ampicillin / Generic mfg. - LARVOL DELTA

Genotypic and Phenotypic Characterization of Cronobacter spp. Strains Isolated from Powdered Milk Formulas and Dairy Production Environments. (PubMed, Microorganisms) - "All strains exhibited resistance to cephalothin, 18 were resistant to ceftazidime and 11 to ampicillin. All strains carried plasmids and mobile genetic elements. The multidrug resistance and presence of virulence genes in these isolates highlight the significant risk that C. sakazakii-contaminated powdered dairy products pose to public health, underscoring the need to adopt proper hygienic manufacturing practices and effectively implement HACCP in their production."

Journal • Infectious Disease • ST13

Resistance Mechanisms of Rhizospheric Bacillus and Pseudomonas Strains Against Heavy Metal Contamination (Cu, Cr and Cd) and Their Antifungal Properties. (PubMed, Microorganisms) - "Additionally, these strains exhibited diverse mechanisms for heavy metal tolerance, including salinity tolerance (up to 600 mM), multi-antibiotic resistance (to imipenem, ampicillin, and sodium fusidate), and the production of viscous, slimy colonies indicative of EPS synthesis...The antifungal assays demonstrated that the strains effectively inhibited the mycelial growth of the fungal isolates, with inhibition percentages varying from 0% to 83.34 ± 2.22%. The strains characterized in this study exhibit considerable potential for application in the bioremediation of metal-contaminated soils and as biocontrol agents."

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Bovine-Derived Acinetobacter indicus Co-Harboring Chromosomal tet(X3) and Plasmid-Located tet(X4) Isolated from Henan, China. (PubMed, Microorganisms) - "The strain exhibited resistance to ampicillin, gentamicin, chloramphenicol, sulfamethoxazole, tetracycline, doxycycline, tigecycline, and omadacycline. Conjugation assay failed to observe the transfer of the tet(X4)-positive plasmid into recipients, E. coli J53 and Salmonella LGJ2. The co-occurrence of tet(X3) and tet(X4) in Acinetobacter may suggest a risk of rapid dissemination of tigecycline resistance and the hidden presence of numerous undetected bacteria co-carrying high-risk ARGs in the agroecological system, both of which should cause particular concern."

Journal • Infectious Disease

Antibiotic Outcomes of Enterococcal Urinary Tract Infections: A Retrospective Analysis from Saudi Arabia and Oman. (PubMed, Pathogens) - "This study highlights the clinical challenges posed by enterococcal UTIs, particularly by E. faecium. Ciprofloxacin remains an effective option, particularly against E. faecalis. Patients with advanced age, critical illness, complicated infections, and liver disease, as well as patients on hemodialysis, require close monitoring to improve outcomes."

Journal • Retrospective data • Hepatology • Infectious Disease • Nephrology • Oncology

Prevalence, Virulence Determinants, and Antimicrobial Resistance of Staphylococcus aureus and Escherichia coli Isolated from Computer Devices Used by Staff and Students at a Northern Thailand University. (PubMed, Pathogens) - "All E. coli isolates were resistant to ampicillin, and 50% displayed multidrug-resistant phenotypes. These findings suggest that computer devices can act as occasional reservoirs of potentially pathogenic and antimicrobial-resistant bacteria in university environments."

Journal • Infectious Disease

Genomic Features and Antimicrobial Susceptibility of Listeria innocua Isolated from Raw Drinking Milk in Poland. (PubMed, Foods) - "All isolates were phenotypically susceptible to benzylpenicillin, ampicillin, meropenem, erythromycin, and trimethoprim-sulfamethoxazole. These findings underscore the importance of ongoing genomic surveillance of L. innocua in food environments and highlight the need to assess the potential risk posed by specific lineages, such as ST492, to food safety."

Journal • Immune Modulation • Immunology

Effect of Biosynthesized Gold and Silver Nanoparticles Using Alchemilla vulgaris Extract and Their Synergistic Action with Subinhibitory Concentrations of Ampicillin Against Staphylococci. (PubMed, Antibiotics (Basel)) - "These findings highlight the importance of rational combination therapy to improve antibiotic effectiveness and reduce bacterial resistance."

Journal • Infectious Disease

Ntimicrobial-resistant Listeria species isolated from beef and beef products sold in Mpumalanga province, South Africa. (PubMed, J Food Prot) - "All 33 isolates of L. monocytogenes were susceptible to five antimicrobial agents (penicillin, ampicillin, amoxicillin-clavulanic acid, gentamicin, and trimethoprim-sulfamethoxazole, which are commonly used in the treatment of listeriosis. Resistance prevalence ranged from 3.0% to 100% for L. monocytogenes and from 1.7% to 100% for Listeria spp., with nalidixic acid showing universal resistance...This is because AMR-L. monocytogenes can transfer resistance genes/plasmids to pathogenic L. monocytogenes, thereby posing both food safety and therapeutic implications."

Journal

Whole-genome characteristics, antimicrobial resistance and virulence of pathogenic Aeromonas veronii from diseased Macrobrachium rosenbergii. (PubMed, J Invertebr Pathol) - "Phenotypic susceptibility testing indicated broad susceptibility to multiple cephalosporins and aminoglycosides, with resistance to several penicillins (ampicillin, piperacillin, oxacillin), tetracycline, and fluoroquinolones (norfloxacin, ciprofloxacin). These findings confirm MRG1 as a pathogenic isolate associated with the mortality event. The complete genome sequence provides a valuable reference for future comparative genomic studies of virulence and resistance variation among A. veronii strains infecting M. rosenbergii."

Journal • Infectious Disease

Prevalence and Antimicrobial Resistance of Escherichia coli Isolated from Chicken Carcasses in Romania: Zoonotic Potential and Public Health Impact. (PubMed, Vet Sci) - "High resistance rates were observed for tetracycline (82.6%), ampicillin (68.3%), and trimethoprim-sulfamethoxazole (61.2%), while multidrug resistance occurred in 34.3% of isolates. The results suggest that poultry carcasses may contribute to the dissemination of resistant and ESBL-producing E. coli, reflecting intestinal carriage and contamination during processing. Strengthened antimicrobial stewardship, systematic resistance monitoring, and improved hygiene practices throughout the poultry production chain are essential to reduce the public health impact of resistant bacteria."

Journal

A One Health assessment of antimicrobial-resistant Enterobacterales in migratory little stints (Calidris minuta) and aquatic ecosystems in the Kenyan Rift Valley. (PubMed, PLoS One) - "Isolates were recovered from fecal samples of C. minuta foraging at the shores of Lakes Bogoria (low anthropogenic activities) and Magadi (high anthropogenic activities), as well as from peripheral freshwater sources shared by birds, humans, livestock and wildlife...Resistance was highest for ampicillin (50%) and lowest for meropenem (1.0%). The predominant MDR phenotype was a combination of resistances to ampicillin, tetracycline, and sulfamethoxazole-trimethoprim...This is the first study to link C. minuta to the antimicrobial resistance (AMR) epidemiological circuit. Our findings underscore the need to include migratory wild birds in AMR surveillance and utilizing whole-genome sequencing to accurately trace the origin and dissemination pathways of AMR strains."

Journal

Antimicrobial Susceptibility Patterns and Outcomes of Neonatal Early-Onset Sepsis over a Decade: Implications for Empirical Therapy in a Tertiary NICU. (PubMed, J Clin Med) - "All GBS isolates (n = 7) were susceptible to benzylpenicillin and vancomycin. Although 90% of E. coli were ampicillin-resistant, 90-95% remained susceptible to third-generation cephalosporins, piperacillin-tazobactam, and aminoglycosides...However, the widespread ampicillin resistance, particularly among E. coli strains, supports consideration of cephalosporin-aminoglycoside combinations or meropenem monotherapy when rapid beta-lactam bactericidal activity is clinically essential. Mortality was higher in E. coli EOS, though not statistically significant, and unrelated to ampicillin resistance."

Journal • Critical care • Infectious Disease • Septic Shock

Antibiotic Prophylaxis and Treatment of Neonatal Group B Streptococcus Disease in the Era of Antimicrobial Resistance. (PubMed, Antibiotics (Basel)) - "β-lactam antibiotics, including penicillin G and ampicillin, remain the cornerstone of both GBS prophylaxis and neonatal treatment, supported by sustained susceptibility, favorable pharmacokinetics, and extensive clinical experience. However, increasing global resistance to macrolides and lincosamides has markedly reduced the reliability of clindamycin and erythromycin, which are commonly used as second-line agents in women with severe penicillin allergy...Available surveillance data demonstrate substantial geographic variability in resistance but consistently low resistance to β-lactams and vancomycin...Alternative agents such as linezolid and teicoplanin exhibit activity against GBS, but their use remains limited by sparse neonatal data and pharmacokinetic variability. Ongoing antimicrobial surveillance, susceptibility-guided therapy, and stewardship initiatives are essential to preserve effective GBS prevention and treatment strategies."

Journal • Review • Allergy • Immunology • Infectious Disease • Septic Shock

Disruption of the Lung Microbiome Early in Life Protects Mice from Systemic Lupus Erythematosus (IMMUNOLOGY 2026) - "It is widely accepted that the gut microbiome plays a role in SLE progression, but there is less data about other mucosal microbiomes, such as in the lung. We administered a mixture of vancomycin, neomycin, ampicillin, and metronidazole (ABX) or phosphate-buffer solution (PBS) via intranasal gavage every 3 days, starting at 4 weeks, until 7 of life (10 administrations) to lupus-prone MRL/lpr mice, collecting urine and weights weekly. We found that intranasal antibiotics conferred protection against lupus, and that the lung microbiome was capable of predicting disease outcomes in lupus-prone mice. We believe that further study of the lung microbiome in inflammatory diseases is important, as it is a major site of microbe-host interaction."

Lung Microbiome • Preclinical • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Systemic Lupus Erythematosus • CD4 • CD8 • IFNG • IL17A • MSLN

The inflammatory response and immune cell status following radiation exposure influence the host's susceptibility to new infections (IMMUNOLOGY 2026) - "Thus, immune cellularity and inflammation control after RE determine the host's ability to clear infection and improve survival. These findings help guide future work to improve MCMs for RE patients."

Immune cell • Hematological Malignancies • Infectious Disease • Inflammation • Pneumococcal Infections • Pneumonia • Septic Shock • Solid Tumor

Photoactivatable diazafluorenone-based ruthenium compounds as a new strategy to combat microbial resistance. (PubMed, J Inorg Biochem) - "Interestingly, the combination of MPD5 with ampicillin showed a synergistic effect against Gram-negative bacteria, while the combination of MPD4 or MPD5 with tetracycline showed a synergistic effect against all bacterial strains, including resistant ones. 71% at 7.8 μg mL-1). Altogether, these data provide exciting evidence for the potential use of these compounds as antimicrobial photodynamic therapeutic agents, enriching the arsenal of metallodrugs."

Journal • Infectious Disease

Trends in a Persistent Strain of Multidrug-Resistant Salmonella Infantis (REPJFX01) in Humans and Chickens - United States, 2010-2023. (PubMed, J Food Prot) - "REPJFX01 isolates are often resistant to antibiotics used for treatment including ampicillin, ceftriaxone, ciprofloxacin, and trimethoprim-sulfamethoxazole. REPJFX01 trends in humans and chickens appear coincident (both occurring during the same time period), suggesting that chicken may be an important reservoir for REPJFX01. Efforts to prevent Salmonella contamination of chicken and strengthen safe handling and cooking of chicken should be prioritized."

Journal • Infectious Disease

A Study of Clinical and Etiological Relation of Urinary Tract Infections in Patients with Type 2 Diabetes Mellitus. (PubMed, Ann Afr Med) - "Adequate glycemic control is crucial for reducing UTI recurrence and morbidity in patients with T2DM."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Type 2 Diabetes Mellitus

Wild-type cutoff values for standard broth microdilution antimicrobial susceptibility testing of Edwardsiella ictaluri and E. piscicida isolates. (PubMed, Dis Aquat Organ) - "WT cutoff values for E. ictaluri against ampicillin, enrofloxacin, erythromycin, florfenicol, gentamicin, oxolinic acid, oxytetracycline, ormetoprim/sulfadimethoxine, and trimethoprim/sulfamethoxazole were ≤1, ≤0.12, ≤128, ≤2, ≤2, ≤0.5, ≤2, ≤0.5/9.5, and ≤0.25/4.8 µg ml-1, respectively. These WT cutoff values provided the CLSI with data needed to approve ECVs which will be included in the next edition of the VET04 supplement. CLSI-approved ECVs resulting from this work will greatly improve antimicrobial resistance surveillance of these bacterial pathogens impacting global aquaculture."

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Antimicrobial resistance and treatment mismatch in culture-proven sepsis among very preterm infants in Chinese NICUs: a cohort study. (PubMed, Lancet Reg Health West Pac) - "Gram-negative bacteria predominated in both EOS (59.0%) and LOS (48.3%), with resistance to cefotaxime and ceftazidime reaching 69.8% and 28.6% in EOS, and even higher rates in LOS. An ampicillin plus ceftazidime regimen would fail to cover 13.3% of EOS cases, while gentamicin-based regimens showed comparable coverage. Nearly all Gram-positive EOS pathogens were susceptible to penicillin/ampicillin, yet 16.6% of definitive therapy involved vancomycin or linezolid...These findings highlight the need to integrate susceptibility and prescribing data to inform national guideline updates and targeted antimicrobial stewardship strategies. This work was funded by China Medical Board (grant #20-370)."

Journal • Critical care • Infectious Disease • Septic Shock

Urinary tract infections, risk factors and antimicrobial resistance patterns in heart failure patients on sodium-glucose transporter 2 inhibitors: Evidence from Jakaya Kikwete Cardiac Institute in Tanzania. (PubMed, PLoS One) - "UTIs are common among HF patients on SGLT2 inhibitors, with E. coli as the predominant pathogen and a concerning resistance to commonly used antibiotics. These findings underscore the need for routine urine culture and sensitivity testing to guide appropriate therapy and promote antimicrobial stewardship, particularly in resource-constrained settings."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Nephrology • Pneumonia

Distribution of Pathogenic Bacteria and Changes in Drug Resistance of Urinary Tract Infections in Children in Southwest China, 2020-2024. (PubMed, Infect Drug Resist) - "coli showed less than 10% resistance to piperacillin/tazobactam, cefoperazone/sulbactam, amikacin and nitrofurantoin, with resistance to quinolones ranging from 31.3% to 51.5%...pneumoniae showed resistance rates of 13.1% and 16.8% to imipenem and meropenem, respectively, from 2020 to 2024...faecium showed significantly higher resistance rates to the tested drugs than E. faecalis, particularly to ampicillin (95.1-97.4% vs 4.9-8.0%)...MRSA showed a higher level of resistance to penicillin, rifampicin, levofloxacin, clindamycin and erythromycin than methicillin-sensitive strains. Over the past five years, the main pathogenic bacteria responsible for pediatric UTIs in southwestern China were E. coli, E. faecium and E. faecalis. Resistance patterns among major uropathogens revealed diverse trends, and the emergence of multidrug-resistant organisms presents a serious therapeutic challenge that warrants close surveillance."

Journal • Infectious Disease • Nephrology • Pediatrics • Pneumonia

LIFE-SAVING AMPUTATION FOR STREPTOCOCCAL TOXIC SHOCK SYNDROME 10 YEARS AFTER KIDNEY TRANSPLANTATION FOR CALCIPHYLAXIS TREATED WITH AUTOLOGOUS SKIN GRAFTING: A CASE REPORT (ISN-WCN 2026) - "Laboratory findings included WBC 10,800/μL, sCr 2.33 mg/dL, BUN 33 mg/dL, CK 580 IU/L, LDH 360 IU/L, and CRP 21.3 mg/dL.Results Initial treatment with meropenem and vancomycin was started for presumed cellulitis...On day 3, blood cultures revealed Streptococcus pyogenes (Group A), and antibiotics were switched to ampicillin and clindamycin...It underscores the importance of early recognition and aggressive intervention, including surgical management, in immunocompromised patients. The unique clinical trajectory—from calciphylaxis treated with skin grafting to KT and late-onset STSS—offers valuable insights into complex infection risks and transplant-related immunological dynamics."

Case report • Clinical • Calciphylaxis • Infectious Disease • Musculoskeletal Pain • Nephrology • Rare Diseases • Septic Shock • Transplant Rejection • Transplantation

MANAGEMENT CHALLENGES IN MEDULLARY SPONGE KIDNEY COMPLICATED BY RHEUMATOID ARTHRITIS AND RECURRENT URINARY TRACT INFECTIONS: A CASE REPORT (ISN-WCN 2026) - "Management becomes challenging when immunosuppression, antimicrobial resistance, and drug allergies limit therapeutic options.Methods A woman in her 60s with rheumatoid arthritis, controlled on sulfasalazine 1,000 mg/day and subcutaneous tocilizumab 162 mg every 2 weeks, was diagnosed with MSK in her 40s after pyelonephritis and diffuse medullary calcifications on non-contrast CT...Urine cultures repeatedly yielded multidrug-resistant Escherichia coli resistant to ampicillin, levofloxacin, and trimethoprim–sulfamethoxazole...Joint symptoms remained under control following the single tocilizumab dose.Conclusion In cases of MSK complicated by immunosuppression, recurrent UTIs may require tailored, stepwise regimens and careful antimicrobial stewardship when resistance and allergies constrain options. A strategic selection and sequencing of agents, including cephalexin (dosage adjusted for body weight), gentamicin, and fosfomycin calcium 9 g/day, was instrumental in..."

Case report • Clinical • Immunology • Infectious Disease • Inflammatory Arthritis • Musculoskeletal Pain • Nephrology • Rheumatoid Arthritis • Rheumatology

TOSUFLOXACIN-INDUCED NEPHROGENIC DIABETES INSIPIDUS IN AN INFANT: A CASE REPORT (ISN-WCN 2026) - "We present a rare case of TFLX-induced crystalline nephropathy that manifests transient nephrogenic diabetes insipidus (NDI).Methods A previously healthy 22-month-old boy with acute otitis media was administered TFLX at a dose of 12 mg/kg/day following unsuccessful treatment with ampicillin and cefditoren pivoxil. This highlights the vulnerability of infants to fluoroquinolone-induced renal complications. When fluoroquinolones are deemed necessary for young children, careful monitoring of parameters such as urine output, specific gravity, and urinary sediment may facilitate the early detection of drug-induced NDI."

Case report • Clinical • Infectious Disease • Metabolic Disorders • Otorhinolaryngology • Pneumonia • Renal Disease