dipyridamole / Generic mfg. - LARVOL DELTA

Potent synergy of DHODH and SREBP inhibition in acute myeloid leukemia via disruption of cholesterol and lipid metabolism. (PubMed, Haematologica) - "Here, we describe a novel DHODH inhibitor, JNJ-74856665, that showed strong efficacy in a subset of AML samples. The transcriptional regulator SREBF2, known to control cholesterol and lipid metabolism, was upregulated in DHODHi sensitive AMLs, and a strong synergy was observed between combination of both DHODHi and the SREBP inhibitor dipyridamole. Our data indicate that combined DHODH and SREBP inhibition is of interest to explore further as a therapeutic target option in AML."

Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Metabolic Disorders • Oncology • SREBF2

Effect of Dipyridamole on Experimental Autoimmune Uveitis: Reprogrammed Immune Cell Landscape and Reduced Th17 Pathogenicity. (PubMed, Invest Ophthalmol Vis Sci) - "DIP ameliorated intraocular inflammation, modulated Th17/Treg balance, and reduced Th17 pathogenicity in EAU, potentially via cAMP-STAT3-PIM1 signaling. These findings highlight DIP as a promising therapeutic candidate for autoimmune uveitis."

Journal • Immunology • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis • CD4 • PIM1

Diagnostic Utility of Longitudinal Flow Gradient for Diagnosis of Obstructive CAD in Rubidium-82 Positron Emission Tomography. (PubMed, J Nucl Cardiol) - "Longitudinal stress MBF gradients derived from 82Rb PET may enhance diagnostic accuracy for obstructive CAD in the LAD territory. No additional diagnostic value was observed in LCX or RCA territories."

Journal • Cardiovascular • Coronary Artery Disease

From Cardiac Stress to Organ Distress: Acute Hepatorenal Dysfunction after Dipyridamole Myocardial Perfusion Imaging. (PubMed, Acta Cardiol Sin) - No abstract available

Journal • Nephrology • Renal Disease

Mycoplasma Pneumoniae-Associated Arterial Ischemic Stroke in Pediatric Patients: Clinical Manifestations and Neuroimaging Findings. (PubMed, Pediatr Neurol) - "MPP-associated AIS resulted in a poor outcome in our cohort. The frequent clinical symptoms included hemiplegic paralysis, somnolence, and aphasia. Despite timely awareness of MPP-associated stroke, current treatments (LMWH and oral aspirin) demonstrated limited efficacy."

Journal • Cardiovascular • CNS Disorders • Hematological Disorders • Infectious Disease • Ischemic stroke • Pediatrics • Pneumonia • Respiratory Diseases

Blockage of the peri-synaptic Schwann cell nicotinic α7 receptor inhibitory drive increases the neuromuscular performance in rats with experimental autoimmune Myasthenia gravis: repurposing dipyridamole usage in myasthenics. (PubMed, Neuropharmacology) - "In conclusion, breaking the PSC-mediated α7nAChRs inhibitory drive with methyllycaconitine and dipyridamole may synergistically improve the neuromuscular performance and prevent fatigue in EAMG rats treated with AChE inhibitors. Therefore, we suggest repurposing the old antiplatelet vasodilator, dipyridamole, as a relatively safe add-on therapy for drug-resistant Myasthenia gravis."

Journal • Preclinical • CNS Disorders • Fatigue • Immunology • Myasthenia Gravis • Pain • SLC29A1

Impact of dual antiplatelet therapy within 72 hours post mild ischemic stroke and transient ischemic attack: meta-analysis. (PubMed, Brain Inj) - "However, the evidence regarding bleeding risk with aspirin and ticagrelor remains highly uncertain, as the estimates are imprecise with extremely wide confidence intervals, and no definitive conclusions can be drawn. Aspirin plus dipyridamole may be a safer, equally effective alternative, underscoring the need for individualized treatment based on thrombotic and hemorrhagic risks."

Journal • Retrospective data • Cardiovascular • Hematological Disorders • Ischemic stroke

Improved accuracy for myocardial blood flow mapping with deep learning-enabled CMR arterial spin labeling (DeepMASL): validation by microsphere in vivo. (PubMed, J Cardiovasc Magn Reson) - "The novel DeepMASL demonstrates much improved accuracy in the quantification of regional MBF at varying levels of coronary artery stenosis, which is correlated strongly with microsphere MBF values. The validated data indicates the potential for this DeepMASL technique to be translated for noncontrast diagnosis of myocardial perfusion deficit in a clinical setting."

Journal • Preclinical • Cardiovascular • Coronary Artery Disease

Dipyridamole alleviates necroptosis and renal inflammation via cAMP/CREB signaling pathways in septic AKI mice. (PubMed, Eur J Pharmacol) - "Dipyridamole alleviates SA-AKI by targeting PDE12, restoring cAMP signaling, and suppressing inflammation and necroptosis. These findings highlight PDE12 as a novel therapeutic target and support dipyridamole as a promising candidate for clinical translation in SA-AKI."

Journal • Preclinical • Acute Kidney Injury • Infectious Disease • Inflammation • Nephrology • Renal Disease • Septic Shock • IL6 • TNFA

Dissolution Profile of Ionizable Drugs in Biorelevant Bicarbonate Buffer at Intermediate Gastrointestinal pH Level. (PubMed, AAPS J) - "For the dissolution tests, febuxostat (FBX), dipyridamole (DPM), dantrolene Na (DNT Na), pioglitazone HCl (PIO HCl), and tosufloxacin tosylate monohydrate (TFLX TS) were employed. The dissolution profiles of ionizable drugs in BCB differed from those in CPB and ACB, especially in the case of the salt-form drugs with an acidic counterion. The floating lid method enables dissolution testing using BCB in the intermediate pH range."

Journal

Kawasaki disease shock syndrome with extreme leukemoid reaction mimicking hematologic malignancy in an IVIG-resistant child: A case report. (PubMed, Medicine (Baltimore)) - "This case emphasizes that KDSS with leukemoid reaction may mimic hematologic malignancy, delaying appropriate immunomodulatory therapy. Extreme leukocytosis (≥70 × 109/L) should not exclude KDSS, especially in children with unexplained fever and shock. Early recognition, adjunctive corticosteroid therapy, and individualized anticoagulation strategies are critical to prevent misdiagnosis and improve outcomes."

Journal • Cardiovascular • Heart Failure • Hematological Disorders • Hematological Malignancies • Hypotension • Leukemia • Oncology • Pediatrics • Vasculitis • CRP

Noninvasive Measurement of Coronary Collateral Flow Capacity in Patients with Chronic Total Occlusion: External Counterpulsattion Reduces the Need for High Risk Percutaneous Coronary Intervention (AHA 2025) - "Noninvasive external counterpulsation (ECP) improves invasively measured collateral flow index, angina and walking time in patients with obstructive CAD.We hypothesized that coronary collateral flow capacity can be measured noninvasively in CTO patients by comparing absolute stress perfusion during vasodilator stress (DIP) which reduces supply side pressure in the collateralized ischemic bed, revealing coronary steal, compared with demand ischemic stress (DBT) which maintains supply side pressure. Twenty sequential patients found to have CTO at angiography prompted by abnormal quantitative PET myocardial perfusion imaging with vasodilator stress using dipyridamole or regadenoson (QPET-DIP) underwent 35 one-hour sessions of ECP, rather than PCI, followed by demand ischemic stress PET using dobutamine (QPET-DBT). Coronary collateral flow capacity can be measured noninvasively with quantitative PET myocardial perfusion imaging. Initial treatment of CTO patients with ECP is..."

Clinical • Non-invasive • Cardiovascular

CYP2C19 GENOTYPES AND RELATIONSHIP WITH ON-TREATMENT PLATELET REACTIVITY STATUS AT HIGH AND LOW SHEAR STRESS ON CLOPIDOGREL IN A TIA/ISCHAEMIC STROKE PATIENT POPULATION IN IRELAND (WSC 2025) - "Few studies concurrently assessed the influence of pharmacogenetics factors on HTPR status and clinical outcomes in ischaemic cerebrovascular disease (CVD) patients, with no prevalence data on CYP2C19 LOF SNPs in CVD patients in Ireland. 103 patients ≤ 4 weeks of TIA/ischaemic stroke on Aspirin (N=22) or Clopidogrel (N=29) monotherapy, or Aspirin+Clopidogrel (N=48) / Aspirin+Dipyridamole (N=4) therapy were recruited to the prospective Optimal Antiplatelet Therapy in TIA and Ischaemic Stroke-International pilot observational study. Almost 1/3 of our CVD study population in Ireland have CYP2C19 LOF SNPs. Further studies should combine pharmacogenetics and HTPR-status to guide antiplatelet therapy because up to 33% of CVD patients predicted to be Intermediate-Poor Metabolisers have adequate P2Y12-inhibition on Clopidogrel."

Clinical • Cardiovascular • CNS Disorders • Ischemic stroke • Vascular Neurology • CYP2C19

High-dose gamma globulin plus dipyridamole for Kawasaki disease in children: An investigation of therapeutic effectiveness. (PubMed, Pak J Pharm Sci) - "Conclusively, for pediatric KD, HD-GG+DIP achieves robust therapeutic outcomes while maintaining a safe side-effect profile. Improvements in coronary artery diameter grading, faster symptom relief and regulated serum inflammatory cytokine levels further support its broader clinical application."

Biomarker • Journal • Inflammation • Pediatrics

The anti-inflammatory repurposing network for bronchiectasis-the EMBARC AIR-NET study (WBC 2024) - "The initial phase of the trial will test doxycycline, dipyridamole and disulfiram. AIR-NET provides a novel platform for therapeutic development in bronchiectasis. The study is open to collaboration with clinical centres and partners wishing to use the platform to test therapeutics. Funded by Lifearc through the Chronic Respiratory Infection Translational Challenge"

Bronchiectasis • Infectious Disease • Inflammation • Pulmonary Disease • Respiratory Diseases • ELANE

The Loading of Dipyridamole and Calcium Sulfate into the Gelatin-Coated Porous Bioceramics to Synergistically Regulate Segmental Bone Regeneration. (PubMed, ACS Appl Mater Interfaces) - "In vivo experiments displayed that the as-prepared scaffolds could recruit and capture endogenous MSCs, mediate the ulnar bone defects to bridge within 12 weeks, and match a desirable degradation rate. The as-prepared scaffolds with high in situ osteogenic activity are attributable to the synergistic effect of four components, which regulated the osteoblastic-osteoclastic imbalance of the bone remodeling cycle."

Journal

Intergrated Nuclear Medicine Imaging Assessment of Amyloid Burden, Sympathetic innervation, and Microvascular function in ATTR-CM (EANM 2025) - "Dynamic stress-rest myocardial perfusion imaging was performed with dipyridamole stress and 201Tl tracer under standard 1-day protocol...Furthermore, resting myocardial blood flow might be related with sympathetic innervation appears impaired in proportion to amyloid deposition. These findings highlight the potential utility of integrated imaging in ATTR-CM assessment."

Amyloidosis • Cardiac Amyloidosis • Cardiomyopathy • Cardiovascular • Genetic Disorders • Immunology • Myocardial Infarction

Effectiveness of Aspirin Plus Dipyridamole Versus Clopidogrel in Preventing Recurrent Ischemic Stroke: A Systematic Review. (PubMed, Cureus) - "Regarding functional outcome recurrence, mortality, bleeding risk, or serious adverse events in patients with acute, mild ischemic stroke, no significant differences were observed between Asp+Dp and clopidogrel, with both regimens being practical and feasible for clinical use. In conclusion, while both therapies demonstrate comparable clinical effectiveness, further research is warranted to evaluate their long-term impact on quality of life in patients with ischemic stroke."

Journal • Review • Cardiovascular • Ischemic stroke

A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole (clinicaltrials.gov) - P2/3 | N=80 | Active, not recruiting | Sponsor: Yunfeng Xia

New P2/3 trial • Movement Disorders • Nephrology • Restless Legs Syndrome • Sleep Disorder

Integrating In Vitro BE Checker with In Silico Physiologically Based Biopharmaceutics Modeling to Predict the Pharmacokinetic Profiles of Oral Drug Products. (PubMed, Pharmaceutics) - " Metoprolol and dipyridamole were selected as model drugs...Conversely, simulations based on lower paddle speed (50 rpm) and shorter pre-FaSSIF infusion time (10 min) underestimated plasma concentrations in humans. These findings suggest that the combination of BE Checker data acquired under high agitation conditions and the in silico mathematical model developed in this study enables accurate prediction of average human PK profiles."

Journal • PK/PD data • Preclinical

Arthritis associated with Kawasaki disease after initial combination therapy with cyclosporine: a case report. (PubMed, Transl Pediatr) - "This study reports a case of KD that required initial treatment with cyclosporine A (CyA) followed by additional infliximab (IFX) and secondary to reactive arthritis. A 5-year-old boy met diagnostic criteria for KD on day 5 of fever and had an intravenous immunoglobulin (IVIG) refractory predictive score of 8 (≥5) was administered ulinastatin, IFX, and three IVIG doses in combination with CyA...Subsequently, acetylsalicylic acid was changed to flurbiprofen and then to dipyridamole due to suspicion of a drug rash...No recurrence of joint symptoms or coronary artery lesions was observed after tapering off of PSL. Based on the evaluation at the start of treatment, although CyA is initially administered in potential IVIG-resistant patients, attention must be paid to secondary reactive arthritis if the patient becomes resistant to treatment and requires IFX treatment."

Journal • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Rheumatology • Seronegative Spondyloarthropathies

Hemorrhage Risk Associated with Anticoagulant and Antiplatelet Drug Combinations: Insights from the USFDA Adverse Event Reporting System. (PubMed, J Clin Med) - "Anticoagulants analyzed included warfarin, rivaroxaban, dabigatran, apixaban, edoxaban, betrixaban, and acenocoumarol; antiplatelets included aspirin, clopidogrel, ticagrelor, cilostazol, prasugrel, and dipyridamole. While our findings highlight potential safety signals related to hemorrhage with antithrombotic drug combinations, they remain hypothesis-generating and should not be interpreted as causal associations. Instead, they provide an initial basis for further validation in well-designed clinical cohorts where comorbidities can be adequately accounted for."

Adverse events • Journal • Hematological Disorders

Evaluation of Left Ventricular Function in Diabetic Patients: Insights from Dipyridamole-induced Heart Rate Variability and G-SPECT Imaging Techniques. (PubMed, Curr Hypertens Rev) - "Reduced HRR during DP stress, combined with G-SPECT, may aid in the assessment of LVD in DM patients, potentially facilitating earlier diagnostic insights."

Journal • Cardiovascular • Diabetes • Heart Failure • Metabolic Disorders

Chronotropic incompetence during exercise or pharmacological stress is associated with reduced survival in patients with chronic coronary syndromes. (PubMed, Eur J Prev Cardiol) - "In patients with chronic coronary syndromes, CI during exercise or pharmacological stress is a simple and objective predictor of survival."

Journal • Atrial Fibrillation • Cardiovascular • Diabetes • Metabolic Disorders

Risk of Complications After Injection Laryngoplasty and Medialization Thyroplasty on Anticoagulation. (PubMed, J Voice) - "Based on analysis of a large healthcare database, IL/MT performed in adult patients on AC is associated with higher rates of postoperative dysphagia and airway compromise but not postoperative hemorrhage/hematoma."

Journal • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease