brimonidine tartrate / Generic mfg. - LARVOL DELTA

A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression (clinicaltrials.gov) - P2 | N=108 | Active, not recruiting | Sponsor: AbbVie | Recruiting ➔ Active, not recruiting | Trial completion date: Jun 2027 ➔ Feb 2027 | Trial primary completion date: Jun 2026 ➔ Feb 2027

Enrollment closed • Platinum resistant • Platinum sensitive • Trial completion date • Trial primary completion date • Breast Cancer • Oncology • Ovarian Cancer • Solid Tumor • BRCA • FOLR1

Latanoprost Acid-Brimonidine, a New Amide Prodrug for Glaucoma Management Based on the Concept of Sustained Release. (PubMed, Molecules) - "In the presence of esterase (0.4 U/mL), the hydrolysis times of LP and LBJ were 4 h and 28 days, respectively. The prolonged hydrolysis time results in sustained APIs release, which is beneficial for the development of a sustained drug release system."

Journal • Glaucoma • Ophthalmology

Efficacy and Safety of Aceclidine in Presbyopia, a Systematic Review and Meta -Analysis. (PubMed, Semin Ophthalmol) - "In the primary analysis of parallel-group trials, aceclidine significantly increased the likelihood of achieving a ≥ 3-line improvement in distance-corrected near visual acuity compared with placebo (RR 6.28, 95% CI 4.22-9.35; I2 = 2.4%) and compared with aceclidine plus brimonidine (RR 5.05, 95% CI 3.04-8.38; I2 = 28.2%). Monotherapy may offer slight efficacy benefits over combination regimens. However, limited study numbers and short follow-up necessitate further large-scale, long-term trials."

Journal • Review • Ophthalmology

An E-interwoven Therapeutic Contact Lens System for Rapid Drug Delivery and Precision Dose Monitoring. (PubMed, Adv Mater) - "A frequency-matching strategy boosts voltage coupling to drive a brimonidine tartrate-loaded hydrogel to achieve high concentrations in the aqueous humor in 20 min, significantly faster than topical eye drops...In acute glaucoma rabbit models, this SCL suppresses peak IOP elevation by 85.7% compared to eye drops. This SCL presents a highly integrated therapeutic platform demonstrating potential for rapid and precise glaucoma treatment."

Journal • Glaucoma • Ophthalmology

Real-world effectiveness and safety of a fixed-dose combination of 0.4% ripasudil and 0.1% brimonidine in the management of uveitic glaucoma. (PubMed, Jpn J Ophthalmol) - "This real-world study in patients with UG showed that RBFC achieves effective IOP control while reducing treatment burden, with good tolerability, supporting its continued use in UG management."

Journal • Real-world evidence • Glaucoma • Ocular Inflammation • Ophthalmology • Uveitis

Diluted brimonidine for improving early postoperative symptoms and subconjunctival hemorrhage after PRK and LASIK. (PubMed, Arq Bras Oftalmol) - "Preoperative administration of low-concentration brimonidine (0.025%) significantly reduced subconjunctival hemorrhage in laser-assisted in situ keratomileusis without comprising flap integrity. It also improved early postoperative symptoms in laser-assisted in situ keratomileusis and photorefractive keratectomy, without affecting pupil diameter. These findings support the use of dilute brimonidine as a safe and effective adjunct to enhance the immediate postoperative experience in refractive surgery."

Clinical • Journal • Hematological Disorders

Peripheral nodulocystic corneal degeneration: a case report. (PubMed, Am J Ophthalmol Case Rep) - "She declined superficial keratectomy, and her symptoms improved with topical cyclosporine, perfluorohexyloctane, and brimonidine...This case highlights a unique presentation of corneal degeneration and cause of peripheral corneal bullae. The interplay between corneal degeneration, systemic inflammatory disease, and prior refractive surgery warrants further investigation."

Journal • Inflammation • Musculoskeletal Pain

Oral Clonidine and Brimonidine Eye Drops Attenuated Sertraline Discontinuation Symptoms. (PubMed, Biol Psychiatry) - No abstract available

Journal

Diastereoselective and green synthesis of novel Hexahydro Imidazo [1,2-a] pyrimidine, from Azlactones, Brimonidine and Clonidine. (PubMed, Sci Rep) - "Their structures were confirmed by single-crystal X-ray crystallography, as well as IR, 1H NMR, 13C NMR spectroscopy, and LCMS analysis. Surprisingly, this reaction was diastereoselective, yielding cis-imidazo[1,2-a]pyrimidines 4b-g and trans-imidazo[1,2-a]pyrimidines 6a-g in cyclocondensation reaction of brimonidine 1 or clonidine 2 with azlactones 3a-g, respectively."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Glaucoma • Hypertension • Ophthalmology • Psychiatry

Prognostic factors associated with visual field recovery in non-arteritic anterior ischemic optic neuropathy. (PubMed, PLoS One) - "No significant association was observed between topical eye drop treatment, including brimonidine and netarsudil, and visual field recovery (p = 0.723). However, RNFL thickness measured at initial visit by OCT did not reliably predict recovery. These findings highlight that baseline functional status remain as the most important predictor of visual field recovery in NAION."

Biomarker • Journal • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain

Loss of Consciousness in a Child Following Accidental Ingestion of Brimonidine Ointment: A Case Report. (PubMed, Clin Case Rep) - "Clinicians should maintain a high index of suspicion in toddlers presenting with unexplained drowsiness following exposure. Prompt airway management and supportive care are critical, as naloxone may improve symptoms in these cases."

Journal • CNS Disorders • Depression • Ophthalmology • Pediatrics • Psychiatry

The Prophylactic Effect of Dexmedetomidine 0.008% Versus Brimonidine 0.2% on IOP Elevation After Nd: YAG Laser Capsulotomy. (PubMed, Pharmacol Res Perspect) - "Brimonidine and apraclonidine are widely used to prevent such elevations. Although dexmedetomidine prevented acute IOP surges, its efficacy was inferior to brimonidine. Further studies should explore optimal dosing, formulations, and long-term safety to clarify its prophylactic potential."

Clinical • Journal • Cardiovascular • Cataract • Glaucoma • Ophthalmology

Clinical Microbial Contamination of Multidose Brimonidine: A Prospective Comparison of Benzalkonium Chloride and Purite® Preservatives. (PubMed, J Ophthalmol) - "In our study, no statistically significant difference was observed between BAK-MDB and PUR-MDB in terms of microbial contamination in caps, first and second drops. The exploratory association between education level and contamination risk will need to be confirmed in larger, adequately powered prospective studies."

Journal • Glaucoma • Ophthalmology

Upneeq vs. Lumify Ptosis (clinicaltrials.gov) - P4 | N=50 | Not yet recruiting | Sponsor: Duke University | Trial completion date: Dec 2026 ➔ Dec 2027 | Initiation date: Mar 2026 ➔ Dec 2026 | Trial primary completion date: Aug 2026 ➔ Aug 2027

Trial completion date • Trial initiation date • Trial primary completion date

Brimonidine Attenuates Choroidal Thinning and Hypoperfusion in Guinea Pigs with Form-Deprivation Myopia: Involvement of NOS and TGF-β1. (PubMed, Eur J Pharmacol) - "Brimonidine showed anti-myopic effects by preserving choroidal thickness and perfusion in FDM guinea pigs, potentially through suppression of the abnormally elevated expression of NOS, TGF-β1, and α-SMA in the choroid. These findings offer new insights and therapeutic targets for pharmacological prevention and control of myopia."

Journal • Ophthalmology • NOS3 • TGFB1

A Neurotensin-Based Targeted Nanosphere Platform for Treating Ocular Hypertension (ARVO 2026) - "Common clinical treatments, including Alphagan and various doses given topically or by injection, did not produce the same fast effect. Overall, these results suggest that our targeted nanospheres may offer a new way to quickly lower eye pressure and potentially protect vision-critical cells from damage."

Glaucoma • Ophthalmology • TGFB1 • TNS1

Fan-shaped secondary lipid keratopathy: clinical features, etiologies, and treatment outcomes (ARVO 2026) - "Etiologies included herpetic keratitis (n=5), brimonidine tartrate (BT) use (n=6), and two cases were classified as unexplained...The two-domain severity scoring system effectively differentiates reversible inflammatory activity from irreversible structural damage and captures differential responses to medical versus surgical treatment. This practical framework offers a consistent method for tracking disease progression and supports tailored treatment strategies in this uncommon yet vision-threatening disorder."

Clinical • Keratitis • Ocular Inflammation • Ophthalmology

A novel alpha2-adrenergic receptor agonist, BL1106, has structural and functional benefits in a blue light model of retinal degeneration (ARVO 2026) - "These findings corresponded with improved ERG function in animals that received BL1106, but not brimonidine on day 14 post-exposure compared to vehicle controls. Conclusions A novel alpha-2 adrenergic agonist, BL1106, preserves retinal thickness and ERG function in a blue light model of retinal degeneration, suggesting its potential as a promising future therapeutic for AMD."

Age-related Macular Degeneration • Dry Age-related Macular Degeneration • Macular Degeneration • Ophthalmology • Retinal Disorders

A Phase 3 Randomized Trial of a Novel Brimonidine Tartrate Ophthalmic Solution With Sodium Hyaluronate (ARVO 2026) - "Side effects were mild and similar between groups. Overall, adding sodium hyaluronate did not reduce effectiveness or safety, offering redness relief in a formulation that may be preferred by some consumers."

Clinical • P3 data • Ophthalmology

Aqueous Column Changes in the Episcleral Veins after Instillation of a Fixed-dose Combination of Ripasudil 0.4% and Brimonidine Tartrate 0.1% (GLAALPHA) (ARVO 2026) - "Conclusions Instillation of GLAALPHA produced a significantly greater increase in aqueous column width in the episcleral veins compared with Ailamide. These findings suggest that GLAALPHA enhances aqueous outflow through the trabecular conventional pathway."

Ophthalmology

Engineered Brimonidine Tartrate Aminosomes as a Mucoadhesive Platform for Sustained Glaucoma Management: Optimization, In Vitro Characterization, and In Vivo Evaluation. (PubMed, Pharmaceutics) - "Non-compartmental pharmacodynamic analysis of IOP-reduction data revealed a 2.8-fold increase in AUC0-24h, 3.5-fold extension in t1/2, and 5.2-fold prolongation in mean residence time (MRT) relative to the standard solution. The optimized Aminosomes demonstrated superior mucoadhesive anchoring, enhanced and sustained therapeutic flux without inducing ocular toxicity, offering a robust strategy for enhancing the pharmacodynamics of BT."

Journal • Preclinical • Glaucoma • Ophthalmology

Acute Intraocular Pressure Elevation During Hemodialysis in a Patient with Glaucoma: A Case Highlighting the Need for Prompt Recognition and Surgical Intervention (NKF-SCM 2026) - "On admission, treatment was geared towards use of acetazolamide with increase in dosing until intraocular goal pressure is achieved...Maximal medical therapy (latanoprost, cosopt, brimonidine, pilocarpine, prednisolone, atropine) reduced IOP to 58 mmHg...Timely surgical intervention preserved eyesight and avoided delays in hemodialysis, emphasizing interdisciplinary management between nephrology and ophthalmology for at-risk patients. Intra-HD tonometry allowed us to ascertain the diagnosis, expedite surgery and monitor the efficacy of the surgical intervention."

Clinical • Cardiovascular • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Diabetic Nephropathy • Diabetic Retinopathy • Glaucoma • Hypertension • Immunology • Nephrology • Ophthalmology • Renal Disease • Respiratory Diseases • Retinal Disorders

Efficacy of ripasudil-brimonidine fixed-dose combination in secondary glaucoma associated with uveitis: a retrospective study. (PubMed, Jpn J Ophthalmol) - "RBFC was associated with significant IOP reduction in eyes with uveitis-associated or steroid-induced OH, without compromising visual function. These findings suggest that RBFC may be a useful therapeutic option for inflammation-related secondary glaucoma."

Journal • Retrospective data • Cardiovascular • Conjunctivitis • Glaucoma • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Uveitis

Brimonidine Therapy for Protection From Noise-Induced Hearing Loss. (PubMed, Aging Cell) - "Mice exposed to noise could temporarily restore their hearing thresholds; however, their auditory function in old age remained significantly worse than those that received brimonidine-mediated cochlear protection in youth. These findings highlight the importance of enhancing noise protection from an early age."

Journal • Otorhinolaryngology

Identification of Brimonidine as a Novel Substrate of Organic Cation Transporters OCT2 and MATE1 Expressed in Human Eye. (PubMed, Invest Ophthalmol Vis Sci) - "Both OCT2 and MATE1 were expressed in the cornea, the conjunctiva, and the ciliary body. These results imply that OCT2 and MATE1 may play a role in brimonidine uptake into the human eye and may contribute to the interindividual variability of brimonidine concentrations and effects."

Journal • Cardiovascular • Glaucoma • Ophthalmology • SLC22A1 • SLC22A2