Dromos (propionyl carnitine) / Leadiant Biosci - LARVOL DELTA

Virulence and resistance adaptation of Streptococcus agalactiae Ib/ST261 infecting bullfrogs in Hainan, China between 2019 and 2023. (PubMed, Braz J Microbiol) - No abstract available

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Clonal and plasmid-mediated dissemination of CTX-M-14-producing Escherichia coli within a single cattle farm in Japan. (PubMed, Front Microbiol) - "Additionally, ST1148, ST1261, and ST1431 were isolated from other calves, while ST448 isolates from the farmer and calf 3 exhibited a large genetic distance (3,891 core SNPs) and distinct cgSTs...Other resistance genes, including tet(A) and mcr-3.1, were encoded on separate plasmids. These findings underscore the possible role of IncI1 plasmids in bridging resistance gene flow across host boundaries and emphasize the benefit of integrated One Health genomic surveillance to monitor and mitigate antimicrobial resistance transmission."

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Biological characterization, sequence type distribution and drug resistance profiling of Mycoplasma hyorhinis field isolates from pigs in Chongqing, China. (PubMed, Front Vet Sci) - "The isolates belonging to 11 novel STs, ST226, ST227, ST228, ST229, ST230, ST260, ST261, ST262, ST263, ST264 and ST265, were clustered separately from other reference isolates in the database...In vitro susceptibility testing showed that the isolates were inhibited by low concentrations of tiamulin (MIC: ≤ 0.25 μg/ml), doxycycline (MIC: ≤ 0.25-1 μg/ml), ciprofloxacin (MIC: ≤ 0.25-2 μg/ml), florfenicol (MIC: 0.5-2 μg/ml), kanamycin (MIC: ≤ 0.25-4 μg/ml), enrofloxacin (MIC: 0.5-4 μg/ml) and berberine hydrochloride (MIC range: 1-8 μg/ml). However, the MICs of erythromycin were high (MIC: 32-≥128 μg/ml) for all isolates...Our findings demonstrated the diversity of STs among M. hyorhinis isolates in Chongqing. The high MICs of M. hyorhinis isolates to macrolides and lincomycin suggested that the use of lincomycin for the treatment of M. hyorhinis infections should be carefully evaluated."

Journal • CNS Disorders • Conjunctivitis • Immunology • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pneumonia • Respiratory Diseases

Recombinase-aided amplification assay for rapid detection of imipenem-resistant Pseudomonas aeruginosa and rifampin-resistant Pseudomonas aeruginosa. (PubMed, Front Cell Infect Microbiol) - "MLST analysis showed a strong correlation between the sequence types ST-1639, ST-639, ST-184 and IRPA, while ST-261 was the main subtype of RRPA. In conclusion, we have developed a rapid and efficient RAA (Recombinase-Aided Amplification) detection method that offers significant advantages in terms of speed, simplicity, and cost-effectiveness (especially in time and equipment aspect). This novel approach is designed to meet the demands of clinical diagnostics."

Journal • Infectious Disease

Epidemiological significance of Achromobacter spp. chronic lung infection in patients with cystic fibrosis (ECFS 2022) - "(ST36, ST261, ST184) are transmissive and widely spread among CF patients in Russia... Studies have shown that chronic lung infection caused by emerging pathogens Achromobacter spp. can be of both non-hospital and hospital origin. The results confirmed the clinical and epidemiological significance of the bacteria Achromobacter spp."

Clinical • Cystic Fibrosis • Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Dark-pigmented biodeteriogenic fungi in etruscan hypogeal tombs: New data on their culture-dependent diversity, favouring conditions, and resistance to biocidal treatments. (PubMed, Fungal Biol) - "The type of covering of the dromos may influence the risk of outer contamination. Fungal occurrence can be favoured by root penetration."

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[VIRTUAL] Monitoring the distribution and genotypic diversity of Burkholderiales bacteria in Russian cystic fibrosis patients in the year of the COVID-19 pandemic (ECFS 2021) - "Only one child was infected with epidemic A. ruhlandii ST261 dominated in the microbiome...Burkholderiales are detected in the samples of both children and adult CF patients. The lung microbiome monitoring is important for timely identification and eradication of Burkholderiales to prevent the chronisation of the lung infection."

Clinical • Cystic Fibrosis • Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Novel Coronavirus Disease • Pulmonary Disease • Respiratory Diseases

Comparative genomics confirms a rare melioidosis human-to-human transmission event and reveals incorrect phylogenomic reconstruction due to polyclonality. (PubMed, Microb Genom) - "Next, phylogenomic analysis of all isolates, including the mother's mixed ST-259/ST-261 sputum sample, was performed to investigate the effects of mixtures on phylogenetic inference...Although phylogenomics can provide clues about the presence of mixtures within WGS datasets, our results demonstrate that this methodology can lead to phylogenetic misinterpretation if mixed genomes are not correctly identified and omitted. Using current bioinformatic tools, we demonstrate a robust method for bacterial mixture identification and strain parsing that avoids these pitfalls."

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"... Isabel Fiel, Prodromos (Mike) Hytiroglou (Greece), @wz2145, and @ALBoothMD ! #liverpath #livermtg19" (@liverpath)

Microevolution of aquatic Streptococcus agalactiae ST-261 from Australia indicates dissemination via imported tilapia and ongoing adaptation to marine hosts or environment. (PubMed, Appl Environ Microbiol) - "Here we show that this lineage is likely to have been distributed widely by the global trade in tilapia for aquaculture, with probable introduction into Australia in the 1970s and subsequent dissemination in wild fish populations. We report variability in the polysaccharide capsule amongst this lineage, but identify a cohort of common surface proteins that may be a focus of future vaccine development to reduce the biosecurity risk in international fish trade."

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