SR1375
/ Shanghai SIMR Biotech
- LARVOL DELTA
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April 15, 2025
Novel Therapeutic for Diabetic Kidney Disease through Targeting Lp-PLA2 in Immune Cells and Damaged Renal Parenchymal Cell
(ERA 2025)
- "The efficacy of the proprietary Lp-PLA2 inhibitor SR1375 on renal function were tested in a mice model of diabetic nephropathy (HFD-Unx-STZ-DKD model) and a rat model of hypertensive nephropathy (DOCA-salt-HTN model)...Conclusions Our results suggest a functional role for Lp-PLA2 in the pathogenesis of DKD, providing preclinical and clinical proof-of-concept for Lp-PLA2 inhibitors as a novel therapeutic approach for patients with DKD. A Phase 2 clinical trial in DKD patients is scheduled to be conducted in the second half of 2025."
Immune cell • Chronic Kidney Disease • Diabetic Nephropathy • Inflammation • Nephrology • Renal Disease • LA2G7
March 16, 2025
Development of SR1375, a Novel Lipoprotein-Associated Phospholipase A2 Inhibitor as an Effective Oral Drug Candidate for Pneumonia With Comorbidities
(ATS 2025)
- P2 | "SR1375 shows promise as a novel therapeutic option for elderly pneumonia patients with multiple comorbidities. A Phase 2 registrational clinical trial focusing on this population was initiated in China in 2024. Clinical trial web link https://clinicaltrials.gov/study/NCT06577558?term=sr1375&rank=1."
Late-breaking abstract • Acute Lung Injury • Cardiovascular • Chronic Kidney Disease • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases • IL6 • TNFA
February 12, 2025
Efficacy and Safety of SR1375 in Adult Patients with CAP
(clinicaltrials.gov)
- P2 | N=240 | Recruiting | Sponsor: Shanghai SIMR Biotechnology Co., Ltd. | Not yet recruiting ➔ Recruiting
Enrollment open • Infectious Disease • Pneumonia
June 01, 2024
Efficacy and safety of SR1375 in hospitalized patients with pneumonia combined with underlying disease: a randomized, double-blind, placebo-parallel controlled trial
(ERS 2024)
- "On the basis of the widespread use of glucocorticoids in patients, SR1375 was still able to show modulation of key biomarkers, superior efficacy to conventional treatment (improvement in 7-category ordinal scale) and a favourable safety profile. Notably, patients in the 3 mg group had better efficacy than 10 mg when compared to the placebo group (-0.38 vs -0.06, p=0.05). In the subgroup of patients with concomitant interstitial pulmonary fibrosis, there was a trend towards a more pronounced therapeutic improvement in the 7-category ordinal scale (-0.44 vs -0.23, p=0.05)."
Clinical • Immunology • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases • Systemic Inflammatory Response Syndrome
August 29, 2024
Efficacy and Safety of SR1375 in Adult Patients With CAP
(clinicaltrials.gov)
- P2 | N=240 | Not yet recruiting | Sponsor: Shanghai SIMR Biotechnology Co., Ltd.
New P2 trial • Infectious Disease • Pneumonia
November 22, 2023
A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SR1375
(clinicaltrials.gov)
- P1 | N=72 | Completed | Sponsor: SIMR (Australia) Biotech Pty Ltd. | Active, not recruiting ➔ Completed
Trial completion
February 10, 2023
The Pharmacokinetics (PK), Pharmacodynamics(PD), Safety, Tolerability of SR1375 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=32 | Completed | Sponsor: Shanghai SIMRD Biotechnology Co., Ltd. | Active, not recruiting ➔ Completed | Trial completion date: Mar 2023 ➔ Oct 2022 | Trial primary completion date: Mar 2023 ➔ Oct 2022
Trial completion • Trial completion date • Trial primary completion date
December 14, 2022
A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SR1375
(clinicaltrials.gov)
- P1 | N=72 | Active, not recruiting | Sponsor: SIMR (Australia) Biotech Pty Ltd. | Trial completion date: Oct 2022 ➔ Jan 2023
Trial completion date
December 14, 2022
The Pharmacokinetics (PK), Pharmacodynamics(PD), Safety, Tolerability of SR1375 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=32 | Active, not recruiting | Sponsor: Shanghai SIMRD Biotechnology Co., Ltd. | Recruiting ➔ Active, not recruiting | Trial completion date: Oct 2022 ➔ Mar 2023 | Trial primary completion date: Sep 2022 ➔ Jan 2023
Enrollment closed • Trial completion date • Trial primary completion date
August 26, 2022
The Pharmacokinetics (PK), Pharmacodynamics(PD), Safety, Tolerability of SR1375 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=32 | Recruiting | Sponsor: Shanghai SIMRD Biotechnology Co., Ltd. | Active, not recruiting ➔ Recruiting
Enrollment open
August 03, 2022
A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SR1375
(clinicaltrials.gov)
- P1 | N=72 | Active, not recruiting | Sponsor: SIMR (Australia) Biotech Pty Ltd. | Recruiting ➔ Active, not recruiting | Trial completion date: Jul 2022 ➔ Oct 2022
Enrollment closed • Trial completion date
July 15, 2022
The Pharmacokinetics (PK), Pharmacodynamics(PD), Safety, Tolerability of SR1375 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=8 | Active, not recruiting | Sponsor: Shanghai SIMRD Biotechnology Co., Ltd. | Not yet recruiting ➔ Active, not recruiting | N=32 ➔ 8
Enrollment change • Enrollment closed
June 16, 2022
The Pharmacokinetics (PK), Pharmacodynamics(PD), Safety, Tolerability of SR1375 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=32 | Not yet recruiting | Sponsor: Shanghai SIMRD Biotechnology Co., Ltd.
New P1 trial
December 06, 2021
A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SR1375
(clinicaltrials.gov)
- P1; N=72; Recruiting; Sponsor: SIMR (Australia) Biotech Pty Ltd.; Trial completion date: Mar 2022 ➔ Jul 2022; Trial primary completion date: Mar 2022 ➔ Jul 2022
Clinical • Trial completion date • Trial primary completion date
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