beta alethine (Ax-101) / AxImmune - LARVOL DELTA

[VIRTUAL] Ax-101, an immunostimulatory small molecule, markedly enhances the antitumor activity of PD1 immune checkpoint blockade in multiple preclinical solid tumor models (AACR 2021) - P1/2 | "Consistent with Ax-101 activity depending on a functional immune system, delayed type hypersensitivity (DTH) testing showed all responders to be DTH+ (5 tumor reduction, 4 SD); 5 anergic (DTH-) patients had SD at best (2 SD, 3 worse). Current Ax-101 clinical development will leverage its beneficial immunostimulatory properties to augment the efficacy of anti-PD1 inhibitors such as pembrolizumab, nivolumab and cemiplimab."

Checkpoint inhibition • Preclinical • Bladder Cancer • Follicular Lymphoma • Hematological Malignancies • Lymphoma • Melanoma • Multiple Myeloma • Oncology • Solid Tumor • IFNG • IL10 • IL2 • TNFA