tranexamic acid oral / Generic mfg. - LARVOL DELTA

Comparing the Efficiency of Microneedling and Tranexamic Acid Versus Microneedling and Vitamin C in the Treatment of Infraorbital Hyperpigmentation. (PubMed, Adv Biomed Res) - "The patients' consent showed no considerable difference between the two sides. Unfavorable incidents were non-permanent, with no dramatic diversity between both sides except for burning that lasted longer with microneedling and vitamin C. Both tranexamic acid and vitamin C, in combination with microneedling, appear to be impressive modalities for the management of infraorbital hyperpigmentation with no remarkable side effects."

Clinical • Journal

EVALUATING SAFETY AND OUTCOMES OF ONE-WEEK PEDICLE DIVISION IN PARAMEDIAN FOREHEAD FLAP REPAIRS: A SINGLE-CENTER RETROSPECTIVE STUDY (WRMC 2026) - "Intraoperative tranexamic acid use was more common in early cases (P3 weeks (n = 99)."

Retrospective data • Aesthetic Medicine • Infectious Disease • Otorhinolaryngology

BAR-TAX - Tranexamic Acid in Bariatric Surgery. (clinicaltrials.gov) - P=N/A | N=1000 | Active, not recruiting | Sponsor: Santa Maria Hospital - GVM Care & Research

New trial

Effectiveness of Medical Management in Heavy Menstrual Bleeding: A Prospective Cohort Study. (PubMed, Cureus) - "Medical management of HMB was effective in reducing menstrual blood loss and improving hemoglobin levels. LNG-IUS offered the most significant benefit with high compliance, but treatment choice should be individualized based on patient needs and clinical profile."

Journal • Women's Health

Lack of Fibrinolysis May Explain Tranexamic Acid's Lack of Efficacy in Reducing Hematoma Expansion (ISC 2026) - "Thus, tranexamic acid seems unlikely to have a biologically plausible mechanism to reduce hematoma expansion and improve patient outcomes. These results suggest that alternative therapeutic mechanisms, such as agents promoting coagulation cascade activation, may be more effective in preventing hematoma expansion in ICH patients."

Clinical • Cardiovascular • Cerebral Hemorrhage • Hematological Disorders • Mood Disorders

Comparative Efficacy of Interventions for Supratentorial Stroke: A Bayesian NMA with Meta-Regression (ISC 2026) - "Pharmacologic options (e.g., tranexamic acid, atorvastatin, cerebrolysin) showed no significant benefit for mortality or function compared with standard care. For acute supratentorial ICH, surgical approaches—especially minimally invasive endoscopic evacuation—yield superior 6-month survival and functional outcomes compared with medical therapy alone. Conventional craniotomy confers a moderate survival advantage. Pharmacologic adjuncts did not improve hard outcomes in this network."

Clinical • Cardiovascular

Patient blood management and surgery: Impact of new surgical techniques on transfusion needs. (PubMed, Vox Sang) - "These innovations have significantly reduced the need for transfusion in surgical practice. They enhance patient safety by minimizing bleeding and transfusion-related risks."

Journal • Review • Anesthesia • Hematological Disorders

A Retrospective Study of Bloodless Administration of Cellular Therapy in a Community Medical Center in an Outpatient and Inpatient setting: Patient Characteristics and Outcomes (TCT-ASTCT-CIBMTR 2026) - "Tranexamic acid, romiplostim and Epoetin alfa-epbx support are allowed. In this retrospective cohort of patients receiving ASCT or CarT under a bloodless therapy protocol, we have seen excellent cell recovery, toxicity, and 30-day mortality outcomes in both BL-ASCT and BL-CarT recipients. There is a trend for increased hospitalization in BLCT, largely due to inpatient administration of product and monitoring. We suggest that patients who cannot receive blood products should be considered for BL-ASCT or BL-CarT."

Retrospective data • Hematological Malignancies • Infectious Disease

Risk-stratified perioperative tranexamic acid utilization for total hip and knee arthroplasty: Analysis of trends of the past decade. (PubMed, Bull Hosp Jt Dis (2013)) - "Despite the rapid growth in TXA utilization over the past decade in THA and TKA, patients at high risk of VTE and ischemia are still less likely to receive perioperative TXA."

Journal • Cardiovascular • Myocardial Infarction • Orthopedics • Pain • Venous Thromboembolism

Statement of Retraction: The effect of prophylactic oral tranexamic acid plus buccal misoprostol on blood loss after vaginal delivery: a randomized controlled trial. (PubMed, J Matern Fetal Neonatal Med) - No abstract available

Journal

Reply to Editorial Comment on "Tranexamic acid for the management of hematuria: A systematic review". (PubMed, Urology) - No abstract available

Journal

Safety and Efficacy of Tranexamic Acid in Hepatic Surgery: Systematic Review and Meta-Analysis of Randomized Controlled Trials. (PubMed, J Surg Oncol) - "Interpretation of these findings is limited by substantial heterogeneity among included studies (I² = 82%). While TXA appears effective in reducing intraoperative bleeding, its use may confer a higher risk of postoperative thromboembolic complications, suggesting that TXA administration during hepatic resection should be selective and individualized rather than routine."

Journal • Retrospective data • Review • Cardiovascular

Response to Letter: "The Great Tranexamic Acid Debate, In Reply to: Tranexamic Acid in Rhytidectomy: A Split-Face Multi-Institutional Study". (PubMed, Facial Plast Surg Aesthet Med) - No abstract available

Clinical • Journal • Aesthetic Medicine

Letter: The Great Tranexamic Acid Debate, In Reply to: "Tranexamic Acid in Rhytidectomy: A Split-Face Multi-Institutional Study" by Klimczak et al. (PubMed, Facial Plast Surg Aesthet Med) - No abstract available

Clinical • Journal • Aesthetic Medicine

In Vitro, Ex Vivo and Clinical Trial of Brightening Serum Using a Novel Delivery System on Subjects With Moderate to Severe Dyschromia. (PubMed, J Cosmet Dermatol) - "The multiple active ingredients in CBS-TRV target melanogenesis in a variety of ways, and both in vitro and clinical studies demonstrated significant improvements in skin tone and pigmentation."

Clinical • Journal • Preclinical • Dermatitis • Dermatology • Inflammation

Prophylactic Tranexamic Acid in Low-Risk Repeat Cesarean Delivery: A Randomized Controlled Trial (clinicaltrials.gov) - P=N/A | N=204 | Not yet recruiting | Sponsor: Ege University

New trial

Guideline on the emergency management of critical bleeding in patients with immune thrombocytopenia. (PubMed, Blood Adv) - "Motivated by the life-threatening nature of the condition, the panel made strong recommendations for the combined use of high-dose corticosteroids, high-dose IVIG, platelet transfusions, tranexamic acid, and TPO-RAs for the emergency management of adults and children with a critical ITP bleed."

Journal • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Immune Thrombocytopenic Purpura • Pediatrics • Thrombocytopenia • Thrombocytopenic Purpura • Thrombosis

Allogeneic blood transfusion after hip fracture: risk factors and associated outcomes. (PubMed, Bull Hosp Jt Dis (2013)) - "Surgeons should be cognizant of transfusion risk factors such as repair with long cephalomedullary nail and poorer matched outcomes correlated with patients receiving transfusions."

Journal • Retrospective data • Hematological Disorders • Musculoskeletal Diseases • Orthopedics

Tranexamic Acid Associated With Reduced Postoperative Transfusion Rates in Hip Fracture Surgery: A Retrospective Study. (PubMed, Cureus) - "Conclusion Administering intraoperative TXA is associated with reduced postoperative transfusion rates and improved postoperative haemoglobin levels in hip fracture patients, while not increasing VTE events. Further research in this field should focus on determining an ideal dose, mode of delivery, and timing of TXA administration to optimise its efficacy."

Journal • Retrospective data • Anesthesia • Cardiovascular • Hematological Disorders • Musculoskeletal Diseases • Orthopedics • Respiratory Diseases • Venous Thromboembolism

Tranexamic acid bolus plus drip paradoxically increases complement activation: A PATCH trial secondary study. (PubMed, J Trauma Acute Care Surg) - "A 1 g bolus plus 1 g drip of TXA paradoxically increased complement activation at 24 hours in the TXA group. These findings support that TXA is essential in the inflammatory pathway after trauma. The delayed increase in complement may reflect the timing of TXA dosing and the shift to urokinase as the main plasminogen activator at later time points after injury. These results raise important questions about the optimal dosing of TXA in trauma patients."

Journal • Hematological Disorders

Availability, cost, and budget impact of lifesaving postpartum hemorrhage interventions in public hospitals in Zambia: A cross-sectional survey. (PubMed, Int J Gynaecol Obstet) - "While oxytocin is universally available, access to critical treatments such as TXA and advanced interventions remains limited. The low cost of preventive interventions contrasts with the high cost of managing severe PPH, which is exacerbated by system fragmentation. Strengthening primary-level facilities with essential commodities, surgical capacity, and training is critical to containing costs and reducing maternal mortality due to PPH."

HEOR • Journal • Hematological Disorders • Postpartum Hemorrhage

Hereditary hemorrhagic telangiectasia patient with pulmonary arteriovenous malformation: A case report. (PubMed, Medicine (Baltimore)) - "HHT should be suspected in patients presenting with recurrent bleeding at multiple sites. Genetic testing is essential for confirming the diagnosis, while a combination of endoscopic, interventional, and antiangiogenic therapies plays a crucial role in management. Despite these treatments, controlling bleeding remains challenging, highlighting the importance of individualized, multidisciplinary care."

Journal • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Hematological Disorders • Nephrology • Pulmonary Embolism • Renal Disease • ENG

Postoperative Oral Tranexamic Acid in Patients Undergoing Primary Total Joint Arthroplasty (clinicaltrials.gov) - P4 | N=101 | Not yet recruiting | Sponsor: Mayo Clinic | Initiation date: Dec 2025 ➔ Jun 2026

Trial initiation date • Orthopedics

TRAPP- Protocol for Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa. (PubMed, Matern Fetal Med) - P3 | "This large-scale, adequately powered, multicenter randomized placebo-controlled trial is designed to determine whether the routine prophylactic use of tranexamic acid during cesarean delivery in patients with placenta previa will offer clinical benefits that outweigh the associated risks. ClinicalTrials.gov NCT05811676 (March 15, 2023)."

Clinical • Journal • Hematological Disorders • Postpartum Hemorrhage

The Impact of Local Tranexamic Acid Infiltration on Periorbital Ecchymosis and Edema in Rhinoplasty: A Triple-Blinded Randomized Controlled Trial. (PubMed, Aesthet Surg J Open Forum) - "Participants were randomly allocated to receive either local infiltration consisting of TXA (1 mg/mL) combined with lidocaine and epinephrine (n = 40) or a control solution containing identical components, except TXA (n = 40). The local infiltration of TXA did not lead to a statistically significant reduction in periorbital edema, ecchymosis, or intraoperative bleeding among rhinoplasty patients compared with a placebo. These findings suggest that local infiltration may not provide the same benefits in rhinoplasty procedures as those documented with systemic administration routes."

Journal • Aesthetic Medicine