clobetasol propionate topical / Generic mfg. - LARVOL DELTA

Photobiomodulation, Er:YAG Laser, and Clobetasol in the Treatment of Oral Lichen Planus. (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Medical University of Silesia

New trial • Dermatology • Dermatopathology • Lichen Planus

P024 Anakinra for recalcitrant pyoderma gangrenosum with Achilles tendon exposure. (PubMed, Br J Dermatol) - "He was commenced on ciclosporin with initial improvement, but uptitration was limited to 3 mg kg-1 per day due to the development of significant renal impairment, which required medical admission. Treatment was switched to adalimumab fortnightly...After 14 months of treatment, all areas of ulceration are almost completely healed with one area of mild overgranulation, currently being treated with topical clobetasol propionate...It also reveals the importance of regular wound care and lower-limb compression in the setting of ulcers at this site. Anakinra represents a potentially effective treatment option with a relatively low side-effect profile."

Journal • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Dermatology • Diabetes • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hypertension • Immunology • Inflammatory Bowel Disease • Metabolic Disorders • Nephrology • Oncology • Pain • Pyoderma Gangrenosum • Renal Disease • Thrombosis • Type 2 Diabetes Mellitus • Vasculitis • Venous Ulcer

BG13 Pemphigoid vegetans of the buttocks. (PubMed, Br J Dermatol) - "A variety of treatment modalities have been reported in the literature, including topical corticosteroids, dapsone, tetracyclines and systemic steroids (Kim J, Chavel S, Girardi M, McNiff JM. J Cutan Pathol 2008; 35: 1144-7). However, the rarity of this condition necessitates further discussion to optimize management strategies."

Journal • Bullous Pemphigoid • CNS Disorders • Dermatology • Dermatopathology • Eosinophilia • Immunology • Inflammation

BI05 Cemiplimab toes: a new entity in the expanding spectrum of immune checkpoint inhibitor skin toxicities. (PubMed, Br J Dermatol) - "As pain was severe, the initial concern was of a vasculitic process and oncology started prednisolone 2 mg kg-1 per day (120 mg per day) and flucloxacillin, with symptoms improving rapidly...Although she responded well to oral steroids and suspending cemiplimab, her skin flared with subsequent cycles with prednisolone doses below 10 mg per day despite topical treatment with clobetasol propionate, tacrolimus and calcipotriol-betamethasone ointments, fludroxycortide tape, Fucibet cream and potassium permanganate soaks...Clinically some features were reminiscent of 'COVID toes', but the underlying mechanism is unknown. This case of 'cemiplimab toes' is a striking reminder of the ever-evolving spectrum of cutaneous irAEs associated with immunotherapy and the challenges in diagnosing and managing these effectively to mitigate morbidity while continuing oncological treatment."

Checkpoint inhibition • Journal • Atopic Dermatitis • Dermatitis • Dermatology • Hematological Disorders • Immunology • Myositis • Non-melanoma Skin Cancer • Novel Coronavirus Disease • Oncology • Pain • Squamous Cell Carcinoma • Squamous Cell Skin Cancer • Vasculitis

BI21 Intermittent and progressive pustular psoriasis during chemotherapy cycles in a toddler. (PubMed, Br J Dermatol) - "Just before his next chemotherapy cycle (cisplatin and etoposide), the rash recurred as a pruritic pustular eruption across the frontal and retroauricular scalp; skin biopsy suggested nonspecific subacute eczematous dermatitis...Topical ivermectin and ketoconazole did not help...A second biopsy was taken due to clinical suspicion of psoriasis, and 10 days of oral prednisolone was given to try to clear his skin for autologous stem cell transplantation (HSCT)...He was treated with topical calcipotriol and mometasone 0.1%, with consideration of acitretin should he not improve. Fortunately, the rash settled with topical therapy and time. After completing proton radiotherapy prior to tumour resection, he had six cycles of maintenance immunotherapy (dinutuximab) with no recurrence of the rash, despite monthly GCSF, and good cell counts, and has now completed his oncological therapy."

Journal • Atopic Dermatitis • Bone Marrow Transplantation • Contact Dermatitis • Dermatitis • Dermatology • Epstein-Barr Virus Infections • Herpes Simplex • Herpes Zoster • Immunology • Neuroblastoma • Oncology • Psoriasis • Pustular Psoriasis • Solid Tumor • Transplantation • Varicella Zoster

BI27 Treatment of recalcitrant eczema in a patient with B-cell and natural killer cell lymphopenia of unknown cause. (PubMed, Br J Dermatol) - "He had tried superpotent topical corticosteroids and oral prednisolone, as well as emollients, none of which had improved his symptoms...Tralokinumab was trialled for 12 weeks, as this has a single therapeutic target (interleukin-13), but unfortunately there was no improvement. Following discussion with the immunologists, he was commenced on upadacitinib as this was felt to have a more targeted immunosuppressive effect above agents such as methotrexate and dupilumab. We await his next follow-up appointment to assess response. This case highlights the complexity of treating an immunocompromised individual with immunosuppressive agents, when the cause of their immunosuppression is unknown."

Journal • Atopic Dermatitis • Cutaneous T-cell Lymphoma • Dermatitis • Dermatology • Herpes Zoster • Immunology • Infectious Disease • Mycosis Fungoides • Oncology • Solid Tumor • Thymoma • Thymus Cancer • Varicella Zoster • BTK • GATA2 • IL13

CPC06 Darier-Roussy disease (subcutaneous sarcoidosis): a rare presentation of cutaneous nodules in pulmonary sarcoidosis. (PubMed, Br J Dermatol) - "Treatment involved a weaning course of oral prednisolone combined with topical clobetasol propionate, resulting in significant symptom improvement. This case is notable as subcutaneous nodules are a rare manifestation of sarcoidosis. Documenting such presentations enhances understanding of this uncommon condition and aids in distinguishing it from other differential diagnoses, such as panniculitis or lipomas."

Journal • Cardiovascular • Dermatitis • Dermatology • Fatigue • Gastrointestinal Disorder • Immunology • Infectious Disease • Pain • Sarcoidosis

The TRIBECA Study (TRIessence/Byqlovi for Easier CAtaract Surgery) (clinicaltrials.gov) - P4 | N=40 | Not yet recruiting | Sponsor: Research Insight LLC

New P4 trial • Cataract • Ophthalmology

Evaluation of the effect of clobetasol propionate on circulating cortisol and growth velocity in children with atopic dermatitis: a modelling and simulation study. (PubMed, Dermatology) - "Surface area affected by AD should be considered when assessing the risk of systemic side effects. CP can be applied up to 20% of the BSA of a child (> 1 year old) without clinically relevant changes to circulating cortisol levels. In contrast to the systemic effects of oral corticosteroids, the short-term use of CP has no impact the growth velocity of paediatric subjects with AD."

Clinical • Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pediatrics

Disseminated herpes simplex virus type 1 treated with ixekizumab in a patient with erythrodermic psoriasis: A case report. (PubMed, World J Clin Cases) - "This case highlights the diagnostic and therapeutic challenges of managing EP in the setting of biologic therapy. Disseminated cutaneous HSV-1 should be considered in immunosuppressed patients presenting with new vesicular eruptions, and prompt PCR testing with early antiviral therapy is essential. A multidisciplinary approach is critical to balance immunosuppression for disease control with infection risk."

Journal • Bipolar Disorder • CNS Disorders • Critical care • Dermatology • Dermatopathology • Eosinophilia • Fibrosis • Gastroenterology • Hematological Disorders • Hepatology • Herpes Simplex • Immunology • Infectious Disease • Liver Cirrhosis • Mood Disorders • Psoriasis • Psychiatry

LASER-LICH1: Laser vs Clobetasol for Lichen Sclerosus (clinicaltrials.gov) - P3 | N=246 | Completed | Sponsor: Ruhr University of Bochum | Recruiting ➔ Completed | Trial completion date: Jul 2025 ➔ Oct 2025 | Trial primary completion date: Apr 2025 ➔ Jul 2025

Trial completion • Trial completion date • Trial primary completion date • Dermatology

Case series of mycosis fungoides with marked clinical resemblance to seborrheic dermatitis (ISDS 2025) - "Six months later, the lesion had progressed into a dry, cracked plaque with thick scale that was refractory to topical hydrocortisone, clobetasol, and ketoconazole...Seven months later, the lesion proved refractory to tacrolimus, topical hydrocortisone, and bexarotene (75 mg) that had been prescribed for another MF lesion...Taken together, these three cases highlight key clinical features that help distinguish SD-like MF from SD: unilateral presentation, asymmetry, poor response to standard SD therapies, and history of MF; histopathology may be diagnostic, as in cases 1 and 2, or equivocal, as in case 3. For patients with MF and new lesions or rashes, we thus recommend a combination of total body skin exams, repeat biopsies, and molecular analysis for clonality."

Clinical • Atopic Dermatitis • Cutaneous T-cell Lymphoma • Dermatitis • Dermatology • Immunology • Mycosis Fungoides • Oncology • Psoriasis • Seborrheic Dermatitis

A Persistent Scalp Plaque Resistant to Conventional Therapies (ISDS 2025) - "A KOH exam was inconclusive, so a fungal culture was obtained, and she was started on another 4-week course of oral terbinafine and ketoconazole 2% shampoo, with minimal improvement...She was diagnosed with systemic sarcoidosis and treated with topical clobetasol, tacrolimus, intralesional Kenalog, minocycline, and methotrexate, resulting in significant improvement. The various clinical morphologies of scalp sarcoidosis make prompt diagnosis difficult and, thus, appropriate treatment is often delayed. This case contributes to clinical practice by highlighting that clinical findings alone are insufficient for diagnosis and the value of early biopsy in persistent scalp plaques of ambiguous etiology."

Dermatitis • Dermatology • Immunology • Ocular Inflammation • Ophthalmology • Psoriasis • Sarcoidosis • Uveitis • ERBB3

Time-Dependent Changes in Salivary Antioxidants After 5-ALA Photodynamic Therapy vs. Clobetasol in Oral Lichen Planus: A Randomized Clinical Trial. (PubMed, Int J Mol Sci) - "Overall, ALA-PDT and topical clobetasol both modulated the salivary redox profile, primarily through short-term depletion of enzymatic and non-enzymatic antioxidants with incomplete recovery over 6 months, and no clear redox superiority of one modality over the other was demonstrated. These findings are hypothesis-generating and underscore the need for larger, longer-term studies with broader redox panels and more advanced between-group analyses."

Clinical • Journal • Dermatology • Dermatopathology • Lichen Planus • Pain • CAT

Photodynamic Therapy with 5-Aminolevulinic Acid Versus Topical Corticosteroids in the Treatment of Oral Lichen Planus: A Randomized Clinical Trial with Lesion Site-Specific Analysis. (PubMed, Pharmaceutics) - " ALA-PDT, especially when applied to non-keratinized oral mucosa, provides superior and longer-lasting therapeutic outcomes than topical CT. The application of novel ALA-loaded emulgel enhances treatment efficacy and tolerability, supporting PDT as a promising alternative for OLP management."

Clinical • Journal • Dermatology • Dermatopathology • Lichen Planus • Pain

VULIS-3T: Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy. (clinicaltrials.gov) - P=N/A | N=45 | Not yet recruiting | Sponsor: Milosz Pietrus

New trial • Dermatology

Evening Slide Symposium (ASDP 2025) - "Her eruption was unresponsive to topical urea, ammonium lactate, and petroleum jelly as well as clobetasol ointment 0.05%...He was on tacrolimus, everolimus and prednisone as well as prophylaxis with valgangicolvir and sulfamethoxazole-trimethoprim...She was on methotrexate, adalimumab and prednisone 1mg as needed for joint swelling. She failed treatment with mupirocin, topical steroids, and oral antihistamines...Case 14 Case Summary This 67-year-old male presented with a bullous eruption on the bilateral lower legs, which developed approximately three days after an infusion of tocilizumab for his rheumatoid arthritis, which he had previously received two weeks prior. Topical triamcinolone treatment was not helpful...The provided clinical history was "rule out angioma". Session Chairs"

B Cell Lymphoma • Back Pain • Chronic Lymphocytic Leukemia • Congestive Heart Failure • Contact Dermatitis • Dermatitis • Dermatology • Diabetes • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Grave’s Disease • Heart Failure • Hematological Disorders • Hematological Malignancies • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Inflammatory Bowel Disease • Leukemia • Lyme Disease • Lymphoma • Lymphoplasmacytic Lymphoma • Metabolic Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Nephrology • Neutropenia • Non-Hodgkin’s Lymphoma • Pruritus • Rare Diseases • Renal Disease • Rheumatoid Arthritis • Rheumatology • Septic Shock • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus • Ulcerative Colitis • Waldenstrom Macroglobulinemia

Acquired Perforating Dermatosis (APD) Masquerading as Calciphylaxis in a Patient with ESKD and Uncontrolled Secondary Hyperparathyroidism (KIDNEY WEEK 2025) - "Management and Outcome: Dialysis frequency was restored to thrice weekly with a goal Kt/V ≥ 1.4, a non-calcium phosphate binder, and topical clobetasol plus oral antihistamines relieved pruritus...Discussion APD, seen in 4–11 % of end-stage kidney disease cases, should be suspected when papules appear in haemodialysis patients with poorly controlled chronic kidney disease–mineral-bone disorder; severe hyperphosphataemia, a high calcium–phosphate product and secondary hyperparathyroidism trigger collagen degeneration, intractable pruritus and transepidermal elimination that can masquerade as calciphylaxis. Prompt skin biopsy differentiates the two entities, sparing patients unnecessary calciphylaxis therapy and redirecting management to improving dialysis adequacy, normalising mineral metabolism and treating itch."

Clinical • Calciphylaxis • Chronic Kidney Disease • Dermatology • Diabetes • Diabetic Nephropathy • Endocrine Disorders • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Metabolic Disorders • Nephrology • Orthopedics • Pruritus • Rare Diseases • Renal Disease • Secondary Hyperparathyroidism

Successful treatment of Lichen Sclerosis with off-label use of Upadacitinib (ACAAI 2025) - "Intravaginal steroids and topical clobetasol were ineffective. Discussion Lichen sclerosis is a chronic mucocutaneous autoimmune condition predominantly affecting the genital area.1 It is hypothesized to be driven by T cell–mediated inflammation with elevated pro-inflammatory cytokines like interferon-gamma, signaling via the JAK-STAT pathway.2,3 Given the crucial role of JAK-STAT signaling in cytokine regulation, LS may benefit from the immunomodulatory effects of JAK inhibitors, which are increasingly used in dermatology due to oral administration and favorable safety profiles.2,4 These inhibitors may offer a promising option for refractory LS characterized by cytokine dysregulation. Further clinical studies are required to confirm safety and efficacy in a broader population.3,4."

Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Overactive Bladder • Urinary Incontinence • Urology • IFNG

Scratch the Surface of Grover's Disease (ACAAI 2025) - "Topical clobetasol propionate, a ceramide-rich moisturizer, oral antihistamines, and a five-day prednisone taper failed to improve his symptoms. The concurrent presence of MBCL and transient IgG4 elevation in an otherwise asymptomatic patient challenges traditional diagnostic paradigms and illustrates the necessity for comprehensive evaluation. Moreover, the confounding influence of recent corticosteroid therapy underscores the importance of repeat immunophenotyping once patients are off immune-modulating medications."

Dermatology • Geriatric Disorders • Hematological Disorders • Pruritus • CD5

Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study (clinicaltrials.gov) - P4 | N=250 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Jan 2026 ➔ Aug 2026 | Trial primary completion date: Oct 2025 ➔ Mar 2026

Trial completion date • Trial primary completion date • Alopecia • Dermatology • Immunology

Contact Allergy to Topical Corticosteroids in Atopic Dermatitis: The Importance of Allergen Selection and Formulation in Diagnostic Accuracy (ISAD-RAJKA 2025) - "Patch testing was performed using the Polish Baseline Series and extended allergens including hydrocortisone acetate (ointment), hydrocortisone butyrate (alcoholic solution), and clobetasol propionate...While sensitization to gentamicin was observed more frequently in the AD group, this difference did not reach statistical significance. Patients with AD are at increased risk of clinically relevant contact allergy to corticosteroids. The pharmaceutical form of the allergen plays a decisive role in test sensitivity, underscoring the need for expanded and formulation-appropriate corticosteroid markers in diagnostics."

Allergy • Atopic Dermatitis • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Medical Management of an Infusion Site Extravasation Injury After Peripheral Intravenous Infusion of Ado-Trastuzumab Emtansine in a 38-Year-Old Woman with Breast Cancer: A Case Report. (PubMed, Am J Case Rep) - "She was treated with a topical steroid (clobetasol), topical calcineurin inhibitor (tacrolimus), oral antibiotic (cefadroxil), high-dose vitamin D (ergocalciferol), and pain management (gabapentin) with almost complete resolution in 4 weeks. CONCLUSIONS This case report describes a T-DM1 skin extravasation treated with multimodal medical measures as opposed to a more conservative approach. We reaffirm that the use of port access when administering T-DM1 is critical to prevent extravasation, and we recommend multimodal management, including antibiotics and topical therapies, to prevent infection and expedite wound healing if extravasation occurs."

Journal • Breast Cancer • Dermatology • Hormone Receptor Breast Cancer • Infectious Disease • Oncology • Pain • Solid Tumor

Salivary and Serum Cytokine Levels in Oral Chronic Graft-Versus-Host Disease: A Longitudinal Study on the Role of IL-6, IL-1α, and IL-17. (PubMed, J Oral Pathol Med) - "While IL-6 and IL-17 play roles in cGVHD, only IL-17 showed significant reduction after topical steroid therapy. This suggests IL-17's potential as a marker for inflammatory activity in cGVHD. Serum IL-17 may serve as a useful biomarker in oral cGVHD. Future studies with larger cohorts are needed to further validate these findings and explore the role of salivary cytokines in disease monitoring."

Journal • Observational data • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Inflammation • Mucositis • Oral Cancer • Pain • Stomatitis • Transplantation • IL17A • IL6

Acute Scrotal Ulcers in a 34-Year-Old Male With an Excellent Treatment Response: A Case Report. (PubMed, Cureus) - "The patient was diagnosed with JGVS and was treated with methylprednisolone 24 mg, tapered over two months, in combination with doxycycline 100 mg BID for one month, and topical clobetasol under occlusion, with complete healing in two months and no relapse. Typically, patients are young, usually under 30 years old; however, this patient was slightly older. While exclusive scrotal involvement is common, this patient also exhibited smaller satellite ulcers on the adjacent thigh."

Journal • CNS Disorders • Dermatology • Epstein-Barr Virus Infections • Rare Diseases • Vasculitis