tranexamic acid oral / Generic mfg. - LARVOL DELTA

Comparison of the antioxidant effect of Pycnogenol with other substances used in the treatment of melasma: a systematic review (AAD 2026) - "Descriptors included melasma, Pycnogenol, pine bark extract, antioxidants, oxidative stress, glutathione, vitamin C, tranexamic acid, and ferulic acid, combined with the boolean operator “AND.” Clinical, in vitro, in vivo, original studies, and reviews were included...Conclusions Pycnogenol appears promising as an adjuvant therapy for melasma, reducing lesion severity and improving quality of life. Evidence remains insufficient for standalone use, and it is best applied alongside topical depigmenting agents and photoprotection."

Review • Dermatology • Dermatopathology

Risk of Cardiovascular and Thromboembolic Events With Oral Tranexamic Acid for Melasma: A Retrospective Cohort Study (AAD 2026) - "Oral TXA use in women with melasma was not associated with increased cardiovascular or thromboembolic risk. These findings support its safety in this population, although clinical caution is still warranted."

Retrospective data • Cardiovascular • Dermatology • Dermatopathology • Hematological Disorders • Myocardial Infarction • Pulmonary Embolism • Respiratory Diseases

Integrated Approaches for Melasma Treatment: A Systematic Review (AAD 2026) - "Integrating chemical peels and drug delivery, particularly tranexamic acid, consistently augmented outcomes... Integrated approaches offer superior efficacy and patient satisfaction for melasma versus monotherapies. Careful modality selection, customized protocols, strict photoprotection, and practitioner expertise are crucial for optimizing results and reducing adverse events, especially in ethnic skin."

Review • Aesthetic Medicine • Dermatology • Dermatopathology

Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty (clinicaltrials.gov) - P=N/A | N=350 | Not yet recruiting | Sponsor: NYU Langone Health

New trial • Orthopedics • Pain • Rheumatology

Perioperative Tranexamic Acid Reduces Bleeding and Wound Complications in Post-Bariatric Abdominoplasty: A Retrospective Cohort Study. (PubMed, Life (Basel)) - "Hemoglobin changes, seroma, and infection rates were similar between groups. Perioperative TXA use in post-bariatric abdominoplasty is associated with significantly fewer bleeding-related and wound complications without increased adverse effects, supporting its use in this high-risk population."

Journal • Retrospective data • Aesthetic Medicine • Infectious Disease

Tranexamic Acid for The Treatment of Gastrointestinal Bleeding (clinicaltrials.gov) - P=N/A | N=48 | Completed | Sponsor: Indonesia University | Suspended ➔ Completed | N=336 ➔ 48

Enrollment change • Trial completion • Gastroenterology

Therapeutic Effects of Single and Combined Anti-Disseminated Intravascular Coagulation (DIC) Drugs in a Rat Venom-Induced Consumption Coagulopathy (VICC) Model Using Yamakagashi (Rhabdophis tigrinus) Venom. (PubMed, Toxins (Basel)) - "However, combined administration of recombinant thrombomodulin α and tranexamic acid extended rat survival and partially restored blood coagulation markers. Therefore, the combination of recombinant thrombomodulin α and tranexamic acid might represent a useful therapeutic regimen for yamakagashi venom exposure."

Journal • Preclinical • Hematological Disorders

Tranexamic Acid-Associated Hyaluronic Acid Exhibits Enhanced Oxidative Stability: A Comparative Rheological Study. (PubMed, Biomolecules) - " The association of TXA with HA confers a marked protection against oxidative-induced viscoelastic degradation, preserving macromolecular network integrity and elastic behavior. These findings suggest that TXA modulates oxidative stress-related rheological failure of HA through mechanisms distinct from chemical cross-linking."

Clinical • Journal • Immunology • Osteoarthritis • Pain • Rheumatology • Seronegative Spondyloarthropathies

Efficacy of Intra-Articular Tranexamic Acid in Reducing Early Postoperative Swelling and Pain Following Arthroscopic ACL Reconstruction: A Randomized Comparative Study. (PubMed, J Knee Surg) - "No adverse events were reported in either group.Intra-articular TXA significantly improves early postoperative outcomes in arthroscopic ACL reconstruction by reducing pain, swelling, and wound soakage. TXA is safe and may be considered a part of enhanced recovery protocols in ACL surgery."

Journal • Orthopedics • Osteoarthritis • Pain

Investigating the Influence of Tranexamic Acid on Adipocyte Differentiation in an In Vitro Model. (PubMed, Ann Plast Surg) - "Clinically relevant concentrations of TXA do not impair adipose progenitor cell viability, proliferation, adipogenic differentiation, or thermogenic responsiveness in vitro. These findings support the cellular safety of TXA use in liposuction and fat grafting and provide reassurance as adoption of TXA continues to expand in plastic and reconstructive surgery."

Journal • Preclinical • Aesthetic Medicine • FABP4

Epidemiology, clinical characteristics, and treatment patterns in patients with Von Willebrand disease: retrospective data from an Austrian tertiary care center (OeGHO-AHOP 2026) - "On-demand hemostatic therapy was given in 76.9%: desmopressin (33.0%), tranexamic acid (22.9%), and VWF concentrates (27.0%). VWD patients treated at our center were predominantly female and of blood group O. Bleeding was more frequent in type 2 VWD. Prophylactic therapy significantly reduced postoperative bleeding, underscoring the benefit of targeted hemostatic management in clinical practice."

Retrospective data • Hematological Disorders • Hemophilia

Myoclonus associated with tranexamic acid administration in a patient on veno-arterial extracorporeal membrane oxygenation support: A case report. (PubMed, World J Crit Care Med) - "This case highlights a rare neurological complication associated with TXA overdose, occurring in patient with VA-ECMO and CRRT. Clinicians should remain vigilant for such adverse effects in this context."

Journal • Cardiovascular • CNS Disorders • Critical care • Epilepsy • Heart Failure • Movement Disorders • Myocardial Infarction

Multimodal Approach for Recalcitrant Melasma Using Picosecond Laser and Topical JAK Inhibition: A Case Report. (PubMed, J Cosmet Dermatol) - "This case illustrates the potential clinical value of combining pigment-targeted picosecond laser therapy with topical JAK inhibition and visible light-specific photoprotection for recalcitrant melasma. The durable remission achieved supports further investigation into anti-inflammatory and photoreactive pathway modulation as adjunctive strategies in melasma management."

Journal • Aesthetic Medicine • Dermatology • Dermatopathology • Inflammation

Critical care in hematopoietic stem cell transplantation: Common complications and management. (PubMed, World J Crit Care Med) - "Novel therapeutic approaches show promise, including inhaled tranexamic acid protocols for diffuse alveolar hemorrhage showing promising hemostasis rates in cohort studies, though randomized controlled trial data are lacking...Post-transplant cyclophosphamide reduces acute GVHD incidence, while complement inhibition improves outcomes in transplant-associated thrombotic. Early recognition using validated scoring systems and integration of standard ICU protocols with specialized HSCT expertise are essential for optimizing outcomes. Despite advances, significant knowledge gaps remain regarding optimal management strategies for many complications, with most evidence derived from retrospective cohort studies."

Journal • Review • Acute Graft versus Host Disease • Acute Respiratory Distress Syndrome • Bone Marrow Transplantation • Critical care • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Transplantation • Transplantation Associated Thrombotic Microangiopathy

IMPACT OF CLINICAL FACTORS AND HEMOSTATIC AGENTS ON BLEEDING RISK IN KIDNEY BIOPSY: A SCORING MODEL TO GUIDE MINIMAL HOSPITALIZATION (ISN-WCN 2026) - "Carbazochrome sulfonate (OR, 0.69; 95% CI, 0.58–0.85) and its combination with tranexamic acid (OR, 0.79; 95% CI, 0.69–0.90) were associated with reduced bleeding risk, particularly in the subgroup population with proteinuria or nephrotic syndrome...Hemostatic agents, especially carbazochrome-based regimens, may reduce the bleeding risk. K-BIT score offers safe short-stay PKB and substantial resource savings."

Biopsy • Clinical • Acute Kidney Injury • ANCA Vasculitis • Glomerulonephritis • Lupus Nephritis • Nephrology • Renal Disease • Vasculitis

Severe bleeding diathesis after dental extractions: a complex case of coagulation disturbances in a patient with multiple myeloma. (PubMed, Einstein (Sao Paulo)) - "Despite the risk of thrombosis, low-dose tranexamic acid was initiated, resulting in effective hemorrhage control and improved healing of the alveolar sockets. This case illustrates the complex hemostatic imbalance between pro- and anticoagulant factors in a patient with multiple myeloma. It also underscores the diagnostic and therapeutic challenges associated with managing bleeding in patients with a high risk of thrombosis."

Journal • Cardiovascular • Hematological Disorders • Hematological Malignancies • Multiple Myeloma • Oncology • Thrombosis

Use of Tranexamic Acid in Laparoscopic Myomectomy: AAGL Committee Opinion and Practice Guideline Update. (PubMed, J Minim Invasive Gynecol) - No abstract available

Clinical guideline • Journal

Tibial Lengthening with a Motorized Intramedullary Lengthening Nail. (PubMed, JBJS Essent Surg Tech) - "Establish the LLD before surgery, then rely on the machine to determine the length achieved; do not second-guess the machine during lengthening.Correct or prevent rotational, coronal, and sagittal deformity at the time of the MILN insertion surgery.Prioritize safety (i.e., with a percutaneous technique, fasciotomy, and tranexamic acid) to optimize outcomes (i.e., avoidance of complications and achievement of the desired length).Ensure patient compliance with weight-bearing limitations and stretching exercises.Limit weight-bearing until at least 3 cortices have full bridging.MILN removal is recommended after full union is achieved, typically approximately 1 year postoperatively. LLD = limb-length discrepancyMILN = motorized internal lengthening nailPT = physical therapyIM = intramedullary."

Journal • Infectious Disease • Movement Disorders • Musculoskeletal Diseases • Orthopedics • Pain

Diagnostic Evaluation and Therapeutic Approach to Management of Acute Heavy Menstrual Bleeding in Adolescents Utilizing a Clinical Practice Pathway and Comparison of Response by BMI: A 5-Year Retrospective Cohort Study in a Children' Hospital. (PubMed, J Pediatr Adolesc Gynecol) - "While menstrual characteristics and laboratory evaluation varied slightly by BMI, management and treatment outcomes did not."

Journal • Retrospective data • Genetic Disorders

Combined N-acetylcysteine and tranexamic acid attenuate acidosis and fibrinolysis in a swine polytrauma model. (PubMed, J Trauma Acute Care Surg) - "In this swine polytrauma model, the combined administration of NAC and TXA was associated with improved in acid-base status and attenuation of fibrinolysis. While these physiological effects are preliminary, they support additional experimental investigations to clarify mechanisms, reproducibility, and potential translational relevance of NAC+TXA as an adjunct in damage control resuscitation. (J Trauma Acute Care Surg. 2026;00:00-00."

Journal • Hematological Disorders • Hepatology • Liver Failure • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics

Managing heavy menstrual bleeding in adolescents with bleeding disorders: Outcomes from a pragmatic LMIC approach. (PubMed, Blood Cells Mol Dis) - "A low-cost regimen combining progesterone, antifibrinolytic therapy, and iron effectively controls HMB, corrects anemia, reduces transfusion and factor utilization, and improves QOL in adolescents with bleeding disorders in resource-constrained settings."

Journal • Aplastic Anemia • Hematological Disorders • Hemophilia • Immune Thrombocytopenic Purpura • Rare Diseases • Thrombocytopenia • Thrombocytopenic Purpura

Predictors of Infection After Cesarean Delivery. (PubMed, Am J Perinatol) - "Multiple modifiable and non-modifiable factors influence infection after cesarean delivery. This predictive model offers a framework for assessing individualized risk, though its modest performance indicates that further refinement is necessary before it can be confidently applied in clinical decision-making. Future research should aim to enhance predictive accuracy and explore whether risk stratification meaningfully informs prevention or patient counseling strategies."

Journal • Endometriosis • Hematological Disorders • Infectious Disease • Postpartum Hemorrhage

Impact of Inhaled Tranexamic Acid in Pulmonary Hemorrhage in Pediatric Intensive Care Unit (clinicaltrials.gov) - P=N/A | N=100 | Completed | Sponsor: Tanta University

New trial • Critical care • Hematological Disorders • Pediatrics

Tranexamic acid on risks of rebleeding in acute variceal bleeding: a retrospective cohort study on local data in Hong Kong (APASL 2026) - No abstract available

Retrospective data

A Review of Post-Inflammatory Pigmentation Changes: Pathophysiology, Diagnosis and Treatment. (PubMed, J Cutan Med Surg) - "Photoprotection is the cornerstone of PIH management given the photosensitive nature of the condition and is recommended in tandem with other treatment options including topical agents (eg, hydroquinone, retinoids, tranexamic acid), light/laser-based therapies, or chemical peels (glycolic acid and salicylic acid). Despite their use, high-level clinical evidence for these treatment options in PIH remains limited. This review provides an up-to-date overview of PIH pathophysiology, diagnosis and differential diagnosis, and management, and offers expert clinical commentary on practical strategies for identifying, preventing, and managing PIH in routine practice."

Journal • Review • Acne Vulgaris • Aesthetic Medicine • Atopic Dermatitis • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Inflammation • Psoriasis • Thermal Injury