levofloxacin / Generic mfg. - LARVOL DELTA

Clinical Impact of Reduced-Dose Levofloxacin Pre-engraftment Bacterial Prophylaxis in Allogeneic and Autologous HCT Recipients at a Single Institution (HOPA 2026) - "Background: Levofloxacin (LQ) is standard for bacterial infection prophylaxis during hematopoietic cell transplant (HCT) related neutropenia. Of 5,135 transplants, 3,093 were unique patient first allogeneic transplant, 1,719 were unique first autologous transplant, and 323 were non-unique second or more HCT. One-year survival was higher for low dose allogenic HCT patients (78% vs 64%, p<0.0001), and 59% in the ITT group, while no LQ use had 69% survival (p<0.0001). Median days to engraftment after allogeneic HCT was 14-15 (range, 0-42)."

Clinical • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Neutropenia

High Levels of Helicobacter pylori Antimicrobial Resistance in Ireland-A Multicentre Study. (PubMed, Microorganisms) - "Antimicrobial susceptibility testing (AST) was performed using Etests for metronidazole, clarithromycin, levofloxacin, amoxicillin, tetracycline and rifampicin and resistance classified using EUCAST guidelines. Clarithromycin-based triple therapy should no longer be used in Ireland in the absence of pre-treatment AST. Resistance to amoxicillin, tetracycline and rifampicin should be monitored closely."

Journal • Infectious Disease

Antimicrobial Susceptibility and Distribution Characteristics of Mycoplasma pneumoniae Isolates in Beijing, China, from 2017 to 2025. (PubMed, Pharmaceuticals (Basel)) - "We used the broth microdilution method to determine the minimum inhibitory concentrations (MICs) of erythromycin, azithromycin, tetracycline, levofloxacin, and moxifloxacin against these isolates. Erythromycin is no longer suitable as an empirical therapy for MP infections during epidemic periods, whereas azithromycin can be cautiously administered in young children according to age stratification and MIC detection results. Meanwhile, it is imperative to strengthen the prevention and control of cluster MP infections during epidemic phases to reduce the transmission of drug-resistant MP strains."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Genetic Characterization and Biofilm-Forming Capacity of Bacterial Population Isolated from Conjunctival Samples. (PubMed, Antibiotics (Basel)) - "The prevalence of multidrug-resistant conjunctival isolates and their biofilm-forming capacity highlights the clinical importance of biofilm-related resistance and support integrating AMR profiling with biofilm assessment to optimize empirical therapy in bacterial conjunctivitis."

Journal • Conjunctivitis • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Multicenter Analytical Performance Evaluation of the BD Phoenix NMIC-461 Panel for Carbapenemase Classification and Antimicrobial Susceptibility Testing of Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp. (PubMed, Antibiotics (Basel)) - "The BD Phoenix NMIC-461 panel provides reliable AST results for commonly encountered Gram-negative bacterial isolates. Regarding carbapenemase detection, the panel demonstrates high sensitivity but only moderate specificity in classifying carbapenemase-producing organisms (CPO), with a relatively high proportion of positive unclassified isolates among Enterobacterales and low specificity for P. aeruginosa. Overall, the implementation of NMIC-461 testing holds promise for significantly reducing turnaround time in both carbapenemase detection and classification."

Journal • Infectious Disease

Phytochemical Characterization and Biological Assessment of Geranium robertianum L. Ethanolic Extract on Human Salivary Gland Carcinoma Cells. (PubMed, Antioxidants (Basel)) - "The GR extract exhibited moderate antibacterial activity against both Gram-positive and Gram-negative bacteria, with inhibition zones generally comparable to those of levofloxacin. However, the extract was significantly less effective against the P. aeruginosa strain. On A253 human salivary gland carcinoma cells, GR extract elicited a dose-dependent antiproliferative effect, produced morphological changes, and increased ROS and both caspase-3/7 and caspase-9 levels."

Journal • Infectious Disease • Oncology • Salivary Gland Cancer • CASP3 • CASP7 • CASP9

MYCOPLASMA IST3 Results and Antimicrobial Susceptibility in PCR-Positive Urine Samples for Ureaplasma spp. (PubMed, Antibiotics (Basel)) - "In addition to intrinsic resistance, acquired antimicrobial resistance in Ureaplasma and Mycoplasma species appears to be increasing; therefore, treatment decisions should be guided by AST whenever feasible. Clinical laboratories should implement appropriate diagnostic methods for these organisms and perform susceptibility testing when indicated to support clinical decision making and optimize antimicrobial selection."

Journal • Infectious Disease • Nephrology

Hemodialysis Central Venous Catheter-Associated Bloodstream Infection Caused by Stenotrophomonas maltophilia Treated with Cefiderocol and Levofloxacin After Failure of Trimethoprim-Sulfamethoxazole Monotherapy and Device Replacement. (PubMed, Antibiotics (Basel)) - "Case presentation: We describe the case of a 55-year-old female patient with a tunneled hemodialysis central venous catheter (HD-CVC)-associated bloodstream infection caused by S. maltophilia that, after failure of a prolonged SXT monotherapy, was successfully treated by HD-CVC replacement followed by intravenous cefiderocol (FDC) and levofloxacin (LVX). FDC represents an interesting option for complex cases of S. maltophilia bloodstream infections, and the combination with LVX might add benefit in cases associated with biofilm formation on intravascular devices."

Journal • Monotherapy • Infectious Disease

Wild-type MIC distribution and evaluation of epidemiological cut-offs of second-line TB-drugs in susceptible and MDR-TB clinical isolates from Chennai, India. (PubMed, Front Microbiol) - "Building on these findings, the present study systematically evaluated the epidemiological cut-off values and pharmacodynamic profiles of newer and repurposed second-line anti-TB drugs - Bedaquiline, Delamanid, Moxifloxacin, Linezolid, Clofazimine, Levofloxacin, and Pretomanid against the first-line drug-sensitive and isolates that are resistant to Rifampicin and Isoniazid from tuberculosis patients in and around Chennai. Concordantly, pharmacodynamic analyses revealed sub-therapeutic exposure ranges for several newer and repurposed anti-TB drugs, underscoring the potential for treatment failure even in strains classified as susceptible. Collectively, these findings highlight the urgent need for regionally calibrated epidemiological cut-off values to optimize drug dosing, improve MDR-TB treatment outcomes, and strengthen resistance surveillance frameworks."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

RISK OF BACTEREMIA IN LEVOFLOXACIN-RESISTANT EXTENDED-SPECTRUM Β-LACTAMASE-PRODUCING ENTEROBACTERALES COLONIZED RECIPIENTS OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT (EBMT 2026) - "ESBL-colonized patients with neutropenic fever received empirical meropenem. Despite high rectal colonization rates (64%) with CTX-M ESBL and fluoroquinolone-resistant Enterobacterales, ESBL-E BSI incidence was low (5%) after allogeneic HSCT in patients who did not receive fluoroquinolone prophylaxis. Acute GVHD and mucositis, beyond colonization alone, probably contributes to dysbiosis and ESBL-E BSI risk."

Acute Graft versus Host Disease • Bone Marrow Transplantation • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Mucositis • Neutropenia • Transplantation

EFFICACY OF PROPHYLACTIC LEVOFLOXACIN IN PEDIATRIC AUTOLOGOUS HEMATOPOITIC CELL TRANSPLANTATION: A SINGLE CENTER, RETROSPECTIVE ANALYSIS (EBMT 2026) - "In this retrospective analysis, the use of prophylactic levofloxacin was associated with a significantly reduced number of days with febrile neutropenia and days requiring empiric IV broad spectrum antibiotic usage from day 0 through engraftment for pediatric patients undergoing auto-HCT. Length of hospitalization was numerically lower in the prophylaxis group, though this did not reach statistical significance. No statistically significant difference was seen in the proportion of patients who developed C. difficile-associated diarrhea or at least one MDRO within 3 weeks of transplant, though C. difficile rates were numerically lower in the prophylaxis group, nearing statistical significance."

Retrospective data • Brain Cancer • CNS Tumor • Febrile Neutropenia • Germ Cell Tumors • Hematological Disorders • Hematological Malignancies • Lymphoma • Neuroblastoma • Neutropenia • Pediatrics • Rhabdoid Tumor • Sarcoma • Solid Tumor • Transplantation

IMPACT OF ANTIBIOTIC USE IN EARLY FEVER AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE (EBMT 2026) - "All patients received PTCY 50 mg/kg on days +3 and +4, followed by tacrolimus and mycophenolate mofetil as graft-versus-host disease (GVHD) prophylaxis...Eleven patients received tocilizumab for CRS grade ≥2. Levofloxacin prophylaxis was used in 72.8%, and empirical BSA in 82.5% (85/103), mainly piperacillin/tazobactam(67%).A microbiological isolate was the primary cause of fever in 8 (7.8%), all catheter-related: three catheter-related bloodstream infections (S... Early fever after haplo-HSCT with PTCY is common and mostly CRS-related. Only a minority of episodes are infectious. However, most patients received empirical BSA, potentially contributing to pathogen selection and subsequent infectious complications."

Post-transplantation • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Infectious Disease • Inflammation • Pneumonia • Transplantation • CRP

EFFICACY OF PROPHYLACTIC LEVOFLOXACIN IN PEDIATRIC AUTOLOGOUS HEMATOPOITIC CELL TRANSPLANTATION: A SINGLE CENTER, RETROSPECTIVE ANALYSIS (EBMT 2026) - "In this retrospective analysis, the use of prophylactic levofloxacin was associated with a significantly reduced number of days with febrile neutropenia and days requiring empiric IV broad spectrum antibiotic usage from day 0 through engraftment for pediatric patients undergoing auto-HCT. Length of hospitalization was numerically lower in the prophylaxis group, though this did not reach statistical significance. No statistically significant difference was seen in the proportion of patients who developed C. difficile-associated diarrhea or at least one MDRO within 3 weeks of transplant, though C. difficile rates were numerically lower in the prophylaxis group, nearing statistical significance."

Retrospective data • Brain Cancer • CNS Tumor • Febrile Neutropenia • Germ Cell Tumors • Hematological Disorders • Hematological Malignancies • Lymphoma • Neuroblastoma • Neutropenia • Pediatrics • Rhabdoid Tumor • Sarcoma • Solid Tumor • Transplantation

ANTIBACTERIAL PROPHYLAXIS IN AUTOLOGOUS STEM CELL TRANSPLANTATION: CEFPODOXIME VERSUS FLUOROQUINOLONES (EBMT 2026) - "Patients received oral cefpodoxime or fluoroquinolone-based prophylaxis (levofloxacin or moxifloxacin) according to institutional practice... Cefpodoxime was non-inferior to fluoroquinolone-based prophylaxis for key clinical outcomes in ASCT recipients. Given increasing safety and resistance concerns related to fluoroquinolones, cefpodoxime represents a reasonable alternative in selected patients. Prospective randomized studies are warranted to confirm these findings."

Hematological Malignancies • Infectious Disease • Nephrology • Neutropenia • Transplantation

RISK OF BACTEREMIA IN LEVOFLOXACIN-RESISTANT EXTENDED-SPECTRUM Β-LACTAMASE-PRODUCING ENTEROBACTERALES COLONIZED RECIPIENTS OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT (EBMT 2026) - "ESBL-colonized patients with neutropenic fever received empirical meropenem. Despite high rectal colonization rates (64%) with CTX-M ESBL and fluoroquinolone-resistant Enterobacterales, ESBL-E BSI incidence was low (5%) after allogeneic HSCT in patients who did not receive fluoroquinolone prophylaxis. Acute GVHD and mucositis, beyond colonization alone, probably contributes to dysbiosis and ESBL-E BSI risk."

Acute Graft versus Host Disease • Bone Marrow Transplantation • Febrile Neutropenia • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Mucositis • Neutropenia • Transplantation

IMPACT OF ANTIBIOTIC USE IN EARLY FEVER AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION WITH POST-TRANSPLANT CYCLOPHOSPHAMIDE (EBMT 2026) - "All patients received PTCY 50 mg/kg on days +3 and +4, followed by tacrolimus and mycophenolate mofetil as graft-versus-host disease (GVHD) prophylaxis...Eleven patients received tocilizumab for CRS grade ≥2. Levofloxacin prophylaxis was used in 72.8%, and empirical BSA in 82.5% (85/103), mainly piperacillin/tazobactam(67%).A microbiological isolate was the primary cause of fever in 8 (7.8%), all catheter-related: three catheter-related bloodstream infections (S... Early fever after haplo-HSCT with PTCY is common and mostly CRS-related. Only a minority of episodes are infectious. However, most patients received empirical BSA, potentially contributing to pathogen selection and subsequent infectious complications."

Post-transplantation • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Infectious Disease • Inflammation • Pneumonia • Transplantation • CRP

Distribution of Pathogenic Bacteria and Changes in Drug Resistance of Urinary Tract Infections in Children in Southwest China, 2020-2024. (PubMed, Infect Drug Resist) - "coli showed less than 10% resistance to piperacillin/tazobactam, cefoperazone/sulbactam, amikacin and nitrofurantoin, with resistance to quinolones ranging from 31.3% to 51.5%...pneumoniae showed resistance rates of 13.1% and 16.8% to imipenem and meropenem, respectively, from 2020 to 2024...faecium showed significantly higher resistance rates to the tested drugs than E. faecalis, particularly to ampicillin (95.1-97.4% vs 4.9-8.0%)...MRSA showed a higher level of resistance to penicillin, rifampicin, levofloxacin, clindamycin and erythromycin than methicillin-sensitive strains. Over the past five years, the main pathogenic bacteria responsible for pediatric UTIs in southwestern China were E. coli, E. faecium and E. faecalis. Resistance patterns among major uropathogens revealed diverse trends, and the emergence of multidrug-resistant organisms presents a serious therapeutic challenge that warrants close surveillance."

Journal • Infectious Disease • Nephrology • Pediatrics • Pneumonia

Time-series analysis of antimicrobial use and resistance trends in a tertiary hospital in China from 2017 to 2022: implications for national stewardship efforts. (PubMed, J Glob Antimicrob Resist) - "Antimicrobial use declined and resistance improved for several clinically-important Gram-negative pathogens. Rising fluoroquinolone resistance for E. coli highlights the need for ongoing coordinated and targeted antimicrobial stewardship."

Journal • Critical care • Infectious Disease • Pneumonia

Practice Tips From the Updated Helicobacter pylori Treatment Guidelines. (PubMed, Gastroenterol Hepatol (N Y)) - "Since that time, 3 new first-line treatment options have been approved in the United States and knowledge of rising antimicrobial resistance (now above 30% for clarithromycin, levofloxacin, and metronidazole) has been accumulating. This article summarizes these updates with an emphasis on how the current guidelines differ from the previous version. The aim of this article is to present this information in a digestible manner for practicing gastroenterologists and other clinicians who treat patients with H pylori infection."

Journal • Gastric Cancer • Infectious Disease • Oncology • Solid Tumor

SHORTEN-II: Efficacy and safety of 7 versus 14 days of antibiotic treatment for bacteremia produced by Pseudomonas aeruginosa: a multicenter, randomized (SHORTEN-2) clinical trial with a DOOR/RADAR analysis. (clinicaltrialsregister.eu) - P4 | N=306 | Recruiting | Sponsor: Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla | Not yet recruiting ➔ Recruiting

Enrollment open

WHEN THE LINE TURNS LETHAL: SEQUENTIAL CATHETER-RELATED BLOODSTREAM INFECTIONS WITH PSEUDOMONAS AERUGINOSA AND STERNOTROPHONOMAS MALTOPHILIA IN A HEMODIALYSIS PATIENTS (ISN-WCN 2026) - "Consequently, the catheter was replaced, and the patient was administered a 10-day course of intravenous antibiotics consisting of Meropenem 1g twice daily and Levofloxacin 750mg every 48 hours.Following this treatment, the patient remained afebrile. Given that fluoroquinolones demonstrate susceptibility rates as high as 80-90% for some isolates, they represent a strong empirical antibiotic choice in such cases.Conclusion Hemodialysis catheter has dual role not only as a lifeline but also as a potential source of lethal infection. The recurrent CRBSIs with P. aeruginosa and S. maltophilia highlight the perils of biofilm formation and the emergence of multidrug-resistant pathogens in vulnerable patients."

Clinical • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Genetic Disorders • Infectious Disease • Metabolic Disorders • Nephrology • Obesity • Renal Disease

A CASE OF RENAL CYST INFECTION DEVELOPING FULMINANT DRUG-INDUCED IMMUNE THROMBOCYTOPENIC PURPURA DURING MULTIPLE ANTIBIOTIC THERAPY (ISN-WCN 2026) - "On Day 1, levofloxacin (LVFX) 500 mg/day was initiated, and on Day 2, clindamycin (CLDM) 1.2 g/day and meropenem (MEPM) 1 g/day were administered intravenously. However, his C-reactive protein level rose, so teicoplanin (TEIC) 2 g/day was added on day 4...Considering the half-lives of each drug, asciminib, LVFX, CLDM, and MEPM's blood concentrations were estimated to be negligible on Day 23, while DA was expected to retain a few percent of its C-max...To our knowledge, there have been four reports of DITP caused by TEIC, but none caused by DA.Conclusion We present a case of polycystic kidney disease that required selective arterial embolization due to renal cyst hemorrhage associated with fulminant DITP. Through TDM, analysis using drug half-life data, and a literature review, we estimated that TEIC was the causative agent among the six suspected drugs.This abstract was also submitted for the 352nd Annual Meeting of the Kyushu Branch of the Japanese Society of..."

Clinical • Genetic Disorders • Hematological Disorders • Immune Thrombocytopenic Purpura • Infectious Disease • Nephrology • Polycystic Kidney Disease • Renal Disease • Thrombocytopenic Purpura • CRP

HIDDEN BURDEN OF TUBERCULOSIS IN CKD 5- ON MAINTENANCE HEMODIALYSIS : EXPERIENCE FROM A TERTIARY CARE CENTRE IN TAMIL NADU, INDIA (ISN-WCN 2026) - "All patients received renal-adjusted ATT, most commonly rifampicin, isoniazid, levofloxacin, and pyrazinamide on alternate days...Early suspicion, routine screening for latent TB, and individualized dosing are essential to improve outcomes. Larger multicentric studies and a dedicated dialysis-TB registry could help develop uniform diagnostic and treatment protocols for this vulnerable population.highlights the hidden burden and atypical presentation of tuberculosis among CKD 5D patients in Tamil Nadu."

Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Pulmonary Disease • Respiratory Diseases • Septic Shock • Tuberculosis

TUNNEL INFECTIONS DUE TO MULTIDRUG-RESISTANT MYCOBACTERIUM ABSCESSUS REQUIRING CATHETER REMOVAL IN A PERITONEAL DIALYSIS PATIENT (ISN-WCN 2026) - "Physical examination showed erythema and pus expression at the tunnel fistula, while laboratory findings demonstrated no systemic inflammatory response.Download: Download high-res image (376KB)Download: Download full-size imageDownload: Download high-res image (284KB)Download: Download full-size imageResults TI was diagnosed, and levofloxacin (LVFX) was initiated empirically...In line with the 2007 American Thoracic Society (ATS)/ Infectious Diseases Society of America (IDSA) statement emphasizing the necessity of foreign body removal, this case reinforces the importance of individualized treatment strategies that integrate pathogen susceptibility profiles with patient-specific clinical factors. Further research and consensus are needed to establish optimal management approaches for NTM-related catheter infections in PD."

Clinical • Cardiovascular • Chronic Kidney Disease • Diabetic Nephropathy • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Inflammation • Nephrology • Nontuberculous Mycobacterial Disease • Orthopedics • Renal Disease • Respiratory Diseases • Systemic Inflammatory Response Syndrome • Tuberculosis

MANAGEMENT CHALLENGES IN MEDULLARY SPONGE KIDNEY COMPLICATED BY RHEUMATOID ARTHRITIS AND RECURRENT URINARY TRACT INFECTIONS: A CASE REPORT (ISN-WCN 2026) - "Management becomes challenging when immunosuppression, antimicrobial resistance, and drug allergies limit therapeutic options.Methods A woman in her 60s with rheumatoid arthritis, controlled on sulfasalazine 1,000 mg/day and subcutaneous tocilizumab 162 mg every 2 weeks, was diagnosed with MSK in her 40s after pyelonephritis and diffuse medullary calcifications on non-contrast CT...Urine cultures repeatedly yielded multidrug-resistant Escherichia coli resistant to ampicillin, levofloxacin, and trimethoprim–sulfamethoxazole...Joint symptoms remained under control following the single tocilizumab dose.Conclusion In cases of MSK complicated by immunosuppression, recurrent UTIs may require tailored, stepwise regimens and careful antimicrobial stewardship when resistance and allergies constrain options. A strategic selection and sequencing of agents, including cephalexin (dosage adjusted for body weight), gentamicin, and fosfomycin calcium 9 g/day, was instrumental in..."

Case report • Clinical • Immunology • Infectious Disease • Inflammatory Arthritis • Musculoskeletal Pain • Nephrology • Rheumatoid Arthritis • Rheumatology