doxazosin mesylate / Generic mfg. - LARVOL DELTA

Painful Multiple Piloleiomyomas: Analgesic Efficacy of Doxazosin (EADV 2026) - No abstract available

Clinical • Solid Tumor

Cardiovascular effects of doxazosin in the treatment of prostatic hyperplasia. (PubMed, Drugs Context) - "Risk-of-bias assessment identified 2 reports at low risk, 10 with some concerns, 1 at high risk, 1 observational study of moderate quality, and 2 secondary reviews for which Cochrane Risk of Bias 2 and the Newcastle-Ottawa Scale were not applicable. Doxazosin was not associated with statistically significant average changes in blood pressure or heart rate, but the increased occurrence of vertigo warrants counselling and monitoring, particularly in older patients at risk of falls."

Journal • Benign Prostatic Hyperplasia • Cardiovascular • Otorhinolaryngology • Pain • Vertigo

DOXY: Alpha-1 Blockade for Alcohol Use Disorder (AUD) (clinicaltrials.gov) - P2 | N=184 | Active, not recruiting | Sponsor: Brown University | Recruiting ➔ Active, not recruiting | Trial completion date: Aug 2026 ➔ Dec 2026 | Trial primary completion date: Aug 2026 ➔ Dec 2026

Enrollment closed • Trial completion date • Trial primary completion date • Addiction (Opioid and Alcohol)

Preoperative Diagnosis of Bladder Paraganglioma Followed by Robot-Assisted Partial Cystectomy: A Case Report. (PubMed, IJU Case Rep) - "To avoid the potential risk associated with TUR, preoperative alpha-adrenergic blockade with doxazosin was administered, followed by robot-assisted partial cystectomy...Recognition of characteristic imaging findings may facilitate preoperative diagnosis and safe surgical management of bladder paraganglioma. Robot-assisted partial cystectomy was a feasible minimally invasive treatment option."

Journal • Bladder Cancer • Neuroendocrine Tumor • Oncology • Solid Tumor

Long term adherence to prescribed cardiovascular medications in patients after percutaneous coronary intervention (ESC 2026) - "Adherence to DOACs, calcium channel blockers, and doxazosin was 100%...Non‑adherence to atorvastatin however was 12%. Long‑term adherence to prescribed cardiovascular medications, especially statins, was suboptimal. Long‑term adherence to prescribed cardiovascular medications, especially statins, was suboptimal. Non‑adherence and the presence of undocumented medications persisted even among patients who consented to TDM, indicating that TDM is superior to self-reported medication adherence. This supports the clinical value of TDM in identifying discrepancies in medication use and supporting patient‑centred adherence‑improvement strategies."

Adherence • Clinical • Cardiovascular

Anesthetic Management of Hypertensive Urgency in a Patient with Metastatic Endometrial Cancer and Suspected Pheochromocytoma Undergoing Emergency Laparotomy (ASA 2026) - "She was stabilized in the ICU with a nicardipine infusion and doxazosin, achieving blood pressure <120/80 mm Hg. Following RSI, intraoperative hypertension was managed with nicardipine boluses and β1-selective blockers."

Clinical • Metastases • Endometrial Cancer • Hypertension • Oncology • Solid Tumor

Recurrent Hypertensive Crisis in Pheochromocytoma: How Effective Is Preoperative Alpha-Blockade? (ASA 2026) - "After 20 days of doxazosin therapy, the patient underwent adrenalectomy but again demonstrated hypertension following induction, though less severe. This case highlights persistent hemodynamic instability despite guideline-directed α-blockade. In the context of emerging literature questioning its efficacy in preventing perioperative hypertensive crises, these findings suggest α-blockade may not reliably mitigate risk and underscore the need for vigilant monitoring and immediate access to rapidly titratable vasoactive therapy."

Cardiovascular • Hypertension • Solid Tumor

HeartMate 3 Implantation in a patient with Unresected Functional Pheochromocytoma (ASA 2026) - "Preoperative optimization included selective alpha blockade with doxazosin and transition from milrinone to dobutamine. Induction was performed with etomidate, midazolam, and fentanyl; maintenance with sevoflurane and remifentanil to avoid catecholamine release and over stimulation. Following CPB separation, refractory right ventricular failure required temporary OxyRVAD support, decannulated on POD 11. The patient was discharged on hospital day 50."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Solid Tumor

Anesthetic Management for the Resection of a Metabolically Active Bladder Paraganglioma (ASA 2026) - "Preoperatively, he was placed on doxazosin for alpha blockade...This was managed with a multimodal pharmacologic approach, including nicardipine, esmolol, vasopressin, and nitroglycerin. Notably, this case was performed with hemodynamic monitoring via non-invasive continuous arterial monitoring. The patient recovered well and was discharged home on post-operative day one."

Solid Tumor

Spine separation Surgery on Patient with metastatic Pheochromocytoma (ASA 2026) - "Patient was already on a stable regiment of doxazosin and carvedilol.Patient underwent diagnostic angiogram embolization of radicular arteries one day prior.Intra-operative course involved preparation for anticipated extreme blood pressurelability from epidural tumor manipulation as well as spine protocol infusions to ensureadequate monitoring of SSEPs, EMG, and motors signals. Patient underwentsuccessful tumor resection/decompression and transferred to NCCU for postoperativecare."

Clinical • Metastases • Surgery • Solid Tumor

A case of cardiac paraganglioma in a patient with SDHC-related hereditary paraganglioma pheochromocytoma syndrome. (PubMed, Eur Heart J Case Rep) - "Treatment with doxazosin followed by surgical resection was performed, confirming the diagnosis of cardiac paraganglioma on pathology. Whilst rare, cardiac paragangliomas can be hormonally active and symptomatic, necessitating operative management. Accurate differentiation from similar masses on imaging aids in guiding preoperative hormonal evaluations and medical management, as well as in conducting genetic testing to identify causative mutations and assess heritability."

Journal • Infectious Disease • Oncology • Solid Tumor • SDHC

Breaking the Cycle of Polypharmacy: A Case Report of Renal Denervation in Resistant Hypertension. (PubMed, J Clin Med) - "Importantly, successful blood pressure reduction enabled major simplification of pharmacotherapy, including complete discontinuation of clonidine, loop diuretic therapy, and long-acting nitrates, together with marked dose reduction in doxazosin. Beyond achieving satisfactory blood pressure control, RDN may facilitate meaningful reduction in medication burden, potentially improving treatment adherence, quality of life, and long-term cardiovascular risk. Written informed consent was obtained from the patient for both the procedure and the publication of this case report."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Kidney Cancer • Nephrology • Oncology • Pulmonary Disease • Solid Tumor

Anesthetic Management of Multiple Endocrine Neoplasia Type 2A (MEN2A) Syndrome With Contralateral Recurrent Pheochromocytoma: A Case Report. (PubMed, Cureus) - "She was managed preoperatively on doxazosin and metoprolol...This case highlights the importance of meticulous preoperative optimization, vigilant intraoperative monitoring, and readiness with vasoactive agents in managing pheochromocytomas in patients with MEN2A. A multidisciplinary approach is essential to achieve a safe anesthetic course and a favorable outcome in such high-risk scenarios."

Journal • Adrenal Cortex Carcinoma • Anesthesia • Endocrine Disorders • Hypotension • Oncology • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Medullary Carcinoma

Ruptured pheochromocytoma presenting with acute myocardial injury and hemoperitoneum. (PubMed, JCEM Case Rep) - "The patient was stabilized medically and treated with preoperative α-adrenergic blockade using doxazosin, followed by successful surgical resection...Postoperatively, the patient had an uneventful recovery, with normalization of blood pressure and no recurrence of symptoms during follow-up. This case highlights the diagnostic and therapeutic challenges posed by pheochromocytoma presenting as acute myocardial injury and complicated by spontaneous tumor rupture with hemoperitoneum."

Journal • Acute Coronary Syndrome • Adrenal Cortex Carcinoma • Cardiovascular • Hypertension • Hypotension • Neuroendocrine Tumor • Oncology • Pain • Solid Tumor

Effect of Fourth-Line Antihypertensive Therapy on Clinic Systolic Blood Pressure in Resistant Hypertension: A Systematic Review and Meta-Analysis. (PubMed, Blood Press) - "Pairwise comparisons against placebo showed that aldosterone targeted therapies produced the largest reductions in SBP, with lorundrostat (MD -11.70 mmHg [95% CI -16.07, -7.33]) and baxdrostat 2 mg (MD -10.10 [-12.63, -7.58]) showing comparable effects, while baxdrostat 1 mg (MD -8.56 [-11.08 to -6.04]) demonstrated reductions similar in magnitude to spironolactone (MD -7.95 [-10.10, -5.80]). β-blockers, including bisoprolol (MD = -6.71 mm Hg), also demonstrated modest SBP reductions, while aprocitentan 12.5 mg reduced SBP by -3.80 mmHg [-6.65, -0.95]...Significant increases in any adverse events were observed with aprocitentan 25 mg (RR 1.89 [1.39, 2.57]) and doxazosin (RR 1.55 [1.09, 2.20])...Due to transitivity violations across trials, indirect comparative rankings remain invalid. Future trials are required to establish efficacy and assess outcomes."

Journal • Retrospective data • Review • Cardiovascular • Hypertension

Selpercatinib Induced Regression of Bilateral Pheochromocytomas in A Patient with MEN2B and Metastatic Medullary Thyroid Carcinoma (ENDO 2026) - "She was treated with vandetanib (2016–2020), then switched to cabozantinib due to disease progression. Cabozantinib was discontinued after two months and replaced with sorafenib due to side effects...Bilateral pheochromocytomas were diagnosed and doxazosin was initiated. Follow-up showed response and approximately 8 months after Selpercatinib initiation a PET/CT demonstrated stable liver and lung MTC metastases, stable bone metastases, and a substantial reduction in adrenal mass size (left 4.4 × 3.9 cm, SUV 3.7; right 3.0 × 3.7 cm, SUV 3.7). Conclusion Marked adrenal tumor regression temporally associated with selpercatinib suggests potential activity of selective RET inhibition against MEN2B-associated pheochromocytoma, in addition to its established efficacy in RET-driven MTC."

Clinical • Metastases • Adrenal Cortex Carcinoma • Oncology • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Medullary Carcinoma

A Rare Case of Combined Pheochromocytoma and Primary Diffuse Large B-Cell Lymphoma within A Giant Adrenal Tumor (ENDO 2026) - "A CT-guided biopsy (scant, predominantly necrotic tissue) was interpreted as EBV-positive large B-cell lymphoma, and he underwent six cycles of R-CHOP, including high-dose prednisone (100 mg daily), without hypertensive crisis...Biochemical evaluation revealed markedly elevated plasma metanephrines 12.0 nmol/L (0–0.49), plasma normetanephrine >50 nmol/L (0–0.89), plasma norepinephrine 14,888 pmol/L (reference 1,050–4,800), epinephrine 1,674 pmol/L (≤330) and dopamine 622 pmol/L (≤240)...Preoperative preparation included alpha-adrenergic blockade with doxazosin, high salt and fluid intake, followed by beta-blockade, and metyrosine 4 days prior to surgery due to the large tumor size and marked biochemical activity... Our case highlights the diagnostic and management challenges posed by a rare combined pheochromocytoma and primary lymphoma in the same adrenal tumor. This case reinforces the need for comprehensive hormonal assessment of retroperitoneal masses to guide..."

Clinical • Adrenal Cortex Carcinoma • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Endocrine Cancer • Hematological Malignancies • Hypertension • Large B Cell Lymphoma • Lymphoma • Neuroendocrine Neoplasm • Non-Hodgkin’s Lymphoma • Oncology • Solid Tumor • GATA3 • SDHB • SYP

Menacing Metastatic Pheochromocytoma & Forsaken Follow-Up (ENDO 2026) - "He was restarted on doxazosin with biopsy deferral until appropriate blockade...Multidisciplinary discussions led to a plan of initiating outpatient belzutifan...In such cases, engaging multidisciplinary teams and incorporating early screening for social determinants of health are essential to achieving timely diagnosis. Medical complexity combined with social barriers hinder the recognition of high-risk conditions, such as PCC."

Metastases • Cardiovascular • Hepatology • Hypertension • Solid Tumor

Functional Head and Neck Paraganglioma in A Patient with SDHB Mutation Background (ENDO 2026) - "After alpha-adrenergic blockade with doxazosin, he underwent left adrenalectomy...Normetanephrine-secreting PGLs are exceedingly rare and usually of carotid-body or vagal nerve origin. Patients with familial SHDB mutations require lifelong surveillance for recurrent PGLs, RCC, GIST with ongoing biochemical monitoring, comprehensive genetic evaluation, and advanced functional imaging."

Clinical • Neuroendocrine Tumor • Renal Cell Carcinoma • Solid Tumor • SDHB

Pediatric Extra-Adrenal Pelvic Paraganglioma with SDHB Mutation: A Rare Case Presenting Diagnostic and Management Challenges (ENDO 2026) - "Isradipine, labetalol, and doxazosin were given at that time with symptomatic improvement. This case underscores diagnostic delays due to subtle and episodic symptomatology, the surgical challenges posed by complex pelvic anatomy resulting in positive margins, and the critical importance of postoperative surveillance. Because SDHB mutations carry a high risk for malignancy, lifelong biochemical and radiographic surveillance is mandatory. This case further highlights the value of multidisciplinary coordination and long-term surveillance in hereditary endocrine syndromes, where both risk of recurrence and quality-of-life outcomes must be carefully managed."

Clinical • Cardiovascular • CNS Disorders • Endocrine Disorders • Hypertension • Neuroendocrine Tumor • Pediatrics • Sleep Disorder • Solid Tumor • SDHB

Catecholamine-Induced Cardiomyopathy in Pheochromocytoma: Contrasting Two Divergent Clinical Outcomes (ENDO 2026) - "Case 2: A 62-year-old male with Hashimoto's hypothyroidism, prior pulmonary embolism/DVT on warfarin, and bilateral adrenal masses not followed for 3 years presented with perioperative supraventricular tachycardia and hypertension (systolic >220 mmHg)...He received traditional neurohormonal blockade and doxazosin...These cases compare and contrast the widely variable cardiac outcomes that patients can present with. Early recognition, appropriate diagnostic evaluation, timely surgical intervention, and continued surveillance are essential to prevent irreversible myocardial injury."

Clinical • Clinical data • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Diabetes • Endocrine Disorders • Heart Failure • Hypertension • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • Pulmonary Embolism • Respiratory Diseases • Solid Tumor • Type 2 Diabetes Mellitus • Ventricular Tachycardia

Management of Biochemically Silent Pheochromocytomas and Implications for Surgical Practice in Von-Hippel-Lindau Syndrome (ENDO 2026) - "In the absence of hypertension, we started with low-dose Doxazosin at 1 mg PO daily and did not have to increase the dose during the pre-operative period. After successful alpha-blockade, we initiated beta-adrenergic blockade with low-dose propranolol to achieve a resting heart rate of 80 beats per minute...She now undergoes yearly surveillance with imaging and laboratory tests. Recognizing BSP's prevents the potential risk of hypertensive crisis during major surgeries, as this can reduce complications and lower morbidity and mortality in patients."

Cardiovascular • Endocrine Disorders • Hypertension • Myocardial Infarction • Respiratory Diseases • Solid Tumor • Von Hippel-Lindau Syndrome

A Diagnostic Enigma Unraveled: A Rare Case of Syndromic Bilateral Pheochromocytomas in Multiple Endocrine Neoplasia Type 2A (ENDO 2026) - "Biochemical evaluation demonstrated abnormal dexamethasone suppression testing with cortisol 13.4 μg/dL (4.8–19.2) and dexamethasone 312 ng/dL (>200), suppressed ACTH 6 pg/mL (6–50), DHEA-S 64 μg/dL (57–522), aldosterone < 5 ng/dL ( < 28) with renin 3.39 ng/mL/hr (0.25–5.8), and profound hypothyroidism with TSH 700 μIU/mL (0.4–4.5), free T4 0.17 ng/dL (0.8–1.7), and total T3 < 20 ng/dL (80–200)...The patient was treated with intravenous levothyroxine, initiated on alpha-adrenergic blockade with doxazosin, and started on cinacalcet...Current evidence favors total adrenalectomy, reserving cortical-sparing approaches for select cases at experienced centers. This case highlights diagnostic complexity and surgical risk in MEN2A-associated bilateral adrenal disease."

Clinical • Endocrine Disorders • Gastroenterology • Hypertension • Nephrology • Rare Diseases • Renal Disease • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Medullary Carcinoma • RET

A Catecholamine-Secreting Adrenal Tumor Discovered via Noninvasive Prenatal Screening in A Pregnant Patient with Lynch Syndrome (ENDO 2026) - "Although the patient was asymptomatic with normal blood pressure, she was initiated on doxazosin to reduce the risk of hypertensive crisis...Neuroblastomas are extremely rare in adults and are rarely associated with Lynch syndrome. To our knowledge, this case represents the first case of a neuroblastoma identified through cfDNA screening from maternal blood."

Clinical • Non-invasive • Adrenal Cortex Carcinoma • Genetic Disorders • Genito-urinary Cancer • Neuroblastoma • Oncology • Solid Tumor

Diagnostic Challenges of A Rare Extra-Adrenal Paraganglioma in Von Hippel-Lindau Syndrome (ENDO 2026) - "She was treated with aggressive alpha blockade with doxazosin and phenoxybenzamine and underwent Gamma Knife Radiotherapy, leading to initial symptom relief and successful weaning of alpha blockers...Functional imaging with DOTATATE was pivotal in establishing diagnosis and guiding management. Although surgical resection remains standard of care, stereotactic radiosurgery may be an alternative in selected patients, with care taken to maintain aggressive alpha blockade to prevent perioperative catecholamine overload."

Cardiovascular • Endocrine Disorders • Gastrointestinal Neuroendocrine Tumor • Genito-urinary Cancer • Hypertension • Neuroendocrine Tumor • Otorhinolaryngology • Renal Cell Carcinoma • Solid Tumor • Von Hippel-Lindau Syndrome