ampicillin / Generic mfg. - LARVOL DELTA

Bacteraemia with Meningitis Caused by Listeria Innocua of Unknown Source in an Elderly Patient with Type 2 Diabetes Mellitus: A Case Report and Literature Review. (PubMed, Eur J Case Rep Intern Med) - "Listeria innocua, although considered non-pathogenic in healthy individuals, can cause severe bacteraemia and meningitis in elderly patients with poorly controlled diabetes mellitus.Third-generation cephalosporins are not effective against all Listeria species; empiric treatment in patients >65 years with diabetes mellitus and meningitis must include ampicillin.Recent molecular studies have identified some atypical L. innocua strains carrying virulence genes, challenging the traditional view of the harmlessness of this species."

Journal • Cardiovascular • CNS Disorders • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Oncology • Pain • Type 2 Diabetes Mellitus

KLEBSIELLA PNEUMONIAE-INDUCED NEONATAL SEPTIC SHOCK REQUIRING EXTRACORPOREAL MEMBRANE OXYGENATION IN A LATE-TERM INFANT (WRMC 2026) - "Cefepime and Ampicillin were started. This case highlights the importance of recognizing signs of neonatal sepsis for prompt admission. Klebsiella pneumoniae-induced pneumonia can progress rapidly to severe septic shock requiring ECMO. Educating families regarding severity of neonatal sepsis is critical to initiate timely treatment."

Cardiovascular • Hematological Disorders • Hypotension • Infectious Disease • Leukopenia • Metabolic Disorders • Neutropenia • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock

Penicillin Allergy Evaluation in Pediatric Patients: Safety of Testing without MDM and the Role of Testing to Ampicillin and Duplicate PrePen® (AAAAI 2026) - "Among 265 patients with negative skin testing who underwent oral challenge to a penicillin (primarily Conclusions Penicillin skin testing using penicillin G, PrePen®, and ampicillin—without MDM testing—demonstrated a NPV of 98%. Inclusion of ampicillin identified an additional 33 patients (26.4%) with positive results. These findings suggest MDM may not be necessary in pediatric penicillin allergy testing protocols and that ampicillin should be considered an essential component of penicillin testing."

Clinical • Allergy • Immunology • Pediatrics

Biochemical and structural analyses of metallo-β-lactamase VIM-28: impact of substitutions at residues 224 and 228 on substrate profile, stability, and zinc affinity. (PubMed, Microbiol Spectr) - "Compared with VIM-26 (R228S), VIM-28 displayed decreased Km (12.5 for VIM-28 vs 513 μM for VIM-26; 9.66 vs 150 μM) and increased kcat/Km(15.3 vs 1.81 μM-1s-1; 28.6 vs 5.89 μM-1s-1) for ampicillin and cephalothin, respectively...The combined L224H/R228S substitutions in VIM-1 increased the catalytic efficiency of the enzyme for ceftazidime by more than one order of magnitude...Notably, the R228S substitution improved zinc binding and thermal stability, supporting enzyme function under zinc-limited host conditions. These findings reveal mechanisms driving MBL diversity and highlight evolutionary strategies sustaining antibiotic resistance."

Journal

Prevalence of methicillin-resistant Staphylococcus aureus and multidrug resistance among food handlers in a hospital food and nutrition unit in Rio de Janeiro, Brazil. (PubMed, Lett Appl Microbiol) - "High resistance rates were observed for penicillin, erythromycin, and ampicillin. Methicillin-resistant S. aureus (MRSA) represented 29% of hand isolates and 47% of nasal isolates, and 26% were multidrug resistant. These findings indicate that food handlers may act as reservoirs and transmission sources of antimicrobial resistance in hospital food service settings, highlighting the need for continuous monitoring, strict hygiene practices, and antimicrobial stewardship programs."

Journal • Infectious Disease

Antimicrobial resistance of bacteria isolated in a resource-limited region: the experience of the North Kivu Provincial Reference Laboratory in the Democratic Republic of the Congo. (PubMed, Front Med (Lausanne)) - "In E. coli, resistance exceeded 60% to ampicillin, amoxicillin/clavulanate, and ciprofloxacin...pneumoniae showed uniform resistance to ampicillin and high resistance to cefuroxime, cefotaxime, gentamicin, and colistin...Recommended actions include participation in WHONET/GLASS program and antibiotic stewardship. In the interim, empiric strategies should favor nitrofurantoin for uncomplicated cystitis, judicious aminoglycoside use where appropriate, early culture, and prompt de-escalation, reserving carbapenems for severe ESBL-risk presentations."

Journal • Infectious Disease • Pneumonia

Molecular basis of ampicillin resistance: combinatorial mechanisms and future strategies. (PubMed, World J Microbiol Biotechnol) - No abstract available

Journal • Review

Hidden carriers: multidrug-resistant bacteria in hedgehogs from a wildlife rescue centre. (PubMed, Front Vet Sci) - "coli isolates were obtained on MacConkey agar (MCA) and MCA with cefotaxime and confirmed by MALDI-TOF MS...More than half of the isolates (37/69; 54%) were multidrug-resistant, with resistance most frequently observed to ampicillin and nalidixic acid...The presence of sequence types and resistance genes commonly associated with human and veterinary infections further supports the relevance of rehabilitated wildlife to the broader epidemiology of AMR. Enhancing biosafety practices and antimicrobial stewardship in wildlife rescue operations is therefore essential to mitigate zoonotic risks within a One Health framework."

Journal • CNS Disorders • Infectious Disease • Psychiatry

Role of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Predicting In-Hospital Mortality in Patients With Diabetic Foot Ulcers Undergoing Amputation: A Retrospective Study. (PubMed, Cureus) - "Elevated postoperative NLR and PLR are independent predictors of in-hospital mortality in DFU patients undergoing MLLA. These readily available biomarkers can assist in early risk stratification and guide postoperative management. The study also provides region-specific data on microbial prevalence and antibiotic susceptibility, supporting more targeted empiric therapy in this high-risk population."

Journal • Retrospective data • Diabetes • Metabolic Disorders

Differences in β-lactamase activity and carbapenem resistance among the Bacillus cereus group. (PubMed, Antimicrob Agents Chemother) - "Although all B. luti isolates lacked carbapenemase genes, they exhibited higher minimum inhibitory concentration (MIC) ranges for ampicillin and meropenem...All B. luti isolates and some B. mosaicus and B. cereus s.s. isolates displayed constitutive enzyme activity for penicillin G, whereas most B. mosaicus and B. cereus s.s. isolates displayed inducible activity, and five displayed silent activity...This is the first study to demonstrate interspecies variability within the B. cereus group regarding the presence of carbapenemase genes and β-lactam resistance profiles. These findings provide crucial insights into β-lactam resistance mechanisms in this bacterial group and provide a foundation for further research."

Journal • Infectious Disease

Preferential Encapsulation of DNA Impurities Derived from pAAV Plasmid Backbone into Recombinant Adeno-Associated Virus Capsids. (PubMed, Hum Gene Ther) - "These samples contained 0.49-3.80% detectable DNA impurities derived from the three plasmids, as estimated by the ampicillin resistance gene (ampR)...Analysis of the terminal sequences of the long reads containing backbone sequences revealed that 92.7-98.4% of them contained Rep-binding elements. These results indicate that the pAAV backbone in linear DNA form was cleaved from pAAV-ZsGreen1 by Rep78/68 nicking at trs in the nucleus, and that the single-stranded DNA was efficiently translocated into the capsids through the encapsulating machinery, similar to the rAAV genome."

Journal • Gene Therapies

Listeriosis - a retrospective study of 5 years on risk factors and clinical outcomes at a tertiary care hospital in Islamabad, Pakistan. (PubMed, Access Microbiol) - "Ampicillin-based regimens were the most frequently used treatments, and all isolates were sensitive to the tested antibiotics...This study highlights how listeriosis poses substantial morbidity and mortality risk, especially in pregnant cases. There is also a critical data gap, emphasizing the need for better diagnostic strategies, timely and targeted interventions, awareness of the clinical team and public health surveillance to reduce the burden of this often-overlooked infection in Pakistan."

Clinical data • Journal • Retrospective data • Cardiovascular • Chronic Kidney Disease • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Oncology • Pain • Renal Disease • CRP

Incidence and pattern of antimicrobial resistance of main bacterial isolates from patients with communityacquired urinary tract infections in North of Iraq. (PubMed, Arch Ital Urol Androl) - "Community-acquired UTI pathogens in Sulaimani  showed high resistance to widely used oral antibiotics, while carbapenems and nitrofurantoin remained effective. Higher resistance was especially noted among older adults, men, and patients with diabetes or renal disease. These findings highlight the need for improved empirical therapy and ongoing resistance surveillance."

Journal • Cardiovascular • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease

Antibacterial capacity interactions between Aristotelia chilensis (Mol.) Stuntz leaf extract and commercial antibiotics. (PubMed, Nat Prod Res) - "Combining the extract with ampicillin or chloramphenicol, the extract reduced the MICs of the antibiotics by up to six-fold. The interaction of maqui leaf extracts with conventional antibiotics was found to significantly enhance antibacterial activity, reducing required antibiotic doses and highlighting their relevance in combating antimicrobial resistance."

Journal • Infectious Disease

Adsorptive elimination of antibiotics from contaminated water utilising customised zirconia: material synthesis, characterisation, and efficiency in tetracycline and ampicillin removal. (PubMed, J Environ Manage) - "Interference assays demonstrated that cations commonly present in surface waters exerted minimal impact on antibiotic uptake, underscoring the sorbent's high selectivity and resistance to competitive ionic effects. Taken together, these findings demonstrate that microparticulate ZrO2 is a promising material for ampicillin and tetracycline removal from water, reducing ecotoxicity and contributing to antimicrobial resistance mitigation."

Journal

Tracking Antimicrobial Resistance in Typhoidal Salmonella, 2020-2024: Output from An Antimicrobial Resistance Surveillance Network in New Delhi, India. (PubMed, Indian J Med Microbiol) - "Susceptibility to traditional first-line agents is improving, and multidrug resistance is low; however, fluoroquinolone resistance remains high. Ongoing AMR surveillance and prudent antibiotic use are essential to sustain treatment efficacy."

Journal • Infectious Disease

Design of Ampicillin Loaded-Electrospun Citric Acid/PVA/Dextran Nanofibers for In Vivo Wound Healing Applications: Synthesis and In Vivo Assessment. (PubMed, Chem Biodivers) - "The obtained results demonstrated that controlled local delivery of AMP through optimized CA-cross-linked PVA/Dex NFs markedly accelerates wound healing. Therefore, the developed AMP-loaded CA/PVA/Dex electrospun nanofibrous mats represent a novel, biocompatible, and effective wound dressing platform with strong potential for clinical wound management."

Journal • Preclinical • Addiction (Opioid and Alcohol)

Musculoskeletal infections caused by Salmonella Typhi: A series of two case reports in immunocompetent adults. (PubMed, Trop Doct) - "The isolates were susceptible to ceftriaxone, ciprofloxacin, azithromycin, cotrimoxazole, and ampicillin, but resistant to chloramphenicol. Both patients were immunocompetent, with no history of trauma, diabetes, or haemoglobinopathy, and responded well to antibiotic therapy. These cases highlight the need for clinical awareness of atypical presentations of S. Typhi osteomyelitis and the importance of timely diagnosis in endemic regions."

Journal • Diabetes • Infectious Disease • Inflammation • Metabolic Disorders • Mood Disorders • Musculoskeletal Diseases • Pain

Drug-resistant genes, virulence characteristics, and molecular typing of clindamycin-resistant Streptococcus agalactiae in late pregnancy. (PubMed, Front Cell Infect Microbiol) - "All strains were susceptible to penicillin, ampicillin, linezolid, vancomycin, and tigecycline. In contrast, resistance rates to erythromycin, levofloxacin, and tetracycline were 95.5%, 60.1%, and 56.7%, respectively...Clindamycin-resistant S. agalactiae in late-pregnancy women in Shandong Province, China exhibits a broad resistance spectrum, diverse molecular types, and significant regional heterogeneity. These findings underscore the need for continued surveillance and region-specific strategies for preventing neonatal S. agalactiae infections."

Journal • Infectious Disease

Infectious mononucleosis with ampicillin rash and a positive rapid streptococcal antigen test: a case report. (PubMed, Fukushima J Med Sci) - "We report a 22-year-old woman with fever, sore throat, lymphadenopathy, and a generalized erythematous rash after a 7-day course of amoxicillin-clavulanate. Serology confirmed acute Epstein-Barr virus infection, and throat culture revealed only alpha-hemolytic streptococci. This case underscores the diagnostic overlap between IM and streptococcal pharyngitis, the need for caution in interpreting rapid antigen tests, and the importance of avoiding unnecessary antibiotics in suspected viral illness."

Journal • Epstein-Barr Virus Infections • Infectious Disease • Otorhinolaryngology

Transplacental passage of ampicillin: Implications for antenatal therapy. (PubMed, Placenta) - "This study using an ex vivo placenta perfusion model, revealed only moderate transplacental transfer of ampicillin. This finding, in the context of the retrieved serum concentrations, suggests that adjusted dosing may be required in severe conditions to optimize drug exposure, emphasizing the need for further pharmacokinetic research in pregnancy."

Journal • Infectious Disease • Septic Shock

Early-life antibiotics and childhood allergy: a multi-center cohort. (PubMed, Allergy Asthma Clin Immunol) - "Allergic conditions affect about one third of children treated with antibiotics in early life. While allergic conditions tended to decrease with age, no association was observed between antibiotic number/class and later allergy, except for a hypothesis-generating signal toward lower odds with TMP-SMX."

Journal • Allergy • Immunology • Pediatrics

Predicting antimicrobial resistance in Staphylococcus aureus using machine learning: Insights from a five-year surveillance study. (PubMed, Comput Biol Chem) - "Among ML models, Random Forest achieved the best overall performance across most antibiotics, Logistic Regression was optimal for ampicillin, and Gradient Boosting for linezolid. Vancomycin, linezolid, penicillin, and SXT achieved precision and recall above 0.92, demonstrating strong predictive reliability...aureus remains a major clinical threat in Saudi Arabia, with high MDR rates but preserved efficacy of last-line antibiotics. This study highlights the value of combining multi-center surveillance with interpretable machine learning approaches to support antimicrobial stewardship, enhance early resistance prediction, and inform data-driven clinical decision-making, particularly in settings where rapid molecular diagnostics may be limited."

Journal • Infectious Disease

Uncommon susceptibility as an epidemiological tracer: clonal tracking of ampicillin-susceptible Enterococcus faecium using IR Biotyper FTIR (ESCMID Global 2026) - No abstract available

Clinical

Infrared spectroscopy (FTIR) for the rapid identification of ampicillin resistance in bacteria causing urosepsis (ESCMID Global 2026) - No abstract available