dipyridamole / Generic mfg. - LARVOL DELTA

Impact of Coronary Microvascular Dysfunction on Left Ventricular Function After Percutaneous Coronary Intervention: Assessment With Combined Dipyridamole-Exercise Stress and Myocardial Strain/Work. (PubMed, Echocardiography) - P=N/A | "Combined DExE with myocardial strain/work analysis effectively evaluates LV function in CMD. Decreased CFVR post-PCI is associated with impaired LV function and worse 1-year quality of life outcomes, underscoring the need for close cardiac function monitoring in post-PCI CMD individuals."

Journal • Cardiovascular • Coronary Artery Disease

Safety and tolerability of pharmacologic stress with the selective A2A adenosine receptor agonist regadenoson for the assessment of myocardial ischemia: results from 5780 consecutive patients in a cardiology practice. (PubMed, Clin Res Cardiol) - "Overall, regadenoson demonstrated very good tolerability. The development of the selective A2A adenosine receptor agonist regadenoson, compared to classical non-selective adenosine, represents a significant advancement in non-invasive imaging diagnostics of myocardial ischemia, using myocardial scintigraphy and other modalities such as MRI. Since adenosine is contraindicated in patients with bronchial asthma/COPD, regadenoson has become the diagnostic agent of choice in these cases, although it must be considered that very rare instances (< 0.1%) of life-threatening events can occur, necessitating that antidotes such as theophylline and atropine be readily available."

Journal • Asthma • Cardiovascular • Chronic Obstructive Pulmonary Disease • Hypotension • Immunology • Myocardial Ischemia • Pain • Pulmonary Disease • Respiratory Diseases

TEG PLATELET MAPPING ASSAY IN A CASE OF RECURRENT IN-STENT THROMBOSIS IN A P2Y12 INHIBITOR NON-RESPONDER (ACC 2026) - "Relevant medications included aspirin 81 mg and clopidogrel 75 mg daily...The patient was discharged on apixaban 5 mg BID and ticagrelor 90 mg BID...The patient was transitioned to aspirin-dipyridamole BID, prasugrel 30 mg daily, and warfarin with an increase in ADP inhibition to 81% and no further thrombotic events. TEG platelet mapping is a useful tool in assessing adequate ADP inhibition in post catheterization patients with P2Y12 inhibitor resistance."

Clinical • Cardiovascular • Hematological Disorders • Myocardial Infarction • Thrombosis

Synergistic effects of HDAC inhibitor tucidinostat and ENT inhibitor dipyridamole in T-cell malignancies. (PubMed, Sci Rep) - No abstract available

Journal • Oncology

Normal Values of Myocardial Blood Flow and Flow Reserve with Rubidium-82 PET in Low-Risk Patients. (PubMed, J Nucl Cardiol) - "This study establishes sex- and age-specific lower reference limits for stress MBF and MFR in low-risk CAD patients. Females exhibited higher stress MBF and MFR than males, while both values declined with age in both sexes. These findings underscore the necessity of incorporating sex- and age-adjusted reference values when interpreting MBF and MFR in clinical practice."

Journal • Cardiovascular • Coronary Artery Disease

Design and rationale of the AIR-NET trial: a randomised, open-label, multifactorial, multicentre, adaptive platform trial using a range of repurposed anti-inflammatory treatments to improve outcomes in patients with bronchiectasis within the EMBARC clinical research network. (PubMed, ERJ Open Res) - "Participants with bronchiectasis confirmed by computed tomography, daily sputum production and evidence of active airway neutrophilic inflammation (based on a positive lateral flow test for neutrophil elastase (NE) activity), across 10 sites in the UK, will be randomised to one of several repurposed drugs with published evidence of effects on neutrophilic inflammation and acceptable safety profile (oral dose: disulfiram 400 mg once daily; dipyridamole 200 mg twice daily; doxycycline 100 mg once daily; n=42 per arm) or usual care, according to arm-specific eligibility criteria, and treated for 28 days. Key secondary end-points include time-to-first exacerbation, quality of life questionnaires, neutrophil function and safety. AIR-NET will establish a multi-centre network with integrated clinical and translational capabilities for the investigation of therapies in bronchiectasis aiming to identify key anti-inflammatory mechanisms and effective re-purposed treatments."

Journal • Bronchiectasis • Inflammation • Pulmonary Disease • Respiratory Diseases • ELANE

Impact of CYP2C19 genotyping on clopidogrel therapy adjustments in patients with stroke or TIA. (PubMed, Eur J Hosp Pharm) - "In the ETZ cohort, 31.9% of genotyped patients (26.9% intermediate metabolisers and 5% poor metabolisers) had impaired CYP2C19 metabolism. Genotype and phenotype information led to changes in clopidogrel therapy in nearly all of these patients, with the most common adjustment being a switch to ASA and dipyridamole combination therapy."

Journal • Cardiovascular • Preventive care • CYP2C19

REAL208, a Liposome-based Formulation of Phosphodiesterase Inhibitor, Protects Acute Kidney Deficiency in Mice. (PubMed, Pharm Res) - "These findings demonstrated that liposomal dipyridamole exerts robust renoprotective effects by preserving mitochondrial function, suppressing oxidative stress, and attenuating inflammation. REAL208 represents a promising therapeutic strategy for AKI and warrants further translational and clinical investigations."

IO biomarker • Journal • Preclinical • Acute Kidney Injury • Cardiovascular • Inflammation • Nephrology • Renal Disease • Reperfusion Injury • BCL2 • KIM1 • PPARG

An AI-based approach accelerates the discovery of protein-protein interaction modulators targeting NCS-1. (PubMed, Eur J Med Chem) - "The crystal structure of NCS-1 in complex with dipyridamole elucidates its mechanism of modulation. Our findings highlight the potential of AI to streamline and accelerate the discovery of novel therapeutic PPI modulators."

Journal • DRD2 • NCS1

Clinical Experience Using Drug-Calibrated Dilute Thrombin Time for Monitoring Bivalirudin in Pediatric Ventricular Assist Devices (ISHLT 2026) - "Antiplatelet regimens received for >50% of VAD support were aspirin (ASA) (63%), clopidogrel (8%), dipyridamole (4%), ASA/clopidogrel (8%), and ticagrelor/dipyridamole (4%). Median bivalirudin level (bleeding 2.1 vs thrombotic 2.3 mcg/mL) and aPTT (bleeding 93 vs 89 sec) within 48 hours preceding event did not differ (both p>0.05). Single (55%), dual (25%), or no (20%) antiplatelet therapies were received prior to event.Conclusion Monitoring bivalirudin using drug-calibrated bivalirudin dTT is a reasonable strategy that appears associated with excellent TTR, lower incidence of CVA (<10%) and similar bleeding rates compared to national trends."

Clinical • Cardiomyopathy • Cardiovascular • Heart Failure • Pediatrics • Thrombosis

Coronary Artery Disease and Axillary Lymphadenopathy Post COVID-19 Vaccine Administration: Insights from Tl-201 Myocardial Perfusion Imaging. (PubMed, In Vivo) - "Our findings indicate a potential link between mRNA COVID-19 vaccination and cardiac issues detected via MPI, as well as an increase in axillary lymphadenopathy. Although further prospective studies are warranted to establish causality, our findings underscore the importance of post-vaccination monitoring, particularly in symptomatic patients, and the need of continued efforts to comprehensively assess vaccine safety to help reduce mortality rates."

Journal • Cardiovascular • Coronary Artery Disease • Infectious Disease • Novel Coronavirus Disease

Differentiating ischemic from healthy myocardium using cardiovascular magnetic resonance dipyridamole rest and stress T1 mapping. (PubMed, Sci Rep) - No abstract available

Journal • Cardiovascular

Phosphodiesterase inhibitors as emerging therapeutics for skeletal disorders: A comprehensive review of mechanisms and repurposing potential. (PubMed, Bone Rep) - "In preclinical models, inhibitors that target PDE3 (e.g., cilostazol, milrinone), PDE4 (roflumilast, apremilast), and PDE5 (e.g., sildenafil, avanafil, vardenafil) exhibit promising anabolic, anticatabolic, and anti-inflammatory effects on skeletal tissues. Broad-spectrum inhibitors such as pentoxifylline and dipyridamole also demonstrate dual benefits in terms of bone regeneration and joint preservation...Understanding the mechanism of action of PDE inhibitors can facilitate their translation into the clinic, help with their application in combined therapies, or minimize their potential adverse effects. This approach offers a cost-effective and viable path toward novel therapies for musculoskeletal health."

Journal • Review • Cardiovascular • Immunology • Inflammatory Arthritis • Musculoskeletal Diseases • Osteoarthritis • Osteoporosis • Pain • Rheumatoid Arthritis • Rheumatology

Paradoxical ST-segment depression at high blood flow in ANOCA: a hypothesis-generating analysis. (PubMed, Int J Cardiovasc Imaging) - "Vasodilator-induced ST-segment depression was observed more frequently at higher stress MBF, particularly in ANOCA, raising the possibility of a paradoxical "high-flow ischemia" phenotype. These observations are hypothesis-generating and highlight the need for further studies to clarify underlying mechanisms and prognostic relevance."

Journal • Cardiovascular • CNS Disorders • Coronary Artery Disease • Depression • Mood Disorders • Pain • Psychiatry

Non-invasive Coronary Functional Tests in Patients with Angina and Non-obstructive Coronary Artery Disease. (PubMed, Eur Cardiol) - "The NI-CFTs included hyperventilation, a dipyridamole stress test and a cold pressor test...In ANOCA patients, the results of NI-CFTs performed with transthoracic Doppler echocardiography of the left anterior descending coronary artery showed a high correlation with coronary function abnormalities detected using I-CFTs. Our data suggest that NI-CFTs deserve investigation in larger multicentre studies to assess their usefulness in guiding clinical management of ANOCA patients."

Journal • Cardiovascular • Coronary Artery Disease

The Influence of Music on Patient' Overall Experience, Perception and the Quality of Myocardial Perfusion Imaging Procedure. (PubMed, Nucl Med Mol Imaging) - "Integrating music into MPI alleviates anxiety, improves exercise performance, mitigates non-cardiac dipyridamole side effects. Music greatly improves nuclear medicine practices and patient care quality."

Journal • CNS Disorders • Depression • Mood Disorders • Pain • Psychiatry

Mulberroside A inhibits NLRP6 to prevent alveolar macrophage efferocytosis and lung-derived SAA3-platelet transport in high fructose-induced hippocampal inflammation. (PubMed, Phytomedicine) - "These results suggested that mulberroside A inhibited NLRP6 to prevent alveolar macrophage efferocytosis and lung-derived SAA3-platelet transport in high fructose-induced hippocampal inflammation."

Journal • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • NLRP6

Cranial Defect Reconstruction With Custom 3D-Printed Hydroxyapatite Scaffolds Augmented With rhBMP-2 or Dipyridamole in a Nonhuman Primate Model. (PubMed, J Tissue Eng Regen Med) - "Reconstructing critically sized cranial defects with custom 3D-printed hydroxyapatite scaffolds was successful and yielded favorable results in this model. Scaffolds augmented with rhBMP-2 demonstrated superior bone ingrowth, integration, and mechanical properties, highlighting their potential as a viable alternative to autografts and allograft materials for cranioplasty."

Journal • Preclinical • ADORA2A • BMP2

Integrative miRNA-mRNA Network and Molecular Dynamics-Based Identification of Therapeutic Candidates for Paroxysmal Nocturnal Hemoglobinuria. (PubMed, Pharmaceuticals (Basel)) - "Molecular docking and molecular dynamics simulations showed stable binding of these potential drugs to the critical molecules, indicating a viable molecular interaction foundation. Leflunomide, Dipyridamole, and Pentoxifylline may serve as promising therapeutic agents for PNH, and the hsa-miR-23a-3p/CXCL8 regulatory axis could play a pivotal role in the pathogenesis and progression of PNH."

Journal • Aplastic Anemia • Cardiovascular • Complement-mediated Rare Disorders • Hematological Disorders • Paroxysmal Nocturnal Hemoglobinuria • Rare Diseases • Thrombosis • CXCL12 • CXCL8 • HES1 • MIR23A

Antithrombotic agents in the treatment of severe mental illness: A systematic review and meta-analysis of randomized controlled trials. (PubMed, Neurosci Biobehav Rev) - "We included 12 randomized trials investigating aspirin, cilostazol, and dipyridamole in a total of 742 patients with schizophrenia, major depression, and bipolar disorder. The therapeutic potential of ATAs in SMI remains uncertain. Well-powered RCTs investigating clinically relevant outcomes in clearly defined populations are needed."

Journal • Retrospective data • Review • Bipolar Disorder • Cardiovascular • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia

40 Hz flicker preconditioning protects nonarteritic anterior ischemic optic neuropathy via adenosine signaling. (PubMed, Commun Biol) - "Furthermore, neuroprotection by 40 Hz flicker was abolished by treatment with the equilibrative nucleoside transporter inhibitor dipyridamole and the A1 receptor antagonist DPCPX. These findings establish 40 Hz flicker as a non-invasive, adenosine-mediated IPC strategy, suggesting a potentially safe and translational approach for protecting against NAION and other ocular ischemic disorders."

Journal • Cardiovascular • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain

Dipyridamole-associated pulmonary edema: discovery of a new potential adverse reaction signal based on the FAERS database. (PubMed, Expert Opin Drug Saf) - "The combination of dipyridamole and other drugs was prone to bleeding adverse events, suggesting a multifaceted safety profile that warrants careful clinical consideration. These findings underscore the need for tailored safety monitoring strategies and more nuanced risk-benefit assessments in the clinical use of dipyridamole."

Journal • Cardiovascular • Ischemic stroke • Myocardial Ischemia • Respiratory Diseases

Structural categorization and identification of electrostatic interactions in two proposed human serum albumin dimerization patterns and dipyridamole interaction. (PubMed, Turk J Chem) - "Importantly, these dimer configurations do not disrupt Sudlow's drug-binding sites, as the dipyridamole docking analysis shows strong affinity for sites I and III without affecting their utility in engineered drug delivery. Our findings open new avenues for structure-based mutagenesis and nanoparticle design strategies centered on HSA dimerization dynamics."

Journal • Oncology

Network Meta-analysis of different traditional Chinese medicine injections combined with conventional western medicine in treatment of coronary heart disease complicated with heart failure (PubMed, Zhongguo Zhong Yao Za Zhi) - ": show:(1) clinical total effective rate improvement, the top three surface under the cumulative ranking curve(SUCRA) rankings were Shuxuetong Injection + conventional western medicine, Sodium Tanshinone Ⅱ_A Sulfonate Injection + conventional western medicine, and Shuxuening Injection + conventional western medicine.(2) Left ventricular ejection fraction(LVEF) improvement, the top three SUCRA rankings were Xuesaitong Injection + conventional western medicine, Shenqi Fuzheng Injection + conventional western medicine, and Ginkgo Leaf Extract and Dipyridamole Injection + conventional western medicine.(3) Brain natriuretic peptide(BNP) reduction, the top three SUCRA rankings were Sofren Injection + conventional western medicine, Shenmai Injection + conventional western medicine, and Shuxuetong Injection + conventional western medicine.(4) N-terminal pro-brain natriuretic peptide(NT-proBNP) reduction, the top three SUCRA rankings were Shengmai Injection + conventional western..."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • CRP • NPPB

Diagnosis and treatment of multisystem amyloidosis associated with SGPL1 mutation: A case report and review of the literature. (PubMed, Medicine (Baltimore)) - "SGPL1 mutation may cause multisystem amyloidosis by disrupting S1P homeostasis and increasing monoclonal IGA-κ protein production, leading to amyloidosis. This case highlights the importance of genetic screening and an improved understanding of SGPL1 gene mutations."

Journal • Review • Amyloidosis • Cardiovascular • Dyslipidemia • Fatigue • Gastroenterology • Gastroesophageal Reflux Disease • Glomerulonephritis • Hepatology • Inflammation • Liver Failure • Metabolic Disorders • Nephrology • Renal Disease