Coronavirus Vaccine / Western University - LARVOL DELTA

Assessment of the immune response induced by ChAdOx1 nCoV-19 Oxford-AstraZeneca, Sputnik V, and BNT162b2 Pfizer-BioNTech vaccines during the COVID-19 epidemic outbreak in the Mexican population: Gene expression of the cytokine storm. (PubMed, Infect Genet Evol) - "Longitudinal studies with appropriate controls are needed to establish the biological significance of these transcriptional patterns."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • CD79A • FCGR3A • IL10 • IL2

A community-engaged public health research and outreach program for immigrant and racialized workers in meat processing during the COVID-19 pandemic. (PubMed, BMC Public Health) - "During public health crises, community-academic-healthcare partnerships can rapidly implement multicultural CBPR strategies to engage immigrant and racialized workers concurrently in research and public health outreach."

Journal • Infectious Disease • Novel Coronavirus Disease

Refractory pemphigus vulgaris temporally associated with mRNA COVID-19 vaccination (CDA 2026) - "Methods/ A 42-year-old woman developed recurrent blistering eruptions on the shoulders approximately four weeks after receiving the second dose of the mRNA-1273 COVID-19 vaccine...Initial skin biopsies were nondiagnostic with nonspecific findings, and empiric treatment with doxycycline did not result in clinical improvement...Adjunctive therapy with mycophenolate sodium and azathioprine failed to achieve disease control...The patient remains in partial remission on rituximab, azathioprine 50 mg daily, and low-dose prednisone... This case adds to the emerging evidence of rare autoimmune blistering disease following mRNA COVID-19 vaccination. While causality cannot be definitively established, the close temporal association, absence of alternative triggers, and refractory disease course support vaccine-associated immune activation. Clinicians should maintain heightened suspicion of PV in persistent post-vaccination blistering eruptions, even without early mucosal..."

Dermatology • Immunology • Infectious Disease • Novel Coronavirus Disease • Pemphigus Vulgaris

Vaccine Hesitancy in Black/African Americans With Rheumatic Diseases (clinicaltrials.gov) - P=N/A | N=60 | Active, not recruiting | Sponsor: Northwestern University | Trial completion date: Mar 2027 ➔ Dec 2027

Trial completion date • Infectious Disease • Inflammatory Arthritis • Novel Coronavirus Disease • Rheumatology

Strengthening access to and confidence in COVID-19 vaccines among equity-deserving populations across Canada: An exploratory qualitative study. (PubMed, PLoS One) - "This study highlights the divide between well-intentioned strategies and interventions and the reality of on-the-ground implementation. The findings offer valuable insights and can inform the implementation of strategies to distribute vaccines equitably in future large-scale vaccination efforts in Canada and globally."

Journal • Infectious Disease • Novel Coronavirus Disease

Serious Adverse Drug Reactions (sADRs) Involving Hematology and Resulting in Black Box Warnings or FDA Non-Approval: Results from the First Quarter Century of RADAR/Sonar (ASH 2024) - "Results : sADRs were frequently identified based on very small case series, including ticlopidine-and clopidogrel associated thrombotic thrombocytopenic purpura (22 and 10 patients, respectively), thalidomide- and lenalidomide-associated venous thromboembolism (9 and 5 patients, respectively), rituximab-associated progressive multi-focal leukoencephalopathy (22 patients), peginesatide-associated fatal anaphylaxis (5 patients), and COVID-19 vaccine associated immune thrombocytopenia (1 patient)...Time from FDA approval to sADR discovery was a median of 5 years (range, 0 months (thalidomide-associated venous thromboembolism) to 34 years (ciprofloxacin-associated neuropsychiatric toxicity)...Discussion : RADAR/SONAR has proven to be a very important adjunct to FDA and pharmaceutical manufacturer-led safety investigations for hematology, paralleling the success in medical oncology and in cardiology. Going forward, independent centers of excellence for safety-focused..."

Adverse drug reaction • Cardiovascular • CNS Disorders • Hematological Disorders • Immune Thrombocytopenic Purpura • Infectious Disease • Psychiatry • Thrombocytopenia • Thrombocytopenic Purpura • Venous Thromboembolism

Leveraging Canadian Health Care Worker Volunteers to Address COVID-19 Vaccine Misinformation on Facebook: Qualitative Program Evaluation Study. (PubMed, J Med Internet Res) - "The Informed Choice Project provided an opportunity to increase self-efficacy and confidence for more than a dozen health care professionals and students while engaging in vaccine-related conversations on social media. To enhance both participant satisfaction and compliance, future interventions should consider using a self-paced format, flexible hours, and highlight the vitality of health care professionals as key advocates for trusted sources of information for the public."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

The role of trust in engaging community-based task forces and agencies among minoritized communities during a public health emergency. (PubMed, Can J Public Health) - "Community leaders play an instrumental role in establishing and sustaining trust in vaccine promotion among community members. Trust established among community leaders and ambassadors enabled vaccine promotion efforts among minoritized communities. These findings may help to further strengthen community engagement for future public health emergency responses."

Journal • Infectious Disease • Novel Coronavirus Disease

Early mortality in patients with cancer and COVID-19 infection treated with immunotherapy. (PubMed, BMC Cancer) - "Immunotherapy does not seem to increase the risk of 30-day mortality in patients with COVID-19 infections compared to published outcomes of patients with cancer and COVID-19. Mortality was associated with certain clinical characteristics that need to be carefully examined when prescribing immunotherapy during future comparable pandemics."

Journal • Retrospective data • Infectious Disease • Lung Cancer • Novel Coronavirus Disease • Oncology • Solid Tumor

The Influence of Financial Incentives on Vaccination Hesitancy: A Narrative Review of Recent Research. (PubMed, Vaccines (Basel)) - "The effectiveness of financial incentives in boosting vaccination rates seems to differ significantly based on the region and context. They tend to be more effective in economically disadvantaged developing countries. In contrast, in developed nations, they may be ineffective or counterproductive due to various confounding factors such as financial background, lack of trust in the healthcare system, and/or lack of patient education. In resource-rich areas, educational programs often yield better results, and addressing widespread mistrust in healthcare systems and governmental policies through transparency is essential. Ultimately, employing tailored incentives alongside public education could enhance vaccination acceptance, particularly in culturally diverse countries like the United States, where understanding community preferences is crucial."

Journal • Review • Infectious Disease • Novel Coronavirus Disease

Vaccine Hesitancy in Black/African Americans With Rheumatic Diseases (clinicaltrials.gov) - P=N/A | N=60 | Active, not recruiting | Sponsor: Northwestern University | Recruiting ➔ Active, not recruiting

Enrollment closed • Infectious Disease • Inflammatory Arthritis • Novel Coronavirus Disease • Rheumatology

Vaccine Hesitancy in Black/African Americans with Rheumatic Diseases (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Northwestern University | Trial completion date: Jul 2027 ➔ Mar 2027

Trial completion date • Infectious Disease • Inflammatory Arthritis • Novel Coronavirus Disease • Rheumatology

Perspectives of primary care nurses on the organization of the COVID-19 vaccine rollout: a qualitative study. (PubMed, BMC Prim Care) - "Findings highlight the critical roles of primary care nurses in mass vaccination campaigns, underscoring the need for targeted information, effective training, streamlined coordination, better integration into primary care, and more equitable compensation. Integrating these services into primary care can enhance future vaccination efforts by leveraging nurses' expertise to improve vaccine access and delivery."

Journal • Infectious Disease • Novel Coronavirus Disease

SARS-CoV-2 seroprevalence and associated risk factors in adult outpatients from Western Romania, January to March 2023: a seroepidemiological assessment after three years of COVID-19 pandemic. (PubMed, Infect Dis (Lond)) - "The multivariate logistic regression analysis revealed that SARS-CoV-2 seroprevalence was associated with age, associated cancer disease, smoking status, number of COVID-19 vaccine doses received and number of previously diagnosed SARS-CoV-2 infections...After three years of COVID-19 pandemic, 9 in 10 Romanian adults were previously infected, before or after vaccination, with the highest rates of infection in unvaccinated individuals and the lowest among vaccinated persons with a booster. Our results confirm that vaccination remains a highly effective measure to prevent SARS-CoV-2 infection."

Journal • Infectious Disease • Novel Coronavirus Disease • Oncology • Respiratory Diseases

IPNA clinical practice recommendations on care of pediatric patients with pre-existing kidney disease during seasonal outbreak of COVID-19. (PubMed, Pediatr Nephrol) - "A notable observation is the potential correlation between COVID-19 vaccines and specific kidney disorders. However, establishing a direct causal link remains elusive. In summary, our research accentuates the critical need for specialized pediatric kidney care during global health crises and reaffirms the continuous research imperative, especially regarding vaccination ramifications."

Journal • Review • Infectious Disease • Nephrology • Novel Coronavirus Disease • Pediatrics • Renal Disease • Respiratory Diseases

Perceived Effectiveness of Public Health Unit Partnerships With Faith-Based and Other Community-Based Organizations to Promote COVID-19 Vaccination Among Ethnoracial Communities. (PubMed, Int J Public Health) - "Across Ontario, 23 (82.1%) respondent PHUs worked with FBOs during the COVID-19 vaccine rollout with activities ranging from informing FBOs of vaccine availability, to using places of worship as sites for vaccine administration and co-creating educational materials on immunization that were faith- and culturally sensitive. FBOs can be a valuable community partner as PHUs work to increase the reach and uptake of public health interventions. Ongoing monitoring and evaluation of the impact of FBO engagement on vaccine confidence and uptake among ethnoracial communities is needed to inform future community engaged vaccine programming in Ontario."

Journal • Licensing / partnership • Infectious Disease • Novel Coronavirus Disease

Facilitators and challenges in collaboration between public health units and faith-based organizations to promote COVID-19 vaccine confidence in Ontario. (PubMed, Int J Equity Health) - "Engaging with faith-based communities is an ongoing process that requires time, flexibility, and patience, but it is necessary to improve vaccine confidence and equity access among population groups made structurally vulnerable. Lessons learned from this research can guide the implementation of future vaccination programs."

Journal • Infectious Disease • Novel Coronavirus Disease

Community-Engaged Curriculum Development Using Racial Justice and Biomedical Lenses to Address COVID-19 Vaccine Hesitancy in Black Individuals with Rheumatologic Conditions (ACR Convergence 2024) - "Strategies to reduce racial inequities in COVID-19 vaccine uptake must acknowledge the root causes of vaccination hesitancy and address nuanced concerns that drive vaccine avoidance amongst Black individuals. Longstanding community academic partnerships are essential to develop culturally relevant trial materials."

Clinical • Infectious Disease • Novel Coronavirus Disease • Preventive care • Rheumatology

Understanding COVID-19 vaccine hesitancy in Canada. (PubMed, Vaccine) - "Our findings demonstrate the necessity for a new framework to understand and address vaccine hesitancy. A better theoretical account of vaccine hesitancy has important implications for future vaccination efforts, specifically within the context of new variants and low booster vaccination rates in Canada."

Journal • Infectious Disease • Novel Coronavirus Disease

A Qualitative Analysis of the Functions of Primary Care Nurses in COVID-19 Vaccination. (PubMed, J Adv Nurs) - "This study addresses a knowledge gap by describing the vaccination-related roles of primary care nurses during the pandemic. Findings illustrate that nurses demonstrated adaptability through their engagement in vaccine education, administration, outreach and advocacy. This research informs resource allocation, policy development and workforce planning for future vaccination efforts during a pandemic response."

Journal • Infectious Disease • Novel Coronavirus Disease

Anti-PF4 positivity and platelet activation after Ad26.COV2·S vaccination in Brazil. (PubMed, Vaccine) - "Vaccination with Ad26.COV2·S vaccine led to a very low frequency of low-titer positive anti-PF4 antibodies, elevation of D-dimer, and mild thrombocytopenia, with no associated clinically relevant increase in thromboinflammatory markers and platelet activation."

Journal • Cardiovascular • Hematological Disorders • Infectious Disease • Novel Coronavirus Disease • Thrombocytopenia • Thrombocytopenic Purpura • Thrombosis

Weighing the risks and benefits: Parental perspectives on COVID-19 vaccines for 5- to 11-year-old children. (PubMed, Vaccine) - "Our results indicate that improved transparency on how evidence is developed and why recommendations and mandates shift during the pandemic would foster trust in the government and public health agencies. Open communication with health providers on the potential risks and benefits would also improve caregivers confidence in the vaccine."

Journal • Infectious Disease • Musculoskeletal Diseases • Novel Coronavirus Disease • Orthopedics

Predictors of COVID-19 vaccine acceptability among refugees and other migrant populations: A systematic scoping review. (PubMed, PLoS One) - "Vaccine hesitancy and a lack of trust in COVID-19 vaccines have become significant public health concerns within migrant populations. These findings may help in providing information for current and future vaccine outreach strategies among migrant populations."

Journal • Review • Infectious Disease • Novel Coronavirus Disease

COVID-19 vaccine uptake among Ontario physicians: a descriptive population-based retrospective cohort study. (PubMed, BMJ Open) - "In Ontario, within 14 months of COVID-19 vaccine availability, 86.8% of physicians had three doses of a COVID-19 vaccine, compared with 45.6% of the general population. Findings may signify physicians' confidence in the safety and effectiveness of COVID-19 vaccines."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

A qualitative examination of the experiences and perspectives of interprofessional primary health care teams in the distribution of the COVID-19 vaccination in Ontario, Canada. (PubMed, PLoS One) - "PHC teams were an instrumental component in supporting COVID-19 vaccinations in Ontario. The involvement of PHC in future vaccination efforts is key but requires additional resourcing and inclusion of PHC in decision-making. This will ensure provider well-being and maintain collaborations established during COVID-19 vaccination."

Journal • Infectious Disease • Novel Coronavirus Disease