X-376 / Betta Pharma - LARVOL DELTA

[VIRTUAL] Role of snoRNA-mediated ribosome modifications in resistance to TKI in lung cancer (EACR 2021) - "Material and Methods Cell pair of EML4-ALK H3122 parental (H3122-S) and resistant (H3122-R) to ALK inhibitors (crizotinib or X-376) was used to analyze snoRNA expression by RNA-seq and 2’Ome levels by RiboMETH-seq, a novel OMICs approach. Conclusion Several data suggest that snoRNA and ribosome chemical modification are involved in lung cancer resistance. Understanding contribution of snoRNA-mediated ribosome modification on translational reprogramming may offer new insights in lung cancer management."

Lung Cancer • Oncology • Solid Tumor • EML4

[VIRTUAL] Role of snoRNA-mediated ribosome modifications in resistance to TKI in lung cancer (EACR 2021) - "Material and Methods Cell pair of EML4-ALK H3122 parental (H3122-S) and resistant (H3122-R) to ALK inhibitors (crizotinib or X-376) was used to analyze snoRNA expression by RNA-seq and 2’Ome levels by RiboMETH-seq, a novel OMICs approach. Conclusion Several data suggest that snoRNA and ribosome chemical modification are involved in lung cancer resistance. Understanding contribution of snoRNA-mediated ribosome modification on translational reprogramming may offer new insights in lung cancer management."

Lung Cancer • Oncology • Solid Tumor • EML4

[VIRTUAL] Role of snoRNA-mediated ribosome modifications in resistance to TKI in lung cancer (EACR 2021) - "Material and Methods Cell pair of EML4-ALK H3122 parental (H3122-S) and resistant (H3122-R) to ALK inhibitors (crizotinib or X-376) was used to analyze snoRNA expression by RNA-seq and 2’Ome levels by RiboMETH-seq, a novel OMICs approach. Conclusion Several data suggest that snoRNA and ribosome chemical modification are involved in lung cancer resistance. Understanding contribution of snoRNA-mediated ribosome modification on translational reprogramming may offer new insights in lung cancer management."

Lung Cancer • Oncology • Solid Tumor • EML4

[VIRTUAL] Role of snoRNA-mediated ribosome modifications in resistance to TKI in lung cancer (EACR 2021) - "Material and Methods Cell pair of EML4-ALK H3122 parental (H3122-S) and resistant (H3122-R) to ALK inhibitors (crizotinib or X-376) was used to analyze snoRNA expression by RNA-seq and 2’Ome levels by RiboMETH-seq, a novel OMICs approach. Conclusion Several data suggest that snoRNA and ribosome chemical modification are involved in lung cancer resistance. Understanding contribution of snoRNA-mediated ribosome modification on translational reprogramming may offer new insights in lung cancer management."

Lung Cancer • Oncology • Solid Tumor • EML4

Parkinson’s Disease 6-OHDA model characterization using pharmacological MRI and MR spectroscopy in rats. (Neuroscience 2016) - "Lastly, phMRI was performed using spin-echo EPI with time resolution of 2 s and in-plane spatial resolution of 390x390 μm, 13 x 1.5 mm slices covering whole cerebrum. Taken together our data emphasizes high utility of non-invasive translatable functional magnetic resonance imaging and spectroscopy for PD research. Altered 1H-MRS metabolites profile, disrupted functional connectivity and responses to dopaminergic stimulation revealed by phMRI can serve as relevant targets for drug-testing and efficacy studies."

Biosimilar • Gene Therapies • Parkinson's Disease

Structure/Function Studies of the α4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses. (PubMed, Front Mol Neurosci) - "...The substitutions K59 and X390 were also present in the genome of an ancient Denisovan individual, indicating thathas been a pseudogene for at least 30,000-50,000 years...Using gene knockdown and a dominant-negative GlyR α4amutant, we found that GlyR α4a contributes to touch-evoked escape behaviors in zebrafish. Thus, although GlyR α4 is unlikely to be involved in human startle responses or disease states, this subtype may contribute to escape behaviors in other organisms."

Journal • Biosimilar • CNS Disorders • Ophthalmology • Pain