doxazosin mesylate / Generic mfg. - LARVOL DELTA

Impact of presurgical beta-blockade on surgical outcomes in patients with PPGLs. (PubMed, Endocr Relat Cancer) - "Beta-blockade was more frequently used in patients with higher fasting plasma glucose and plasma metanephrine levels, and treated with higher doses of phenoxybenzamine and doxazosin...We found that presurgical beta-blockade was more commonly used in patients with more clinically active tumors. The higher rate of intraoperative arrhythmia in patients pretreated with beta-blockers seems to be related to the more frequent use of phenoxybenzamine in this group and not directly with the use of beta-blocker."

Clinical • Journal • Retrospective data • Cardiovascular • Oncology • Solid Tumor

Dapagliflozin for treatment of sickle cell nephropathy: A multi-centre experience (ASH 2025) - "Thirty-five patients (90%)were receiving disease-modifying therapy for sickle cell disease (23 patients taking hydroxyurea and 12patients on a regular transfusion programme). Six patients were also prescribed anti-hypertensivetherapy (amlodipine, doxazosin or indapamide) and 6 patients were prescribed erythropoietinstimulating agents (ESA).Mean eGFR prior to starting dapagliflozin was 50ml/min/1.73m2 (standard deviation 14ml/min/1.73m2).There was a small reduction in eGFR shortly after commencing dapagliflozin treatment: mean decreaseof 5ml/min/1.73m2 (95% confidence interval 2-7ml/min/1.73m2, P<0.001), evaluated in 36 patients witheGFR measured at least one month (median 4.5months) after starting dapagliflozin...Dapagliflozinappeared generally well tolerated, with a few patients experiencing a recognised complication of urinarytract infections. A small rise in creatinine is expected during initial treatment due to a reduction inintraglomerular pressure caused by..."

Clinical • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Diabetic Nephropathy • Genetic Disorders • Heart Failure • Hematological Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Sickle Cell Disease • Type 2 Diabetes Mellitus

Differential Risks of Dementia, Depression, and Injury Among Common α-Blockers, with Tamsulosin as the Reference Drug: A Real-World Cohort Study in Men with Lower Urinary Tract Symptoms. (PubMed, J Clin Med) - "Patients were grouped by α-blocker type-tamsulosin, doxazosin, terazosin, alfuzosin, silodosin, or prazosin-and matched 1:1 using propensity scores to adjust for demographic, clinical, and psychosocial variables. Given its favorable profile, alfuzosin may be the preferred agent in patients at elevated risk of cognitive or psychiatric disorders. These findings highlight the need for individualized α-blocker selection and long-term pharmacovigilance in BPH management."

Journal • Real-world evidence • Alzheimer's Disease • Benign Prostatic Hyperplasia • CNS Disorders • Dementia • Depression • Mental Retardation • Oncology • Psychiatry

GLANCE-aided snapshotting for sustainable integration of synchronous spectrofluorimetry and micellar boosting for nanoscale assay of tolterodine binary mixtures in crucial matrices. (PubMed, Sci Rep) - "Tolterodine tartrate (TLD) has recently demonstrated remarkable synergism when combined with either of two α1-adrenergic antagonists, doxazosin mesilate (DXZ) or terazosin hydrochloride dihydrate (TRZ), for treating urinary tract issues. The outcomes demonstrated the excellence of the designed methodology over reported approaches, offering proficient sensitivity, sustainability, facility, and practicability across diverse crucial matrices. These findings provide compelling evidence that the proposed work serves as an efficient, eco-friendly quantification tool for use in quality control, biological, and environmental sectors, fostering a more eco-conscious and sustainable scientific community."

Journal

Non-Catalytic Inhibitors of the p38/MK2 Interface: Repurposing Approved Drugs to Target Neuroinflammation in Alzheimer's Disease. (PubMed, J Med Chem) - "Virtual screening of FDA-approved drugs prioritized nilotinib, a BCR-ABL inhibitor, as a putative PPI disruptor...Guided by these findings, we developed a lysate-based TR-FRET ultrahigh-throughput assay that identified additional inhibitors, including α1-adrenergic antagonists doxazosin, terazosin, and alfuzosin. These compounds suppressed cytokine induction via docking groove blockade. Together, these results establish a non-ATP-competitive approach for selectively targeting the p38/MK2 complex and highlight the translational potential of drug repurposing to modulate neuroinflammation in Alzheimer's disease."

Journal • Alzheimer's Disease • CNS Disorders • Inflammation • ABL1 • BCR

Prostate cancer evolution after COVID-19-related prostatitis in a TMPRSS2-altered patient: a case report and review of the molecular interface between SARS-CoV-2 and prostate oncogenesis. (PubMed, Front Oncol) - "Although symptoms improved with antibiotics, LUTS persisted and were managed with finasteride and doxazosin. This is the first documented case suggesting a potential link between COVID-19-related prostatitis and subsequent prostate cancer in a TMPRSS2::ERG-altered patient without hereditary predisposition. Although causality cannot be established, the findings highlight a hypothesis-generating interface between viral infection, inflammation, and oncogenesis that warrants further study."

Journal • Breast Cancer • Genito-urinary Cancer • Infectious Disease • Novel Coronavirus Disease • Oncology • Prostate Cancer • Respiratory Diseases • Solid Tumor • ERG • PTEN • TMPRSS2

A case report of blood pressure fluctuation, inverted Takotsubo cardiomyopathy, and pulmonary embolism: searching for a link. (PubMed, Eur Heart J Case Rep) - "Perioperative administration of oral doxazosin and bisoprolol allowed a successful laparoscopic right adrenalectomy after 3-month anticoagulation. Despite the lack of established recommendations for managing BP and HR fluctuations in patients with Pheo, the coexistence of PE further complicates the clinical management of this condition, suddenly modifying the haemodynamic status and increasing the risk of major bleeding events from the neoplastic mass. Patients presenting with ITC, PE, and Pheo require a multidisciplinary approach involving a cardiologist, hypertension specialist, and surgeon to resolve this intriguing clinical condition."

Journal • Cardiomyopathy • Cardiovascular • Hypertension • Hypotension • Oncology • Pain • Pulmonary Embolism • Respiratory Diseases • Solid Tumor

Medical Management of Pheochromocytoma in a 95-Year-Old Woman: A Case Report of Long-Term Conservative Therapy (KIDNEY WEEK 2025) - "By March 2020, phenoxybenzamine was increased to 10 mg TID; doxazosin 2 mg TID. Metoprolol was added but later changed to nebivolol. Clonidine 0.1 mg PRN was initiated in April 2023...Despite age >90, CKD, and severe aortic stenosis, BP was largely controlled without surgical intervention. Conservative therapy may be a durable and effective alternative in select high-risk patients."

Case report • Clinical • Cardiovascular • Chronic Kidney Disease • Hypertension • Hypotension • Infectious Disease • Pneumonia • Respiratory Diseases • Solid Tumor

Cerebral Salt-Wasting Syndrome Masquerading as Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in a Patient with Subdural Hemorrhage (KIDNEY WEEK 2025) - "His home medications included insulin, losartan, mirtazapine, and doxazosin...To prevent worsening hyponatremia with ongoing natriuresis, he was started on sodium tablets, urea tablets, and fludrocortisone...The common etiologies of CSWS include central nervous system pathologies, the most common being aneurysmal subarachnoid hemorrhage. This case underscores the importance of monitoring volume status and electrolytes in neurologically injured patients with hyponatremia."

Clinical • Benign Prostatic Hyperplasia • Cachexia • Cardiovascular • CNS Disorders • Diabetes • Heart Failure • Hematological Disorders • Hypertension • Metabolic Disorders • Musculoskeletal Diseases • Nephrology • Orthopedics • Subarachnoid Hemorrhage

Doxazosin GITS (gastrointestinal therapeutic system) is an actor to consider in the control of hypertension. A narrative review. (PubMed, Hypertens Res) - "Multiple barriers-including cost, side effects, therapeutic complexity, and physician inertia-impede effective management, particularly in aging populations and low-resource settings. This review evaluates the therapeutic role of doxazosin, particularly in its extended-release gastrointestinal therapeutic system formulation, as a potential adjunct in contemporary hypertension treatment, including resistant hypertension."

Journal • Review • Cardiovascular • Hypertension

The Discovery of α-Adrenoceptor Antagonists as a Potential New Treatment Option for Uveal Melanoma. (PubMed, Biomolecules) - "Drug screening with UM spheroids revealed that prazosin and doxazosin dose-dependently reduced viability, whereas terazosin, alfuzosin, silodosin, tamsulosin, and phenoxybenzamine were found to be inefficient. This suggests a tumor-preventive effect through the blockade of α1A-AR. The present study highlights the responses of UM spheroids to α-AR antagonists and demonstrates that prazosin, doxazosin, or RS17053 may be a treatment option for preventing UM tumor recurrence or metastasis."

Journal • Eye Cancer • Hepatocellular Cancer • Melanoma • Ocular Melanoma • Oncology • Solid Tumor • Uveal Melanoma • AR

ADRENAL OVERDRIVE: PHEOCHROMOCYTOMA UNLEASHING THYROID STORM AND MULTIORGAN FAILURE (CHEST 2025) - "A Burch-Wartofsky Score of 65 was highly suggestive of thyroid storm, and treated with propranolol, propylthiouracil, and hydrocortisone.During transport, the patient became hypoxic, altered, and bradycardic...Doxazosin was initiated and additional diagnostic testing, including the 24-hour urine metanephrines/normetanephrine, which were elevated 4,361/766 μg/24hr, and serum metanephrines/normetanephrine were elevated to 2,954.3/1,395.6 pg/mL... This case highlights the importance of a thorough diagnostic evaluation, emphasizing the need for clinicians to consider pheochromocytoma in the assessment of refractory hyperthyroidism. Early recognition and management are key to reducing mortality in these patients who are already at high risk."

Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Hematological Disorders • Hypertension • Movement Disorders • Neuroendocrine Tumor • Oncology • Solid Tumor

CHALLENGES IN THE MANAGEMENT OF PHEOCHROMOCYTOMA AND CORONARY ARTERY DISEASE REQUIRING CABG: A CASE REPORT (CHEST 2025) - "Continuous nicardipine IV was started to address the hypertensive emergency, which was weaned off after a dose of doxazosin...Her hypertension improved on a regimen of valsartan, nifedipine, and hydralazine... While both pheochromocytoma and cardiovascular disease are so closely intertwined, there is no standard practice when treating both severe CAD and pheochromocytoma simultaneously. Unfortunately, there is little information regarding survival rates and procedural progression when treating these two conditions simultaneously. Given the high risk nature of these diseases and procedures, further investigation needs to be conducted."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Coronary Artery Disease • Heart Failure • Hypertension • Myocardial Infarction • Oncology • Solid Tumor

Use of STRIVE Hi for Critical Airway Narrowing and Tracheal Deviation with Concurrent Pheochromocytoma Concern (ASA 2025) - "Following four weeks of alpha-blockade with doxazosin, intraoperative hypertension was managed with phentolamine. Airway management was achieved using Spontaneous Respiration with Intravenous Anesthesia and High-Flow Nasal Oxygen (STRIVE Hi), which provided oxygenation and ventilation while maintaining spontaneous breathing in a critically narrowed airway."

Anesthesia • Cardiovascular • Hypertension • Pulmonary Disease • Solid Tumor

Resection of a Cardiac Paraganglioma with Active Secretion of Dopamine (ASA 2025) - "The patient was asymptomatic at baseline but was started on metoprolol and doxazosin 2 weeks prior to surgery. The patient underwent a sternotomy, cardiopulmonary bypass, and uneventful resection of the cardiac paraganglioma with reinforcement of the superior vena cava using a pericardial patch."

Cardiovascular • CNS Disorders • Solid Tumor

Novel Compounds in Targeting the α1-adrenoceptor for Antihypertensive Therapy. (PubMed, Cardiovasc Hematol Agents Med Chem) - "Terazosin, doxazosin, tamsulosin, and alfuzosin are examples of α1-adrenoceptor antagonists that have antihypertensive properties; however, they are linked to considerable side effects, including headaches, dizziness, reproductive problems, and postural hypotension. In the last several years, a number of novel α1-adrenergic antagonists have been synthesised by modifications of various pharmacophores such as Isochroman-4-one, Quinazolines, Piperazine, and Quinazoline-triazole, etc. The present review highlights recently synthesized α1-adrenoceptor antagonists for the management of hypertension, and emphasizes their structure-activity relationship and subtype selectivity."

Journal • Cardiovascular • Hypertension • Hypotension • Myocardial Infarction • Pain

A double-blind, randomized, placebo-controlled trial of doxazosin for posttraumatic distressing dreams and sleep disturbance in men and women with posttraumatic stress. (PubMed, J Clin Sleep Med) - P2 | "Doxazosin demonstrated statistically significant, clinically modest effects on prespecified sleep diary measures of distressing dream and sleep outcomes relative to placebo, but no effects based on clinical interview and survey measures. Ongoing research is therefore critical to improve treatment options for both males and females, for whom treatment benefits may differ, and to improve measurement in distressing dreams research so as to further develop targeted and effective treatment solutions."

Clinical • Journal • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder • Sleep Disorder

Ozempic, Travel, and Troublesome Diarrhoea: Lessons from a Transplant Case (EUSEM 2025) - "Current medications included apixaban, allopurinol, doxazosin, torasemide, flecainide, bisoprolol, methylprednisolone, ciclosporin, mycophenolic acid, and sodium hydrogen carbonate.On examination, he was afebrile (36.1°C), normotensive (BP 120/70 mmHg), tachycardic (HR 123 bpm), and had normal oxygen saturation (SpO₂ 98%). This suggests that an otherwise self-limiting episode of traveller's diarrhoea may have been exacerbated by cumulative burden of chronic immunosuppression and previous gastrointestinal insults by Ozempic.Following nephrology consultation, recommendations included withholding mycophenolic acid and torasemide, and initiating ciprofloxacin and ornidazole. Despite advice, patient declined hospital admission for rehydrationThis case highlights the importance of careful medication review—including consideration of newer agents such as semaglutide—and vigilance for complications in transplant recipients presenting with gastrointestinal..."

Clinical • Acute Kidney Injury • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Hypertension • Immunology • Metabolic Dysfunction-Associated Steatotic Liver Disease • Nephrology • Renal Disease • Transplantation

Role of β and α1-adrenoceptors in pancreatic regulation of glucose homeostasis, apoptosis, and fibrosis in dexamethasone-treated rats: A new insight into β-arrestin2 crosstalk with cAMP, PKA-ERK1/2-CREB, and PKB-FOXO1 signaling pathways. (PubMed, Int J Immunopathol Pharmacol) - "Dexamethasone impaired glucose homeostasis, expanded islet mass, and triggered pancreatic cell apoptosis and fibrosis via upregulated BAX/Bcl-2 expression ratio, downregulated cAMP, upregulated PKA, ERK1/2, and CREB expression with elevated PKB activity and reduced FOXO1 expression. % Level of β-arrestin2 was reduced in pancreatic islets and elevated in exocrine pancreas in relation to the aforementioned modulations. Blockade of β- or α1-adrenoceptors significantly ameliorated these effects, with combined blockade yielding superior benefits. Carvedilol's effects were largely β-mediated, with minor α1 involvement. Low-dose phenylephrine yielded modest improvement, supporting a context-dependent, protective role of α1-adrenoceptor activation during metabolic stress. The dependence of drugs' effects on β-arrestin2 highlights its potential as a central regulator of pancreatic remodeling and a promising target in IR-linked pathologies."

IO biomarker • Journal • Preclinical • Fibrosis • Immunology • Metabolic Disorders • ARRB1 • BAX • BCL2 • FOXO1

Drug Repurposing for Targeting Cancer Stem-like Cells in Glioblastoma. (PubMed, Cancers (Basel)) - "These mainly included antidiabetics (e.g., Metformin, Phenformin, and Sitagliptin), antihypertensives (e.g., Nicardipine, Doxazosin, and Prazosin), antimicrobials (e.g., Pyrvinium pamoate, Flubendazole, and Clofazimine), and central nervous system-acting drugs (e.g., Chlorpromazine, Fluvoxamine, and Disulfiram)...Also significant were those drugs tested in combination, resulting in increased sensitivity to Temozolomide (TMZ), the standard pharmacological treatment available for GBM...Importantly, major translational barriers remain, like limited blood-brain barrier penetration and the lack of robust clinical trials. In conclusion, drug repurposing is an affordable and suitable strategy to target GSCs, impairing cell viability, reducing stemness, and enhancing their sensitivity to TMZ, which has potential that should be further explored to improve patients' clinical outcomes."

Journal • Review • Brain Cancer • Glioblastoma • Glioma • Oncology • Solid Tumor

A Case of Benidipine-Induced Lichenoid Drug Eruption (EADV 2025) - "Considering the temporal relationship, benidipine was discontinued based on the suspicion of benidipine-induced LDE and doxazosin was initiated. This case expands the spectrum of adverse cutaneous reactions associated with calcium channel blockers, underscoring the importance of prompt recognition and management of LDE. Clinicians should remain vigilant for LDE in patients presenting with compatible eruptions following antihypertensive therapy, particularly when involving less commonly implicated agents like benidipine."

Clinical • Cardiovascular • Dermatopathology • Hypertension • Inflammation • Lichen Planus

Effects of doxazosin as adjuvant to abiraterone on viability and apoptosis of metastatic castration-resistant prostate cells cancer (mCRPC) PC3. (PubMed, Narra J) - "Furthermore, the combined treatment showed a significantly higher mean apoptosis percentage compared to abiraterone alone (4.79%; 95%CI: 0.41-9.18; p=0.029), and doxazosin alone (10.99%; 95%CI: 6.61-15.38; p=0.001). These findings suggest that doxazosin, traditionally used as an α1-blocker for lower urinary tract symptoms (LUTS), could offer a novel therapeutic approach for mCRPC patients."

Journal • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Target the Heart: A New Axis of Alzheimer's Disease Prevention. (PubMed, J Dement Alzheimers Dis) - "Co-administering a low dose of cyclosporine A with select cardiac drugs could be a potentially effective treatment strategy for preventing Alzheimer's disease occurrence and simultaneously treating cardiovascular dysfunction, while mitigating the side effects associated with higher doses of cyclosporine A. Given that heart disease precedes Alzheimer's disease in many patients, physicians may be able to create a treatment regimen that addresses both con-ditions. Our results suggest that a calcineurin inhibitor combined with simvastatin, irbesartan, cilostazol, doxazosin, or nebivolol is the most promising candidate for future exploration."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia • Heart Failure

Adjunctive Doxazosin before Ureterolithotripsy to Improve Successful Access Rate: A Retrospective Analysis. (PubMed, Arch Esp Urol) - "Doxazosin can be safely and effectively used before semi-rigid and flexible ureteroscopy."

Journal • Retrospective data • Urolithiasis • ADRA1B

A Case Report on the Use of Doxazosin to Improve Outcomes in a Patient With a KCNT1 Genetic Variation. (PubMed, J Child Neurol) - "Doxazosin was found to have a high degree of inhibitory activity in both wild-type and mutant cell lines and, as a result, was trialed with this patient. The patient experienced a decrease in unplanned hospitalizations in addition to a dramatic decrease in seizure burden with the initiation of doxazosin with minimal side effects."

Journal • CNS Disorders • Epilepsy • Pediatrics