mitomycin / Generic mfg. - LARVOL DELTA

Modeling the human bladder tissue using three dimensional in vitro approaches as a tool for drug screening platforms. (PubMed, Acta Biomater) - "NMIBC usually affects the mucosa and submucosa of the bladder tissue, requiring tumor resection, followed by intravesical administration of mitomycin-C. MIBC commonly affects the deeper layers of bladder, being associated with the origin of metastases, and it is recommended to perform a radical cystectomy followed by cisplatin-based neoadjuvant chemotherapy...Organoids, spheroids, and hydrogels are established drug screening tools. 3D models show strong potential for translation into clinical applications."

Journal • Preclinical • Review • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor

Atypical hemolytic uremic Syndrome Triggered by malignancy and drug exposure: A systematic review and meta-analysis (ASH 2025) - "Tacrolimus was the mostreported drug trigger (n=6)followed by gemcitabine (n=5), vincristine (n=5), bevacizumab (n=3), carfilzomib (n=3), 6-mercaptopurine(n=2), methotrexate (n=2), and mitomycin (n=2). Aflibercept, bactrim, bleomycin, capecitabine, cisplatin, cyclophosphamide, cytarabine,dasatinib, deferasirox, dinutuximab, estarylla, ketoprofen, L-asparaginase, modakafusp alfa, PEG-asparaginase, sunitinib, syntheticpsychoactive drugs, tamoxifen, and topotecan were reported as potential triggers for aHUS in one patient each...The pooled rate of treatment with eculizumab was 74% (95% CI, 0.629-0.842, p < 0.01, I2 = 72%),and the pooled rate of renal recovery was 65% (95% CI, 0.525-0.761, p < 0.01, I2 = 55%)...AKI and hematological abnormalities in these patients should prompt an emergent work-up and treatment. Current evidenceis primarily derived from case reports, so prospective trials are necessary to establish the incidence, associations, triggers, and outcomes..."

Retrospective data • Review • Acute Kidney Injury • Acute Lymphocytic Leukemia • Anemia • Atypical Hemolytic Uremic Syndrome • B Acute Lymphoblastic Leukemia • Biliary Cancer • Breast Cancer • Cholangiocarcinoma • Complement-mediated Rare Disorders • Genito-urinary Cancer • Hematological Malignancies • Hepatocellular Cancer • Hodgkin Lymphoma • Leukemia • Lung Cancer • Lymphoma • Multiple Myeloma • Nephrology • Neuroblastoma • Oncology • Ovarian Cancer • Pancreatic Cancer • Prostate Cancer • Renal Cell Carcinoma • Renal Disease • Solid Tumor • Thrombocytopenia • Urothelial Cancer

P145 Sebaceous carcinoma management guidelines. (PubMed, Br J Dermatol) - "The evidence about other treatment options such as chemotherapy, immunotherapy, targeted therapies, cryotherapy and mitomycin is sparse, and can be assessed on an individual-case basis with multidisciplinary team involvement. Prognosis is dependent on complete excision of SC with margin-controlled surgery. The follow-up recommendation is every 6 months for 3 years, then annually with examination of the entire skin and lymph nodes, with consideration for genetic testing if the criteria for Muir-Torre syndrome are met."

Clinical guideline • IO biomarker • Journal • Review • Ocular Melanoma • Oncology

Hypo-fractionated radical radiotherapy with concurrent mitomycin C and capecitabine in muscle-invasive bladder cancer – A single institution prospective phase II study (ESMO Asia 2025) - "Background: Chemoradiotherapy with Mitomycin C (MMC) and 5-fluorouracil is the standard non-surgical treatment for non-metastatic muscle invasive bladder cancer. Hypofractionated radical radiotherapy with MMC and capecitabine in patients with muscle-invasive bladder cancer unfit or unwilling for surgery is well tolerated, with acceptable toxicity and high compliance. We recommend testing this schedule in future phase III studies in bladder cancer."

Clinical • P2 data • Bladder Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Oncology • Solid Tumor

IMGeS study: A prospective, multicentre, phase II trial of sequential intravesical mitomycin-C and gemcitabine therapy in BCG-unresponsive high-risk NMIBC ineligible for or declining radical cystectomy (ESMO Asia 2025) - P2 | "The primary endpoint is 1-year high-risk recurrence-free survival (HRFS); secondary endpoints include progression-free, cystectomy-free, cancer-specific, and overall survival, as well as safety and tolerability. Exploratory endpoints include biomarker analyses from tumor, urine, and blood."

Clinical • IO biomarker • P2 data • Bladder Cancer • Oncology • Urothelial Cancer

Comparison of efficacy and safety of capecitabine plus mitomycin, 5-FU plus mitomycin, and 5-FU plus cisplatin regimens for definitive chemoradiotherapy in anal squamous cell carcinoma: A single-center retrospective study (ESMO Asia 2025) - "Although CRT regimens, such as capecitabine plus mitomycin (Cape+MMC), 5-fluorouracil plus mitomycin (FU+MMC), and 5-fluorouracil plus cisplatin (FP) are widely used, their comparative efficacy and safety remain unclear. Cape+MMC, FU+MMC, and FP regimens showed comparable efficacy with acceptable safety profiles in patients with stage I–III ASCC. Given the high CR and survival rates, all three regimens may be considered viable treatment options."

Retrospective data • Anal Carcinoma • Oncology • Squamous Cell Carcinoma

Assessment of macular vessel density by optical coherence tomography angiography after sub-scleral trabeculectomy in patients with primary open angle glaucoma. (PubMed, BMC Ophthalmol) - "OCTA revealed significant postoperative improvement in deep macular vessel density and FAZ metrics following SST with MMC. These findings highlight the vascular benefits of surgical IOP reduction in restoring macular microcirculation among patients with POAG."

Journal • Glaucoma • Ophthalmology

Current Challenges of Managing Fibrosis Post Glaucoma Surgery and Future Perspectives. (PubMed, J Clin Med) - "Traditional anti-fibrotics such as Mitomycin C (MMC) and 5-fluorouracil (5-FU) have greatly improved bleb survival but are not without their complications. As surgical techniques continue to advance and overall safety improves, there is a growing need to explore other novel therapeutics that offer increased efficacy and favourable safety profiles. This review aims to provide insight into the pathophysiology of wound healing as well as discuss current and emerging strategies being developed to address wound healing post glaucoma filtration surgery."

Journal • Review • Fibrosis • Glaucoma • Immunology • Ophthalmology

Rationale and Emerging Evidence on the Potential Role of HoLEP-Mediated Relief of Bladder Outlet Obstruction in NMIBC Outcomes Through Optimal Management of Chronic Urinary Retention. (PubMed, Cancers (Basel)) - "Chronic urinary retention and BOO appear to be modifiable functional factors that may influence NMIBC recurrence and intravesical therapy performance. HoLEP is a promising option to optimize bladder emptying in carefully selected patients, but its oncologic impact remains unproven and should be considered hypothesis-generating pending prospective, risk-adjusted studies."

Journal • Review • Benign Prostatic Hyperplasia • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • Urology

Polygenic variants in DNA repair genes are associated with neurodevelopmental disorders, regression and increased burdens of somatic variants and short tandem repeat expansions. (PubMed, Genet Med) - "Our findings suggest that polygenic DDR gene variants may contribute to developmental regression in NDDs by promoting the accumulation of somatic variants and STR expansions."

Journal • CNS Disorders • Developmental Disorders • Hematological Disorders • Psychiatry

Outcomes of PreserFlo MicroShunt in Japanese Glaucoma Patients With a History of Glaucoma Surgery. (PubMed, J Glaucoma) - "PMS implantation significantly lowered IOP and reduced the need for medications in eyes with a history of glaucoma surgery, regardless of prior conjunctival manipulation. These findings support the role of PMS as a safe and effective option for further surgical intervention in this population."

Journal • Retrospective data • Cataract • Glaucoma • Ophthalmology

Detailed surgical technique for endoscopic urethroplasty in the treatment of anastomotic stenosis and bladder neck contracture. (PubMed, Transl Androl Urol) - "Steroids and mitomycin C have shown some benefit, but refractory cases may require complex abdominoperineal repairs...The surgical technique is described in detail, along with tips and pearls for each group. Ultimately, we describe a minimally invasive surgical technique that utilizes healthy mucosal tissue to offer a long-lasting, and potentially permanent, solution to bladder neck complications following prostate surgery without the need for open or robotic surgical methods."

Journal

Global insights into the management of BCG-unresponsive non-muscle invasive bladder cancer: a narrative review of provider surveys. (PubMed, Transl Androl Urol) - "Preferences for intravesical chemotherapy agents differed by region: gemcitabine (Gem) was commonly used in the US and Arab countries; epirubicin and doxorubicin were favored in China; mitomycin C (MMC) was preferred in Europe. While most urologists were familiar with gemcitabine/docetaxel (Gem/Doce), its actual use in clinical practice remained limited...Notably, at the time of the surveys, newly Food and Drug Administration (FDA)-approved therapies like nadofaragene and pembrolizumab were rarely used. Global practice patterns for BCG-unresponsive disease vary widely across regions, highlighting the need for a more unified, consensus-driven approach to the use of evolving bladder-sparing therapies and clinical guidelines."

Journal • Review • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • Urology

Reinterventions After PreserFlo Implantation: A Report on Results in Clinical Practice. (PubMed, J Ophthalmol) - "Surgery was performed as per the manufacturer's recommendations and combined with mitomycin C (MMC) application (0.2 mg/mL, 2 min)...Reintervention rate was higher in eyes treated with ≥ 3 drugs. Surgeons should consider adding additional measures to prevent fibrosis when implanting PreserFlo in these eyes."

Journal • Fibrosis • Glaucoma • Immunology • Ophthalmology

Broad-Spectrum Antimicrobial Treatment Targeted Through Drug Conjugation to Vancomycin. (PubMed, Adv Healthc Mater) - "The drug of choice is mitomycin C, which has documented activity against persister cells. In vivo evaluation in the implant-associated osteomyelitis model in mice reveals robust targeting and good tolerance to the treatment with no signs of toxicity. However, the limited therapeutic efficacy indicates that more work is needed to match the developed treatment to an appropriate disease model."

Journal • Infectious Disease • Inflammation

Squamous cell carcinoma of unknown primary in the pelvis after complete remission following chemoradiotherapy: A case report. (PubMed, World J Clin Cases) - "This case highlights the potential role of chemoradiotherapy in managing pelvic squamous cell CUP, achieving durable remission in selected patients."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Unknown Primary • KRT20

Complications and oncologic outcome in bladder cancer patients receiving radical cystectomy after intravesical instillation treatment. (PubMed, PLoS One) - "To our knowledge, this is the first matched pair analysis that evaluates the impact of intravesical treatment on postoperative complications for patients with NMIBC receiving RC. Intravesical treatment with BCG or mitomycin did not deteriorate postoperative complications in NMIBC patients after RC, irrespective of the final histopathology stage. Oncologic outcomes were similar in both groups."

Journal • Retrospective data • Bladder Cancer • Cardiovascular • Coronary Artery Disease • Genito-urinary Cancer • Oncology • Solid Tumor

Amniotic Membrane in Excimer Laser Surface Ablation (ELSA): Mechanisms for Haze Prevention and Broader Ocular Surface Optimisation. (PubMed, Ophthalmol Ther) - "Mitomycin C (MMC) is widely used intraoperatively for haze prophylaxis and has multi-study support; however, its antiproliferative, anti-fibrotic action does not directly address early inflammation, epithelial barrier restoration or neuroregeneration, and use remains off-label with heterogeneous protocols...This review outlines a complementary paradigm: MMC targets downstream fibrosis, whilst patch-AMT acts earlier on inflammation, epithelial repair, protease imbalance (including MMP-9) and neurotrophic support. With major international guidelines now recognising sutureless patch-AMT for regeneration and inflammation/oxidative stress control in dry eye, prospective refractive-cohort trials with standardised product/placement protocols, long-term follow-up, patient-reported outcomes and embedded health-economic evaluation are warranted to define AMT's role alongside MMC in routine ELSA."

Journal • Review • Dry Eye Disease • Fibrosis • Immunology • Inflammation • Ocular Inflammation • Ophthalmology • Transplantation • MMP9

Corneal Actinic Keratosis in an Elderly Farmer: A Rare Case Report. (PubMed, Case Rep Ophthalmol) - "The patient was treated with topical mitomycin C 0.02% and topical prednisolone acetate 1% postoperatively...Clinical suspicion, combined with histopathological examination, is crucial for diagnosis. Surgical excision followed by topical chemotherapy offers effective management and reduces the risk of recurrence or malignant transformation."

Journal • Actinic Keratosis • Anesthesia • Cataract • Dermatology • Oncology • Ophthalmology • Squamous Cell Carcinoma

Risk factors for failure in minimally invasive bleb surgery: a systematic review. (PubMed, Am J Ophthalmol) - "This review identified demographic and preoperative factors associated with MIBS failure. These findings may guide patient selection and future studies; however, the low certainty of evidence warrants cautious interpretation."

Journal • Review • Cardiovascular • Glaucoma • Ophthalmology

Mitomycin C plus carboplatin followed by paclitaxel vs. standard doxorubicin-cyclophosphamide followed by paclitaxel-carboplatin neoadjuvant therapy in BRCA1/2-associated breast cancer (SABCS 2025) - "All patients in the control group had alopecia grade II, whereas patients in the MCbP-T group didn't report this side effect. ConclusionIn BRCA1/2-associated TNBC, the efficacy of MCbP-T regimen is comparable with standard anthracycline-based platinum-containing chemotherapy but demonstrates a significantly lower rate of adverse effects."

Clinical • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • BRCA1 • BRCA2

Endoscopic transnasal repair of choanal atresia: clinical characteristics and outcomes from a main tertiary hospital in Syria. (PubMed, Am J Otolaryngol) - "Endoscopic transnasal repair of CA was shown to be safe and effective in a resource-limited setting, with recurrence and complication rates comparable to international reports. Routine use of stents, steroids, mitomycin C, or laser showed no clear benefit, supporting selective rather than standard application. These findings contribute regional data to the global literature and underscore the need for larger multicenter studies to refine prognostic factors and optimize long-term outcomes."

Journal • Cardiovascular • Pediatrics

Antifibrotics in glaucoma surgery: current practices and future directions. (PubMed, Curr Opin Ophthalmol) - "While MMC remains the gold standard antifibrotic agent for glaucoma surgery, there are numerous antifibrotic agents in development with safer side effect profiles and similar success rates that may change the surgical practice of glaucoma."

Journal • Glaucoma • Ophthalmology

Drugs and toxins associated with pulmonary arterial hypertension: from established culprits to novel threats. (PubMed, ERJ Open Res) - "At the 7th World Symposium on Pulmonary Hypertension (2024), carfilzomib and mitomycin C were added as definitely associated with PAH, while bevacizumab and bortezomib were considered as possibly associated with PAH. In cases of suspected PAH following drug or toxin exposure, specific measures are required, including pharmacovigilance reporting, echocardiography, right heart catheterisation to confirm the diagnosis and potential initiation of targeted treatment. Here, we review the latest updates on PAH associated with drugs and toxins."

Journal • Review • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Inhibiting Postoperative Fibrosis in Glaucoma Filtration Surgery Through Porous PLLA/RGD Membrane Mediated Local/Sustained Delivery of Mitomycin C. (PubMed, Transl Vis Sci Technol) - "The as-prepared PLLA/RGD/MMC membrane could be a potential candidate for inhibiting scaring formation after GFS in the future. This work shed some light to the developments and applications of MMC loaded electrospinning membrane for inhibiting postoperative fibrosis in GFS."

Journal • Fibrosis • Glaucoma • Immunology • Ophthalmology