ketamine / Generic mfg. - LARVOL DELTA

Impact of Adjuvant Analgesics on Outcomes of Spinal Cord and Peripheral Nerve Stimulation: A Scoping Review. (PubMed, Pain Med) - "This review indicates that adjunctive analgesic therapy may play a significant role in either enhancing or attenuating analgesic benefits from SCS and PNS. By optimizing the use of analgesic medications, it may be possible to restore or enhance pain relief from both SCS and PNS."

Journal • Neuralgia • Pain

Current evidence for the role of rapid-acting antidepressants (RAAD) in bipolar depression? A perspective and plan for action. (PubMed, Biol Psychiatry) - "The following RAAD substance classes have been or are currently being investigated as possible treatments for bipolar depression: NMDA antagonists and indirect AMPA agonists (ketamine, esketamine, riluzole, felbamate), GABAA (gamma-aminobutyric acid A) activators or positive allosteric modulators (zuranolone, pregnenolone, PEA), psychedelics (psilocybin, 5-MeO-DMT), muscarine receptor antagonists (scopolamine), and kappa opioid receptor antagonists (navacaprant). Recent research into RAADs demonstrates the growing field of novel mechanisms of action in the pharmacological treatment of bipolar depression. However, there is an urgent need for well-controlled clinical studies on RAADs in bipolar depression to expand treatment options and improve outcomes for millions of affected individuals worldwide."

Journal • Review • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Psychiatry

Laparoscopic Anatomy of the Coelomic Cavity Organs in Female Red-Eared Slider (Trachemys scripta Elegans). (PubMed, Vet Med Int) - "Anesthesia was induced with ketamine and diazepam and continued using the inhaler method. The use of laparoscopic technique is a practical and reliable way to examine the organs of the coelomic cavity. Although this method requires factors such as the ability of the surgeon to use the device, it is a noninvasive technique that helps the surgeon in accessing the organs away from the cutting site."

Journal • Anesthesia

Ketamine-induced cholangiopathy (PubMed, Ugeskr Laeger) - "A subsequent magnetic resonance cholangiopancreatography and endoscopic ultrasound found no explanation for the dilated common bile duct. This case report describes a presumed rare case of ketamine-induced cholangiopathy, an important differential diagnosis of otherwise unexplained cholangiopathy."

Journal • Infectious Disease • Pain

A Study of Spontaneous Self-Injurious Behavior and Neuroimaging in Rhesus Macaques. (PubMed, Research (Wash D C)) - "Notably, a series of administration of low-dose ketamine had no effect on SIB and the physical index. Our integrative multi-omic approach elucidates the neurobiological phenotype of spontaneous SIB in macaques, highlighting the value of the SIB model for pathogenetic investigation and therapeutic development in human NSSIs."

Journal • Metabolic Disorders

Altered AMPA receptors density associated with ketamine response in treatment-resistant depression: PET study using [11C]K-2. (EANM 2025) - No abstract available

CNS Disorders • Depression • Mood Disorders • Psychiatry

Different dexmedetomidine combinations with sevoflurane, ketamine, or propofol lead to varying clinical and laboratory outcomes in rabbits. (PubMed, Am J Vet Res) - "These findings may assist in selecting anesthetic protocols in rabbits by balancing intraoperative stability and quality of recovery. The results are applicable to both clinical and experimental veterinary settings."

Journal • Preclinical • Anesthesia

ANA01: Anesthetics and Analgesics in Children (clinicaltrials.gov) - P=N/A | N=460 | Recruiting | Sponsor: Kanecia Obie Zimmerman | Trial completion date: Jun 2025 ➔ Sep 2026 | Trial primary completion date: Jun 2025 ➔ Aug 2026

Trial completion date • Trial primary completion date • Anesthesia • Pain

Widefield Imaging Reveals Distinct Whole-Cortex Dynamics During Anesthetic-Induced Unconsciousness. (PubMed, Anesth Analg) - "The general anesthetics induced unique cortical signal patterns, with the RSC emerging as a key region in which specific oscillatory patterns manifested. The observed 1.5 to 2.5 Hz oscillations in the RSC under different anesthetic conditions suggest a common underlying mechanism for anesthesia-induced LOC. Understanding these spatiotemporal patterns can help improve the monitoring and management of anesthesia."

Journal • Anesthesia • THY1

Ketamine's impact on mood after day-case surgery and its relation to obesity: a randomised controlled trial in women undergoing fractional curettage. (PubMed, BMC Womens Health) - P4 | "Our study showed that compared with the patients in the control group, a single subanaesthetic intravenous dosage of ketamine did not improve the total mood scores of patients in the ketamine group, as measured by the POMS questionnaire. On the other hand, obesity was an independent predictor of improvement in total mood scores among patients who received 0.5 mg/kg ketamine. Further studies are needed to evaluate the relationship between ketamine, obesity and patients' emotional recovery after surgery."

Clinical • Journal • Anesthesia • CNS Disorders • Depression • Genetic Disorders • Obesity • Pain • Psychiatry

Effects of Atorvastatin and Gemfibrozil on Mice Corpus Cavernosum In Vitro. (PubMed, Fundam Clin Pharmacol) - "Mouse corpus cavernosum tissues are dissected under ketamine and xylazine anesthesia...No change was observed in responses of the tissues to acetylcholine, nitroprusside, and electrical field stimulation when incubated with atorvastatin or gemfibrozil...Atorvastatin and gemfibrozil caused these effects via endothelial nitric oxide. When all the results are evaluated, not only did the two drugs show no unfavorable effects, but they may also have some beneficial effects on erectile functions."

Journal • Preclinical • Anesthesia • Cardiovascular • Erectile Dysfunction

TIVA: Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia (clinicaltrials.gov) - P1/2 | N=40 | Completed | Sponsor: Minia University | Recruiting ➔ Completed | Trial completion date: Apr 2024 ➔ Mar 2025 | Trial primary completion date: Apr 2024 ➔ Dec 2024

Trial completion • Trial completion date • Trial primary completion date • Anesthesia

Urinary metabolic ratio of pain management and substance abuse treatment drugs: Drug-drug interactions. (PubMed, J Opioid Manag) - "The 18 drugs include dextromethorphan, oxycodone, hydrocodone, tramadol, morphine, buprenorphine, fentanyl, clonazepam, alprazolam, quetiapine, carisoprodol, tapentadol, ketamine, methadone, impramine, and amitriptyline. The 14 interfering drugs include fluoxetine, paroxetine, bupropion, citalopram, sertraline, venlafaxine, duloxetine, risperidone, trazodone, aripiprazole, cyclobenzaprine, amphetamine, and tetrahydrocannabinol...Using the MR reference intervals of the 18 drug pairs established in an earlier study, and the current DDI system, we can alert providers of unusual metabolism caused by DDIs. This will help providers do better prescribing or review more closely all medications and supplements patients are taking, thus avoiding underdosing or potential medication adverse reactions."

Journal • Pain • Substance Abuse • CYP2C19 • CYP3A4

Urinary metabolic ratio of pain management and substance abuse treatment drugs: Reference intervals. (PubMed, J Opioid Manag) - "These drugs were dextromethorphan, morphine, oxycodone, hydrocodone, quetiapine, tapentadol, tramadol, buprenorphine, clonazepam, fentanyl, imipramine, ketamine, carisoprodol, alprazolam, methadone, and amitriptyline. Ratio values outside of this reference range could be considered to be caused by genetic metabolizing variants, drug-drug interactions, age, or deception. Alerting providers of the variance in metabolism from the expected norm might reduce overdosing or underdosing patients."

Journal • Pain • Substance Abuse

Non-prescribed ketamine use is rising in the UK-including among under 16s. (PubMed, BMJ) - No abstract available

Journal

Robotic Bilateral Ileal Interposition: The Total Intracorporeal Approach. (PubMed, Int Braz J Urol) - "Retro-caecal exposure of the retroperitoneal plane allows a convenient access to ureters. Bilateral ileal interposition can be safely performed in a minimally invasive manner with robotic technique."

Journal • Fibrosis • Immunology

Trends in alcohol withdrawal management by medical toxicologists in the acute care setting: an analysis of the Toxicology Investigators Consortium (ToxIC) Core Registry, 2016-2022. (PubMed, Alcohol Alcohol) - "Use of benzodiazepines alone to manage AWS decreased while phenobarbital, ketamine, and dexmedetomidine use increased. Many patients had severe withdrawal manifestations, and some received alcohol use disorder treatment, suggesting that medical toxicologists see more severe cases in the acute care setting and have an opportunity to address the underlying use disorder."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Psychiatry

Tunable Intranasal Polymersome Nanocarriers Triggered Olanzapine Brain Delivery and Improved In Vivo Antipsychotic Activity. (PubMed, Pharmaceutics) - "In vivo studies in adult male Sprague-Dawley rats assessed pharmacokinetics (plasma and brain concentrations), pharmacodynamic efficacy in a ketamine-induced schizophrenia model, and systemic safety markers including metabolic, hepatic, and testicular oxidative stress indicators. PolyOla-treated rats showed superior antipsychotic performance, reduced extrapyramidal symptoms, and improved systemic safety evidenced by mitigated weight gain, glycemic control, normalized liver enzymes, and reduced oxidative stress. PolyOla offers a safe and effective intranasal delivery platform for Ola, enabling targeted brain delivery and improved management of schizophrenia with reduced peripheral toxicity."

Journal • Preclinical • CNS Disorders • Psychiatry • Schizophrenia

President's message: the dangers of ketamine clinic proliferation. (PubMed, J Addict Dis) - No abstract available

Journal

Surgical Opioid Avoidance Protocol in Pancreas Transplant Recipients (WTC 2025) - "Type of opioid patients were exposed to changed significantly in the post-SOAP cohort with less use of morphine and hydrocodone in favor of more tramadol, ketamine and acetaminophen. Introduction of a multimodal, opioid avoidance protocol yielded similar analgesia in a more surgically complex patient population of pancreas recipients. Despite similar MME exposure, type of opioid used to achieve analgesia changed significantly."

Clinical • Pain • Transplantation

Living Liver Donor Intra-operative Analgesia and Day 1 Pain - Insights from the International LDLT Registry (WTC 2025) - "Donor demographics are shown in table 1 with a summary of surgical approach, systemic analgesia and regional techniques used shown in table 2.Multivariable analysis demonstrated an association between a reduced pain and robotic hepatectomy, and use of remifentanil and dexmedetomidine...Ketamine and regional blocks did not show a statistically significant effect on day 1 pain scores, though an interaction between ketamine used and open hepatectomy was statistically significant (see figure 1).* This analysis highlights modifiable factors influencing early post-operative pain, with surgical techniques demonstrating significant impact. This analysis highlights modifiable factors influencing early post-operative pain, with surgical techniques demonstrating significant impact. These findings encourage further investigation as LDLTregistry.org continues to expand its data collection and improve completeness. Additional data (e.g., dosing of systemic and neuraxial drugs) and..."

Late-breaking abstract • Anesthesia • Pain

The Dreamy Jet Study (clinicaltrials.gov) - P1 | N=40 | Suspended | Sponsor: University of Wisconsin, Madison | Not yet recruiting ➔ Suspended

Trial suspension • Anesthesia

Ketamina: Ketamine Augmentation of ECT in Treatment-Resistant Depression (clinicaltrials.gov) - P3 | N=30 | Recruiting | Sponsor: Università Vita-Salute San Raffaele | Not yet recruiting ➔ Recruiting

Enrollment open • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

SUPER-CAT: Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest (clinicaltrials.gov) - P=N/A | N=80 | Recruiting | Sponsor: University of Milano Bicocca | Trial completion date: Mar 2025 ➔ Sep 2025 | Trial primary completion date: Mar 2025 ➔ Sep 2025

Trial completion date • Trial primary completion date • Cardiovascular • Epilepsy

Ketamina: Ketamine Augmentation of ECT in Treatment-Resistant Depression (clinicaltrials.gov) - P3 | N=30 | Not yet recruiting | Sponsor: Università Vita-Salute San Raffaele

New P3 trial • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry