NTS231
/ NUTSHELL Therapeutics
- LARVOL DELTA
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October 13, 2025
NTS231 is a novel covalent allosteric molecular glue of the KEAP1-CUL3 E3-ligase complex that selectively degrades NRF2 and inhibits tumors with aberrant NRF2 activation
(AACR-NCI-EORTC 2025)
- "Overall, NTS231 exhibits exceptional potency, high selectivity and desirable ADME properties without CYP or hERG inhibition liability. It has also demonstrated good tolerability in preclinical toxicology studies in rats and dogs and is progressing toward IND filing in 2026."
IO biomarker • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • BCL2 • EGFR • KEAP1 • KRAS • MCM3 • PIK3CA
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