DB200 program / Biodexa Pharma - LARVOL DELTA

A Single-Column Gas Chromatography Method for Quantifying Toxic Alcohols. (PubMed, J Appl Lab Med) - "Our single-column headspace GC method provides reliable, robust, and rapid identification and quantification of commonly encountered toxic alcohols. Clinical laboratories relying on direct injection Gas Chromatography (GC) for toxic alcohol analysis face challenges including frequent inlet maintenance, sample carryover, or the need for separate GC systems for volatile and glycol analysis. We summarize our development and optimization of two headspace GC methods for nonderivatized (volatile) and derivatized (glycol) plasma samples that use a single DB-200 analytical column. These methods are comparable to other GC methods, not prone to sample carryover, eliminate the need for multiple GC systems or columns, and are readily applicable to other laboratories that provide toxic alcohol analysis."

Journal • Inherited Retinal Dystrophy • Ophthalmology

Five new U.S. and foreign patents have been granted to DARA BioSciences, Inc. (Dara Biosciences) - DARA also has three promising pre-clinical drug candidate programs, one of which is DB200, a series of compounds that inhibit the enzyme carnitine palmitoyltransferase-1 (CPT-1) for the topical treatment of psoriasis; These drug candidates have the potential to inhibit inflammation and the proliferation of skin cells, thus resulting in decreased reddening and flaking of the skin

Pipeline update • Psoriasis