methylprednisolone oral / Generic mfg. - LARVOL DELTA

Sequential, Multifocal, and Delayed Avascular Necrosis of All Four Major Joints From Hips to Shoulders Following Corticosteroid Therapy. (PubMed, Cureus) - "We describe a 59-year-old male patient who received a tapered regimen of oral methylprednisolone for facial palsy in 2012...This case illustrates delayed, multifocal, steroid-induced osteonecrosis progressively involving both hips and shoulders over more than a decade. This clinical scenario raises an important consideration: whether patients undergoing corticosteroid therapy should receive routine imaging of major joints to facilitate early detection of osteonecrosis and enable timely interventions, such as core decompression, that may delay or prevent progression to end-stage joint destruction requiring arthroplasty."

Journal • CNS Disorders • Orthopedics • Pain

Azithromycin in the Management of Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis (clinicaltrials.gov) - P=N/A | N=30 | Recruiting | Sponsor: Assiut University | Active, not recruiting ➔ Recruiting | Trial primary completion date: Sep 2025 ➔ Dec 2025

Enrollment open • Trial primary completion date • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases

From Euphoria to Cardiac Stress: Role of Oxidative Stress on the Cardiotoxicity of Methylone and 3,4-DMMC. (PubMed, Toxics) - "Synthetic cathinones (SCs), commonly referred to as "bath salts", are a class of novel psychoactive substances (NPSs) that elicit amphetamine-like effects and severe cardiovascular outcomes, including myocardial infarction and sudden cardiac death...Intracellular reactive oxygen/nitrogen species (ROS/RNS) were quantified by fluorescence, and antioxidant effects were evaluated using ascorbic acid, N-acetylcysteine, and Trolox...Taken together, these findings demonstrate for the first time that methylone and 3,4-DMMC exert cardiotoxic effects in vitro, with oxidative stress as a key contributor. The protective effect of ascorbic acid highlights its potential as a therapeutic candidate against SC-induced cardiac injury."

Journal • Cardiovascular • Myocardial Infarction

IMPACT-2: An Evaluation of the Safety and Efficacy of Methylone for the Treatment of PTSD (clinicaltrials.gov) - P2 | N=62 | Completed | Sponsor: Transcend Therapeutics | Active, not recruiting ➔ Completed

Trial completion • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

IMPACT-EXT: An Evaluation of the Long-term Efficacy and Safety of Methylone for the Treatment of PTSD (clinicaltrials.gov) - P2 | N=44 | Completed | Sponsor: Transcend Therapeutics | Enrolling by invitation ➔ Completed | N=150 ➔ 44 | Trial completion date: May 2027 ➔ Oct 2025 | Trial primary completion date: May 2027 ➔ Oct 2025

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

DRESS To Kill: A Case of Severe Drug Reaction Eosinophilia Systemic Symptoms Recurrence with Second-Line anti-Tuberculosis Medication in a 44-Year-Old Asian Woman (APSR 2025) - "Case Report : We report a presentation of DRESS in a 44-year-old Asian female with Multi-Drug Rifampicin Resistant Tuberculosis (MDR-TB)...Cessation of anti-TB drugs and initiation of oral methylprednisolone resulted in clinical improvement and was discharged on a corticosteroid regimen over 14 days. Rechallenging treatment using a graded protocol with second- line MDR-TB agents (Linezolid, Delamanid, Cycloserine, and Levofloxacin) caused recurrence of symptoms, including rash with desquamation, eosinophilia, and elevated liver enzymes...Prednisone was carefully tapered over six months...Knowledge, early recognition, early cessation, prompt management are of important to minimize morbidity and mortality. Furthermore, outpatient follow up is vital to prevent relapses and long-term sequelae including organ damage, infections, and mental health complications."

Clinical • Autoimmune Hepatitis • Eosinophilia • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Respiratory Diseases • Tuberculosis

A Phase 1 Trial Evaluating the Addition of Lenalidomide to Relapsed/Refractory Multiple Myeloma Patients Progressing on Ruxolitinib and Methylprednisolone (ASH 2023) - "Initially, subjects received oral RUX 15 mg twice daily and oral methylprednisolone 40 mg every other day. This three-drug combination is well tolerated and is able to extend the benefit of RUX-based treatment for these patients. The promising results from this phase 1 clinical trial demonstrate a potential novel, all oral therapeutic approach for treating RRMM patients."

Clinical • P1 data • Graft versus Host Disease • Hematological Malignancies • Immunology • Multiple Myeloma • Myelofibrosis • Oncology • Polycythemia Vera

Long-Term Effect of Oral Methylprednisolone on Kidney Outcomes in Patients with IgAN: TESTING-ON, a Post-Trial Observational Study (KIDNEY WEEK 2025) - P | "The reduction of time averaged proteinuria among those who received methylprednisolone was no longer evident whilst the between group differences in annual eGFR slope remained significant throughout the post-trial period. Conclusion The beneficial effect of oral methylprednisolone on kidney failure and related outcomes in individuals with high-risk IgA nephropathy persisted out to a median follow-up of 6.4 years."

Clinical • Late-breaking abstract • Observational data • Glomerulonephritis • IgA Nephropathy

Retinoic Acid plus Hydroxychloroquine Sulfate and Methylprednisolone in Patients with Erosive Oral Lichen Planus: A Randomized and Controlled Clinical Trial (ChiCTR) - P4 | N=146 | Not yet recruiting | Sponsor: Shanghai Ninth People's Hospital， Shanghai JiaoTong University School of Medicine; Shanghai Ninth People's Hospital， Shanghai JiaoTong University

New P4 trial • Dermatology • Dermatopathology • Lichen Planus

Fever of Unknown Origin Secondary to Necrotizing Hepatic Granulomas: A Rare Case of Idiopathic Granulomatous Hepatitis (ACG 2025) - "Despite initial treatment with posaconazole, symptoms worsened...Because of ferritin and IL-2 elevation, colchicine was trialed but was complicated by influenza-related fevers. She was discharged on oral 32mg methylprednisolone once daily, trimethoprim/sulfamethoxazole once daily for prophylaxis, and furosemide for hypervolemia...MR abdomen demonstrating numerous bilobar ill-defined peripherally enhancing and diffusion restricting liver lesions. Conglomerate lesion at the dome measuring 4.9 x 4 cm viewable in this cut."

Clinical • Hepatitis B • Hepatology • Immunology • Infectious Disease • Inflammation • Influenza • Respiratory Diseases • Rheumatology • Sarcoidosis • Tuberculosis • IL2

Analysis of the Clinical Efficacy of Vitamin D in the Treatment of Sudden Deafness (ChiCTR) - P=N/A | N=101 | Recruiting | Sponsor: The First People's Hospital of Yinchuan; The First People's Hospital of Yinchuan

New trial • Otorhinolaryngology

WHEN TARGETED THERAPIES BACKFIRE: A CASE OF ALECTINIB-INDUCED LUNG INJURY (CHEST 2025) - "The patient was then switched from methylprednisolone to oral prednisone at a dose of 1mg/kg/day and discharged...The patient was subsequently initiated on lorlatinib, a third-generation ALK inhibitor... Pneumonitis due to ALK-inhibitors remains a challenging diagnosis. The importance of monitoring for potential adverse effects of targeted therapies is emphasized in this case, underscoring the need for prompt therapeutic adjustments to optimize patient outcomes."

Clinical • Cough • Infectious Disease • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Pneumonia • Respiratory Diseases • Solid Tumor • ALK • CRP

Susac syndrome - different treatment approaches for one disease (analysis of case series). (PubMed, Neurol Sci) - "The described cases highlight differences in the course of the disease and response to immunosuppressive therapy. Patients initially responded very well to high doses of GCS and IVIG. However, in addition to long-term remissions, relapses also developed. Therefore, individual treatment based on the principles of personalized medicine is necessary."

Journal • Review • Immunology • Ophthalmology • Otorhinolaryngology • Rare Diseases

Sex Differences Across Corticosteroid Response and Outcomes in IgA Nephropathy. (PubMed, Kidney Int Rep) - "Participants with IgAN were randomized to 6 to 9 months of oral methylprednisolone or placebo...Total eGFR rate of decline over 2 years was greater in males compared with females by 3.13 ml/min per 1.73 m2/yr (95% CI: 0.92-5.34, P = 0.006). Methylprednisolone improves kidney outcomes in IgAN, regardless of sex; however, males experience poorer kidney outcomes than females."

Journal • Glomerulonephritis • IgA Nephropathy • Nephrology • Renal Disease

INTESTINAL HISTOPLASMOSIS, AN INFECTION TO CONSIDER IN THE DIFFERENTIAL DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE (UEGW 2025) - "Treatment was started with oral methylprednisolone at a dose of 1 mg/kg, with a decrease in the stool rhythm...Amphotericin B was prescribed with prophylaxis of opportunistic infections with trimethoprim-sulfamethoxazole...Intestinal involvement is rare, with a preference for the ileocecal region in the form of deep ulcers that can simulate an outbreak of Crohn disease, as in our case. The use of immunosuppressants, especially anti-TNF-alpha, may worsen its course, highlighting the importance of a broad differential diagnosis, taking into account the patient's epidemiological characteristics."

Anemia • Crohn's disease • Dermatology • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • CD4 • CRP

The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty (clinicaltrials.gov) - P4 | N=100 | Not yet recruiting | Sponsor: F. Johannes Plate | Trial completion date: Dec 2025 ➔ Dec 2027 | Trial primary completion date: Oct 2025 ➔ Oct 2027

Trial completion date • Trial primary completion date • Immunology • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatology

Hyperbilirubinemia with Unusual Dermatologic Signs: A Diagnostic Puzzle. (PubMed, Acta Med Indones) - "Treatment with ursodeoxycholic acid (UDCA) and high-dose oral methylprednisolone showed clinical improvement but persisted in transaminitis with a normal ultrasonographic appearance. This case emphasizes the importance of recognizing cutaneous signs in systemic diseases and the need for a comprehensive diagnostic approach in resource-limited settings."

Journal • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Primary Biliary Cholangitis

EASE-NMO: Eculizumab For the Acute Attack of Neuromyelitis Optica Spectrum Disorder (clinicaltrials.gov) - P2 | N=110 | Recruiting | Sponsor: Tianjin Medical University General Hospital

New P2 trial • CNS Disorders • Neuromyelitis Optica Spectrum Disorder • Rare Diseases

Late-Onset Autosomal Recessive Dystrophic Epidermolysis Bullosa: A Case Report (EADV 2025) - "Materials & A 73-year-old female patient with a 3-day history of widespread skin eruption and pruritus that started after a seven-day use of betahistine dihydrochloride 24 mg, oral vitamin D3, and Ginkgo biloba prescribed for tinnitus...The patient received oral methylprednisolone, and eroded lesions were treated topically... The absence of symptoms in the patient's parents and the presence in both the patient and her siblings confirm autosomal recessive inheritance, with both parents likely being carriers. The late-onset presentation in this patient is noteworthy, as it may reflect a milder phenotype associated with this specific mutation. The triggering of symptoms following medication use, absence of oral mucosal involvement, and overlapping drug eruption contribute to the atypical clinical presentation of this patient."

Case report • Clinical • Dermatology • Mood Disorders • Otorhinolaryngology • Pruritus • COL7A1

Widespread atypical lichen planus in 2 Filipinos (EADV 2025) - "Case 1 was managed with NB-UVB phototherapy (3x/week for 3 months), oral acitretin 10 mg daily, halobetasol ointment (AM), and tacrolimus 0.1% ointment (PM), resulting in approximately 95% improvement with residual hyperpigmentation...The patient showed marked improvement, with almost 90% flattening of lesions and residual excoriations and hyperpigmentation, after treatment with halobetasol 0.5 mg ointment (AM), tacrolimus 0.1% ointment (PM) and oral methylprednisolone 16 mg OD x 2 weeks... These two cases emphasize the clinical variability of lichen planus in brown skin and the potential for misdiagnosis in atypical presentations. Dermoscopy and histopathology are essential tools for accurate diagnosis. Early recognition and a multimodal treatment approach can lead to significant clinical improvement and reduce disease chronicity."

Dermatology • Dermatopathology • Immunology • Lichen Planus • Pruritus • Rare Diseases • COL7A1

Successful management of recalcitrant pemphigoid with Dupilumab: a three-case report (EADV 2025) - "Adjuvant therapy with doxycycline (100 mg twice daily) and dapsone (titrated to 100 mg/day) was ineffective, with both patients remaining corticosteroid-dependent...Initial disease control was achieved with topical clobetasol propionate alone; however, a significant worsening occurred postpartum, requiring treatment with oral methylprednisolone (0.5 mg/kg/day). Subsequent escalation to azathioprine (100 mg/day) and dapsone (100 mg/day) proved insufficient... Dupilumab appears to be a promising therapeutic option for patients with refractory autoimmune subepidermal blistering diseases, especially in cases where conventional treatments are contraindicated or ineffective. These cases contribute to the growing number of reports supporting its off-label use."

Case report • Clinical • Bullous Pemphigoid • Dermatology • Dermatopathology • Immunology • Pruritus

Pemphigus vulgaris and nephrotic syndrome in a pediatric patient (EADV 2025) - "Materials & A 14-year-old girl diagnosed with PV a year before, was readmitted to the dermatology department for another severe PV flare while being on oral methylprednisolone and azathioprine. To our knowledge this is the second reported case of PV and FSGS and further adds to the short list of associations between PV and kidney diseases, despite the kidney being a frequent target of immune-mediated injury. The occurrence of nephrotic syndrome and PV in our case, as well as their parallel control by the B-cell depleting agent rituximab may suggest a common pathogenic mechanism. PV is the best known IgG4 mediated autoimmune disease but similar immunopathological mechanisms are considered also in myasthenia gravis, thrombotic thrombocytopenic purpura, autoimmune encephalitis, and glomerulonephritis."

Clinical • Amyloidosis • Chronic Kidney Disease • CNS Disorders • Dermatology • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Hematological Disorders • Immunology • Lupus Nephritis • Myasthenia Gravis • Nephrology • Pediatrics • Pemphigus Vulgaris • Renal Disease • Thrombocytopenic Purpura

A Case of Early-Onset, Steroid-Resistant DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) Following Antiepileptic Drug Use (EADV 2025) - "She was started on oral methylprednisolone (48 mg/day for 3 days, reduced to 32 mg/day), along with cetirizine, but her symptoms did not improve. DRESS syndrome symptoms typically appear 2-8 weeks after starting the causative drug. However, in cases triggered by antiepileptic drugs, the onset may occur earlier. While systemic corticosteroids are the first-line treatment, they may be insufficient in severe or resistant cases."

Clinical • Dermatitis • Dermatology • Eosinophilia • Immunology • Subarachnoid Hemorrhage

Nodular Rosacea: A Case Series of Three Patients with Clinical, Histopathologic, and Differential Diagnostic Insights (EADV 2025) - "Prior treatment with clobetasol and high-dose prednisone was ineffective... All patients were treated with oral methylprednisolone (16 mg/day tapered after 1 week), azithromycin (500 mg three times weekly for 6 weeks), topical metronidazole (0.75% cream in the morning), and ivermectin (1% cream at night)... Nodular rosacea may mimic various dermatoses including seborrheic dermatitis, pseudolymphoma and histoid leprosy, complicating diagnosis. This case series emphasizes the importance of using immunohistochemistry and special staining techniques to differentiate nodular rosacea from these conditions. A combined treatment approach, including oral anti-inflammatory agents, topical antimicrobials, and isotretinoin, proved to be highly effective in achieving long-term remission in all cases."

Clinical • Acne Vulgaris • B Cell Lymphoma • Dermatitis • Dermatology • Fibrosis • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Pruritus • Rosacea • Seborrheic Dermatitis • CD20

Methylprednisolone Taper After Total Knee Replacement (clinicaltrials.gov) - P4 | N=101 | Completed | Sponsor: Emory University | Active, not recruiting ➔ Completed

Trial completion • Immunology • Musculoskeletal Diseases • Orthopedics • Pain • Rheumatology