metformin/gliclazide / Generic mfg. - LARVOL DELTA

Insight into the Hypoglycemic Effects of Pinus nigra Arn. Bark Extracts Through In Silico and In Vivo Analysis. (PubMed, Plants (Basel)) - "The ethanol extract reduced glycaemia, improved glucose tolerance, and favourably modulated dyslipidaemia, with additive effects observed in combinations with metformin or gliclazide. These findings suggest activity relevant to hypoglycaemic-relevant activity of P. nigra bark extract in vivo; however, comprehensive chemical profiling, mechanistic confirmation, and safety evaluation are required before translational consideration."

Journal • Preclinical • Diabetes • Dyslipidemia • Metabolic Disorders • Pain • PTPN1

Prurigo Pigmentosa in an Adult Male: A Diagnostic Challenge Unmasked by Diabetes Mellitus (EADV 2025) - "He was initially diagnosed with folliculitis barbae by his general practitioner and prescribed a short course of oral flucloxacillin and topical mometasone, with limited improvement...An eight-week course of oral erythromycin was prescribed... Prurigo pigmentosa is a rare inflammatory dermatosis typically reported in East Asian women, but it can affect a wider demographic. This case was diagnostically challenging due to the patient's atypical profile and absence of a prior diabetes diagnosis. The case highlights the clinical variability and potential for misdiagnosis of prurigo pigmentosa, particularly in men where it can mimic other conditions."

Clinical • Dermatology • Diabetes • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Metabolic Disorders • Novel Coronavirus Disease • Psoriasis • Type 2 Diabetes Mellitus

A combination of gliclazide and metformin attenuates obesity-induced polycystic ovary syndrome in female Wistar rats. (PubMed, Heliyon) - "Estradiol valerate (0.8 mg/kg) was also given to all obese rats to induce polycystic ovarian syndrome. Treatment with M and G alone and in combination significantly (p < 0.0001) restored the serum IL-6, NrF2, and NF-κB levels as compared to DCG. The results inveterate that the M and G combination (M100+G10, and M300+G10) was useful in treating obesity-induced infertility due to antioxidant properties, hypolipidemic effects, and modulation of inflammatory markers."

Journal • Preclinical • Genetic Disorders • Infertility • Obesity • Polycystic Ovary Syndrome • Sexual Disorders • IL6 • NFKB1

Characteristics of purchases of hypoglycemic agents in pharmacy retail sector in 2016-2020 years dynamics (PubMed, Probl Endokrinol (Mosk)) - "In 2020, metformin gliclazide, a combination of glibencladimide with metformin, glibenclamide and vildgaliptin remain leaders in the number of purchased packages. The purchase leaders in terms of budget share are: metformin, gliclazide, liraglutide, vildagliptin and dapagliflozin There are positive trends in the demand for more effective innovative hypoglycemic drugs, however, the affordability of drugs still dominates over the feasibility of their clinical use, and a high percentage of drug turnover in the commercial sector might indicates insufficient funding for drug provision for patients with diabetes mellitus."

Journal • Diabetes • Metabolic Disorders

Effects on Glycemic Control by Combination Therapy of Gliclazide-Metformin and Insulin in Type 2 Diabetes Mellitus Patients (ADA 2023) - "This study showed improvement in the overall glycemic control (HbA1c, FBG and blood sugar 2hours ABF) during the study period. Both groups of drugs are effective in controlling blood glucose but individual group has unique beneficial effect.Key words: Type 2 diabetes mellitus, Glycemic control, Glicazide-Metformin"

Clinical • Combination therapy • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus