BMP-7 / University of Central Florida - LARVOL DELTA

Bone Regeneration Drug BMP-7 Mitigates Ponatinib-Induced Cardiotoxicity via Inhibition of Pyroptosis and Modulation of TGF-β/SMAD Signaling Pathway. (PubMed, Cells) - "These findings identify inflammation-induced pyroptosis as a central driver of the pathological changes in PON-induced cardiotoxicity. Notably, our work highlights BMP-7's capacity to inhibit these disease-related alterations. Collectively, these results expand on the current knowledge of the mechanistic framework of PON-induced cardiotoxicity, while also emphasizing BMP-7 as a promising therapeutic candidate with potential translational relevance."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Malignancies • Inflammation • Leukemia • Myocardial Infarction • Oncology • BMP7 • TGFB1

BMP-7 Treatment Ameliorates PTEN-Akt Mediated Apoptosis and Adverse Cardiac Remodeling in Ponatinib-Induced Cardiotoxicity. (PubMed, Pharmaceuticals (Basel)) - " These results suggest that BMP-7 might inhibit PON-induced cardiotoxicity. Furthermore, our findings pave the way for future translational studies with BMP-7, which can demonstrate the therapeutic potential of BMP-7 in a clinical setting."

IO biomarker • Journal • Cardiovascular • Chronic Myeloid Leukemia • Hematological Malignancies • Leukemia • Oncology • BAX • BCL2 • BMP7 • CASP3 • PTEN

PTEN-AKT pathway attenuates apoptosis and adverse remodeling in ponatinib-induced skeletal muscle toxicity following BMP-7 treatment. (PubMed, Physiol Rep) - "Furthermore, BMP-7 treatment significantly (p < 0.05) attenuated ponatinib-induced apoptosis, BAX/Bcl2 ratio, decreased PTEN, and increased cell survival protein AKT, decreased adverse muscle remodeling, and improved muscle function. Overall, we provide evidence that ponatinib-induces apoptosis leading to sarcopenia and muscle myopathy with decreased function which was attenuated by BMP-7."

Journal • Fibrosis • Immunology • Myositis • Oncology • Sarcopenia • BCL2 • CASP3 • PTEN

BMP-7 Attenuates Sarcopenia and Adverse Muscle Remodeling in Diabetic Mice via Alleviation of Lipids, Inflammation, HMGB1, and Pyroptosis. (PubMed, Antioxidants (Basel)) - "We report, for the first time, that increased hyperlipidemia aggravates inflammation-induced pyroptosis, resulting in significant muscle loss, sarcopenia, and adverse skeletal muscle remodeling in diabetic muscle myopathy. Interventional treatment with BMP-7 attenuates hypercholesterolemia-induced inflammation-mediated sarcopenia and adverse muscle remodeling, suggesting BMP-7 could be a potential treatment option for diabetic muscle myopathy."

Journal • Preclinical • Diabetes • Dyslipidemia • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Muscular Atrophy • Myositis • Sarcopenia • HMGB1 • TGFB1

[VIRTUAL] Bmp-7 Ameliorates Lipid Accumulation Induced, Hmgb1 Initiated Pyroptosis Leading To Sarcopenia, Muscle Deterioration And Adverse Muscle Remodeling In Diabetes (AHA 2021) - "We report for the first time that increased hyperlipidemia aggravates inflammation involved cellular pyroptosis that induces significant muscle cell loss and adverse remodeling in diabetic muscle myopathy. Targeting pyroptosis and lipid accumulation in muscle cells, with BMP-7 improves diabetic muscle pathophysiology and muscle function. These findings shows BMP-7 as a potential therapeutic option to treat diabetic myopathy."

Diabetes • Dyslipidemia • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Myositis • Sarcopenia • HMGB1 • SMAD2 • SMAD3 • TGFB1

BMP-7 Attenuates Inflammation-Induced Pyroptosis and Improves Cardiac Repair in Diabetic Cardiomyopathy. (PubMed, Cells) - "In conclusion, BMP-7 attenuated inflammation-induced pyroptosis, adverse cardiac remodeling, and improved heart function via the TLR4-NLRP3 inflammasome complex activated by novel signaling Nek7/GBP5. Our BMP-7 pre-clinical studies of mice could have significant potential as a future therapy for diabetic patients."

Journal • Cardiomyopathy • Cardiovascular • Diabetes • Immunology • Inflammation • Metabolic Disorders • CD14 • CD31 • IL18 • IL1B • IL6 • ITGAM • KIT • MMP9 • TLR4 • TNFA