Caldolor (ibuprofen) / Grifols, Cumberland - LARVOL DELTA

IV meloxicam returns for treatment of pain. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Pain

Intravenous acetaminophen/ibuprofen (Combogesic IV). (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Pain

Comparison of intravenous ibuprofen pharmacokinetics between Caucasian and Chinese populations using physiologically based pharmacokinetics modeling and simulation. (PubMed, Eur J Pharm Sci) - "This study indicates that the pharmacokinetic profile and the parameters of intravenous ibuprofen are analogous in Caucasian and Chinese populations, either adults or children. In addition, this study provides effective evidence that the dosing scheme of intravenous ibuprofen in Chinese children can remain the same as the regimen that the original company (Caldolor®) provided."

Journal • PK/PD data • Pain • Pediatrics

"$CPIX CALDOLOR® NOW FDA APPROVED FOR TREATMENT OF FEVER & PAIN IN INFANTS #FDAapproval#StockMarket #trading https://t.co/nfrl7u3GC0" (@stock_titan)

FDA event • Pain

Comparison of the Analgesic Effects of Scalp Nerve Block and Intravenous Ibuprofen Applications Under the Guidance of Nociception Level Index (NoL) in Patients Undergoing Elective Supratentorial Craniotomy (clinicaltrials.gov) - P4 | N=102 | Recruiting | Sponsor: Ankara University

New P4 trial • Oncology • Pain • Solid Tumor

[VIRTUAL] Preliminary Results of a Phase II Study to Determine the Safety of Defibrotide in Children and Adolescents with Sickle Cell Disease-Associated Acute Chest Syndrome (IND 127812) (ASH 2020) - P2 | "There was no evidence of hemorrhage in any patient despite four patients receiving concomitant ketorolac or ibuprofen...Further accrual is needed to determine clinical significance of improvements in cardiac and/or pulmonary function. This study was funded in part by a grant from Jazz Pharmaceuticals."

Clinical • P2 data • Allergy • Genetic Disorders • Hematological Disorders • Hematological Malignancies • Hypertension • Infectious Disease • Leukemia • Novel Coronavirus Disease • Oncology • Pain • Pulmonary Arterial Hypertension • Sickle Cell Disease • Transplantation • ANGPT2 • CD31 • FLT1 • IL6 • TNFA

3 ways you may be able to boost your vaccine response - "'Get a vaccine when it is most convenient to you. Immune cells circulate around the body 24/7. But if you can prioritize getting it in the morning, you may get a small advantage,' said Chin-Hong....'Both Tylenol and NSAIDs like ibuprofen may prevent inflammation and theoretically reduce the ability of the immune system to respond to a vaccine,' said Chin-Hong."

Media quote • Novel Coronavirus Disease

Pilot Study to Collect and Evaluate Data on the Use of IV* Ibuprofen in the Treatment of an Acute Migraine Attack (clinicaltrials.gov) - P4 | N=44 | Completed | Sponsor: Thomas Jefferson University | Unknown status ➔ Completed | N=120 ➔ 44

Enrollment change • Trial completion • CNS Disorders • Migraine

Angioedema During Elective Outpatient Procedure (ASA 2022) - "History significant for rash/itching from multiple substances ( peanuts, Percocet, chlorhexidine, Latex, sea cucumber) without history of edema/swelling...Patient had received Cefazolin, Caldolor, Rocuronium as part of their intraoperative care. Patient was given Dexamethasone and transported to PACU while intubated and sedated with Dexmedetomidine. Patient was able to be extubated later that day."

Clinical • Cardiovascular • Gastroenterology • Pruritus

Nonopioid drugs for pain. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Immunology • Neuralgia • Osteoarthritis • Pain • Rheumatology

Comparison table: Some nonopioid analgesics for pain. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Pain

"$CPIX Caldolor® Now FDA Approved For Pre-Operative Administration https://t.co/6kLcGJRQKl #fdaapproval" (@stock_titan)

FDA event

Ibuprofen and ulcers: What Rep. Debbie Dingell’s emergency surgery can teach us (The Washington Post) - "Stress also is not widely believed by experts to have a significant effect on ulcer formation, and research hasn't presented conclusive findings. 'It's very hard to measure stress and identify that as the cause for ulcers,' said Marie Borum...About 2 to 10 percent of ulcer patients will experience a perforated ulcer, which often manifests as 'acute, severe and diffuse abdominal pain,' Borum said."

Media quote

[VIRTUAL] Utilization of brentuximab vedotin desensitization protocol after a severe allergic reaction (ASHP 2020) - "After being diagnosed with stage 4 Hodgkin’s lymphoma, the patient received 6 cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine regimen over a 6-month period. The patient was then determined to have refractory disease and received 4 cycles of bendamustine and brentuximab vedotin as salvage therapy...For both desensitization therapies, the patient required pre-medication administrations of acetaminophen, famotidine, diphenhydramine, methylprednisolone, and a selective 5-hydroxytryptamine receptor antagonist. Additional acetaminophen, diphenhydramine, ibuprofen and calcium carbonate was requested by the patient for symptom control...The patient is scheduled for a 12-month follow-up computed tomography scan to detect signs of recurrent lymphoma. This case demonstrated successful utilization of brentuximab vedotin desensitization protocol."

Clinical • Allergy • Atrial Fibrillation • Cardiovascular • Critical care • Fatigue • Hematological Disorders • Hematological Malignancies • Hodgkin Lymphoma • Hypotension • Immunology • Infectious Disease • Lymphoma • Oncology • Pain • Pneumonia • Pruritus • Respiratory Diseases • Septic Shock • Thrombocytopenia • Transplantation • TNFRSF8

Impact of a multimodal analgesic protocol modification on opioid consumption after cesarean delivery: a retrospective cohort study. (PubMed, J Matern Fetal Neonatal Med) - "There was a significant decrease in the need for and the dose of rescue opioid medications with the new protocol. This highlights the importance of optimizing the choice of agents, as well as route and timing of administration of the components of the postoperative multimodal analgesic regimen."

Journal • Retrospective data • Anesthesia • Gynecology • Obstetrics • Pain

Efficacy and Safety of Ibuprofen Plus Paracetamol in a Fixed-Dose Combination for Acute Postoperative Pain in Adults: Meta-Analysis and a Trial Sequential Analysis. (PubMed, CNS Drugs) - "The ibuprofen plus paracetamol FDC is conclusively an effective analgesic against placebo in acute postoperative, moderate to severe pain in adults. It is also superiorly well tolerated, including at the higher dose of 292.5-400 mg ibuprofen/975-1000 mg paracetamol; however, safety outcomes were inconclusive. Future studies need to confirm the safety of FDC and its benefits against other marketed analgesics in postoperative pain."

Journal • Retrospective data • Pain • Pediatrics

Therapeutic Potential of Russelioside B as Anti-Arthritic Agent in Freund's Adjuvant-Induced Arthritis in Rats. (PubMed, J Ethnopharmacol) - "These findings suggested that the anti-arthritic effect of RB was mediated through the reduction of the rheumatoid markers, anti-inflammatory and antioxidant action, inhibition of cartilage and bone degenerative enzymes as well attenuation of bone loss and osteoclastogenesis."

Journal • Immunology • Inflammatory Arthritis • Osteoporosis • Rheumatoid Arthritis • Rheumatology • IL1B • IL6 • MPO • NFKB1 • TNFA

Cost-effectiveness of Oral Versus Intravenous Ibuprofen Therapy in Preterm Infants With Patent Ductus Arteriosus in the Neonatal Intensive Care Setting: A Cohort-based Study. (PubMed, Clin Ther) - "This is the first cost-effectiveness evaluation of oral versus intravenous formulations of ibuprofen among infants with PDA. The oral ibuprofen might be associated with an enhanced ductal closure at a considerably lower cost. The study results support recent trends in neonatal intensive care unit practices in favor of the oral administration of ibuprofen."

HEOR • Journal • Critical care

The Mediation of Central Cyclooxygenase and Lipoxygenase Pathways in Orexin-Induced Cardiovascular Effects. (PubMed, Brain Res) - "Interestingly, central pretreatment with a non-selective COX inhibitor, ibuprofen, or a non-selective LOX inhibitor, nordihydroguaiaretic acid, partially reversed pressor and tachycardic cardiovascular responses evoked by central administration of OX. In summary, our findings show that the central treatment with OX causes pressor and tachycardic cardiovascular responses along with an increase in posterior hypothalamic extracellular total prostaglandin concentrations. Furthermore, our results also demonstrate that central COX and LOX pathways mediate, at least in part, centrally administered OX-evoked pressor and tachycardic responses, as well."

Journal • Cardiovascular

An integrated study of metabolomics and transcriptomics to reveal the anti-primary dysmenorrhea mechanism of Akebiae Fructus. (PubMed, J Ethnopharmacol) - "Akebiae Fructus could effectively alleviate the symptoms of primary dysmenorrhea, regulate metabolic disorders, and control the related gene expression in primary dysmenorrhea. The study may provide clues for further study of Akebiae Fructus treatment on primary dysmenorrhea."

Journal • Immunology • Inflammation • Metabolic Disorders • Pain • Women's Health • CLU

Opioid-free multimodal analgesia pathway to decrease opioid utilization after cesarean delivery. (PubMed, J Obstet Gynaecol Res) - "MAP Implementation after CD significantly reduced inpatient and outpatient opioid consumption compared to pre-MAP results while maintaining high patients' satisfaction with pain control."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Pain • Psychiatry

[VIRTUAL] Combination use of IV acetaminophen and ibuprofen for patent ductus arteriosus closure in neonates (ASHP 2020) - "Patient data collected will include: patient gestational age, corrected age, gender, weight, acetaminophen dosage, ibuprofen dosage, duration of therapy, indication for use (diagnosis), ductus arteriosus size before and after therapy, grade of intraventricular hemorrhage (IVH), laboratory values before and during treatment (serum creatinine, urine output, AST, ALT, and platelet count) to monitor for adverse effects of therapy, co-morbidities, and necessity of advanced treatment. This data will be assessed utilizing appropriate descriptive and/or inferential statistics."

Hematological Disorders • Hepatology

[VIRTUAL] Comparison of acetaminophen versus ibuprofen for closure of patent ductus arteriosus (PDA) in preterm infants (ASHP 2020) - "Purpose: Standard PDA treatments include indomethacin and ibuprofen... Acetaminophen is a reasonable treatment option for PDA closure in preterm neonates and may have a more favorable side effect profile when compared to ibuprofen. Further research should be conducted in order to determine the impact of early initiation of treatment."

Critical care • Gastrointestinal Disorder • Renal Disease

[VIRTUAL] Retrospective review of indomethacin versus acetaminophen for patent ductus arteriosus: a single center study (ASHP 2020) - "Historically, indomethacin and ibuprofen have been used for closure, but acetaminophen can also be used...We estimate the resolution of hsPDA for intravenous indomethacin to be 40%. A sample size of 162 treatment courses was calculated to detect a 20% between group difference with 80% power."

Retrospective data • Review • Gastrointestinal Disorder • Hematological Disorders • Retinal Disorders • Retinopathy of Prematurity • Thrombocytopenia

[VIRTUAL] Inpatient and Outpatient Opioid Use in Colorectal Surgery Patients (ASHP 2020) - "Multi-modal therapy (acetaminophen, methocarbamol, ibuprofen, naproxen, gabapentin, and others) was prescribed to 89.6% of patients at time of discharge... During hospitalization, a patient's pain is more acute in the immediate post- operative period. Patients received a multimodal approach to their pain control in order to target a variety of pain receptors; however, a large back bone was the opioid therapy they received. Limiting the number of prescribed inpatient and outpatient opioids will reduce inappropriate use, dependence, and the potential for overdose."

Clinical • Addiction (Opioid and Alcohol) • CNS Disorders • Pain