Vulnofast gel (RLP-068)
/ Molteni Therap
- LARVOL DELTA
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August 14, 2025
Antimicrobial Photodynamic Activity of the Zn(II) Phthalocyanine RLP068/Cl Versus Antimicrobial-Resistant Priority Pathogens.
(PubMed, Int J Mol Sci)
- "Our results demonstrated the significant microbicidal activity of RLP068/Cl against all of the tested strains regardless of their resistance phenotype, with particularly prominent activity against Gram-positive bacteria (range of bactericidal concentrations 0.05-0.1 µM), which required significantly lower exposure to photosensitizer compared to Candida and Gram-negative species (range 5-20 µM). Overall, these findings support the potential use of RLP068/Cl-mediated aPDT as an effective therapeutic strategy for the management of localized infections caused by MDR organisms, particularly when conventional therapeutic options are limited."
Journal • Infectious Disease
July 29, 2025
PHOTAC: Photodynamic Therapy With Topical Application of a Zn(II) Phthalocyanine (RLP068/Cl) and Red Light for the Treatment of Moderate-to-severe Acne Vulgaris
(clinicaltrials.gov)
- P=N/A | N=10 | Not yet recruiting | Sponsor: Università degli Studi di Brescia
New trial • Acne Vulgaris • Dermatology
November 15, 2024
Assessment of therapeutic response to photodynamic therapy with the Zn-Phthalocyanine RLP068/Cl versus topical Clindamycin in patients affected by Hidradenitis Suppurativa: a comparative clinical pilot study.
(PubMed, Photochem Photobiol Sci)
- "Its efficacy remains reliable even in more severe cases when combined with adalimumab. Furthermore, photoactivated RLP068/Cl was well tolerated with no adverse events reported. Therefore, photodynamic therapy following RLP068/Cl application represents a novel therapeutic option for hidradenitis suppurativa with potential implications for antibiotic stewardship in dermatology."
Journal • Dermatology • Hidradenitis Suppurativa • Immunology • Pain
February 02, 2023
Photodynamic therapy with RLP068/Cl as a new advancement in local treatment of HS
(EHSF 2023)
- "Content: Patients attending our outpatient-clinic with symmetrical groin or axilla HS lesions (inflammatory nodules or abscesses) treated with adalimumab or about to start topical clindamycin were consecutively enrolled. Red-light PDT with RLP068/Cl is time-consuming for both patients and clinicians, but it may be a new adjuvant/alternative safe treatment in patients with poor response to therapy and with a high number of exacerbations/year. Furthermore, it could be faster in reducing pain compared with topical clindamycin. Finally, PDT seems not to induce antimicrobial resistance."
Acne Vulgaris • Dermatology • Hidradenitis Suppurativa • Inflammation • Pain
February 02, 2023
Photodynamic therapy with Zn(II) phthalocyanine (RLP068/Cl) for hidradenitis suppurativa
(EHSF 2023)
- "PDT with RLP068/Cl represent an interesting therapeutic option in the landscape of the future treatment of HS as monotherapy for mild HS or in association with biologics for moderate-severe HS."
Dermatology • Hidradenitis Suppurativa • Infectious Disease • Pain
October 26, 2021
Photodynamic Therapy With RLP068 and 630-nm Red LED Light in Foot Ulcers in Patients With Diabetes: A Case Series.
(PubMed, Int J Low Extrem Wounds)
- "In all cases, examined photodynamic therapy with photosensitizer RLP068 and red light at 630 nm was found to reduce lesion area and inflammation and to ensure the decrease of bacterial load, hence reducing treatment times and antibiotics use, improving patient outcomes, and reducing the incidence of amputations. The simultaneous combination of photodynamic therapy with other ancillary physical-based treatments such as therapeutic magnetic resonance or Bio-Electro-Magnetic-Energy-Regulation was observed to be safe, time-saving, and able to lead to faster healing."
Clinical • Journal • Cardiovascular • Diabetes • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Pain
March 06, 2021
New Perspective to Improve Care of Patients with Infected Diabetic Foot Ulcer: Early Economic Impact of the Use of Photodynamic Therapy with RLP068 (Based) System.
(PubMed, Clinicoecon Outcomes Res)
- "Considering the inpatient setting, the use of the PDT-RLP068 system would result in saving even with the modest impact on the time needed to activate the healing process. The early economic evaluation performed suggested that, if the claimed effectiveness of the technology demonstrated in case reports and in preliminary clinical studies can be confirmed in larger population studies, and allowing for shortening of the time needed to activate the healing process, the PDT-RLP068 system could offer the chance to improve care for DFI patients without compromising the sustainability of the system."
Clinical • HEOR • Journal
June 23, 2020
Photodynamic Topical Antimicrobial Therapy for Infected Diabetic Foot Ulcers in Patients With Diabetes: A Case Series.
(PubMed, Int J Low Extrem Wounds)
- "In this article, a case series of 22 DFU treated with photoactivated RLP068 at 5 different centers in Italy is presented. Considering microbial agents reduction, ulcer healing facilitation, healing rate (9 DFUs out of 22), and amputation rate (only 1 case over 22), the decrease in the cost of DFU seems to be a point in favor of RLP068 and its cost-effectiveness."
Clinical • Journal • Diabetes • Metabolic Disorders
March 13, 2020
Efficacy and safety of photodynamic therapy with RLP068 for diabetic foot ulcers: a review of the literature and clinical experience.
(PubMed, Drugs Context)
- "Among these, we would like to focus on RLP068, whose antimicrobial activity has been widely demonstrated in preclinical studies and in a clinical trial. This article reports previously published evidence and presents four unpublished clinical cases of DFUs treated in the real-life setting with PDT."
Clinical • Journal • Review
February 21, 2020
Antimicrobial Photodynamic Therapy in Infected Diabetic Foot Ulcers: A Multicenter Preliminary Experience.
(PubMed, J Am Podiatr Med Assoc)
- "Similar effects of the first treatment were observed in sample B. In both samples, the ulcer area showed a significant reduction during follow-up, even in patients with ulcers infected with gram-negative germs or with exposed bone. RLP068 seems to be a promising topical wound management procedure for the treatment of infected diabetic foot ulcers."
Clinical • Journal
December 18, 2018
Photodynamic therapy in infected venous and mixed leg ulcers: a pilot experience.
(PubMed, J Wound Care)
- "To assess the tolerability and efficacy of photodynamic therapy (PDT) with RLP068, a novel phthalocyanine-derived photosensitiser, in controlling the bacterial load in different leg ulcers, due to vascular pathophysiology...The treatment was generally well tolerated. Studies with a greater number of patients and a control group are planned to confirm these results."
Journal
September 15, 2019
The benefits of antimicrobial photodynamic therapy with RLP068 in the management of diabetic foot ulcers.
(PubMed, Drugs Context)
- "A clinical trial demonstrated that PDT with RLP068 reduced the microbial load of diabetic ulcers in 62 patients. This article reports previously published evidence and presents four, unpublished, clinical cases treated in the real-life setting."
Journal • Review
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