Dromos (propionyl carnitine) / Leadiant Biosci - LARVOL DELTA

Recombinase-aided amplification assay for rapid detection of imipenem-resistant Pseudomonas aeruginosa and rifampin-resistant Pseudomonas aeruginosa. (PubMed, Front Cell Infect Microbiol) - "MLST analysis showed a strong correlation between the sequence types ST-1639, ST-639, ST-184 and IRPA, while ST-261 was the main subtype of RRPA. In conclusion, we have developed a rapid and efficient RAA (Recombinase-Aided Amplification) detection method that offers significant advantages in terms of speed, simplicity, and cost-effectiveness (especially in time and equipment aspect). This novel approach is designed to meet the demands of clinical diagnostics."

Journal • Infectious Disease

Epidemiological significance of Achromobacter spp. chronic lung infection in patients with cystic fibrosis (ECFS 2022) - "(ST36, ST261, ST184) are transmissive and widely spread among CF patients in Russia... Studies have shown that chronic lung infection caused by emerging pathogens Achromobacter spp. can be of both non-hospital and hospital origin. The results confirmed the clinical and epidemiological significance of the bacteria Achromobacter spp."

Clinical • Cystic Fibrosis • Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Dark-pigmented biodeteriogenic fungi in etruscan hypogeal tombs: New data on their culture-dependent diversity, favouring conditions, and resistance to biocidal treatments. (PubMed, Fungal Biol) - "The type of covering of the dromos may influence the risk of outer contamination. Fungal occurrence can be favoured by root penetration."

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[VIRTUAL] Monitoring the distribution and genotypic diversity of Burkholderiales bacteria in Russian cystic fibrosis patients in the year of the COVID-19 pandemic (ECFS 2021) - "Only one child was infected with epidemic A. ruhlandii ST261 dominated in the microbiome...Burkholderiales are detected in the samples of both children and adult CF patients. The lung microbiome monitoring is important for timely identification and eradication of Burkholderiales to prevent the chronisation of the lung infection."

Clinical • Cystic Fibrosis • Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Novel Coronavirus Disease • Pulmonary Disease • Respiratory Diseases

Comparative genomics confirms a rare melioidosis human-to-human transmission event and reveals incorrect phylogenomic reconstruction due to polyclonality. (PubMed, Microb Genom) - "Next, phylogenomic analysis of all isolates, including the mother's mixed ST-259/ST-261 sputum sample, was performed to investigate the effects of mixtures on phylogenetic inference...Although phylogenomics can provide clues about the presence of mixtures within WGS datasets, our results demonstrate that this methodology can lead to phylogenetic misinterpretation if mixed genomes are not correctly identified and omitted. Using current bioinformatic tools, we demonstrate a robust method for bacterial mixture identification and strain parsing that avoids these pitfalls."

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"... Isabel Fiel, Prodromos (Mike) Hytiroglou (Greece), @wz2145, and @ALBoothMD ! #liverpath #livermtg19" (@liverpath)

Microevolution of aquatic Streptococcus agalactiae ST-261 from Australia indicates dissemination via imported tilapia and ongoing adaptation to marine hosts or environment. (PubMed, Appl Environ Microbiol) - "Here we show that this lineage is likely to have been distributed widely by the global trade in tilapia for aquaculture, with probable introduction into Australia in the 1970s and subsequent dissemination in wild fish populations. We report variability in the polysaccharide capsule amongst this lineage, but identify a cohort of common surface proteins that may be a focus of future vaccine development to reduce the biosecurity risk in international fish trade."

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