EB120 / Enterome, Takeda - LARVOL DELTA

Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication. (PubMed, Stem Cell Reports) - "Using a multi-omics approach, we established cerebral organoid (CBO) at day 60 (EB60) and day 120 (EB120) to model immature and mature developmental stages...Consistently, pharmacological lipid reduction attenuated SARS-CoV-2 infection. Our findings establish a mechanistic link between intrinsic brain maturation and viral susceptibility mediated by lipid remodeling, suggesting lipid-lowering strategies as potential candidates for therapeutic repurposing in COVID-19."

Journal • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Respiratory Diseases

Alu RNA pseudoknot alterations influence SRP9/SRP14 association. (PubMed, RNA) - "Small angle X-ray scattering followed by atomistic computation structure prediction suggests the BC200 Alu domain and its U-turn mutant both possess a canonical Alu RNA fold, while EB120 lacks one. Our results highlight the structural diversity of Alu RNA, and the impact mutations may have on Alu RNA function."

Journal • ARID1A