CAR.B7-H3 T / UNC Lineberger Comprehensive Cancer Center - LARVOL DELTA

Phase I Study of Autologous CAR T-Cells Targeting the B7-H3 Antigen in Recurrent Epithelial Ovarian (clinicaltrials.gov) - P1 | N=7 | Active, not recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Recruiting ➔ Active, not recruiting | N=21 ➔ 7 | Trial primary completion date: Feb 2025 ➔ Feb 2024

Enrollment change • Enrollment closed • Trial primary completion date • Epithelial Ovarian Cancer • Oncology • Ovarian Cancer • Solid Tumor • BRCA • CD276 • MUC16

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc (clinicaltrials.gov) - P1 | N=36 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Trial primary completion date: Oct 2024 ➔ May 2030

CAR T-Cell Therapy • Trial primary completion date • Brain Cancer • CNS Tumor • Glioblastoma • Oncology • Solid Tumor • CD276

Autologous CAR-T Cells Targeting B7-H3 in PDAC (clinicaltrials.gov) - P1 | N=27 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Not yet recruiting ➔ Recruiting

CAR T-Cell Therapy • Enrollment open • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • CD276

Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells (clinicaltrials.gov) - P1 | N=27 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Not yet recruiting ➔ Recruiting

CAR T-Cell Therapy • Enrollment open • Oncology • Ovarian Cancer • Solid Tumor

Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells (clinicaltrials.gov) - P1 | N=42 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Not yet recruiting ➔ Recruiting

CAR T-Cell Therapy • Enrollment open • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer

Autologous CAR-T Cells Targeting B7-H3 in PDAC (clinicaltrials.gov) - P1 | N=27 | Not yet recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Initiation date: Jun 2024 ➔ Sep 2024

CAR T-Cell Therapy • Trial initiation date • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • CD276

Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells (clinicaltrials.gov) - P1 | N=27 | Not yet recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Initiation date: Mar 2024 ➔ Jul 2024

CAR T-Cell Therapy • Trial initiation date • Oncology • Ovarian Cancer • Solid Tumor

Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells (clinicaltrials.gov) - P1 | N=42 | Not yet recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center

New P1 trial • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer

Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells (clinicaltrials.gov) - P1 | N=27 | Not yet recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center

CAR T-Cell Therapy • New P1 trial • Oncology • Ovarian Cancer • Solid Tumor

Autologous CAR-T Cells Targeting B7-H3 in PDAC (clinicaltrials.gov) - P1 | N=27 | Not yet recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center

CAR T-Cell Therapy • New P1 trial • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • CD276

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc (clinicaltrials.gov) - P1 | N=36 | Recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center | Not yet recruiting ➔ Recruiting | Trial primary completion date: May 2030 ➔ Oct 2024

CAR T-Cell Therapy • Enrollment open • Trial primary completion date • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • CD276

Phase I Study of Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc (clinicaltrials.gov) - P1 | N=36 | Not yet recruiting | Sponsor: UNC Lineberger Comprehensive Cancer Center

CAR T-Cell Therapy • New P1 trial • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • CD276