Nexplanon (etonogestrel implant) / Organon - LARVOL DELTA

Hormonal long-acting reversible contraceptives use and potential impact on environment: A mathematical model. (PubMed, Int J Gynaecol Obstet) - "Use of hormonal LARCs is associated with a substantially lower annual environmental waste footprint impact compared with COCs and nonuse of contraception, owing to reduced solid waste generation and fewer disposable menstrual hygiene products used."

Journal • Long-acting Reversible Contraceptives

Immediate postpartum etonogestrel implant placement and breastfeeding-can we safely abandon the 24-hour rule? (Letter-to-the-Editor). (PubMed, Am J Obstet Gynecol) - No abstract available

Journal

Pulmonary embolism of subdermal contraceptive implant: lung-sparing precision removal. (PubMed, BMJ Case Rep) - "We report the case of a woman in her late 20s with a non-palpable Nexplanon implant, found within a segmental branch of the right lower lobe pulmonary artery...This case highlights a precision surgical approach to remove a pulmonary artery-embedded contraceptive implant without sacrificing lung parenchyma. It underscores the importance of shared decision-making and a tailored, multidisciplinary approach in managing rare device-related complications."

Journal • Cardiovascular • Long-acting Reversible Contraceptives • Pain • Pulmonary Embolism • Respiratory Diseases

Effectiveness of the etonogestrel implant: an economic model of immediate postpartum use on pregnancy outcomes. (PubMed, J Med Econ) - "A Markov model with 1-year time horizon simulated pregnancy outcomes among 1,000 women 18-49 years initiating 1 of 8 hormonal contraceptives for postpartum contraception: progestin-only oral contraception (OC), combined OC, progestin-only injectable, etonogestrel/ethinyl estradiol vaginal ring, norelgestromin/ethinyl estradiol transdermal patch, 3- or ≥5-year levonorgestrel IUD, and the etonogestrel implant. The immediate postpartum provision of the etonogestrel implant produced the greatest cost savings due to fewer short-interval pregnancies and related expenditures. These results highlight the etonogestrel implant as a cost-effective option for clinicians seeking to reduce short-interval pregnancy and health system costs."

Journal • Long-acting Reversible Contraceptives

FEATS: Failed Endometrial Ablation Treatment With Implantable Progesterone (FEAT) Study (clinicaltrials.gov) - P2 | N=0 | Withdrawn | Sponsor: Saskatchewan Health Authority - Regina Area | Terminated ➔ Withdrawn

Trial withdrawal • Women's Health

Survey of Birth Control Practices in People with Epilepsy of Child-bearing Potential (PWECP) – Single Center Data (AES 2025) - "9/102 (8.8%) participants reported using contraception to prevent seizures.The most common antiseizure medications used were levetiracetam, 54/102 (52.9%), and lamotrigine 35/102 (34.3%) (Table 2). These results suggest that there are gaps in contraception counseling and awareness among PWECP. OCPs are the most commonly used contraceptive in PWECP as well as the NSFG. Use of depot medroxyprogesterone acetate and etonogestrel implants was higher in our sample than in the NSFG.This project will be expanded to multiple sites across the United States to obtain large-scale data."

Clinical • CNS Disorders • Epilepsy • Long-acting Reversible Contraceptives

Deep implant removal: The impact of implant depth and positioning. (PubMed, Int J Gynaecol Obstet) - "Difficult implant removals, including surgical extractions, are strongly associated with inadequate placement and fibrosis. These factors significantly increase the complexity of removal, emphasizing the need for proper insertion training and early identification of high-risk cases to reduce surgical interventions."

Journal • Fibrosis • Immunology • Long-acting Reversible Contraceptives

Depression, Anxiety, and Stress in Adolescents Using the Etonogestrel Implant: A Prospective Cohort Study. (PubMed, J Pediatr Adolesc Gynecol) - "Use of the etonogestrel implant was not associated with significant changes in depression, anxiety, or stress symptoms among adolescents over six months. The findings support the psychological safety of the method and suggest that mood symptoms are more common in this population and are more likely related to developmental factors than to contraceptive use."

Journal • CNS Disorders • Depression • Long-acting Reversible Contraceptives • Mood Disorders • Psychiatry

Subdermally Placed Implanon Migration Into the Pectoralis Muscle and Its Removal in a Resource-Limited Setup: A Case Report and Brief Literature Review. (PubMed, Clin Case Rep) - "Due to their effectiveness, convenience, and reversibility, single-rod etonogestrel devices such as Implanon and Nexplanon are increasingly popular as long-acting reversible contraceptive methods...Ultimately, ultrasound-guided removal was successfully performed by a multidisciplinary team. This case highlights the importance of image-guided techniques for safe and effective implant retrieval, rather than relying on blind surgical exploration."

Journal • Long-acting Reversible Contraceptives

SDRIFE due to Nexplanon®: A Rare Reaction to a Widely Used Contraceptive (ACAAI 2025) - "Commonly implicated drugs include beta-lactam antibiotics, especially amoxicillin, but other antibiotics such as clindamycin, metronidazole, and fluconazole have also been reported. The temporal relationship and resolution following removal suggest a strong causal link. Clinicians should consider hormonal implants in the differential diagnosis of symmetric intertriginous rashes, particularly in patients recently exposed to systemic medications or devices."

Dermatitis • Gastrointestinal Disorder • Immunology • Long-acting Reversible Contraceptives

ETONOGESTREL IMPLANT (EI) DOES NOT IMPACT OVARIAN RESERVE AND OOCYTE YIELD DURING FERTILITY PRESERVATION: THE LARGEST PUBLISHED COHORT STUDY TO DATE (ASRM 2025) - No abstract available

Venous Thromboembolism Occurrence in the Setting of Nexplanon Insertion with Multiple Risk Factors: A Case Report. (PubMed, Healthcare (Basel)) - "She was started on anticoagulation, had the Nexplanon removed, and recovered well. This case highlights the importance of clinical suspicion for VTE in the postpartum period, presenting a postpartum VTE coinciding with a subdermal implant placement."

Journal • Cardiovascular • Diabetes • Gestational Diabetes • Gynecology • Metabolic Disorders • Venous Thromboembolism

Contraceptive Knowledge and Counseling among OB-GYN and Family Medicine Physicians. (PubMed, Kans J Med) - "More OB-GYN physicians (6.7%, n = 3) reported performing over 80 Nexplanon® insertions compared to FM physicians (0.0%, n = 0; p <0.0001). Contraceptive knowledge did not differ significantly between OB-GYN and FM physicians. However, advanced training was associated with greater comfort in both prescribing and performing contraceptive procedures."

Journal • Gynecology • Long-acting Reversible Contraceptives • Obstetrics

Progestagens for pain symptoms associated with endometriosis. (PubMed, Cochrane Database Syst Rev) - "In individuals with endometriosis, oral progestagens compared with placebo likely reduce overall pain and dysmenorrhoea and may reduce pelvic pain. Compared with other hormonal suppression strategies, the evidence is less certain due to the small number of studies for each comparison and outcome. Despite such limitations, this update provides a comprehensive overview and valuable insights on progestagen treatment for endometriosis, emphasising the nuanced balance between efficacy, adverse effects, and patient satisfaction."

Clinical • Journal • Review • Endometriosis • Gynecology • Long-acting Reversible Contraceptives • Musculoskeletal Pain • Pain • Women's Health

Early-third-trimester uterine rupture in an unscarred primigravida with a didelphic uterus: a case report. (PubMed, J Med Case Rep) - "Uterine didelphys is rarely associated with early-third-trimester pre-labor uterine rupture, but when it occurs, it results significant feto-maternal comorbidity. Therefore, it is advisable to screen every primigravida mother for uterine anomalies in addition to performing fetal anatomical scans in the early trimester. This is crucial because the complications associated with this anomaly can be unexpected and may lead to maternal and fetal morbidity and mortality due to delayed treatment."

Journal • Critical care • Gynecology • Hematological Disorders • Obstetrics

CONTRACEPTIVE ONE-ROD IMPLANTS REMOVALS: A SIMPLE AND QUICK PROCEDURE IN A FAMILY PLANNING CLINIC (FIGO 2025) - " We conducted a cross-sectional study with women requesting etonogestrel (ENG) implant removal (Implanon NXT, Organon, Oss, The Netherland)... ENG implant removal is a simple and quick procedure in most cases, with both physicians and patients reporting low levels of difficulty and minimal pain, respectively. There is no difference in the difficulty or pain reported by patients according to HCP's training. Removal challenges were observed in cases involving non-palpable implants or implants surrounded by fibrotic tissue."

Fibrosis • Immunology • Long-acting Reversible Contraceptives

IMPLANET Clinical Trial: Norethisterone for prolonged bleeding in etonogestrel implant users (FIGO 2025) - P4 | "NETA (10 mg/day) effectively stops prolonged bleeding from ENG implants, marking the first randomized trial demonstrating progestin efficacy for this indication. Name of public trials registry in which the study has prospective registration: Treatment of Prolonged Uterine Bleeding of Etonogestrel (ENG)-Releasing Implant. URL of registration: https://clinicaltrials.gov/study/NCT04047875."

Clinical • Infectious Disease

Pharmacogenomics of the Etonogestrel Contraceptive Implant: A Genome-Wide Association Study of Steady-State Etonogestrel Concentrations. (PubMed, O G Open) - P=N/A | "Despite enhanced coverage for known pharmacogenomic variants, we found no significant associations between interindividual variability in contraceptive implant pharmacokinetics and genetic loci directly involved in exogenous steroid hormone metabolism."

Biomarker • Journal • Long-acting Reversible Contraceptives • CCDC88C • CHRNA9 • RNF114 • SYNE1

How to detect and remove deep or nonpalpable contraceptive implants ? A technical note. (PubMed, J Gynecol Obstet Hum Reprod) - "Despite modifications to the inserter and insertion site, the prevalence of deep implants is still estimated at 1/1000. In this technical note, we describe strategies for safely locating and removing deep implants."

Journal • Long-acting Reversible Contraceptives

Safety and effectiveness of contraception among women with solid organ transplants: an updated systematic review. (PubMed, Contraception) - "While limited, this evidence can be used by health care providers and women with solid organ transplants in counseling and shared decision-making about contraception. Further studies are needed to address concerns about contraceptive use among women with transplants, such as the risk of thrombosis and other cardiovascular risks with hormonal contraceptive use."

Journal • Review • Cardiovascular • Hematological Disorders • Infectious Disease • Long-acting Reversible Contraceptives • Solid Organ Transplantation • Thrombosis • Transplantation

Norethisterone for Prolonged Uterine Bleeding Associated with Etonogestrel Implant (IMPLANET): A Randomized Controlled Trial. (PubMed, Am J Obstet Gynecol) - "Short-term use of 10 mg/day NETA effectively and safely stopped prolonged bleeding in etonogestrel implant users. However, it does not prevent bleeding recurrence."

Journal • Infectious Disease • Women's Health

Atypical Neuropathic Symptoms Following Nexplanon: Possible Role of Edema-Induced Nerve Compression. (PubMed, Cureus) - "Although typical adverse events include localized pain and nerve irritation along specific dermatomes, diffuse neuropathic symptoms are uncommon. This case report suggests that subclinical edema-induced nerve compression, often accompanied by an inflammatory response, may contribute to such atypical presentations."

Journal • Inflammation • Long-acting Reversible Contraceptives • Neuralgia • Pain

Removal of 2-Rod Subdermal Implant Identified on X-Ray: A Case Report. (PubMed, Clin Case Rep) - "Case report of a 37-year-old Colombian patient seeking removal of a subdermal implant, initially believed to be the single-rod Nexplanon implant. However, following extraction, it was identified as the 2-rod international subdermal implant alternative, Jadelle. This case highlights the need for US health care providers to be cognizant of non-US subdermal alternatives given the rising presence of foreign-born patients they may encounter in their practice."

Journal • Long-acting Reversible Contraceptives

SCD CURE: Effects of the Contraceptive Implant in Women With Sickle Cell Disease (clinicaltrials.gov) - P4 | N=22 | Recruiting | Sponsor: University of Pennsylvania | Trial completion date: Jun 2025 ➔ Jun 2026 | Trial primary completion date: Jun 2025 ➔ Jun 2026

Trial completion date • Trial primary completion date • Genetic Disorders • Hematological Disorders • Long-acting Reversible Contraceptives • Sickle Cell Disease

Body Composition and Sport Performance Among Young Female Soccer Players Using Subdermic Etonogestrel (clinicaltrials.gov) - P1 | N=40 | Suspended | Sponsor: Maíta Poli de Araújo | Not yet recruiting ➔ Suspended

Trial suspension