Controlled Trial on the Efficacy of Ketamine vs. Electroconvulsive Therapy in Severe Depression with Suicidal Ideation. (PubMed, Neuropsychobiology) - "Ketamine offers a faster reduction in suicidal ideation than ECT, making it a promising acute intervention. Both are effective, safe adjunctive therapies, with treatment choice guided by patient profile and tolerability."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • Suicidal Ideation

Oxidative Stress in Treatment-Resistant and Refractory Depression: A Hidden Therapeutic Target? (PubMed, Mol Neurobiol) - "Integrating the latest scientific evidence, this review describes the mechanisms linking OS to the development of TRD and discusses fast-acting antidepressants extended by a non-pharmacological nutraceutical approach, which appears to fill a therapeutic gap and increase the chances of recovery for chronically ill individuals. An integrated approach aimed at reducing OS may be a key point of leverage in overcoming treatment resistance in the most severe forms of TRD, thereby contributing to modifying the course of the disease and improving prognosis, which makes this approach the most clinically useful."

Journal • Review • CNS Disorders • Depression • Mood Disorders • Psychiatry

Treating chronic pain with low dose ketamine and adjunct therapies within a biopsychosocial approach: a case series. (PubMed, Front Pain Res (Lausanne)) - "These results are preliminary, require replication with validated measures, and represent an opportunity for additional research and hypothesis formation. More clinical research on ketamine and adjunct therapies for chronic pain conditions is warranted to advance treatment options."

Journal • Anesthesia • Pain

Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery (clinicaltrials.gov) - P2 | N=60 | Completed | Sponsor: Assiut University | Active, not recruiting ➔ Completed

Trial completion • Breast Cancer • Oncology • Solid Tumor

KLOE: Ketamine Low dOse Evaluation on Morphine Consumption in Traumatic Patient (clinicaltrials.gov) - P3 | N=140 | Completed | Sponsor: Assistance Publique Hopitaux De Marseille | Recruiting ➔ Completed

Trial completion

Absence of the Ampa Receptor Auxiliary Subunit Tarp-Gamma 2 (Stargazin) Leads to Cochlear Synaptopathy and Progressive Hearing Loss in Female Mice (ARO 2026) - "For in vivo auditory testing, mice were anesthetized with Avertin due to a lethal interaction of the KO with ketamine/xylazine... The sex dependent progressive hearing loss in female TARP-gamma-2 KO mice is reminiscent of the phenotype of female GluA3 KO mice (Rutherford et al., 2023; Pal et al., 2025). In both cases, synaptopathy was associated with terminal swellings and a specific loss of GluA2 subunits. The loss of GluA2 implies an increase in the abundance of calcium-permeable AMPARs at the ribbon synapses, although postsynaptic densities were smaller suggesting fewer overall AMPARs."

Preclinical • Anesthesia • Otorhinolaryngology • CDH23

Auditory Deficits Following Continuous Noise or Single Blast Exposure (ARO 2026) - "We employed a multi-metric auditory framework including tympanometry, wide-band middle-ear muscle reflex (WB-MEMR), otoacoustic emissions (OAEs; swept distortion product, DP; swept stimulus frequency, SF; transient evoked, TE), auditory brainstem response (ABR), and envelope frequency response (EFR) to amplitude-modulated stimuli. Electrophysiology (ABR and EFR) and blast exposures were performed under anesthesia using xylazine (2 mg/kg) and ketamine (20 mg/kg)... Together, these findings demonstrate continuous noise and single blast exposures have unique auditory deficits. Continuous noise at moderate levels caused persistent hearing loss and cochlear damage accompanied by transient temporal processing deficits. On the other hand, single blast exposure at intense levels led to minimal peripheral deficits but persistent temporal processing deficits."

Anesthesia • CNS Disorders • Immunology • Otorhinolaryngology • Vascular Neurology