clobetasol propionate topical / Generic mfg. - LARVOL DELTA

Pediatric alopecia universalis with poliosis post-psychosocial stress: a case report on methotrexate and adjunctive management. (PubMed, Acta Dermatovenerol Alp Pannonica Adriat) - "Initial treatment included topical clobetasol propionate 0.05% for 6 months, topical minoxidil 5% for 12 months, and oral vitamin D supplementation for 6 months, with minimal response. This case highlights psychosocial stress as a potential contributor in pediatric AU and supports a multidisciplinary approach. Methotrexate was effective and well tolerated, and poliosis may be a marker of follicular recovery."

Journal • Alopecia • Immunology • Pediatrics

Rapid Improvement of Refractory Pruritus in Extragenital and Perianal Lichen Sclerosus With Nemolizumab: A Case Report. (PubMed, Cureus) - "Prior treatments included betamethasone dipropionate 0.05% cream, intralesional triamcinolone acetonide, and office-based narrowband ultraviolet B phototherapy, the latter producing remission from 2021 until early 2026 before recurrence...No other topical, systemic, or phototherapy treatment was used after nemolizumab initiation through the first eight weeks...A short pulse of clobetasol 0.05% ointment was initiated for perianal disease at the eight-week visit while nemolizumab was continued. This case suggests that nemolizumab may provide rapid symptomatic relief of refractory pruritus associated with lichen sclerosus, even without early morphologic resolution."

Journal • Dermatology • Dermatopathology • Pruritus • IL31RA

A randomized phase 2 placebo-controlled trial of clobetasol solution for oral chronic graft-versus-host disease therapy. (PubMed, Blood Adv) - P2 | "There is an unmet need for more effective topical therapy to adequately control cGVHD in the oral cavity...These controlled study data demonstrate that 0.05% clobetasol oral rinse is clinically effective and induces measurable tissue-level immunologic changes in the treatment of oral GVHD, including among patients who failed clobetasol ointment. This trial was registered at www.clinicialtrials.gov as #NCT01557517."

Clinical • Journal • P2 data • Chronic Graft versus Host Disease • Endocrine Disorders • Graft versus Host Disease • Immunology • Nephrology • Pain • CXCL10 • IL17A • IL6

Talaromyces marneffei Infection Mimicking Refractory Pyoderma Gangrenosum in Ulcerative Colitis on Combination Immunosuppression (ACG 2026) - "Case Description/ A 54-year-old man with severe ulcerative pancolitis on infliximab (10 mg/kg every 8 weeks), 6-mercaptopurine, and mesalamine presented with a progressively enlarging ulcerative lesion on the dorsal left hand one month after travel to Thailand...Initial treatment with topical corticosteroids failed, and immunosuppression was escalated with oral prednisone, high-potency topical clobetasol, topical ruxolitinib, and increased infliximab dosing to every 6 weeks without improvement...The patient was started on oral itraconazole 200 mg twice daily, resulting in rapid and marked clinical improvement...Lack of response to standard PG therapy should prompt early biopsy with microbial cultures, particularly in immunosuppressed patients with relevant travel exposure. To our knowledge, this represents the first reported case of a rare presentation of cutaneous talaromycosis mimicking PG in an IBD patient on biologic therapy."

Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Pyoderma Gangrenosum • Ulcerative Colitis

A Rare Case of Mesalamine-Induced Accelerated Histiocytoid Sweet Syndrome in a Patient Treated for Colitis (ACG 2026) - "The patient was started on mesalamine suppositories...Mesalamine was discontinued and she was treated with topical clobetasol and oral antihistamines...Middle column: Skin biopsy immunohistochemistry showing a perivascular and interstitial histiocytoid infiltrate with positive staining for CD14, MPO, and MXA. Right column: Erythematous, tender papules on the dorsal hands, forearms, and lower extremities."

Clinical • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Musculoskeletal Pain • Pyoderma Gangrenosum • CD14

Clinical Characteristics, Treatment Patterns, and Outcomes of Pyoderma Gangrenosum in Patients With and Without Inflammatory Bowel Disease (ACG 2026) - "88% (30/34) trialled topical therapy, with the most common agent being Clobetasol...Ustekinumab and JAK inhibitors were trialled by 2 patients each... In this real-world cohort, most patients with PG received antibiotics, corticosteroids, and topical therapies, while approximately half required a biologic treatment, most commonly Infliximab and Adalimumab. 34 patients were included in the study thus far. The mean age at diagnosis of PG was 53 years. 70% (24/34) were female."

Clinical • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Pyoderma Gangrenosum • Ulcerative Colitis

Isolated Nail Lichen Planus With Extensive Involvement: The Importance of Clinicopathologic Correlation and Response to Hydroxychloroquine. (PubMed, Cureus) - "Treatment with systemic prednisone did not result in clinical improvement. Early clinicopathological correlation is essential for diagnosis and timely management. Hydroxychloroquine combined with topical clobetasol may be considered as a therapeutic approach in selected patients with inadequate response to systemic corticosteroids."

Journal • Dermatology • Dermatopathology • Inflammation • Lichen Planus • Pain

Comparison of the Efficacy of Topical 0.05% Clobetasol Propionate and Topical 0.1% Tacrolimus in the Treatment of Early-Stage Mycosis Fungoides (EADV 2026) - No abstract available

Clinical • Cutaneous T-cell Lymphoma • Dermatology • Mycosis Fungoides • Oncology

topical metformin copmared with clobetasol propionate for alopecia areata : clinical outcomes from clinical trial (EADV 2026) - No abstract available

Clinical • Clinical data • Alopecia • Immunology

PROCLAME: Topical Clobetasol Propionate for Inflammatory Hand Osteoarthritis (clinicaltrials.gov) - P2 | N=187 | Not yet recruiting | Sponsor: Assistance Publique - Hôpitaux de Paris

New P2 trial • Immunology • Osteoarthritis • Rheumatology

Drug-Induced Skin Lesions of Bilateral Lower Extremities in an Elderly Patient With Poorly Controlled Diabetes. (PubMed, Clin Case Rep) - "Topical clobetasol propionate was immediately discontinued. During a 2-week follow-up period, his symptoms had resolved significantly."

Journal • Atopic Dermatitis • Dermatology • Diabetes • Immunology • Metabolic Disorders

A Persistent Flexural Dermatosis Unmasking Adult Langerhans Cell Histiocytosis: A Case Report. (PubMed, Cureus) - "The patient was treated with topical clobetasol propionate, local wound care, and treatment of secondary bacterial superinfection, resulting in marked improvement of the vulvar and intertriginous lesions during follow-up...LCH should be considered in the differential diagnosis of persistent erosive vulvar and intertriginous lesions that are unresponsive to conventional therapies. Early biopsy is crucial to avoid diagnostic delay and to ensure appropriate staging and management."

Journal • Breast Cancer • Dermatology • Langerhans Cell Histiocytosis • Oncology • Solid Tumor • CD1a

Comparative Efficacy of Terbinafine, Itraconazole, and Griseofulvin in Treatment of Steroid-Modified Tinea. (PubMed, Indian Dermatol Online J) - "Itraconazole appears to be the most effective for steroid-modified tinea, with superior clinical and quality-of-life outcomes. Steroid misuse, driven by pharmacist recommendations, underscores the need for public health interventions."

Journal • Dermatology

Zosteriform Lichen Planus in a Young Woman: A Case Report of the Diagnostic Challenges and Psychodermatologic Associations. (PubMed, Cureus) - "Treatment with topical clobetasol propionate 0.05% resulted in marked clinical improvement, while subsequent recurrences remained temporally associated with periods of increased perceived stress and responded to reintroduction of topical corticosteroid therapy together with stress-management strategies. This case highlights the diagnostic challenges of clinically diagnosed ZLP in a resource-limited setting and demonstrates the importance of systematic clinical reasoning when biopsy is not feasible, while reaffirming that histopathologic confirmation remains the preferred method whenever available. It also supports formal psychosocial assessment as a valuable adjunct to the multidisciplinary management of selected patients with recurrent, stress-associated inflammatory skin disease."

Journal • Dermatology • Dermatopathology • Herpes Zoster • Inflammation • Lichen Planus • Varicella Zoster

Oral Candidiasis in Patients With Oral Lichen Planus Receiving Topical Corticosteroids: A Retrospective Cohort Study. (PubMed, Oral Dis) - "Oral candidiasis is common in corticosteroid-treated OLP. Risk is driven by disease severity and modifiable local factors, supporting targeted prevention and monitoring."

Journal • Retrospective data • Addiction (Opioid and Alcohol) • Candidiasis • Dental Disorders • Dermatology • Dermatopathology • Infectious Disease • Lichen Planus • Xerostomia

Common Medications Prescribed by Oral Medicine Practitioners in Saudi Arabia: A Cross-Sectional Study. (PubMed, J Multidiscip Healthc) - "The most frequently prescribed analgesics were ibuprofen and paracetamol, whereas antibiotic, antifungal, and antiviral prescriptions showed significant variations according to practitioner experience, with consultants and specialists prescribing a broader range of antibiotics than residents. Topical corticosteroids, particularly clobetasol propionate, were widely used, and prednisolone was the most frequently used systemic immunosuppressant...Particularly the use of antibiotics and immunosuppressants varies according to practitioner experience. The findings in this study highlight the need for improved adherence to prescription guidelines, enhanced pharmacovigilance training, and broader implementation of smoking‑cessation counseling to support holistic patient care in KSA."

Journal • Observational data • Pain • Tobacco Cessation

BRAFV600E-Mutant Non-Langerhans Cell Histiocytosis Clonally Related to Remitted Acute Myeloid Leukemia. (PubMed, J Cutan Pathol) - "Work up demonstrated isolated cutaneous involvement without AML relapse; therefore, the skin lesions were treated with shave excision, topical tacrolimus 0.1% ointment, and topical clobetasol 0.05% cream without further systemic treatment. The acquired BRAF V600E mutation illustrates the potential for divergent myeloid differentiation and likely explains the emergence of a clonal NLCH after successful AML treatment. Genetic analysis in NLCH can establish clonality with associated hematologic malignancies, uncover actionable mutations, and guide treatment."

Journal • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Hematological Disorders • Hematological Malignancies • Langerhans Cell Histiocytosis • Leukemia • Oncology • Transplantation • BCOR • BRAF • CCND1 • CD163 • CD1a • CD20 • CD68 • DNMT3A • F13A1 • IDH1 • KMT2A • TP53

COEXISTING DIAGNOSES OF IATROGENIC CUSHING'S SYNDROME AND PYODERMA GANGRENOSUM DUE TO INAPPROPRIATE TOPICAL CORTICOSTEROID USAGE IN AN OLDER PATIENT. (PubMed, Acta Endocrinol (Buchar)) - "On the other hand, to the best of our knowledge, ICS cases coexisting with pyoderma gangrenosum (PG) have not been reported before in the geriatric population. Herein, we aimed to present a 67-year-old female patient who developed ICS and was accompanied by PG due to long-term use of topical clobetasol 17-propionate therapy."

Journal • Cushing’s Disease • Dermatology • Endocrine Disorders • Pyoderma Gangrenosum

DoE-oriented optimization of a chitosan-based nanoemulgel of clobetasol propionate for therapeutic intervention in psoriasis. (PubMed, RSC Adv) - "The Cp-NE gel had a pH of 6.13 and a viscosity of 6799 cps, making it suitable for topical use...Stability studies showed excellent stability at 5 ± 3 °C and 25 ± 2 °C/60 ± 5% RH. The Cp-NE gel exhibited favorable physicochemical properties, sustained release, enhanced skin permeation, and stability, highlighting its potential for psoriasis treatment."

Journal • Dermatology • Immunology • Inflammation • Psoriasis • IL6 • TNFA

Evaluation of early antioxidant and anti-inflammatory effects of Ecballium elaterium (L.) A. rich balm in rats with imiquimod-induced psoriasis. (PubMed, Front Pharmacol) - "This study evaluated the therapeutic efficacy of Ecballium elaterium (EE) balm compared with clobetasol propionate (0.05%) (CLO) in rats with psoriasis-like lesions induced by topical imiquimod (IMQ). In an imiquimod-induced psoriasis rat model, Ecballium elaterium balm reduced disease severity, oxidative stress, and inflammatory markers, with systemic biochemical changes. Despite these promising findings, this research is still in its early stages based on a single preclinical model."

Journal • Preclinical • Dermatology • Immunology • Oncology • Psoriasis • CAT • TNFA

Economic Burden and Cost Differences Between Branded and Generic Topical Antifungals in India. (PubMed, Cureus) - " The market for topical antifungal agents demonstrates substantial price variation among available products. Regulatory authorities, pharmaceutical manufacturers, and clinicians must collaborate to achieve optimal reductions in drug costs. Strict implementation of cost regulation policies, along with increased awareness among clinicians regarding the rational selection of cost-effective therapies, is essential."

HEOR • Journal • Dermatology

Superficial Pyoderma Gangrenosum of the Penis (BAD 2026) - "His rheumatoid arthritis was controlled with methotrexate and baricitinib...Management was changed to aciclovir...The ulcerated area was treated with clobetasol propionate and resolved over the course of 4 weeks...The detection may have been due to contamination from his perioral HSV. The case highlights the atypical and dramatic appearance of superficial pyoderma gangrenosum and the differentials in an immunosuppressed individual."

Herpes Simplex • Immunology • Inflammatory Arthritis • Pyoderma Gangrenosum • Rheumatoid Arthritis

Review of Skin Depigmentation Practices and Cutaneous Malignancy. (PubMed, J Clin Aesthet Dermatol) - "Skin bleaching agents have a powerful presence among a broad population, yet the consequences of their use in skin of color are poorly understood and potentially dangerous. Based on the available literature, there is potential for skin bleaching practices to be implicated as the causative agent for cutaneous SCC, especially in darker skin phenotypes. Therefore, there is a growing need for dermatologists to address this topic as a major public health concern with high morbidity and potential mortality to prompt further investigation."

Journal • Review • Genetic Disorders • Oncology • Skin Cancer • Squamous Cell Carcinoma • Squamous Cell Skin Cancer

Pagetoid reticulosis (Woringer-Kolopp disease) mimicking eczema: a case report with immunophenotypic analysis and literature review. (PubMed, Front Immunol) - "Following a definitive diagnosis of localized PR, the patient was treated with topical clobetasol propionate twice daily, resulting in substantial clinical resolution...For treatment-refractory acral plaques, a high index of clinical suspicion is paramount. Early biopsy with appropriate immunophenotypic evaluation is essential to avoid diagnostic delay and guide effective local treatment, including radiotherapy or surgical excision."

Journal • Review • Atopic Dermatitis • Cutaneous T-cell Lymphoma • Dermatology • Hematological Malignancies • Immunology • Lymphoma • Mycosis Fungoides • Oncology • T Cell Non-Hodgkin Lymphoma • CD2 • CD4 • CD5 • CD7 • CD8 • TNFRSF8

To Evaluate and Compare the Effectiveness of Topical Amlexanox, Curcuma Longa Extract, and Clobetasol Propionate in the Treatment of Oral Lichen Planus: An Original Research. (PubMed, J West Afr Coll Surg) - "Amlexanox and Curcuma longa extract reduce the signs and symptoms of OLP to a tolerable level, with improvement remaining static after the cessation of therapy. Clobetasol propionate causes complete remission of signs and symptoms of OLP, but there is a higher chance of recurrence."

Journal • Dermatology • Dermatopathology • Immunology • Lichen Planus • Pain