Natesto (testosterone) / Acerus, Medac, Hyundai Pharm, Eu Hwa Pte LTD, Aytu BioPharma - LARVOL DELTA

Trabecular bone score (TBS) in women with primary ovarian insufficiency (POI) and its correlation with bone mineral density. (ISGE 2026) - "All 7 primary amenorrhea had osteoporosis (spine T score <-2.5) and had TBS<1.2 and 1.2-1.35 in 3 and 4 women respectively... TBS is emerging as a complimentary tool in evaluation of osteoporosis as it assesses bone architecture and compliments fracture risk assessment by DEXA scan. The combination of BMD measurement by DEXA and TBS have the potential for early assessment of poor bone health in women with POI. Timely diagnosis, counseling, and intervention may alleviate some of these consequences."

Clinical • Chronic Kidney Disease • Endocrine Disorders • Musculoskeletal Diseases • Nephrology • Orthopedics • Osteoporosis • Renal Disease • Women's Health

Plasticity-Inducing Percutaneous Peripheral Nerve Stimulation for Treating Neck Pain: A Blinded, Randomised Clinical Trial. (PubMed, Eur J Pain) - P=N/A | "Plasticity-inducing protocols applied through percutaneous peripheral nerve stimulation are an effective non-pharmacological treatment. They represent a clinically relevant option for pain management that could influence clinical practice as well as future fundamental and clinical research."

Clinical • Journal • Musculoskeletal Pain • Pain • TNS3

Improvement of Mechanical Properties and Electrical Resistivity in Giant Magnetostrictive Tb-Dy-Fe Alloy via Co-Addition of Al and Si Elements. (PubMed, Materials (Basel)) - "Microstructural characterization revealed that Al partially substitutes Fe atoms in the matrix phase while promoting Al(Tb,Dy)Fe2 nanocluster, whereas Si preferentially segregated to grain boundary regions forming Tb2Si3 and TbSi1.75 phases...Accompanied by enhancement of mechanical property and electrical resistivity, TDF-AlSi alloy maintained a high magnetostriction strain of 1212 ppm (200 kA/m, 10 MPa pre-compressive stress). The findings of the present study offer valuable theoretical and experimental insights with regard to the optimization of the performance of magnetostrictive Tb-Dy-Fe alloys."

Journal • Musculoskeletal Diseases • Orthopedics

Testosterone and Neural Function (clinicaltrials.gov) - P1 | N=15 | Recruiting | Sponsor: VA Office of Research and Development | Trial completion date: Mar 2026 ➔ Sep 2026 | Trial primary completion date: Dec 2025 ➔ Sep 2026

Trial completion date • Trial primary completion date • CNS Disorders • Orthopedics

AAPM MEDICAL PHYSICS PRACTICE GUIDELINE 10.b: Scope of practice for clinical medical physics. (PubMed, J Appl Clin Med Phys) - "This report is an update of MPPG10.a, published in 2018, and provides the current minimum guidelines for the scope of practice for clinical medical physics as it has evolved to meet emerging needs and changes in practice...While must is the term to be used in the guidelines, if an entity that adopts the guideline has shall as the preferred term, the AAPM considers that must and shall have the same meaning. Should and Should Not: Used to indicate a prudent practice to which exceptions may occasionally be made in appropriate circumstances."

Clinical guideline • Journal

Is trabecular bone score associated with appendicular lean mass? (PubMed, Osteoporos Int) - "ALMI was associated with TBS after controlling for age, sex, FMI, and abdominal tissue thickness."

Journal • Musculoskeletal Diseases • Orthopedics • Osteoporosis • Rheumatology • Sarcopenia

Clinical characteristics of patients with SALL1-related disorder. (PubMed, Pediatr Nephrol) - "SALL1-related disorders exhibit broad phenotypic variability. Some cases present with atypical features overlapping with TBS BOR-like syndrome or isolated CAKUT, rather than with typical TBS1. These findings enhance the understanding and diagnosis of SALL1-related disorders."

Journal • Chronic Kidney Disease • Nephrology • Otorhinolaryngology • Renal Disease • AFF1

Efficient preparation and structural characterization of theabrownins from fermented summer green tea with Aspergillus cristatus (MK346334) in submerged fermentation. (PubMed, Food Chem) - "Both TBs1 and TBs2 exhibited good performance in antioxidant activity. This study confirmed the feasibility of the dialysis in TBs preparation and provided further support for the structural and functional study of TBs."

Journal

Protection of naringenin chalcone by a pathogenesis-related 10 protein promotes flavonoid biosynthesis in Marchantia polymorpha. (PubMed, New Phytol) - "Several phenylpropanoid and flavonoid genes were downregulated in Mppr10.5 and Mpchalcone isomerase-like plants. This suggests PR10 proteins promote flavonoid biosynthesis by selectively binding unstable intermediates (NC), protecting them from degradation or undesirable nonenzymatic conversions and facilitating their transport to subsequent pathway steps."

Journal

Natesto Spermatogenesis Reboot (clinicaltrials.gov) - P4 | N=13 | Completed | Sponsor: University of Florida | Recruiting ➔ Completed | N=30 ➔ 13 | Trial completion date: Dec 2024 ➔ Apr 2025 | Trial primary completion date: Dec 2024 ➔ Apr 2025

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Endocrine Disorders

Evaluation of thrombospondin 1 as a novel biomarker in pediatric-onset systemic lupus erythematosus. (PubMed, BMC Pediatr) - "In light of the current data, the efficacy of TBS-1 as a biomarker in pSLE diverged from its performance in adult SLE. In summary, TBS-1 shows potential as a biomarker for pSLE, particularly in hematological manifestations. Further investigations are essential to delve into the immunomodulatory roles of TBS-1 in the autoimmune pathways of pSLE."

Biomarker • Journal • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Pediatrics • Systemic Lupus Erythematosus • THBS1

Exploring the Addition of Mango Peel in Functional Semolina Sourdough Bread Production for Sustainable Bio-Reuse. (PubMed, Antioxidants (Basel)) - "Overall, the MPP-10 bread received a higher score (6.51) than the control (CTR) bread (5.6) and the MPP-5 bread (6.11). The total phenolic content of the fortified breads ranged from 44.760 to 98.931 mg gallic acid equivalents (GAE)/g, and the antiradical activity ranged from 15.213 to 29.461 mmol trolox equivalent antioxidant activity (TEAC)/100 g, depending on the percentage of enrichment."

Journal

Association of Bone Erosion and Microarchitecture with Disease Activity and Damage in Sjögren's Disease (ACR Convergence 2024) - "DXA did not indicate osteopenia or densitometric osteoporosis, with TBS 1.420 ± 0.09... HR-pQCT is a valuable tool for identifying joint erosions and bone microarchitecture changes in SjD patients. Joint erosion is common in SjD. Systemic bone involvement correlates with the disease damage index, highlighting the importance of detailed bone assessment for better management and treatment."

Immunology • Inflammatory Arthritis • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Osteoporosis • Rheumatoid Arthritis • Rheumatology • Sjogren's Syndrome

A CASE OF ANAPHYLAXIS TO CARDIAC ULTRASOUND ENHANCING AGENT (ACAAI 2024) - "She was treated with IM Epinepherine, IV Diphenhydramine and Methylprednisolone...Baseline tryptase was persistently elevated (12- 13ng/mL) and HaT testing revealed an extra-allelic copy of TBSB1. Risk of hypersensitivity reaction with UAEs should be considered in selection of cardiac imaging modalities. Anaphylactic/ anaphylactoid reactions can occur with administration of UAEs in patients without allergy to PEG and should prompt evaluation for conditions predisposing to anaphylaxis, including HaT and systemic mastocytosis."

Clinical • Dermatology • Immunology • Pruritus • Urticaria

Tubulin interaction at tubulin-binding sequence 1 (TBS1) is required for proper surface expression and TRPV1 channel activity. (PubMed, Life Sci) - "Such ligand-sensitivity is altered in response to Taxol or Nocodazole. We demonstrate for the first time the functional significance of TRPV1-tubulin complex and endorse microtubule dynamics as a parameter that can alter TRPV1 channel functions. These findings can be relevant for several physiological functions and also in the context of chemotherapy-induced neuropathic pain caused by various microtubule stabilizing chemotherapeutic drugs Thus, this characterization may indicate TRPV1 as a potential therapeutic target relevant for chemotherapeutic drug-induced peripheral neuropathies, neurodegeneration and other neurological disorders."

Journal • CNS Disorders • Neuralgia • Pain

Trabecular bone score and bone frailty: an Italian observational retrospective study. (PubMed, Minerva Obstet Gynecol) - "Our results seem to suggest that low level of TBS may detect patients that could be more prone to bone frailty consistently with age and BMD at both vertebral and cortical level. However, its role in clinical practice should be refined."

Journal • Retrospective data

A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing. (PubMed, Nucleic Acids Res) - "For the remaining 25 proteins we found that UTP3/SAS10 assists the nucleolar localization of five proteins (MPP10, UTP25, EMG1 and the two UTP-B components UTP12 and UTP13), likely through its interaction with nuclear importin α...Mechanistically, we found that UTP3 facilitates the degradation of processed 5'ETS by recruiting the RNA exosome component EXOSC10 to the nucleolus. These findings lay the groundwork for studying the mechanism of cytoplasm-to-nucleolus trafficking of SSU processome components."

Journal

Multi-scale modelling of location- and frequency-dependent synaptic plasticity induced by transcranial magnetic stimulation in the dendrites of pyramidal neurons. (PubMed, bioRxiv) - "The plasticity modelling framework enables precise simulations of LTP-like cellular effects with high spatio-temporal resolution, enhancing the efficiency of parameter screening and the development of plasticity-inducing rTMS protocols. First rigorously validated model of TMS-induced long-term synaptic plasticity in ex- tended neuronal dendrites that goes beyond point-neuron and mean-field modellingRobust simulations of experimental data on LTP-like plasticity in the proximal dendrites of CA1 hippocampal pyramidal cells evoked by 10 Hz repetitive magnetic stimulation (rMS)Replication of distal synaptic plasticity for a local electrical theta burst stimulation (TBS) protocolPrediction of distal and proximal LTP-like plasticity for rMS TBS1 Hz rMS does not induce long-term depression."

Journal • CNS Disorders • Depression • Psychiatry

Skeletal effects among pre and postmenopausal women with hypoparathyroidism (HypoPT); data from the Canadian National Hypoparathyroidism Registry (CNHR) (ENDO 2024) - "Seven (7/8) were on bisphosphonate therapy (i.e., alendronate), and 3 females were on denosumab...Among PMF (n=48) the mean total hip T-score was -0.20 (SD=1.65), L1-L4 T-score -0.24 (SD=1.88), FN T-score -0.43(SD=1.59), and 1/3R T-score -0.94(SD=1.23).TBS scores in premenopausal women were normal (TBS=1.41(SD=0.10)) however the TBS was partially degraded among PMF (TBS= 1.28(SD=0.15))... The effects of hypoPT on bone strength needs further study2. Our data suggests that bone quality maybe impaired in PMF with hypoPT as noted by the presence of degraded TBS scores and the presence of fragility fracture in this population.Reference 1.Khan AA et al Canadian national hypoparathyroidism registry: an overview of hypoparathyroidism in Canada. Endocrine 2021."

Clinical • Endocrine Disorders • Hypoparathyroidism • Musculoskeletal Diseases • Orthopedics • Renal Disease

Systematic Analysis of the Role of Chromatin Remodeling on Co-Expression of Functionally Related Gene Clusters in Saccharomyces cerevisiae (ASM Microbe 2024) - "The ribosomal biogenesis gene cluster of MPP10 and MRX12 has been dissected thoroughly, with this pair dependent on maintaining their genomic position as neighbors for proper transcriptional coordination with the rest of their gene family...We have identified a previously uncharacterized role for BUR2, CTI1, IES3, and SDS3, in the regulation of the ribosomal biogenesis gene clusters. Our current work is expanding our analysis to integrate and characterize the role of chromatin remodeling of functional clusters during induction of the environmental stress response."

AFF2

Natesto Spermatogenesis Reboot (clinicaltrials.gov) - P4 | N=30 | Recruiting | Sponsor: University of Florida | Trial completion date: Jan 2024 ➔ Dec 2024 | Trial primary completion date: Dec 2023 ➔ Dec 2024

Trial completion date • Trial primary completion date • Endocrine Disorders

The Effects of Natesto For Treatment Of Hypogonadism (clinicaltrials.gov) - P1 | N=0 | Withdrawn | Sponsor: Baylor College of Medicine | N=40 ➔ 0 | Not yet recruiting ➔ Withdrawn

Enrollment change • Trial withdrawal • Endocrine Disorders • Infertility • Sexual Disorders

Reconstruction of medial meniscus posterior portion deficiency in pigs with an autologous patellar tendon graft: an experimental study. (PubMed, J Orthop Surg Res) - "Autologous patellar tendon graft reconstruction of the MMPP can generate a fibrocartilage-like regenerative meniscus. Both reconstruction and pull-out repair can preserve the structural integrity of the meniscus, promote healing of the MMPP, delay meniscal degeneration, and protect the knee cartilage."

Journal • Infectious Disease

Testosterone and Neural Function (clinicaltrials.gov) - P1 | N=15 | Recruiting | Sponsor: VA Office of Research and Development | Not yet recruiting ➔ Recruiting

Enrollment open • CNS Disorders • Orthopedics

Acetylation of transcription factor BpTCP20 by acetyltransferase BpPDCE23 modulates salt tolerance in birch. (PubMed, Plant Physiol) - "Chromatin immunoprecipitation sequencing showed that BpTCP20 binds to NeuroD1, T-box, and two unknown elements (termed TBS1 and TBS2) to regulate target genes...In addition, we identified dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (BpPDCE23), an acetyltransferase that interacts with and acetylates BpTCP20 to enhance its binding to DNA motifs. Together, these results suggest that BpTCP20 is a transcriptional regulator of salt tolerance, whose activity is modulated by BpPDCE23-mediated acetylation."

Journal • DLAT • NEUROD1