velneperit (S-2367) / Shionogi - LARVOL DELTA

S2367: Mediastinal Biopsies Made Eas(ier) (CAP 2023) - "4. Develop a morphologic, immunophenotypic, and potentially molecular approach to spindle cell neoplasms in the mediastinum."

Biopsy • Endocrine Cancer • Germ Cell Tumors • Hematological Malignancies • Lymphoma • Neuroendocrine Tumor • Oncology • Solid Tumor • Spindle Cell Sarcoma • Thymic Carcinoma • Thymoma • Thymus Cancer

Whole-Genome Sequencing Elucidates the Epidemiology of Multidrug-Resistant Acinetobacter baumannii in an Intensive Care Unit. (PubMed, Front Microbiol) - "MLST identified 12 unique sequence types, a novel ST (ST2367) was founded...Our results demonstrated that WGS was a discriminatory technique for epidemiological healthcare-infection studies. The technique should greatly benefit the identification of epidemic situations and controlling transmission events in the near future."

Clinical • Journal • Critical care • Infectious Disease

Loss of SPEG Inhibitory Phosphorylation of RyR2 Promotes Atrial Fibrillation. (PubMed, Circulation) - "Studies in S2367 knock-in mouse models showed a causal relationship between reduced S2367 phosphorylation and AF susceptibility. Thus, modulating SPEG activity and phosphorylation levels of the novel S2367 site on RyR2 may represent a novel target for AF treatment."

Journal • Atrial Fibrillation • Cardiovascular

New and emerging drug molecules against obesity (J Cardiovasc Pharmacol Ther) - PMID: 24064009; “Cetilistat, a lipase inhibitor is claimed to have superior safety profile to orlistat...have limited success in early clinical development include velneperit, tesofensine, and beloranib .Tesofensine is a triple monoamine re-uptake inhibitor, velneperit acts as a neuropeptide Y5 receptor antagonist and beloranib is a methionine amino peptidase 2 inhibitor.”

Review • Obesity

Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain: An Experimental and Clinical Genetic Study. (PubMed) - "This study demonstrated that CTSG is a pronociceptive mediator in both animal model and human study. CTSG represents a new target for pain control and a potential marker to predict patients who are prone to develop chronic pain after surgery."

Journal • Biosimilar • Immunology • Inflammation • Pain

Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population. (PubMed) - Am J Med Genet B Neuropsychiatr Genet - "Our results confirmed that NRG1 was a shared common susceptibility gene for major mental disorders in Han Chinese population."

Journal • Biosimilar • Depression • Schizophrenia

Shionogi: R&D Meeting (Shionogi) - Anticipated go/no-go decision for P3 trial in Japan for obesity in FY 2013

Anticipated new P3 trial • Anticipated trial initiation date • Obesity

Proteomic and Membrane Lipid Correlates of Reduced Host Defense Peptide. (PubMed, Antibiotics (Basel)) - "Surprisingly, the mutant showed differential regulation of only a single protein when cultivated aerobically (FadB), and only a small number of proteins under anaerobic growth conditions (AdhE, DapE, Ddh, Ald1, IlvA1, AgrA, Rot, SA2366, and SA2367). Corresponding to FadB impact on lipid remodeling, membrane fatty acid analyses showed that the snoD mutant contained more short chain anteiso-, but fewer short chain iso-branched chain fatty acids under both aerobic and anaerobic conditions vs. the parental strain. Based upon these proteomic and membrane compositional data, a hypothetical "network" model was developed to explain the impact of the snoD mutation upon tPMP susceptibility."

Journal