VS-605 / Vidasym - LARVOL DELTA

[VIRTUAL] TOLEROGENIC DENDRITIC CELLS IN RHEUMATOID ARTHRITIS PATIENTS: NEWS AND PROMISES (EULAR 2021) - "Objectives: The aim of our study is to describe the properties of tolerogenic DCs, generated with dexamethasone in patients with RA and their influence on autologous T-cells...The stimulation activity dexDCs after incubation with LPS were not increase (4692 vs 6053 cpm, p=0.7). The data obtained indicate that dexDCs from RA patients have the main tolerogenic features and stable in inflammatory environment that proves their potential in the treatment of rheumatoid arthritis."

Clinical • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • CD14 • CSF2 • IL10 • TNFA

Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study. (PubMed, Crit Care Med) - "EA-230 was safe in patients undergoing on-pump cardiac surgery. It did not modulate interleukin-6 plasma concentrations but appeared to exert beneficial renal and cardiovascular effects and shortened in-hospital length of stay."

Clinical • Journal • Acute Kidney Injury • Anesthesia • Cardiovascular • Chronic Kidney Disease • Critical care • Immune Modulation • Immunology • Inflammation • Nephrology • Renal Disease • IL6

[VIRTUAL] CM.CVS.605 - New Glucose-Lowering Agents With CV Benefits: Working... But How? (AHA 2020) - "Note: This session is OnDemand and will be available from the start of the conference November 13, 2020 at 9:00 am until the end of the conference November 17, 2020, 8:30pm CT"

Topical Injection of Tranexamic Acid via a Drain Plus Drain-Clamping to Reduce Blood Loss in Degenerative Lumbar Scoliosis Surgery. (PubMed, Orthop Surg) - "Topical injection of TXA retrogradely via a drain at the end of a degenerative lumbar scoliosis operation and clamping the drain for an hour can effectively decrease the postoperative blood loss and the length of hospitalization without increasing the complication rate."

Journal • Cardiovascular • Hematological Disorders • Pulmonary Embolism • Venous Thromboembolism

Altered Serum Levels of Renin-Angiotensin System Markers in Migraine. (PubMed, Headache) - "Altogether, our results suggest the participation of RAS in migraine pathophysiology, but not in its severity."

Journal • CNS Disorders • Depression • Migraine • Mood Disorders • Pain • Psychiatry

Role of CA-125 in achieving optimal secondary cytoreduction (SGO 2020) - "Patients whose recurrence was found by CA-125 were more likely to have higher CA-125 at initial cancer diagnosis (median 914 vs 605, P = 0.020) and have had stage IV disease (27.4% vs 22.8%, P < 0.001)... In our retrospective cohort study, we did not find that routine CA-125 screening was associated with higher rates of optimal SCS. In contrast, we found that those diagnosed by CA-125 were less likely to undergo SCS compared to other groups. In addition, there was no difference in rate of optimal SCS or in OS."

CA125

Role of CA-125 in achieving optimal secondary cytoreduction (SGO 2020) - "Patients whose recurrence was found by CA-125 were more likely to have higher CA-125 at initial cancer diagnosis (median 914 vs 605, P = 0.020) and have had stage IV disease (27.4% vs 22.8%, P < 0.001)... In our retrospective cohort study, we did not find that routine CA-125 screening was associated with higher rates of optimal SCS. In contrast, we found that those diagnosed by CA-125 were less likely to undergo SCS compared to other groups. In addition, there was no difference in rate of optimal SCS or in OS."

CA125

Role of CA-125 in achieving optimal secondary cytoreduction (SGO 2020) - "Patients whose recurrence was found by CA-125 were more likely to have higher CA-125 at initial cancer diagnosis (median 914 vs 605, P = 0.020) and have had stage IV disease (27.4% vs 22.8%, P < 0.001)... In our retrospective cohort study, we did not find that routine CA-125 screening was associated with higher rates of optimal SCS. In contrast, we found that those diagnosed by CA-125 were less likely to undergo SCS compared to other groups. In addition, there was no difference in rate of optimal SCS or in OS."

CA125

Role of CA-125 in achieving optimal secondary cytoreduction (SGO 2020) - "Patients whose recurrence was found by CA-125 were more likely to have higher CA-125 at initial cancer diagnosis (median 914 vs 605, P = 0.020) and have had stage IV disease (27.4% vs 22.8%, P < 0.001)... In our retrospective cohort study, we did not find that routine CA-125 screening was associated with higher rates of optimal SCS. In contrast, we found that those diagnosed by CA-125 were less likely to undergo SCS compared to other groups. In addition, there was no difference in rate of optimal SCS or in OS."

CA125

Circulating branched-chain amino acids and incident heart failure in type 2 diabetes: The Hong Kong Diabetes Register. (PubMed, Diabetes Metab Res Rev) - "Circulating levels of BCAAs are independently associated with incident HF in patients with T2D. Prospective cohort analysis and randomized trials are needed to evaluate the long-term safety and efficacy of using different interventions to optimize BCAAs levels in these patients."

Journal

Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis. (PubMed, J Med Invest) - "Activin promotes occurrence of endometriosis. Inflammatory cytokines are also elevated by activin administration,suggesting that they may contribute to progression of endometriosis J. Med. Invest. 66 : 123-127, February, 2019."

Journal • Preclinical

Mesenteric lymph nodes as alternative site for pancreatic islet transplantation in a diabetic rat model. (PubMed, BMC Surg) - "Although islet engraftment in lymph nodes is possible, islet transplantation in lymph nodes in rats resulted in few improvements of glucose parameters."

Journal • Preclinical

Characterizing tumor invasiveness of glioblastoma using multiparametric magnetic resonance imaging. (PubMed, J Neurosurg) - "An RIC cutoff value of 0.89 significantly predicted shorter OS (median 384 vs 605 days, p = 0.002) and PFS (median 244 vs 406 days, p = 0.001).CONCLUSIONSDTI-q abnormalities displayed higher tumor load and hypoxic signatures compared with CE abnormalities, whereas CE regions potentially represented the tumor proliferation edge. Integrating the extents of invasion visualized by DTI-q and CE images into clinical practice may lead to improved treatment efficacy."

Journal