AC430 / Daiichi Sankyo - LARVOL DELTA

Comparative pangenomics of the Corynebacterium kroppenstedtii complex reveals species structure and accessory genome diversity. (PubMed, Front Microbiol) - "These findings provide a lineage-resolved genomic framework for the CKC, demonstrating an open pangenome with substantial species- and lineage-associated accessory diversity. The results further identify AC410-like resistance-associated genomic backgrounds and a candidate lipid-iron locus for future functional investigation."

Journal

The Effects of Silica Fume and Superplasticizer Type on the Properties and Microstructure of Reactive Powder Concrete. (PubMed, Materials (Basel)) - "The optimal superplasticizer (BASF ACE430) was selected for further experiments in order to evaluate the influences of silica fume and superplasticizer content on the same material properties...There were clearly visible trends and local minima and maxima of the measured properties. The optimal reactive powder concrete mixture had a composition of 3.5-4.0% superplasticizer and 15-25% silica fume."

Journal

"Un detallado avance de @scamarzana de lo que iba a ser, ¡y fue! 👉🏻 https://t.co/tueYhVufFO 🎥 Aquí el resultado. Entrevistas que calan con @MerceBoadaR @sergicamara @johnwyattclarke @medinafoto... 👉🏻 https://t.co/ac410ZFDZt #ElValordeLaImagen de @photoespana y @EspacioFTef" (,@danisesena)

Ambit Biosciences: Annual Report 2013 (Ambit Biosciences) - Anticipated US composition of matter patent protection providing generic protection for AC430 and its enantiomer (AC410) and specific protection for AC430 in 2030; Anticipated US composition of matter patent expiry covering stable crystalline forms of AC430 in 2031

Anticipated patent expiry • Immunology