microRNA2911 / Medical School of Nanjing University - LARVOL DELTA

Alleviation of colitis by honeysuckle MIR2911 via direct regulation of gut microbiota. (PubMed, J Control Release) - "The results demonstrated that MIR2911 can be absorbed through the diet and secreted within host small extracellular vesicles (sEVs), acting directly on intestinal bacteria, reducing the abundance of Escherichia-Shigella, and improving colitis symptoms. This study provides a new theoretical basis for the molecular mechanism of TCM therapy and identifies a potential new drug a new drug target for the treatment of colitis."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Honeysuckle-Derived miR2911 Inhibits Replication of Porcine Reproductive and Respiratory Syndrome Virus by Targeting Viral Gene Regions. (PubMed, Viruses) - "Subsequently, through the dual luciferase reporter gene assay and miR2911 overexpression assay, it was demonstrated that miR2911 significantly inhibits the replication of PRRSV by targeting regions of PRRSV Nsp1 and Nsp2. These findings offer new insights for the development of novel anti-PRRSV drugs."

Journal • Preclinical • Infectious Disease • Influenza • Novel Coronavirus Disease • Respiratory Diseases

Lycium barbarum miR2911-loaded exosomes promote spermatogenic function recovery in rats with non-obstructive azoospermia by regulating Wnt/β-catenin signaling pathways (PubMed, Zhonghua Nan Ke Xue) - "Lb-miR2911-loaded exosomes promote spermatogenic function recovery in NOA rats through cross-regulation of the DACT3, Wnt and β-catenin signaling pathways."

Journal • Preclinical • CCND1 • CCNE1 • CCNE2 • CCR6 • IL1B • TNFA

Atypical Plant miRNA cal-miR2911: Robust Stability against Food Digestion and Specific Promoting Effect on Bifidobacterium in Mice. (PubMed, J Agric Food Chem) - "miR2911 specifically entered the cells of Bifidobacterium adolescentis and potentially modulated the gene expression as evidenced by the dual-luciferase assay. The current study provided evidence on the cross-kingdom communication between dietary miRNAs and gut microbes, suggesting that modulating target bacteria using miRNAs for nutritional and therapeutic ends is promising."

Journal • Preclinical

The Role of microRNAs in Arsenic-Induced Human Diseases: A Review. (PubMed, J Agric Food Chem) - "Additionally, exogenous miRNAs derived from plants, such as miR-34a, miR-159, miR-2911, miR-159a, miR-156c, miR-168, etc., among others, can be transported from blood to specific tissue/organ systems in vivo...These special miRNAs could serve as potential biomarkers in the management and treatment of human diseases linked to arsenic exposure. Finally, the protective action of exogenous miRNAs, including antitumor, anti-inflammatory, anti-CVD, antioxidant stress, and antivirus are described."

Journal • Review • Atrial Fibrillation • Cardiovascular • CNS Disorders • Congestive Heart Failure • Diabetes • Heart Failure • Metabolic Disorders • Nephrology • Oncology • Renal Disease • HIF1A • MIR155 • MIR200 • MIR21 • MIR34A • MYC

Inhibitory effect of Lonicera japonica-derived exosomal miR2911 on human papilloma virus. (PubMed, J Ethnopharmacol) - "Our findings indicate that miR2911, an active component present in Lonicera japonica exosomes, inhibits proliferation and induces apoptosis of cervical cancer cells by targeting the E6/E7 genes of HPV16/18. Thus, Lonicera japonica-derived exosomal miR2911 has implications for the development of novel therapeutic strategies for the treatment of HPV-associated cervical cancers."

Journal • Cervical Cancer • Human Papillomavirus Infection • Infectious Disease • Oncology • Solid Tumor • CASP3

Identification of miRNA profile in the peripheral blood and clinical significance of miR-355 and miR-2911 expression in children with Kawasaki disease. (PubMed, Am J Transl Res) - "Expression levels of miR-355 and miR-2911 were significantly up-regulated in peripheral blood of children with Kawasaki disease. miR-355 and miR-2911 could serve as biomarkers for diagnosis of Kawasaki disease."

Journal

The role of microRNAs in neurodegenerative diseases: a review. (PubMed, Cell Biol Toxicol) - "Additionally, exogenous miRNAs derived from homologous plants and defined as botanmin, such as miR2911 and miR168, can be taken up and transferred by other species to be and then act analogously to endogenic miRNAs to regulate the physiological and biochemical processes...3. Demonstrating the effects of up-regulation or down-regulation of each miRNAs on the nervous system."

Journal • Review • Alzheimer's Disease • Cardiovascular • CNS Disorders • Huntington's Disease • Movement Disorders • Multiple Sclerosis • Parkinson's Disease • MIR15 • MIR29A • MIR34A

Berry derived constituents in suppressing viral infection: Potential avenues for viral pandemic management. (PubMed, Clin Nutr ESPEN) - "Owing to the rich source of various antiviral constituents, berries could be an alternative source for managing viral infections. In this review, we provide insights into how berry derived components inhibit viral infection and their clinical usefulness in viral disease management."

Journal • Review • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication. (PubMed, Cell Discov) - No abstract available

Clinical • Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients. (PubMed, Cell Discov) - No abstract available

Clinical • Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Honeysuckle-derived microRNA2911 inhibits tumor growth by targeting TGF-β1. (PubMed, Chin Med) - "Taken together, honeysuckle-derived miR2911 showed an anti-tumor effect in colon cancer through targeting TGF-β1 mRNA. The down-regulation of TGF-β1 promoted T lymphocytes infiltration, and accordingly impeded the colon tumor development."

Journal • Colon Cancer • Colorectal Adenocarcinoma • Colorectal Cancer • Gastrointestinal Cancer • Immunology • Oncology • Solid Tumor • MIR29A • TGFB1

Honeysuckle-derived microRNA2911 directly inhibits varicella-zoster virus replication by targeting IE62 gene. (PubMed, J Neurovirol) - "These results indicated that, by targeting the IE62 gene, MIR2911 may effectively inhibit VZV replication. Our results also suggest a potential novel strategy for the treatment and prevention of diseases caused by VZV infection."

Journal • Herpes Zoster • Infectious Disease • Varicella Zoster