hydromorphone hydrochloride / Generic mfg. - LARVOL DELTA

Morphine and hydromorphone pharmacodynamics in human volunteers: population-based modelling of interindividual response variability and utility. (PubMed, Br J Anaesth) - "There was considerable interindividual variability in pharmacodynamic effect parameters for both morphine and hydromorphone, but no major variability differences between the opioids. Pharmacodynamic potencies for the various endpoints were different between opioids, but of the same order of magnitude for each opioid. The utility function was more favourable for hydromorphone than for morphine. These results might influence patient- and procedure-specific opioid selection."

Journal • PK/PD data • Pain

SAFER-L: Spinal Anesthesia For Enhanced Recovery After Liver Surgery (clinicaltrials.gov) - P=N/A | N=128 | Recruiting | Sponsor: University of Manitoba | Trial completion date: Jan 2026 ➔ Dec 2031 | Trial primary completion date: Dec 2025 ➔ Jul 2031

Trial completion date • Trial primary completion date • Anesthesia • Liver Cancer • Oncology • Pain • Solid Tumor

Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy (clinicaltrials.gov) - P2 | N=78 | Recruiting | Sponsor: Masonic Cancer Center, University of Minnesota | Trial completion date: Jan 2026 ➔ Jan 2028 | Trial primary completion date: Jan 2026 ➔ Jan 2027

Head-to-Head • Trial completion date • Trial primary completion date • Oncology • Pain • Pancreatic Cancer • Small Intestinal Carcinoma • Solid Tumor

Rectus Sheath Block for Analgesia After Gynecological Laparotomy (clinicaltrials.gov) - P4 | N=90 | Completed | Sponsor: Duke University | Recruiting ➔ Completed

Trial completion • Gynecologic Cancers • Oncology

Tramadol use is associated with reduced 28-day mortality in ICU patients after cardiac surgery: a retrospective study based on the MIMIC-IV database. (PubMed, Front Pharmacol) - "Furthermore, tramadol demonstrated superior predictive performance for 28-day mortality (AUC = 0.603) compared to other opioids, including fentanyl, hydromorphone, morphine, and oxycodone AUC range: 0.523-0.597). However, no significant association was found with secondary outcomes like ICU mortality or length of stay. Tramadol administration is independently associated with a significantly lower risk of 28-day mortality in cardiac surgery patients, showing better predictive utility than other common opioids, which may inform postoperative analgesic strategies."

Journal • Retrospective data • Addiction (Opioid and Alcohol) • Cardiovascular • Critical care • Pain

Safety and Efficacy of Low-Dose Methadone as an Adjunctive Therapy with Other Opioids for Cancer-Related Pain (ChiCTR) - P4 | N=70 | Recruiting | Sponsor: Jiangsu Cancer Hospital; Jiangsu Cancer Hospital

New P4 trial • Oncology • Pain

Comparison of Oliceridine and Hydromorphone for Nausea and Vomiting in Patient-Controlled Intravenous Analgesia After Orthopedic Surgery Under Multimodal Analgesia: A Prospective Cohort Study (ChiCTR) - P4 | N=216 | Recruiting | Sponsor: The Second Affiliated Hospital, Zhejiang University School of Medicine; The Second Affiliated Hospital, Zhejiang University School of Medicine

New P4 trial • Orthopedics • Pain

Effect of dexmedetomidine on half of the effective dose of hydromorphine for laparoscopic colorectal surgery in elderly patients (ChiCTR) - P=N/A | N=60 | Completed | Sponsor: Shengjing Hospital Affiliated to China Medical University; Shengjing Hospital Affiliated to China Medical University

New trial

Application of Hydromorphone Combined with Inhalation Anesthesia in Pediatric Amblyopia Surgery (ChiCTR) - P=N/A | N=78 | Completed | Sponsor: Wenzhou Medical University Affiliated Eye Hospital; Wenzhou Medical University Affiliated Eye Hospital

New trial • Anesthesia • CNS Disorders • Ophthalmology • Pediatrics • Strabismus

Dose Optimization and Prediction Modeling of Hydromorphone in Adductor Canal Block for Total Knee Replacement Analgesia (ChiCTR) - P=N/A | N=120 | Recruiting | Sponsor: The Second affiliated Hospital of Zhejiang Chinese Medicine University; The Second affiliated Hospital of Zhejiang Chinese Medicine University

New trial • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

A Comparative Study on the Clinical Effects of Different Doses of Hydromorphone Hydrochloride and Low-dose Esketamine on Catheter-Related Bladder Discomfort in Elderly Male Patients after General Anesthesia (ChiCTR) - P=N/A | N=120 | Recruiting | Sponsor: Affiliated Hospital of Chengdu University; Affiliated Hospital of Chengdu University

New trial • Anesthesia

Application of hydromorphone in analgesia and sedation in mechanically ventilated patients with sepsis (ChiCTR) - P=N/A | N=150 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Nanchang University; The First Affiliated Hospital of Nanchang University

New trial • Anesthesia • Infectious Disease • Respiratory Diseases • Septic Shock

Hydromorphone in Interscalene Brachial Plexus Block: A Clinical Evaluation of Anesthetic Efficacy and Postoperative Analgesia (ChiCTR) - P=N/A | N=99 | Not yet recruiting | Sponsor: The Third People's Hospital of Hefei; The Third People's Hospital of Hefei

New trial • Anesthesia • Orthopedics • Pain

To explore the effective dose of hydromorphone in preventing early postoperative pain after laparoscopic hernia repair in children. (ChiCTR) - P=N/A | N=32 | Completed | Sponsor: The Sixth Affiliated Hospital of Harbin Medical University; The Sixth Affiliated Hospital of Harbin Medical University

New trial • Gastroenterology • Pain

Comparison of the Efficacy and Safety of Hydromorphone versus Morphine in Thoracic Epidural for Perioperative Analgesia: A Prospective, Randomized Controlled,Double-Blind,Non-Inferiority Trial (ChiCTR) - P=N/A | N=126 | Not yet recruiting | Sponsor: Zhongshan Hospital,Fudan University(Xiamen Branch); Zhongshan Hospital,Fudan University(Xiamen Branch)

New trial

Effect of hydromorphone combined with nalbuphine for patient-controlled analgesia on postoperative pain and delirium in patients undergoing laparoscopic surgery (ChiCTR) - P=N/A | N=172 | Not yet recruiting | Sponsor: Binzhou Medical University Affiliated Hospital; Binzhou Medical University Affiliated Hospital

New trial • CNS Disorders • Pain

Guideline-Concordant Sedative and Analgesia Use in Critically Ill Patients Receiving Sustained Neuromuscular Blockade. (PubMed, Crit Care Explor) - "Our findings suggest sedation and analgesia practices with NMBA use in adult ICUs are generally guideline-concordant but require corroboration using more precise, quantitative medication data. Practice variation between hospitals is potentially concerning and warrants further investigation targeting adequacy of sedation and analgesia during NMBA use and assessing the clinical impact of guideline-discordant practices."

Journal • Anesthesia • Critical care • Pain

Effects of hydromorphone-based patient-controlled intravenous analgesia on postpartum depression after cesarean section: a prospective randomized controlled trial. (PubMed, Front Med (Lausanne)) - P4 | "Hydromorphone-based PCIA after cesarean section was associated with lower EPDS scores on postoperative days 3 and 42, improved breastfeeding satisfaction at 72 h, and a lower incidence of dizziness and drowsiness. www.chictr.org.cn, identifier ChiCTR2500105264."

Clinical • Journal • Anesthesia • CNS Disorders • Depression • Pain • Postpartum Depression • Psychiatry

Guideline-Concordant Sedative and Analgesia Use in Critically Ill Patients Receiving Sustained Neuromuscular Blockade. (PubMed, Crit Care Explor) - "Our findings suggest sedation and analgesia practices with NMBA use in adult ICUs are generally guideline-concordant but require corroboration using more precise, quantitative medication data. Practice variation between hospitals is potentially concerning and warrants further investigation targeting adequacy of sedation and analgesia during NMBA use and assessing the clinical impact of guideline-discordant practices."

Journal • Retrospective data • Anesthesia • Critical care • Pain

Safety Analysis of IV Methadone vs. IV Hydromorphone in Post-Procedural Adults. (PubMed, J Pain Palliat Care Pharmacother) - "IV Methadone may be used post-procedurally to manage pain; however, it carries risks of respiratory depression and QTc prolongation. Patients who received methadone also received more opioid and ketamine doses (p < 0.0001). Post-procedural methadone may be unsafe due to increased incidence of respiratory events, possible because of methadone's long half-life causing drug accumulation."

Journal • CNS Disorders • Depression • Pain • Psychiatry

Bilateral Sphenopalatine Ganglion Block in the Management of Headache Associated With Subarachnoid Hemorrhage: Case Report. (PubMed, Pain Med Case Rep) - "SPG blocks show promising potential in the management of persistent headaches following SAH. An initial noninvasive transnasal approach, followed by more invasive techniques when necessary, may provide substantial pain relief and improve patient quality of life. Further research is needed to validate these findings and optimize treatment protocols."

Journal • Acute Lymphocytic Leukemia • B Acute Lymphoblastic Leukemia • CNS Disorders • Epilepsy • Hematological Disorders • Hematological Malignancies • Leukemia • Migraine • Oncology • Pain • Subarachnoid Hemorrhage • Thrombocytopenia

A Study of Intrathecal Hydromorphone for Pediatric Idiopathic Scoliosis Repair (clinicaltrials.gov) - P4 | N=27 | Terminated | Sponsor: Mayo Clinic | N=40 ➔ 27 | Recruiting ➔ Terminated; Study participant #27 had a related adverse event that prompted interim data analysis and additional study participants were not sought.

Enrollment change • Trial termination • Orthopedics • Pain • Pediatrics

PATIENCE: Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid (clinicaltrials.gov) - P2 | N=23 | Terminated | Sponsor: Boston Children's Hospital | N=50 ➔ 23 | Trial completion date: Jun 2024 ➔ Jul 2025 | Recruiting ➔ Terminated | Trial primary completion date: Jun 2024 ➔ Jul 2025; Inadequate patients recruited. Completion of funding

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Pain • Pancreatitis • Pediatrics

Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children's Musculoskeletal Injury: Two Randomized Clinical Trials. (PubMed, JAMA) - P2 | "Adverse events were 4-fold more frequent with hydromorphone. Clinicaltrials.gov Identifier: NCT03767933."

Clinical • Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Pediatrics

Investigating racial/ethnic disparities in opioid use among patients undergoing gastrointestinal cancer surgery. (PubMed, Am J Surg) - "No race-based differences were noted in the use of opioid prescriptions, duration of prescriptions, or mode of opioid administration following GI surgery."

Journal • Esophageal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor