ondansetron intravenous / Generic mfg. - LARVOL DELTA

Extended aprepitant in control of delayed emesis during induction chemotherapy for acute myeloid leukaemia – an multicentric, investigator-initiated, open label randomized controlled trial (ASH 2025) - "Introduction The management of chemotherapy induced nausea and vomiting (CINV) during intensive inductionchemotherapy for acute myeloid leukaemia (AML) is often not optimal due to prolonged infusion ofchemotherapy over 7 days as well as omission of steroids as an anti-emetic due to concern of infections.Addition of single 3-day course of oral aprepitant with ondansetron has shown to improve vomitingcontrol in acute phase (AP), but not in delayed phase (DP) for children with AML...All patients receivedintravenous/oral ondansetron 8mg thrice daily for 10 days with first dose starting half an hour beforeinitiation of chemotherapy on day 1...Patients received a planned chemotherapy regimen ofdaunorubicin 60mg/m2 days 1-3 and continuous infusion of cytarabine 100mg/m2/day for 7 days.Targeted therapies were added along with chemotherapy or chemotherapy were interrupted ordiscontinued based on prevailing clinical scenario as per discretion of local investigator...Adverse effect..."

Clinical • Acute Myelogenous Leukemia • Chemotherapy-Induced Nausea and Vomiting • Febrile Neutropenia • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia

Prevention and Treatment of CINV Caused by TC Regimen in Gynecological Malignant Tumor Patients (clinicaltrials.gov) - P3 | N=143 | Completed | Sponsor: Sichuan Cancer Hospital and Research Institute | Phase classification: P4 ➔ P3

Phase classification • Cervical Cancer • Chemotherapy-Induced Nausea and Vomiting • Endometrial Cancer • Fallopian Tube Cancer • Gynecologic Cancers • Oncology • Ovarian Cancer • Solid Tumor

The Efface of Ketamine vs. Lidocaine in the Management of Pain After Laparoscopic Cholecystectomy (clinicaltrials.gov) - P1 | N=76 | Completed | Sponsor: Liaquat National Hospital & Medical College

New P1 trial • Pain

The Efface of Ketamine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy (clinicaltrials.gov) - P1 | N=78 | Completed | Sponsor: Liaquat National Hospital & Medical College

New P1 trial • Pain

Nano-crystalline Megestrol Acetate for Chemotherapy-induced Nausea and Vomiting (clinicaltrials.gov) - P2 | N=127 | Not yet recruiting | Sponsor: AIPING ZHOU

New P2 trial • Chemotherapy-Induced Nausea and Vomiting

The Efface of Lidocaine vs. Magnesium Sulphate in the Management of Pain After Laparoscopic Cholecystectomy (clinicaltrials.gov) - P1 | N=168 | Completed | Sponsor: Liaquat National Hospital & Medical College

New P1 trial • Pain

Life-Threatening Anaphylaxis Following Intravenous Ondansetron in a Previously Healthy Woman: A Case Report. (PubMed, Cureus) - "We describe a rare case of potentially fatal anaphylaxis following intravenous ondansetron administration in a previously healthy woman. This case highlights the importance of early recognition and intervention in severe hypersensitivity reactions to commonly used drugs."

Journal • Allergy • Cardiovascular • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Hypotension • Immunology • Migraine • Pain

Ondansetron-induced cardiac arrest and cardiomyopathy with successful reversal: a case report. (PubMed, AME Case Rep) - "We report a case of cardiac arrest and cardiomyopathy following a single intravenous (IV) ondansetron dose with successful complete recovery after taking proper clinical interventions...Our case emphasizes the need to be cautious when administering ondansetron, and electrolyte imbalance is considered a risk factor for cardiac arrhythmias following ondansetron administration. It is then imperative that clinicians consider ondansetron-associated cardiac arrest and cardiomyopathy, take preventive measures, and remain vigilant for any unfavorable incidents that may arise."

Journal • Cardiomyopathy • Cardiovascular • Critical care • Endocrine Disorders

Dexamethasone-Ondansetron Combined with Diphenhydramine for Preventing Postoperative Nausea and Vomiting in Thoracoscopic lung surgery: A double blind randomized controlled trial (ChiCTR) - P=N/A | N=200 | Not yet recruiting | Sponsor: Anesthesia and Surgery Center of West China Hospital Sichuan University; West China Hospital Sichuan University

New trial

Comparing the prophylactic effect of ondansetron versus ephedrine on hemodynamic instability caused by spinal anesthesia for cesarean section. (PubMed, J Anaesthesiol Clin Pharmacol) - "No difference was observed in the rate of complications and surgeon satisfaction among groups (P = 0.228 and 0.36, respectively). We found that 10 mg IV ephedrine has a significantly greater prophylactic effect than 8 mg IV ondansetron on spinal-induced hypotension during elective cesarean section."

Clinical • Journal • Anesthesia • Hypotension

Comparison of Aprepitant and Ondansetron for Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy (ChiCTR) - P=N/A | N=310 | Not yet recruiting | Sponsor: The First Affiliated Hospital with Nanjing Medical University; The First Affiliated Hospital with Nanjing Medical University

New trial

Esophageal Obstruction due to Denture Adhesive Masquerading as a Food Bolus (ACG 2025) - "She received conservative treatment with ondansetron, intravenous fluids and improved sufficiently for dismissal home...For our patient diet cola was an effective treatment modality and completely resolved her symptoms.Figure: Figure 1. Index endoscopy with dense caking of material in the distal esophagus and follow-up endoscopy 11 days later showing absence of foreign material and normal mucosa."

Gastrointestinal Disorder • Nephrology • Renal Disease

Postoperative nausea and vomiting in coronary artery bypass graft patients: impact of opioid-sparing analgesia and the need for antiemetic prophylaxis (ASA 2025) - "PONV treatment units, defined as 4 mg IV ondansetron or 10 mg IV metoclopramide, were tracked daily from time of extubation through day seven of ICU stay or through hospital discharge, whichever occurred first... These findings underscore the need for standardized antiemetic prophylaxis alongside opioid-sparing analgesia to optimize perioperative care in CABG patients. Despite a lower PONV incidence, the increased treatment burden in the opioid-sparing group suggests that improved prophylactic strategies are needed to enhance patient recovery. Our results are being used to guide the first iteration of a hospital-wide antiemetic prophylaxis protocol for CABG patients to minimize the incidence of PONV."

Clinical • Addiction (Opioid and Alcohol) • Anesthesia • Cardiovascular

Chewing Gum vs. Ondansetron as Rescue Treatment for PONV in Female Patients (clinicaltrials.gov) - P1 | N=90 | Active, not recruiting | Sponsor: Makassed General Hospital

New P1 trial

Early Morbimortality in Autologous Hematopoietic Cell Transplantation Performed on Outpatient Basis in Persons with Autoimmune Diseases: Experience in 1700 Patients (ECTRIMS 2025) - "The transplant started on an outpatient basis in all cases, following the "Mexican Method" conditioning regimen consisting of intravenous (I.V.) cyclophosphamide (200 mg/Kg, total dose, divided equally in four doses: days -11, -10, -2 and -1), filgrastim, MESNA, and rituximab (1000 mg). The prophylactic treatment consisted of oral cotrimoxazole, acyclovir, itraconazole, ondansetron, I.V. dexamethasone (4 mg on days -11, -10, -2 and -1), and oral dexamethasone (0.5 mg days -9, -8... Following the "Mexican Method" in cases of autoimmune diseases is a safe procedure and could be conducted on outpatient basis. The 28-day mortality was 0.17%, whereas the 28-day morbidity was 3.3%. The rate of early complications decreased over time, most likely reflecting a learning curve effect."

Clinical • Bone Marrow Transplantation • Cardiovascular • CNS Disorders • Febrile Neutropenia • Heart Failure • Immunology • Infectious Disease • Inflammation • Multiple Sclerosis • Pneumonia • Pulmonary Embolism • Respiratory Diseases • Transplantation

Effect of Ondansetron on Intra-procedural Nausea and Vomiting in Patients Undergoing Transcatheter Aortic Valve Replacement With Conscious Sedation: A Before-and-After Study. (PubMed, Cureus) - "Ondansetron prevented IPNV in transfemoral TAVR patients with conscious sedation. These results suggest that pretreatment with ondansetron may be a useful strategy for reducing aspiration risk in procedures requiring conscious sedation, including transfemoral TAVR."

Journal • Anesthesia • Cardiovascular

Prevention and Treatment of CINV Caused by TC Regimen in Gynecological Malignant Tumor Patients (clinicaltrials.gov) - P4 | N=143 | Completed | Sponsor: Sichuan Cancer Hospital and Research Institute | Recruiting ➔ Completed | Trial completion date: Feb 2025 ➔ Jul 2025 | Trial primary completion date: Feb 2025 ➔ Jun 2025

Trial completion • Trial completion date • Trial primary completion date • Chemotherapy-Induced Nausea and Vomiting • Gynecologic Cancers • Solid Tumor

Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=50 | Recruiting | Sponsor: Ondokuz Mayıs University | Not yet recruiting ➔ Recruiting

Enrollment open • Cardiovascular • Pain

NELCER: Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix (clinicaltrials.gov) - P3 | N=348 | Active, not recruiting | Sponsor: Tata Memorial Hospital | Recruiting ➔ Active, not recruiting

Enrollment closed • Cervical Cancer • Oncology • Solid Tumor • Uterine Cancer

The impact of erector spinae plane block on neutrophil-to-lymphocyte ratio and postoperative nausea and vomiting in lumbar spine surgery patients: a protocol for a randomized controlled trial. (PubMed, Front Med (Lausanne)) - P1 | "Patients will be stratified by a preoperative NLR threshold of 2 into two equal groups and further randomized to receive either ultrasound-guided ESPB with ropivacaine or a saline control after anesthesia induction. All participants will receive standard PONV prophylaxis with intravenous ondansetron...This trial will clarify the predictive value of NLR for PONV and assess the efficacy of ESPB in modulating postoperative inflammation and improving recovery in lumbar spine surgery. ClinicalTrials.gov identifier, NCT06127966."

Journal • Anesthesia • Inflammation • Orthopedics • Pain

The Effect of Superficial Cervical Block Application on Postoperative Opioid Consumption in Patients Undergoing Anterior Cervical Discectomy Surgery (clinicaltrials.gov) - P=N/A | N=60 | Completed | Sponsor: Medipol University | Recruiting ➔ Completed | Trial completion date: Jun 2025 ➔ Sep 2025 | Trial primary completion date: Apr 2025 ➔ Aug 2025

Trial completion • Trial completion date • Trial primary completion date • Pain

Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery (clinicaltrials.gov) - P=N/A | N=50 | Not yet recruiting | Sponsor: Ondokuz Mayıs University

New trial • Cardiovascular • Pain

Bioavailability of Oral Ondansetron in Dogs: A Crossover Study. (PubMed, J Vet Pharmacol Ther) - "The purpose of this study was to evaluate the pharmacokinetics of oral (PO) ondansetron compared to intravenous (IV) ondansetron in eight healthy client-owned dogs...Oral bioavailability of ondansetron is very low in healthy dogs, raising concern for the efficacy of ondansetron when given orally at 1 mg/kg. Future studies evaluating pharmacodynamics of ondansetron in nauseous client-owned dogs should be performed to investigate whether plasma drug concentrations are the optimal way to assess the efficacy of oral ondansetron."

Journal

Crisis Not Averted: A Case of Thyroid Storm Following Incomplete Medical Abortion (ATA 2025) - "She was treated with intravenous fluid boluses, intravenous beta blockers, propylthiouracil, and intravenous ondansetron...She was treated with propranolol 10mg q12h and serial labs demonstrated an appropriate decrease in beta-hCG levels...It is possible that earlier administration of misoprostol may have led to a better outcome for our patient. This case underscores the importance of close monitoring of labs and symptoms during pregnancy, especially in patients with prior history of miscarriages or molar pregnancies."

Clinical • Asthma • Cardiovascular • Endocrine Disorders • Immunology • Pulmonary Embolism • Respiratory Diseases

PDPH - N/V: Ondansetron and Dexamethasone for Prevention of PDPH, Nausea, and Vomiting (clinicaltrials.gov) - P4 | N=150 | Completed | Sponsor: Minia University

New P4 trial • Anesthesia • Obstetrics • Pain