levofloxacin / Generic mfg. - LARVOL DELTA

Impact of antibiotic use in early fever after haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide (ASH 2025) - "All patients received PTCY 50 mg/kg on days +3 and +4, followed by tacrolimus and mycophenolate mofetil as graft-versus-host disease (GVHD) prophylaxis...Eleven patients received tocilizumab for CRS grade ≥2. Levofloxacin prophylaxis was used in 72.8% of cases. Most (85/103, 82.5%) received empirical BSA, mainly piperacillin/tazobactam (67%)... The median patient age was 53 years, and 60.3% were male. The most frequent diagnosis was AML (38.8%). Most patients had intermediate disease risk (65.3%) and a high age-adjusted HCT-CI (76%)."

Post-transplantation • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Infectious Disease • Inflammation • Pneumonia • Transplantation • CRP

Emergence and regional spread of extended-spectrum β-lactamase-producing Klebsiella pneumoniae ST307 at a Japanese tertiary-care hospital. (PubMed, Microbiol Spectr) - "ST307 isolates showed higher resistance rates than non-ST307 isolates, particularly to levofloxacin (100% vs 19%)...The identification of a conserved plasmid structure associated with ST307 may provide a useful genetic marker for tracking its spread. Continued molecular surveillance of ST307 and its plasmids is essential to understand the global epidemiology of its evolution and distribution and to inform infection control strategies."

Journal • Infectious Disease • Pneumonia

Clinical evaluation of a commercial culture-free targeted next-generation sequencing test for diagnosis of drug-resistant tuberculosis. (PubMed, Microbiol Spectr) - P=N/A | "The ABL tNGS workflow showed ≥95% sensitivity for rifampicin, isoniazid, and levofloxacin; 92%-93% for pyrazinamide and moxifloxacin; 88% for ethambutol; and 72%-82% for bedaquiline and clofazimine. Further refinement in sample preparation may expand its use to specimens with lower bacterial counts. This study is registered with ClinicalTrials.gov as NCT04239326."

Journal • Next-generation sequencing • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

In silico assessment of neuromuscular blocking agents and fluoroquinolones as ligands of the Mas-related G protein-coupled receptor X2. (PubMed, Pharmacol Rep) - "In contrast to fluoroquinolones, NMBAs displayed different affinity for MRGPRX2. Cellular responses in bench experiments closely reflected the MD predictions. Alanine scanning revealed that the MRGPRX2 binding pocket exhibits low susceptibility to single-site mutations that enhance receptor responsiveness."

Journal • Immunology

Incidence and characteristics of infections in patients with multiple myeloma treated with BCMA bispecific antibodies in British Columbia (ASH 2025) - "Real-world data on infection incidence,microbiology, prophylaxis, and risk factors remain limited.We retrospectively analyzed 60 RRMM patients treated with compassionate access single-agent anti-BCMA bispecifics (teclistamab 95%, elranatamab 5%) in British Columbia (May 2023-June 2025), as perstandard indications...Pneumocystis prophylaxis withtrimethoprim/sulfamethoxazole was used in 95% of patients, prophylactic anti-microbial in the first 3months in 80% (doxycycline 54%, levofloxacin 44%, moxifloxacin 2%); valacyclovir in 100%; G-CSF in 48%.In total, 58% received intravenous immunoglobulin (IVIG), 35% of which initiated prior to first infection,either prior to bispecific (15%) or as primary prophylaxis (20%)...Infections were frequent in RRMM patients receiving anti-BCMA bispecific therapy, particularlyrespiratory infections. Early prophylactic antimicrobials may reduce bacterial infections but rates remainhigh beyond 100 days when these are stopped. Early..."

Clinical • Cardiovascular • Cytomegalovirus Infection • Dermatology • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Herpes Zoster • Infectious Disease • Inflammation • Influenza • Multiple Myeloma • Nephrology • Neutropenia • Otorhinolaryngology • Pneumonia • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections • Septic Shock • Sinusitis • Varicella Zoster

Evaluation of levofloxacine as antibiotic prophylaxis in MDS and AML patients treated with azacitidine: Results from the randomized open-label phase III azabac study (ASH 2025) - "However, several deaths attributed to febrile events in thereference arm suggest a probable benefit of levofloxacine in this setting but the limited size of this trialdoes not enable us to confirm it. Larger studies would be useful to investigate this question."

Clinical • P3 data • Acute Myelogenous Leukemia • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Leukemia • Myelodysplastic Syndrome • Neutropenia

Reduced post-transplant alpha-diversity and domination by enterococcus faecium are associated with increased mortality in pediatric recipients of allogeneic hematopoietic cell transplantation. (ASH 2025) - "Prophylactic antibiotics variedby site: Rome utilized piperacillin/tazobactam (pip/tazo); MSK initially used ceftriaxone but transitionedto levofloxacin in 2020; and BCH used none.During the peri-transplant period (day -30 to day +30), microbiome α-diversity, as measured bySimpson reciprocal index, declined significantly post-HCT (median 4.0 pre- vs. 2.1 post-HCT; p<0.001)indicating substantial microbiome injury. This large, multicenter study highlights significant age- and center-specific variability in gut microbiomediversity and composition during pediatric allo-HCT. We found that reduced post-HCT a-diversity anddomination by Enterococcus faecium were associated with increased mortality."

Clinical • Post-transplantation • Acute Graft versus Host Disease • Graft versus Host Disease • Immunology • Pediatrics • Transplantation

Incidence and risk factors for infections in the real-world setting in newly diagnosed myeloma patients treated with modern induction regimens (ASH 2025) - "All patients received prophylaxis withvalacyclovir and >90% with TMP/SMX, per institutional guidelines. Prophylaxis with levofloxacin was notused routinely...This score also classified patients in threedifferent risk groups across all induction regimens (with or without anti-CD38, VRD, PI or lenalidomide)and among different age groups (p<0.001 in all).In summary, infections remain a significant risk in NDMM treated with modern regimens. Patient-relatedfactors (renal dysfunction and poor PS) identify those at significant risk for serious infections but,importantly, more effective modern induction regimens do not significantly increase this risk in the shortterm. For high-risk patients, preventive strategies and early infection recognition and management arecrucial."

Clinical • Real-world • Real-world evidence • Hematological Malignancies • Infectious Disease • Multiple Myeloma • Nephrology • Renal Disease • Respiratory Diseases

Evaluation of resistance modulation in MDR Pseudomonas aeruginosa and Klebsiella pneumoniae using peppermint oil nanoemulsion: integrating antibacterial assays and molecular modeling. (PubMed, Front Microbiol) - "The bacterial isolates were resistant to Levofloxacin, Penicillin G, Ceftazidime, and amoxicillin-clavulanic acid (AMC). These results position PEONE as a promising, plant-based alternative for combating antibiotic-resistant urinary tract infections. Further in vivo studies are warranted to explore its clinical applicability and safety profile."

Journal • Infectious Disease • Nephrology • Pneumonia

Fever of Unknown Origin and Penetrating Aortic Ulcer Successfully Treated with Thoracic Endovascular Aortic Repair-A Case Report. (PubMed, Diagnostics (Basel)) - "With administration of both ceftriaxone and levofloxacin, a decrease in CRP was monitored (51 mg/L). As sophisticated imaging techniques become more widely used, more PAUs are being detected as incidental abnormalities in individuals without acute aortic syndrome. With adequate management, many people with PAU can live a stable and healthy life without experiencing significant consequences."

Journal • Atherosclerosis • Cardiovascular • Hematological Disorders • Infectious Disease • Oncology • Thrombocytosis • Vasculitis

Multifocal community-acquired MRSA infection: a rare case involving urinary tract, bloodstream, chest wall, and pleura. (PubMed, Ann Med Surg (Lond)) - "The patient was treated with linezolid and levofloxacin, insulin therapy, and nutritional support, and the chest wall abscess was incised and drained...This rare case, with simultaneous urinary, bloodstream, chest wall, and pleural involvement, highlights the importance of early recognition, individualized therapy, and confirmation of resistance using tNGS. The outcome demonstrates the short-term effectiveness of this combined approach."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Mood Disorders • Nephrology • Pain • Respiratory Diseases

Molecular Epidemiology and Antibiotic Resistance of Sheep-Derived Mannheimia haemolytica in Northwestern China. (PubMed, Animals (Basel)) - "Antibiotic susceptibility testing showed sensitivity to ciprofloxacin, azithromycin, gentamicin, and levofloxacin, while resistance was observed for tiamulin and enrofloxacin. These findings indicate a high prevalence and strong pathogenicity of ovine M. haemolytica in Shaanxi, underscore the presence of key resistance traits, and provide a genomic and pathogenic reference to guide region-specific surveillance, therapeutic decisions, and vaccine-oriented control in small ruminant herds. Importantly, these results highlight the need for region-specific monitoring and judicious antibiotic use, which are essential to forestall the spread of resistant strains and to ensure sustainable disease management strategies."

Journal • Respiratory Diseases

Sepsis after the Altemeier procedure: A case report. (PubMed, Medicine (Baltimore)) - "For patients with rectal prolapse who have other comorbid infections or malnutrition, thorough preoperative assessment before the Altemeier procedure is crucial for preventing severe anastomotic leakage."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Septic Shock • CRP

Delayed-Onset Hypoglycemia After Levofloxacin Use in a Diabetic Patient. (PubMed, Case Rep Med) - "In previously documented cases, hypoglycemia occurred within days or less than a week after initiating levofloxacin. This report represents an interesting case of delayed-onset hypoglycemia after initiating levofloxacin in a stably managed diabetic patient on long-term glipizide secretagogue."

Journal • Diabetes • Hypoglycemia • Inflammation • Metabolic Disorders

Evaluation of Synergistic Effect of Colistin with Levofloxacin and Meropenem against Multidrug-resistant Acinetobacter baumannii. (PubMed, J Res Pharm Pract) - "However, only 40% of isolates demonstrated partial synergism with no instances of antagonistic behavior when colistin and levofloxacin were administered together. Levofloxacin and meropenem exhibit respectable synergistic effects when combined with colistin; as a result, these combinations may be clinically assessed for MDR-AB infections."

Journal • Infectious Disease

Sepsis secondary to postoperative Enterococcus gallinarum infection in a patient with rectal cancer: A case report. (PubMed, Medicine (Baltimore)) - "The diagnosis and management of sepsis due to postoperative E gallinarum infection should focus on preventing and controlling postoperative complications, performing early etiological cultures, and selecting appropriate antibiotics."

Journal • Colorectal Cancer • Infectious Disease • Oncology • Pain • Rectal Cancer • Septic Shock • Solid Tumor

A Rare Case of Emphysematous Pyelonephritis Following Retrograde Intrarenal Surgery in an Elderly Man. (PubMed, Am J Case Rep) - "Preoperative urine culture identified Klebsiella aerogenes and Citrobacter koseri, prompting 9 days of perioperative levofloxacin (500 mg/day), which cleared the infection...Urgent percutaneous nephrostomy, catheter replacement, and 11-day ertapenem therapy (1g/day) controlled the infection, and a second RIRS on June 12 cleared the stones, with no complications in 3-month follow-up. CONCLUSIONS Post-RIRS fever/abdominal pain requires urgent imaging to rule out steinstrasse-induced EPN. Early drainage, targeted antibiotics, and staged RIRS are critical for elderly patients with high stone burden, filling the literature gap on this complication."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pain • Renal Calculi • Respiratory Diseases

Eradication Rates of Empiric Helicobacter pylori Treatment Regimens by Race/Ethnicity in a Predominantly Immigrant U.S. Population. (PubMed, Helicobacter) - "Empiric bismuth quadruple therapy had the highest eradication rate while metronidazole and levofloxacin triple therapies had the lowest. Eradication rates may thus serve as a surrogate clinical endpoint when choosing empiric therapies."

Journal • Retrospective data • Infectious Disease

Characterization of Methicillin-Resistant Staphylococcus Aureus Resistance and Hematological Profiles in Diabetic Foot Infections. (PubMed, Clin Lab) - "This study examined the characteristics of DFU-associated MRSA infection, particularly its multidrug resistance features. MRSA infection demonstrated 100% sensitivity to vancomycin and linezolid. The findings suggest that combined detection of MCHC, D-dimer, ALB, ALP, Na+, Cl-, and Ca2+ may serve as a valuable reference for the early identification of DFU-associated MRSA infection in clinical settings. Clinicians should be mindful of MRSA infection risks in patients with DFU and develop individualized anti-infection regimens based on drug sensitivity profiles to improve prognosis."

Journal • Retrospective data • Hematological Disorders • Infectious Disease

First case of bloodstream infection caused by Cupriavidus metallidurans in Japan. (PubMed, IDCases) - "His condition improved with the administration of cefmetazole, cefepime, and levofloxacin, and antibiotic therapy was discontinued on the 17th day after the onset of fever. To date, only five cases of bloodstream infection caused by this species have been reported, in Canada and Italy, and this is the first reported case in Japan. As this bacterium is present in the Japanese environment, reports of its detection may increase in the future, particularly among elderly or immunocompromised patients."

Journal • Cardiovascular • Congestive Heart Failure • Diabetes • Heart Failure • Infectious Disease • Metabolic Disorders • CRP

A Case of Legionella Pneumonia Suspected as Typical Pneumonia After Lung Cancer Surgery, Diagnosed by a Repeat Urinary Legionella Antigen Test. (PubMed, Cureus) - "Outpatient urinary antigen tests for pneumococcus and Legionella were negative, and oral garenoxacin was initiated...Broad-spectrum β-lactams (sulbactam/ampicillin, followed by piperacillin/tazobactam) were ineffective...Subsequent targeted therapy with azithromycin (days 6-8 and 13-15), alongside levofloxacin, resulted in clinical improvement...This case report highlights that a single negative urinary antigen test does not rule out Legionella infection. We accordingly recommend early repeat antigen testing, ideally within one week, for postoperative pneumonia unresponsive to β-lactams, together with prompt macrolide or fluoroquinolone therapy."

Journal • Acute Kidney Injury • Cardiovascular • Diabetes • Infectious Disease • Inflammation • Lung Cancer • Metabolic Disorders • Nephrology • Oncology • Pneumococcal Infections • Pneumonia • Renal Disease • Respiratory Diseases • Solid Tumor

Case Report: Omadacycline in the Treatment of Community-Acquired Pneumonia in a Child With Multiple Antimicrobial Allergies. (PubMed, Clin Case Rep) - "This case report presents a 4-year-old girl with a mixed infection of CAP who exhibited hypersensitivity to multiple antimicrobial agents (piperacillin-tazobactam, ceftazidime, fosfomycin, meropenem, and levofloxacin), was treated with omadacycline followed by doxycycline, and underwent bronchoscopy with bronchoalveolar lavage. Potential adverse effects of omadacycline were evaluated, along with its utilization and dosage in children. Omadacycline has the potential to be a viable alternative anti-infective agent for the treatment of pediatric CAP in the absence of other drug options and with adequate safety evaluation and monitoring."

Journal • Allergy • Immunology • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Comparative safety profile of levofloxacin versus moxifloxacin in first-line tuberculosis therapy: a pharmacovigilance study of the FAERS database. (PubMed, Front Pharmacol) - "HREL could be an option for younger patients (<60 years), though vigilance for hepatotoxicity and IRIS-TB is needed, especially in females. For males on HREM, increased attention to neurological AEs is recommended."

Adverse events • Journal • Eosinophilia • Hepatology • Infectious Disease • Liver Failure • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Targeted detection of Helicobacter pylori resistance to clarithromycin and levofloxacin using single-cell Raman spectroscopy. (PubMed, J Med Microbiol) - "Our results demonstrated that Raman spectroscopy can accurately predict H. pylori antibiotic resistance within 4-6 h, significantly reducing detection time compared with traditional methods.Conclusion. This study provides a promising approach for rapid and accurate detection of H. pylori antibiotic resistance, enabling personalized treatment strategies and improving eradication outcomes."

Journal • Infectious Disease

Pathogen distribution, antimicrobial resistance and attributable cost analysis of neonatal sepsis in neonatal intensive care units: a propensity score matching study. (PubMed, Front Pediatr) - "Antimicrobial resistance analysis revealed high resistance rates of Gram-positive bacteria to penicillin G (94.6%) and oxacillin (89.3%). Gram-negative pathogens exhibited high resistance to levofloxacin (75.0%), ceftriaxone (66.7%), cefepime (66.7%), and meropenem (58.3%)...NS significantly increases the hospitalization resource consumption in NICUs. This study provides key evidence for optimizing antibiotic use strategies and advancing precision healthcare payment reform, and calls for integrating resistance surveillance with cost-control measures to reduce the health economic impact of NS."

HEOR • Journal • Critical care • Infectious Disease • Septic Shock