VariZIG (varicella zoster immune globulin) / Kamada - LARVOL DELTA

A Trial to Evaluate the Safety, Pharmacokinetics and Pharmacodynamic Profile of TNM005 in Healthy Adult Subjectsy (clinicaltrials.gov) - P1 | N=48 | Recruiting | Sponsor: Zhuhai Trinomab Pharmaceutical Co., Ltd. | Not yet recruiting ➔ Recruiting

Enrollment open • Varicella Zoster

A Trial to Evaluate the Safety, Pharmacokinetics and Pharmacodynamic Profile of TNM005 in Healthy Adult Subjectsy (clinicaltrials.gov) - P1 | N=48 | Not yet recruiting | Sponsor: Zhuhai Trinomab Pharmaceutical Co., Ltd.

New P1 trial • Varicella Zoster

Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques. (PubMed, PLoS One) - "Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS."

Journal • Herpes Zoster • Infectious Disease • Varicella Zoster

[VIRTUAL] Prevention of varicella zoster virus infection among adult immunocompromised patients by VariZIG (ECCMID 2021) - "    Conclusions This study demonstrates the efficacy and safety of VariZIG as PEP in one of the largest cohorts of immunocompromised adults to date . No early case of varicella infection was found following exposure, supporting the current recommendations of VariZIG administration."

Clinical • Hematological Disorders • Herpes Zoster • Infectious Disease • Oncology • Pediatrics • Varicella Zoster

Varicella zoster immune globulin (human) (VARIZIG) in immunocompromised patients: a subgroup analysis for safety and outcomes from a large, expanded-access program. (PubMed, BMC Infect Dis) - P=N/A | "These data indicate that VARIZIG may reduce severity of varicella in immunocompromised children and adults."

Clinical • Journal • CNS Disorders • Herpes Zoster • Immunology • Infectious Disease • Pneumonia • Primary Immunodeficiency • Respiratory Diseases • Transplantation • Varicella Zoster

Cutaneous manifestations of systemic viral diseases in neonates: an update. (PubMed) - Curr Opin Pediatr - "Neonatal rashes may be harmless and transient, whereas others may reflect the presence of a severe systemic illness. Recognizing key cutaneous features of viral-associated rashes may aid in the prompt and accurate diagnosis and treatment of neonatal viral illnesses."

Journal • Biosimilar • Immunology • Ophthalmology

Varicella zoster immune globulin (VARIZIG) administration up to 10 days after varicella exposure in pregnant women, immunocompromised participants, and infants: Varicella outcomes and safety results from a large, open-label, expanded-access program. (PubMed, PLoS One) - "Postexposure administration of VARIZIG was associated with low rates of varicella in high-risk participants, regardless of when administered within 10 days postexposure. VARIZIG was well-tolerated and safe in high-risk participants."

Clinical • Journal

Safety and Varicella Outcomes in In Utero-Exposed Newborns and Preterm Infants Treated With Varicella Zoster Immune Globulin (VARIZIG): A Subgroup Analysis of an Expanded-Access Program. (PubMed, J Pediatric Infect Dis Soc) - P=N/A; "Varicella incidence and morbidity were low in in utero-exposed infants and zero in preterm infants who received prophylactic VARIZIG. There were few VARIZIG-related safety concerns."

Clinical • Journal

Chickenpox: An update. (PubMed, Med Mal Infect) - "A tetravalent measles-mumps-rubella-chickenpox vaccine, used in the United States, has a good tolerability in spite of the occurrence of fever and febrile seizures. Routine vaccination would contribute to make savings in France, by reducing direct and indirect costs of chickenpox."

Journal • Review