mesenchymal stem cells / Cell-Easy, CHU Toulouse - LARVOL DELTA

Adipose-Derived Stem Cells in the Treatment of Perianal Fistulas in Crohn's Disease: Rationale, Clinical Results and Perspectives. (PubMed, Int J Mol Sci) - "For the remaining 25% of patients there is room for in situ injection of autologous or allogenic mesenchymal stem cells such as adipose-derived stem/stromal cells (ADSCs). A pivotal phase III-controlled trial using allogenic ADSCs (Alofisel) demonstrated that prolonged clinical and radiological remission can be obtained in nearly 60% of cases with a good safety profile. Future studies should be conducted for a better knowledge of the local effect of ADSCs as well as for a standardization in terms of the number of injections and associated procedures."

Clinical • Journal • Review • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immune Modulation • Immunology • Inflammation • Inflammatory Bowel Disease

Surfing the clinical trials of mesenchymal stem cell therapy in ischemic cardiomyopathy. (PubMed, Stem Cell Res Ther) - "Lastly, pre-conditioning of MSCs and using of exosomes mediated MSCs or genetically modified MSCs may improve the overall therapeutic effect. Future prospective studies establishing a constant procedure for MSCs transplantation are required in order to apply MSC therapy in our daily clinical practice and subsequently improving the overall prognosis of ischemic heart failure patients."

Clinical • Journal • Review • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Immune Modulation • Inflammation • Transplantation • TNFA