Nurtec (riluzole sublingual) / Biohaven - LARVOL DELTA

The Remote Electrical Neuromodulation (REN) wearable reduces medication use for the treatment of chronic pain in migraine patients (PAINWeek 2026) - "Medication types included three categories that were presented to patients using commercial drug names: (1) over-the-counter (OTC; e.g. Advil, Excedrin, Tylenol), (2) first-line prescribed medications including oral triptans (e.g. Imitrex, Maxalt, Relpax) and oral medication for nausea (e.g. Zofran, Reglan, Compazine), (3) second-line prescribed medications including nasal/injectable triptans (e.g. Tosymara, Onzetra, Zembrace, Zoming) and branded new generation medications (Reyvow, Nurtec, and Ubrelvy). Data from 31,516 migraine patients who conducted 148,705 REN treatments were analyzed. Treatment-level analysis showed that 71.1% of the treatments were performed without the use of any prescribed medications (50.6% REN alone, 14.4% REN + OTC meds), while 28.9% were conducted in conjunction with first- or second-line prescribed medications. A patient-level analysis looked at a subset of 2,653 patients who performed at least 10 REN treatments each, in which they reported..."

Clinical • CNS Disorders • Migraine • Pain

Analyzing Google Search Trends for Migraine Surgery and Nurtec in Response to Public Announcements. (PubMed, Plast Reconstr Surg Glob Open) - "The distinct peaks in "Nurtec" RSV align with Food & Drug Administration approvals and marketing campaigns, highlighting the medication's accessibility. Conversely, the consistently low RSV for "migraine surgery" indicates limited awareness, emphasizing the need for enhanced promotion and education regarding surgical interventions."

Journal • Surgery • CNS Disorders • Migraine • Pain

Assessment and management of post-concussive headaches in rugby players: A case Study (AHS 2024) - "At follow up he was given Gabapentin, sphenopalatine ganglion block, Nurtec, Botox injections (occipital nerve block). Identification of post-traumatic headaches in patients with a history of concussions is necessary to reduce severity and frequency of headaches."

Case study • Clinical • CNS Disorders • Migraine • Pain • Vascular Neurology

"Spherix Global Insights would like to congratulate @pfizer on the launch of Zavzpret™ (zavegepant) for the acute treatment of migraine. Zavzpret is the first and only anti-CGRP nasal spray. #migraine #pfizer #zavzpret #ubrelvy #reyvow #nurtec #trudhesa" (,@SpherixNeuro)

Clinical • CNS Disorders • Migraine • Pain

".@LillyPad’s Emgality fails to hit superiority endpoint vs. Nurtec in head-to-head migraine trial #biotech #pharma https://t.co/hh1ApW78er" (,@BioWorld)

Head-to-Head • CNS Disorders • Migraine • Pain

"Keeping my drug use on the DL. (For realz though I am currently high on Nurtec.)" (,@mike_feigin)

"Nurtec is so much better" (,@YARIGHTOKAY)

"خبر عظيم. Would you able to clarify which med was approved? Is it a preventive one (aimovig, emgality...etc) or abortive one (nurtec etc)?" (,@DrMalik_K)

Acute Anxiolytic Effects of Riluzole on Subjects With Social Anxiety Disorder (clinicaltrials.gov) - P2/3; N=20; Completed; Sponsor: Yale University; Active, not recruiting ➔ Completed; Trial completion date: Oct 2020 ➔ Jan 2021

Clinical • Trial completion • Trial completion date • CNS Disorders • Mood Disorders • Psychiatry • Social Anxiety Disorder

Drugs for Migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

"$BHVN Biohaven Signs Cody Ware as Driver for Nurtec® ODT Chevrolet for the 2021 NASCAR Cup Series Season https://t.co/VQ0Z2LWOXR" (,@stock_titan)

"Hi Carolyn, we are the PR agency for Nurtec ODT and want to follow up on your tweet. Can you please follow us so we can send you a message? Thanks!" (,@SamBrownInc)

"$BHVN Biohaven's Nurtec® ODT Partners with Rick Ware Racing for 24 Hours of Daytona Entry https://t.co/ouhNxnfYXX" (,@stock_titan)

"$BHVN Biohaven's Nurtec™ ODT Partners with the Rick Ware Racing Team in the 2021 NASCAR Cup Series https://t.co/CpJvOzZ52X" (,@stock_titan)

"I feel a headache coming on I hate u @Cigna approve my Nurtec" (,@ariellec)

Pain

"Approve my generic Nurtec you cowards @Cigna" (,@ariellec)

"$BHVN FDA Accepts sNDA Of NURTEC ODT For The Preventive Treatment Of Migraine. PDUFA in Q2" (,@BioStocks)

PDUFA date • sNDA • CNS Disorders • Migraine

Novel Therapies in Acute Migraine Management: Small-Molecule Calcitonin Gene-Receptor Antagonists and Serotonin 1F Receptor Agonist. (PubMed, Ann Pharmacother) - "Based on available data, ubrogepant, rimegepant, and lasmiditan should be reserved as second-line therapy and may be safe in patients with cardiovascular risk. Lasmiditan's adverse effect profile may limit its use."

Journal • Cardiovascular • CNS Disorders • Fatigue • Migraine • Pain

Rimegepant (Nurtec ODT) for Acute Treatment of Migraine. (PubMed, JAMA) - No abstract available

Journal • CNS Disorders • Migraine

Rimegepant Orally Disintegrating Tablet for Acute Migraine Treatment: A Review. (PubMed, Ann Pharmacother) - "Rimegepant ODT is an efficacious migraine treatment option with a novel mechanism of action, convenient dosage form, and limited adverse effect profile."

Journal • CNS Disorders • Infectious Disease • Migraine • Nephrology • Pain

"Three new oral products - @LillyPad Reyvow, @Allergan Ubrelvy, @BiohavenPharma Nurtec ODT (rimegepant) - have launched for the acute treatment of migraine, becoming the first novel migraine-specific acute options to launch in two decades." (,@VikramShanbhag)

CNS Disorders • Migraine

"Biohaven accelerates DTC campaign timing for migraine med Nurtec https://t.co/gQ3xhxSUBq" (,@FiercePharma)

CNS Disorders • Migraine

Rimegepant: First Approval. (PubMed, Drugs) - "The orally disintegrating tablet (ODT) formulation of rimegepant (NURTEC ODT) is a small molecule, highly-selective, calcitonin gene-related peptide antagonist that was developed by Biohaven Pharmaceutical Holding Company Ltd as an acute treatment for migraine. In February 2020, rimegepant ODT received its first global approval in the USA for the acute treatment of migraine (± aura) in adults. This article summarizes the milestones in the development of rimegepant leading to its first global approval for acute treatment of migraine (± aura) in adults."

Journal • Review

"New Drug Trials Snapshot available for Nurtec ODT (rimegepant): https://t.co/whcKuljKpi" (,@FDA_Drug_Info)

"#hcne2020stowe @HeadacheCoopNE @alanrapoport Fantastic lecture on new abortives for #migraine treatments Nurtec (Rimegepant) ODT 75 mg 8/month one at onset, Ubrely (Ubrogepant) 50-100 mg 10/month one at onset may repeat in 2hrs, Reywow (lasmitidan) 50-100 mg watch for CNS AEs," (,@MChehrenama)