ampicillin / Generic mfg. - LARVOL DELTA

Antibiotic exposure alters the LEAP-2/ghrelin axis and anti-inflammatory tone in aged male rat liver and adipose tissue. (PubMed, Biogerontology) - "We investigated whether a short course of broad-spectrum antibiotics (vancomycin-metronidazole-neomycin-ampicillin; VMNA) alters LEAP-2 and ghrelin levels in the liver and epididymal white adipose tissue (WAT) of aged male rats, and whether these changes coincide with modifications in IL-10, TNF-α, and IL-1β. These findings demonstrate that even a one-week antibiotic regimen induces tissue-specific alterations in the LEAP-2/ghrelin axis-characterized by reduced hepatic LEAP-2 signaling, suppressed adipose ghrelin, and diminished anti-inflammatory tone. Overall, the data suggest that aged male rats exhibit heightened vulnerability to antibiotic-induced perturbations in LEAP-2/ghrelin regulation, underscoring the interplay between microbiota-related influences, inflammaging, and age-associated metabolic imbalance."

Journal • Preclinical • Inflammation • IL10 • IL1B • TNFA

The promising activity of apple cider vinegar on MDR Klebsiella spp. (K. variicola and K. pneumoniae) emerging pathogens in chicken. (PubMed, Vet Res Commun) - "The Klebsiella isolates exhibited remarkable resistance against ampicillin (94.7%), cefotaxime (89.5%), and ceftazidime (86.9%). Our data indicated multiple health risks linked to phenotypic and genotypic resistance, as well as zoonotic importance. The Apple Cider Vinegar (ACV) possesses significant antibacterial properties."

Journal • Infectious Disease • Pneumonia

Dysbiosis of the gut microbiota induces brain inflammation in neonatal necrotizing enterocolitis via the gut-brain axis (ASH 2025) - "A suspension containing 0.2 g/L ampicillin, 0.2 g/L metronidazole, 0.2 g/L neomycin, and 0.1 g/L vancomycin was provided for lactating female rats to drink freely to establish a pseudo-sterile rat model. (Acknowledgements: This study was supported by National Natural Science Foundation of China,Grant No. 32370139 to Hongying Fan)"

Dysbiosis • Gut Microbiota • Gastrointestinal Disorder • Infectious Disease • Inflammation • Septic Shock • GATA3 • IL1B • IL6 • OCLN • TJP1 • TNFA

Lachnospiraceae-mediated bile acid metabolism promotes ileal epithelial regeneration following graft-versus-host disease damage (ASH 2025) - "Given that the number of ileal Paneth cells was significantlycorrelated with both GVHD clinical and histological scores of the ileum in this model, we utilized Panethcell numbers as a marker of impaired epithelial regeneration and GVHD severity.To investigate the impact of the ileal microbiota on ileal epithelial damage, we depleted the ilealmicrobiota using an antibiotic cocktail (ampicillin, enrofloxacin, metronidazole, and vancomycin) inallogeneic mice after SpTCD...was abrogated by cholestyramine, which binds andsequesters BAs broadly.The use of antibiotics is often necessary in allo-HSCT patients to treat bacterial infections...Preserving the abundance of Lachno spp. ortheir BA metabolic activity may represent a novel therapeutic strategy to enhance epithelial regenerationand reduce the severity of GVHD."

Bone Marrow Transplantation • Graft versus Host Disease • Immunology • Infectious Disease • THY1

Antimicrobial Management Strategies for Multidrug-Resistant Gram-positive Prosthetic Device Infections. (PubMed, Infect Dis Clin North Am) - "This review examines management strategies for methicillin-resistant staphylococci, ampicillin-resistant enterococci, vancomycin-resistant enterococci, and MDR Corynebacterium infections. Vancomycin remains the cornerstone for most resistant organisms, while newer agents like dalbavancin enable outpatient therapy. Critical considerations include recognizing linezolid toxicity during prolonged therapy, and understanding that surgical approach determines outcomes more than antimicrobial selection."

Journal • Review • Infectious Disease

Prevalence and Molecular Epidemiology of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Effects of Antimicrobial Use in Multiple Pig Industry Sectors in Korea. (PubMed, Ann Lab Med) - "Pig-derived E. coli isolates had antimicrobial resistance (AMR) rates of 80.4%, 47.2%, 32.6%, 36.7%, 43.4%, 62.4%, and 72.1% to ampicillin, piperacillin, cefazoline, ciprofloxacin, cotrimoxazole, chloramphenicol, and tetracycline, respectively. The findings highlight the significance of elucidating AMR networks among humans, animals, and the environment. Prudent antimicrobial usage and continuous AMR monitoring in the pig industry are crucial to safeguard food safety."

Journal

Effects of antibiotic treatments on symbiotic bacteria and life history traits of Bemisia tabaci and Trialeurodes vaporariorum (Hemiptera: Aleyrodidae): implications for pest control strategies. (PubMed, J Econ Entomol) - "The antibiotic treatments-tetracycline, rifampicin, and a cocktail of ampicillin, cefotaxime, and gentamicin-significantly altered the abundance of specific symbionts, with notable reductions of Rickettsia in B. tabaci and Arsenophonus in T. vaporariorum. A negative r value was also recorded in B. tabaci following tetracycline treatment. These results highlight the critical role of symbiotic bacteria in whitefly biology and provide insight into the potential consequences of disrupting these associations."

Journal

Assessment of the Antimicrobial Activity of Cistus salviifolius L. and Helichrysum stoechas (L.) DC Extracts and Their Synergistic Potential with Conventional Antibiotics Against Staphylococcus aureus. (PubMed, Int J Mol Sci) - "When combined with antibiotics such as ampicillin, ciprofloxacin, or vancomycin, the extracts of C. salviifolius and H. stoechas predominantly exhibited synergistic (FICI value ≤ 0.5) or additive effects (0.5 < FICI ≤ 1), with some combinations resensitizing resistant strains...The presence of compounds such as myricetin 3 O-galactoside, catechin derivatives, gallic acid, kaempferol, and chlorogenic acid in the extracts may contribute to their anti-Staphylococcus activity. These results demonstrated the dual antimicrobial and antivirulence potential of C. salviifolius and H. stoechas extracts, highlighting their promise as therapeutic agents or adjuvants against S. aureus. These extracts can be promising candidates for further studies on the development of novel strategies targeting multiple pathogenic pathways."

Journal

Photodynamic Inactivation Enhances Antibiotic Efficacy Without Affecting Drug Stability: Insights into Photosensitizer-Antibiotic Combination Therapies. (PubMed, Int J Mol Sci) - "In this study, the tetracationic 5,10,15,20-tetra(4-N,N,N-trimethylammoniophenyl)porphyrin (TMAP4+) was evaluated in combination with ATBs: ampicillin (AMP) and rifampicin (RIF) against Staphylococcus aureus and cephalexin (CFX) against Escherichia coli. Growth curve analyses corroborated these results, showing delayed bacterial growth and decreased maximal optical densities in the combined treatments compared to single agents. Overall, these findings demonstrate that the photodynamic process can potentiate the antimicrobial effect of conventional ATBs without compromising their stability, supporting the potential of PS-ATB combination therapies as a valuable approach to improve antibacterial efficacy and mitigate ATB resistance."

Journal

Procedural Challenges in Soil Sample Preparation for Pharmaceuticals Analysis. (PubMed, Molecules) - "Our results indicate that some compounds can be eliminated even up to 100% (including amoxicillin, ampicillin, and lincomycin) during ultrasonication and/or filtration. This study demonstrates that even problematic compounds, despite their low recovery, can be analyzed by the addition of isotopically labelled internal standards with acceptable accuracy. This finding is particularly important for environmental monitoring, where trace-level detection of pharmaceutical residues is often challenged by matrix complexity and analyte instability."

Journal

Patient with Inflammatory Bowel Disease in a Dental Office-Which Antibiotic to Choose?-Narrative Review. (PubMed, J Clin Med) - " The available evidence suggests that first- and second-line dental antibiotics-amoxicillin, ampicillin, and clindamycin-carry the highest risk of CDI. Tailored, microbiome-conscious antibiotic strategies are essential in dental management of IBD patients. Further clinical research is needed to develop evidence-based guidelines and validate promising adjunctive approaches."

Journal • Review • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Investigation of Phytol as an Inhibitor of the Efflux Pump (QacA/B) in Staphylococcus aureus: in silico and in vitro Studies. (PubMed, Pharm Res) - "However, despite the in silico interactions, the diterpene did not demonstrate direct antibacterial activity nor did it reduce the MIC of ampicillin or ethidium bromide, indicating that it does not function as an EPI."

Journal • Preclinical

Characterization of Lactococcus isolated from diseased yellowtail in Japan using whole-genome sequencing. (PubMed, J Vet Med Sci) - "The isolates showed resistance rates of 85.0% to lincomycin and 12.5% for erythromycin, and no resistance to tetracycline, ampicillin, or florfenicol was detected. Because high lincomycin resistance was observed, susceptibility testing is recommended to guide appropriate antimicrobial selection. Overall, the elucidation of the WGS-based characteristics of field isolates of Lactococcus provides useful information for vaccine use and antimicrobial therapy for the prevention and treatment of lactococcosis."

Journal

Effectiveness of Piper longum Extract as Natural Irrigant on Antimicrobial Properties and Smear Layer Removal: A Scanning Electron Microscope Study. (PubMed, J Contemp Dent Pract) - "There is a growing need for biocompatible and sustainable alternatives to synthetic irrigants, which may cause adverse effects such as tissue toxicity or dentin erosion. This study explores the potential of P. longum, a natural herbal extract with known antimicrobial and anti-inflammatory properties, as an adjunctive irrigant in root canal therapy. How to cite this article: Varshasree S, Sinduja P, Manjesh D, et al. Effectiveness of Piper longum Extract as Natural Irrigant on Antimicrobial Properties and Smear Layer Removal: A Scanning Electron Microscope Study. J Contemp Dent Pract 2025;26(11):1073-1078."

Journal

Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock. (PubMed, Sci Rep) - "Extended-spectrum beta-lactamase (ESBL) and ampicillin resistance gene type C (ampC) in foodborne Citrobacter freundii (C...Also, the investigation of the antibacterial activity of chitosan (CS) 1%, 2%, and chitosan nanoparticles (CSNPs), including the estimation of minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) and their combinations with ciprofloxacin (CIP), were evaluated...The concerning prevalence of PDR like-C. freundii in food animals is brought to light by our results, which also provide credence to the use of 2% CS-CIP and CSNPs-CIP combinations as potential substitute treatments for resistant infections."

Journal • Infectious Disease

The Use of Ampicillin-Medicated Diet to Treat Segmented Filamentous Bacteria in a Mouse (Mus musculus) Colony. (PubMed, J Am Assoc Lab Anim Sci) - "These mice remained negative for 2 additional weeks after treatment cessation. This study shows ampicillin diet is an effective method to eliminate SFB from mouse colonies."

Journal • Preclinical • Infectious Disease

NextGen - Clinical Implication of Next Generation Sequencing (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Dec 2026 ➔ Dec 2028 | Trial primary completion date: Dec 2026 ➔ Dec 2028

Biomarker • Trial completion date • Trial primary completion date • Infectious Disease • Nephrology

Desolvation Synthesis of Peroxidase-like Bovine Serum Albumin-Based Nanoparticles as a Potent Antibiotic Adjuvant To Tackle Drug-Resistant Bacteria. (PubMed, Langmuir) - "Here, the adjuvant activity center of hemin in conjunction with the traditional antibiotic of ampicillin was successfully encapsulated into a three-dimensional macromolecular framework of bovine serum albumin (BSA) to form hemin-BSA-ampicillin nanoparticles (HBA NPs) via a straightforward desolvation process...Furthermore, the formed protein coating on the nanoparticles contributed significantly to the desirable biocompatibility of the obtained nanocomposite. Therefore, the easily prepared, highly biocompatible, and antimicrobial HBA NPs provided a prototype of protein-based antibiotic adjuvants using peroxidase-like nanomaterials with promising therapeutic potential to tackle emerging drug-resistant infectious microbes."

Journal • Infectious Disease

Complete genome sequence of Heyndrickxia oleronia EISK28 isolated from human facial skin. (PubMed, BMC Genom Data) - "Secondary metabolite analysis revealed three biosynthetic gene clusters, and genome-based antibiotic resistance profiling predicted 11 resistance genes, while phenotypic testing confirmed resistance to ampicillin and penicillin. Mobile genetic element screening detected 34 insertion sequences, 2 prophages, and 16 genomic islands but no association with antibiotic resistance genes."

Journal • Dermatology • Infectious Disease • Inflammation • Rosacea

Prevalence and antimicrobial resistance patterns of monophasic Salmonella typhimurium in Hanzhong, China. (PubMed, J Infect Dev Ctries) - "This study highlights the alarming prevalence and high resistance rates of monophasic Salmonella typhimurium in Hanzhong, particularly among vulnerable populations such as young children. The findings underline the urgent need for public health interventions, including enhanced monitoring and antibiotic stewardship, to mitigate the risks associated with this pathogen."

Journal

Rising trend of Enterococcus species as pathogen, and its antimicrobial susceptibility pattern in western Gujarat. (PubMed, J Infect Dev Ctries) - "The rising trend of enterococci and the alarming rates of resistance highlight the need for rational and restricted drug use, with early detection and use of the susceptibility report to prevent treatment failures and spread of resistance."

Journal • Retrospective data • Infectious Disease • Nephrology

Antimicrobial resistance profiles of bacteria from clinical specimens at Amhara Public Health Institute, Bahir Dar, Ethiopia: A retrospective study. (PubMed, PLoS One) - "Both Gram-negative and Gram-positive isolates showed high levels of resistance to commonly used antimicrobial. To address the problem of antimicrobial resistance, healthcare providers should focus on responsible antimicrobial prescribing practices based on local antibiogram data."

Journal • Retrospective data • Cholera • Infectious Disease

Probiotic characteristics and safety evaluation of acid-tolerant lactic acid bacteria isolated from Suancai, a popular fermented vegetable in Northeast China. (PubMed, Folia Microbiol (Praha)) - "Additionally, all strains displayed antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Salmonella paratyphi B. Safety assessment revealed that the strains were sensitive to ampicillin, erythromycin, and penicillin, resistant to gentamycin, and negative for indole production and hemolytic activity. In conclusion, the four selected strains demonstrated favorable probiotic characteristics and safety profile, supporting their potential as candidate probiotics for functional food application."

Journal

The expansion of culturable opportunistic pathogens and antibiotic resistance in mouse gut following antibiotic exposure. (PubMed, Microbiol Spectr) - "Ampicillin (AMP) and imipenem (IPM) treatment led to an acute, exponential, but temporary bloom in absolute abundances of live opportunistic pathogens Enterobacteriaceae and Enterococcus, while not affecting potentially beneficial Lactobacillus...Surprising findings were made that antibiotic uptake can lead to temporary exponential bloom of opportunistic pathogens in mouse gut, and a permanent change of antimicrobial resistance in these pathogens. These findings expand our knowledge on how antibiotic therapy can affect our health and urges caution on casual antibiotic usage."

Journal • Preclinical • Infectious Disease

Genomic epidemiology and plasmid characterization of antimicrobial resistance and virulence in cattle Escherichia coli from China. (PubMed, Microbiol Spectr) - "Resistance to ampicillin (49.5%), cefotaxime (37.4%), and tetracycline (36.3%) was common, with NX showing the highest resistance rate. The strong association between plasmid types and resistance gene burden highlights key targets for surveillance. These findings offer valuable insights into the molecular epidemiology of bovine E. coli and support more effective, region-specific strategies to monitor and control the spread of AMR in livestock."

Journal • Gene Therapies