BMP-7 / University of Central Florida - LARVOL DELTA

PTEN-AKT pathway attenuates apoptosis and adverse remodeling in ponatinib-induced skeletal muscle toxicity following BMP-7 treatment. (PubMed, Physiol Rep) - "Furthermore, BMP-7 treatment significantly (p < 0.05) attenuated ponatinib-induced apoptosis, BAX/Bcl2 ratio, decreased PTEN, and increased cell survival protein AKT, decreased adverse muscle remodeling, and improved muscle function. Overall, we provide evidence that ponatinib-induces apoptosis leading to sarcopenia and muscle myopathy with decreased function which was attenuated by BMP-7."

Journal • Fibrosis • Immunology • Myositis • Oncology • Sarcopenia • BCL2 • CASP3 • PTEN

BMP-7 Attenuates Sarcopenia and Adverse Muscle Remodeling in Diabetic Mice via Alleviation of Lipids, Inflammation, HMGB1, and Pyroptosis. (PubMed, Antioxidants (Basel)) - "We report, for the first time, that increased hyperlipidemia aggravates inflammation-induced pyroptosis, resulting in significant muscle loss, sarcopenia, and adverse skeletal muscle remodeling in diabetic muscle myopathy. Interventional treatment with BMP-7 attenuates hypercholesterolemia-induced inflammation-mediated sarcopenia and adverse muscle remodeling, suggesting BMP-7 could be a potential treatment option for diabetic muscle myopathy."

Journal • Preclinical • Diabetes • Dyslipidemia • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Muscular Atrophy • Myositis • Sarcopenia • HMGB1 • TGFB1

[VIRTUAL] Bmp-7 Ameliorates Lipid Accumulation Induced, Hmgb1 Initiated Pyroptosis Leading To Sarcopenia, Muscle Deterioration And Adverse Muscle Remodeling In Diabetes (AHA 2021) - "We report for the first time that increased hyperlipidemia aggravates inflammation involved cellular pyroptosis that induces significant muscle cell loss and adverse remodeling in diabetic muscle myopathy. Targeting pyroptosis and lipid accumulation in muscle cells, with BMP-7 improves diabetic muscle pathophysiology and muscle function. These findings shows BMP-7 as a potential therapeutic option to treat diabetic myopathy."

Diabetes • Dyslipidemia • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Myositis • Sarcopenia • HMGB1 • SMAD2 • SMAD3 • TGFB1

BMP-7 Attenuates Inflammation-Induced Pyroptosis and Improves Cardiac Repair in Diabetic Cardiomyopathy. (PubMed, Cells) - "In conclusion, BMP-7 attenuated inflammation-induced pyroptosis, adverse cardiac remodeling, and improved heart function via the TLR4-NLRP3 inflammasome complex activated by novel signaling Nek7/GBP5. Our BMP-7 pre-clinical studies of mice could have significant potential as a future therapy for diabetic patients."

Journal • Cardiomyopathy • Cardiovascular • Diabetes • Immunology • Inflammation • Metabolic Disorders • CD14 • CD31 • IL18 • IL1B • IL6 • ITGAM • KIT • MMP9 • TLR4 • TNFA