clobetasol propionate topical / Generic mfg. - LARVOL DELTA

The Effect of Dupilumab on Atopic Dermatitis–Related Emergency Department Visits: A Real-World Analysis (AAD 2026) - "Patients with AD were identified via validated ICD-10 codes and stratified into two cohorts: those treated with dupilumab and those treated with topical corticosteroids such as hydrocortisone, triamcinolone, and clobetasol but without dupilumab. Dupilumab therapy was associated with reduced risk of AD-related ED visits in a large, real-world dataset. These findings highlight the potential of biologic therapy to decrease acute care burden and support its broader role in comprehensive AD management."

Clinical • Real-world • Real-world evidence • Atopic Dermatitis • Dermatitis • Dermatology • Dermatopathology • Immunology • Inflammation • Psoriasis • Vitiligo

A quantitative systematic review of erosive pustular dermatosis in burns: an underrecognized cause of delayed wound healing (AAD 2026) - "Treatment generally included various combinations of high-potency topical corticosteroids (most often clobetasol), oral steroids, and dressing changes, which often led to stabilization, improvement, or resolution...It arises from diverse etiologies. Early recognition is essential to prevent misdiagnosis, avoid unnecessary antimicrobials, and improve outcomes."

Review • Alopecia • Dermatology • Immunology • Inflammation • Thermal Injury

Refractory nasal pemphigus vegetans treated with dupilumab in a patient with multiple contraindications to first-line therapies (AAD 2026) - "Management was complicated by steroid-induced hyperglycemia, dapsone-associated methemoglobinemia, thiopurine methyltransferase deficiency, and a rituximab biosimilar infusion reaction...Based on emerging data on dupilumab’s use towards remission induction in refractory pemphigus vulgaris, we initiated dupilumab 300mg every 4 weeks combined with low-dose mycophenolate mofetil...Treatment was discontinued due to persistent gastrointestinal discomfort, and nasal lesions recurred 13 weeks later despite the use of topical tacrolimus 0.01% ointment and clobetasol 0.05% ointment twice daily. Although prior data on dupilumab for pemphigus vegetans is lacking, dupilumab may represent a steroid-sparing option for pemphigus vegetans in patients who cannot tolerate rituximab or its biosimilars. Prospective research should evaluate dupilumab’s efficacy in achieving and maintaining pemphigus vegetans remission."

Clinical • Bullous Pemphigoid • Chronic Rhinosinusitis With Nasal Polyps • Dermatopathology • Diabetes • Gastrointestinal Disorder • Hematological Disorders • Immunology • Metabolic Disorders • Nasal Polyps • Otorhinolaryngology • Pemphigus Vulgaris • Respiratory Diseases • Sinusitis • Type 2 Diabetes Mellitus

Picosecond Laser as a Novel Minimally Invasive Approach for Digital Calcinosis Cutis: Enhancing Calcium Extrusion Through Photoacoustic Effects (AAD 2026) - "Lesions were refractory to topical sodium thiosulfate and clobetasol... Picosecond 1064 nm laser therapy offers a minimally invasive, well-tolerated approach for calcinosis cutis, softening calcium deposits through photoacoustic effects, enabling extrusion through epidermal fenestrations. This modality may be especially beneficial for small, diffuse, multifocal, surgically inoperable lesions, or for pediatric patients who may not tolerate surgery. Recovery is much faster than surgical excision."

Immunology • Metabolic Disorders • Scleroderma • Systemic Sclerosis

Modified Goeckerman Therapy for Chronic Skin Diseases in a Resource-Limited Setting: A Case Series From Kenya (AAD 2026) - "Each patient completed a minimum 10-day course of therapy consisting of UVB phototherapy administered prior to topical wrap therapy with coal tar and betamethasone dipropionate or clobetasol propionate. To our knowledge, this is the first report of the efficacious use of Goeckerman therapy in mycosis fungoides. Despite decreased utilization of Goeckerman therapy in the U.S., future research is warranted to assess the benefit of Goeckerman therapy for the treatment of chronic skin conditions in resource-limited settings."

Clinical • Atopic Dermatitis • Cutaneous T-cell Lymphoma • Dermatitis • Dermatology • Immunology • Mycosis Fungoides • Plaque Psoriasis • Psoriasis

Canine Shampoo–Induced Allergic Contact Dermatitis: A Case and Review (AAD 2026) - "The eruption persisted for 18 months and was only partially responsive to clobetasol and emollients... Veterinary shampoos should be considered as a potential source of allergen exposure. This case emphasizes the importance of obtaining a detailed exposure history when evaluating localized or unexplained dermatitis."

Clinical • Review • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Vulvar Malignancy Risk in Lichen Sclerosus: Differential Impact of Topical Therapies (AAD 2026) - "High-potency topical steroids, such as clobetasol, are first-line therapy, while topical calcineurin inhibitors (TCIs), including tacrolimus and pimecrolimus, are second-line [3]. These findings corroborate the elevated vulvar malignancy risk in LS at the population level. Clobetasol appeared to be protective against neoplastic transformation, particularly in early disease, while TCIs conferred no increased risk."

Dermatology • Gynecologic Cancers • Oncology • Squamous Cell Carcinoma • Vulvar Cancer

Efficacy and Outcomes of 12-Week Alternating Topical Corticosteroid Regimens in Early-Stage Mycosis Fungoides: A Retrospective Analysis (AAD 2026) - "The most common treatment regimen was clobetasol plus triamcinolone (71.2%)...Lesion morphology emerges as a critical predictor of treatment durability, with mixed lesions associated with earlier recurrence. These findings further guide topical steroid regimens and expectations in specific lesion types.4"

Retrospective data • Cutaneous T-cell Lymphoma • Dermatology • Mycosis Fungoides • Oncology • Pruritus

Ulcerative Necrobiosis Lipoidica in the Setting of Oropharyngeal Epstein-Barr Virus Positive Diffuse LargCell Lymphoma and Glucose-6-Phosphate Dehydrogenase Deficiency: A Case Report (AAD 2026) - "Anti-inflammatory topical clobetasol 0.05% ointment was initiated as well as a saline based solution containing hypochlorous acid for wound cleansing. Due to secondary infection, the patient’s topical regimen was modified to include gentamicin 0.1% ointment and mupirocin 2% ointment followed by eventual broad-spectrum IV antibiotics. Notably, dapsone was avoided due to known G6PD as well as other immunosuppressants in the setting of DLBCL and ongoing chemotherapy with rituximab, cyclophosphamide, doxorubicin, (vincristine), and prednisone (R-CHOP) which had induced neutropenia and thrombocytopenia...Additionally, pegfilgrastim and platelet infusions for neutropenia and thrombocytopenia were administered after initiating R-CHOP. The noninfectious granulomatous reactions may have been an early sign of the underlying lymphoma, suggesting DLBCL as a contributing factor to NL disease pathogenesis."

Case report • Clinical • B Cell Lymphoma • Diabetes • Diffuse Large B Cell Lymphoma • Epstein-Barr Virus Infections • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Metabolic Disorders • Neutropenia • Non-Hodgkin’s Lymphoma • Primary Immunodeficiency • Thrombocytopenia

Vulvovaginal Lichen Planus Treatment Outcomes: A Systematic Review of Novel and Established Therapies (AAD 2026) - "Among monotherapies, systemic corticosteroids showed highest complete resolution (CR) rates at 88.9%, followed by biologics with tildrakizumab achieving 88% CR, and JAK inhibitors with tofacitinib showing 75% CR. Notably, intravaginal hydrocortisone suppositories achieved 54.6% CR compared to only 14.8% with topical clobetasol propionate, demonstrating superior efficacy of mucosal delivery methods...Recurrence rates varied significantly: 84% for topical corticosteroids alone, 11.9% for methotrexate, and only 3.2% for tildrakizumab, suggesting potential disease-modifying effects of certain biologics...Our findings suggest that intravaginal delivery methods outperform topical application, newer targeted therapies show promise even in treatment-refractory cases, and combination approaches are frequently necessary for adequate disease control. The superior efficacy of JAK inhibitors and biologics, combined with lower recurrence rates, offers new hope for patients with..."

Clinical • Review • Dermatology • Dermatopathology • Lichen Planus

Diagnostic and Therapeutic Patterns of Lichen Sclerosus Across Specialties in a Rural Health System (AAD 2026) - "We extracted age, race, diagnosing specialty, and prescription orders for clobetasol, non-clobetasol topical steroids, calcineurin inhibitors, and other treatments... Significant specialty-specific variation exists in lichen sclerosus diagnosis and management, with dermatology emphasizing maintenance and steroid-sparing agents. Enhancing vulvar dermatology education and fostering interdisciplinary consensus on maintenance therapy may improve equitable, patient-centered outcomes, particularly in rural settings with limited dermatology access."

Dermatology • Pruritus

Upadacitinib in Lichen Sclerosus et Atrophicus: A Novel JAK1-Selective Approach (AAD 2026) - "Despite clobetasol and tacrolimus, her disease progressed with new lesions on the mons pubis, clitoral hood, introitus, perineum, trunk, and extremities...The only adverse event was a single episode of genital herpes simplex virus, effectively treated with valacyclovir...To our knowledge, this is the first reported case of LS treated with Upadacitinib. This case illustrates the potential to address both cutaneous inflammation and underlying immune dysregulation in treatment-refractory patients."

Dermatology • Herpes Simplex • Infectious Disease • Inflammation • JAK1

Vulvar Elastosis Mimicking Lichen Sclerosus: Two Cases with Management Implications (AAD 2026) - "Management changed accordingly: Patient 1 improved with a clobetasol taper plus estrogen therapy; Patient 2 transitioned to low-potency hydrocortisone with counseling. Vulvar elastosis is an important LS mimic in symptomatic postmenopausal patients. When H&E is equivocal, order an elastic stain. Correct identification prevents unnecessary long-term ultrapotent corticosteroids and LS surveillance and supports symptom-directed vulvar care."

Clinical • Dermatology • Pruritus • Solid Tumor

BKT300: A novel small molecule with strong anti-inflammatory and immune regulating activity (IMMUNOLOGY 2026) - "In vivo, BKT300 significantly reduced inflammation in the DTH model, decreasing ear swelling, inflammatory infiltration and tissue damage after topical or subcutaneous administration, with greater efficacy than dexamethasone. These findings indicate that BKT300 exerts anti inflammatory effects primarily by inhibiting immune cell migration through disruption of cytoskeletal dynamics and support its further development for immune mediated inflammatory disorders."

Atopic Dermatitis • Dermatitis • Immunology • CD8 • CXCL12 • PRC1

Optimisation of electrospinning parameters to successfully obtain high ratios of medium chain length polyhydroxyalkanoate in electrospun fibres with drug loading for wound healing applications. (PubMed, J Mater Sci Mater Med) - "Current treatment regimens involve the use of topical corticosteroids for prolonged treatment periods...CP and FLU incorporation into the electrospun fibres did not cause any significant decrease in oral mucosal cell viability. Following in vitro wound healing study promising formulations containing 2% and 10% CP and FLU, respectively, were identified."

Journal • Infectious Disease • Pain • Thermal Injury

Nail tattooing: a novel and minimally invasive technique for enhancing drug penetration through the nail. (PubMed, Drug Deliv Transl Res) - "Ciclopirox olamine and clobetasol lacquers were selected as the model formulations. Drug permeation tests conducted on non-treated, filed (mechanically abraded), and tattooed nails demonstrated significantly higher drug permeation in tattooed nails, suggesting the potential of this delivery method. Nail tattooing offers a simple method to enhance topical therapy, allowing treatment initiation in the clinic and continuation at home."

Journal • Dermatology • Immunology • Infectious Disease • Psoriasis

Clinical Trial to Demonstrate That the Dual Laser Therapy is Effective for the Treatment of Vulvar Lichen Sclerosus (clinicaltrials.gov) - P=N/A | N=66 | Completed | Sponsor: Prof. Dr. Volker Viereck | Active, not recruiting ➔ Completed

Trial completion • Dermatology

Pityriasis Amiantacea Secondary to Epidermal Growth Factor Inhibitor Therapy (AAD 2026) - "A 74-year-old woman with metastatic colon adenocarcinoma on folinic acid, fluorouracil, and oxaliplatin developed scalp scaling after initiation of panitumumab in 04/2023. The regimen was later modified with irinotecan, and panitumumab resumed at reduced dosing...Treatment with salicylic acid 6% shampoo, topical clobetasol 0.05% foam, and gentle debridement led to marked improvement within weeks...This case represents the first reported occurrence of Pityriasis Amiantacea (PA) associated with EGFRI therapy. PA is an uncommon scalp disorder characterized by thick, adherent scales that may progress to alopecia.1 Drug-induced PA is rare and has previously been associated only with TNF-α inhibitors.1 EGFRIs, widely used in solid malignancies, cause cutaneous toxicities in up to 90% of patients, including papulopustular eruptions, xerosis, and paronychia.2 Scalp involvement is typically seborrheic dermatitis–like changes, alopecia, or erosive pustular dermatosis, driven by..."

Alopecia • Colon Adenocarcinoma • Colon Cancer • Colorectal Adenocarcinoma • Colorectal Cancer • Dermatitis • Immunology • Seborrheic Dermatitis • Solid Tumor

Bullous Pemphigoid in a Child with Merosin-Negative Congenital Muscular Dystrophy: A Case Report (AAD 2026) - "Treatment with systemic corticosteroids, doxycycline, and topical clobetasol achieved durable disease control, with only rare recurrences at 9 months. The patient's favorable clinical response highlights the effectiveness of combined corticosteroid, antibiotic, and topical therapy. Recognition of this association is important, as early consideration of BP in pediatric vesiculobullous eruptions may prevent misdiagnosis and improve outcomes."

Case report • Clinical • Bullous Pemphigoid • CNS Disorders • Dermatology • Dermatopathology • Eosinophilia • Hematological Disorders • Immunology • Muscular Dystrophy • LAMA2

An Unusual Urticaria: Exploring a Rare Case of a Testosterone-Pellet Induced Rash (AAD 2026) - "After failing a short trial of both clobetasol and prednisone, she was later seen at our clinic in July of 2025, where a full body skin exam revealed urticarial papules and plaques across the trunk and thighs bilaterally...She was prescribed a regimen of topical triamcinolone cream twice a day and mupirocin ointment to apply as needed with gradual improvement. To our knowledge, only one other case of a widespread rash after testosterone pellet treatment has been reported in the literature. The primary aim with this report is to illuminate a rare dermatologic condition that clinicians should be aware of in patients that have either received, or are considering testosterone-pellet therapy."

Clinical • Acne Vulgaris • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pruritus • Urticaria

Pseudo-Cheilitis: An Underreported Condition (AAD 2026) - "Treatment with topical Clobetasol, Tacrolimus, Clotrimazole, and oral Doxycycline showed no improvement...Based on this, treatment with Sertraline, a selective serotonin reuptake inhibitor (SSRI), was initiated, resulting in a marked improvement of cheilitis within 2 months...This may result from repeated, subconscious lip trauma during periods of stress. Clinicians should consider this differential diagnosis when expected therapeutic responses are not observed"

Atopic Dermatitis • CNS Disorders • Depression • Immunology • Mood Disorders

Fat Necrosis with Secondary Abscess Formation at Foscarbidopa-Foslevodopa Infusion Sites: A Novel Cutaneous Adverse Reaction in Parkinson's Therapy (AAD 2026) - "Despite oral cefadroxil, topical clobetasol, and intralesional steroids, nodules recurred at additional sites. Continued nodule development in patients should prompt a risk-benefit discussion with the treating neurologist. Further research is needed to improve infusion site tolerability."

CNS Disorders • Infectious Disease • Mood Disorders • Movement Disorders • Obesity • Parkinson's Disease

Combined methotrexate and short-term superpotent topical corticosteroids compared with prolonged superpotent topical corticosteroids alone in bullous pemphigoid: a multicentre, noninferiority randomised clinical trial. (PubMed, Br J Dermatol) - "Maintenance therapy with low-dose MTX is non-inferior to prolonged STS in terms of survival and is associated with a reduced risk of relapse, at the cost of increased toxicity."

Head-to-Head • Journal • Bullous Pemphigoid • Dermatology • Dermatopathology • Immunology

Targeted Investigation of Microbiome 2 Treat Atopic Dermatitis (TIME-2) (clinicaltrials.gov) - P1 | N=86 | Recruiting | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Phase classification: P1/2 ➔ P1 | Trial completion date: Nov 2026 ➔ Feb 2027

Phase classification • Trial completion date • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Comparison of the effectiveness of photodynamic therapy and topical clobetasol in the treatment of oral lichen planus using fractal dimension analysis and lesion autofluorescence. (PubMed, Dent Med Probl) - "The use of autofluorescence at 405 + 450 nm is an objective method of assessing healing, more accurate than observations under white light."

Clinical • Journal • Dermatology • Dermatopathology • Lichen Planus